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  1. Article ; Online: Development of a focal lesion phantom with clinically relevant lesion characteristics for image quality evaluation of breast ultrasound scanners.

    Browne, J E / Cannon, L M / Fagan, A J / Cournane, S

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2022  Volume 94, Page(s) 65–74

    Abstract: Purpose: Contrast-detail (C-D) and anechoic-target (A-T) detectability are measures of an ultrasound scanner's ability to image lesions of varying contrast and size from background tissue and, as such, they are important tools for grading the imaging ... ...

    Abstract Purpose: Contrast-detail (C-D) and anechoic-target (A-T) detectability are measures of an ultrasound scanner's ability to image lesions of varying contrast and size from background tissue and, as such, they are important tools for grading the imaging capabilities of ultrasound scanners. The objective of this study was to develop a range of contrast- and anechoic-detail phantoms with clinically relevant lesions, of various contrast and sizes, for performance testing of breast ultrasound equipment.
    Methods: Tissue mimicking materials that represent the acoustic properties of breast fibroglandular tissue were produced and moulded to construct a range of C-D and A-T phantoms. Two phantom designs were produced, containing cylindrical and spherical targets. Both phantom types were constructed with contrast targets covering the range anechoic, -1, -2, -3 and -4 dB, with lesion diameters of 1-4 mm, positioned at four clinically relevant depths (10, 25, 40 and 55 mm). An image analysis program was developed to objectively analyse the lesion images and to determine the lesion-signal-noise-ratio (LSNR).
    Results: Both phantoms were used to evaluate the performance of a breast ultrasound scanner. The use of cylindrical phantoms led to an artificially higher image quality performance compared with the more clinically relevant spherical lesion phantom, thus indicating the importance of using the appropriate targets in ultrasound phantoms.
    Conclusion: The spherical lesion phantoms, coupled with the quantitative metric of LSNR, provides a comprehensive approach for performance and quality control testing, as well as the evaluation of advanced ultrasound imaging modes and technologies.
    MeSH term(s) Image Processing, Computer-Assisted ; Phantoms, Imaging ; Ultrasonography
    Language English
    Publishing date 2022-01-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2021.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Outcome prediction model for very elderly critically ill patients.

    Nierman, D M / Schechter, C B / Cannon, L M / Meier, D E

    Critical care medicine

    2001  Volume 29, Issue 10, Page(s) 1853–1859

    Abstract: Context: Very elderly critically ill patients have three possible hospital outcomes: discharge to home, discharge to a skilled nursing or rehabilitation facility, or death. The factors associated with these outcomes are unknown.: Objective: To ... ...

    Abstract Context: Very elderly critically ill patients have three possible hospital outcomes: discharge to home, discharge to a skilled nursing or rehabilitation facility, or death. The factors associated with these outcomes are unknown.
    Objective: To develop a three-outcome prediction model for very elderly critically ill patients.
    Design: Retrospective chart abstraction with ordered logistic regression analysis.
    Setting: Academic medical center.
    Patients: Four hundred and fifty-five patients 85 yrs or older admitted to intensive care units (ICU) during 1996 and 1997.
    Measurements and main results: A fitted ordinal logistic regression predictive model was developed using data from 243 patients hospitalized in 1996, and validated on data from 212 patients hospitalized in 1997. Model variables include age, gender, baseline support level, type of ICU, heart rate at ICU admission, use of mechanical ventilation, vasopressors or a pulmonary artery catheter during the ICU stay, and the development of respiratory, neurologic or hematologic failure or sepsis while in the ICU. When tested on the 1997 data, the model was well calibrated and had a high discriminant index.
    Conclusions: This mathematical model can be used to predict the risks of these three hospital outcomes for this population of patients. These predictions can provide a context when discussing goals and expectations with patients, families, and other healthcare providers and to aid in hospital discharge planning.
    MeSH term(s) Academic Medical Centers ; Aged ; Aged, 80 and over ; Cohort Studies ; Critical Care/methods ; Critical Illness/mortality ; Critical Illness/therapy ; Female ; Follow-Up Studies ; Hospital Mortality/trends ; Humans ; Intensive Care Units ; Length of Stay ; Logistic Models ; Male ; New York City/epidemiology ; Outcome Assessment (Health Care) ; Patient Discharge/statistics & numerical data ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2001-10
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/00003246-200110000-00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acute tumor lysis syndrome complicating fludarabine treatment of prolymphocytic leukemia.

    Cannon, L M / Spilove, L / Rhodes, R / Garfinkel, H / Pezzimenti, J

    Connecticut medicine

    1993  Volume 57, Issue 10, Page(s) 651–654

    Abstract: Tumor lysis syndrome rarely occurs during chemotherapy treatment of indolent lymphoid tumors. This report describes for the first time a case of acute tumor lysis syndrome complicating fludarabine treatment of prolymphocytic leukemia. In this particular ... ...

    Abstract Tumor lysis syndrome rarely occurs during chemotherapy treatment of indolent lymphoid tumors. This report describes for the first time a case of acute tumor lysis syndrome complicating fludarabine treatment of prolymphocytic leukemia. In this particular case the patient had an unexpectedly rapid response to fludarabine 15 days after initiation of the first chemotherapy cycle, which was subsequently complicated by the development of tumor lysis syndrome. Until more data are known concerning fludarabine treatment of prolymphocytic leukemia, cautious monitoring of patients treated with fludarabine should be undertaken, even after completion of the chemotherapy course.
    MeSH term(s) Acute Disease ; Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Fatal Outcome ; Female ; Humans ; Leukemia, Prolymphocytic/drug therapy ; Leukemia, Prolymphocytic/physiopathology ; Tumor Lysis Syndrome/etiology ; Tumor Lysis Syndrome/physiopathology ; Vidarabine/adverse effects ; Vidarabine/analogs & derivatives ; Vidarabine/therapeutic use
    Chemical Substances Antineoplastic Agents ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 1993-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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