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  1. Article ; Online: Atypical Course of a Patient With AIP-Positive Acromegaly: From GH Excess to GH Deficiency and Back to GH Excess.

    García-de-la-Torre, Keren-Sandyn / Kerbel, Jacobo / Cano-Zaragoza, Amayrani / Mercado, Moisés

    JCEM case reports

    2023  Volume 1, Issue 2, Page(s) luad034

    Abstract: Acromegaly/giantism results from the chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1), in more than 96% of cases, due to a GH-secreting pituitary adenoma. Primary treatment of choice is transsphenoidal resection of the ... ...

    Abstract Acromegaly/giantism results from the chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1), in more than 96% of cases, due to a GH-secreting pituitary adenoma. Primary treatment of choice is transsphenoidal resection of the adenoma. More than 30% to 40% of operated cases require adjunctive forms of treatment, be it pharmacological or radiotherapeutical. The multimodal treatment of acromegaly has resulted in substantial improvements in the quality of life and life expectancy of these patients. We herein present the complex case of a patient with acromegaly due to a mammosomatotrope adenoma, with a germ-line AIP (aryl hydrocarbon receptor-interacting protein) mutation, who had a chronic and protracted course of more than 15 years during which he was treated with surgery, somatostatin receptor ligands, dopamine agonist, and the GH receptor antagonist pegvisomant. At one point, he was able to come off medications and was even found to be transiently GH-deficient, only to develop acromegaly again after a couple of years.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Real World Data on the Epidemiology, Diagnosis, and Treatment of Acromegaly: A Registries-based Approach.

    Kerbel, Jacobo / Cano-Zaragoza, Amayrani / Espinosa-Dorado, Rodrigo / García de la Torre, Keren-Enid / Mercado, Moisés

    Archives of medical research

    2023  Volume 54, Issue 6, Page(s) 102856

    Abstract: Introduction: Despite the inherent heterogeneity of the information derived from national registries, they are a useful tool to investigate the epidemiological, clinical, biochemical and treatment outcome characteristics of low prevalence conditions ... ...

    Abstract Introduction: Despite the inherent heterogeneity of the information derived from national registries, they are a useful tool to investigate the epidemiological, clinical, biochemical and treatment outcome characteristics of low prevalence conditions such as acromegaly. Although the information provided by single-center experiences is more homogeneous, these studies usually comprise a limited number of patients and thus, frequently lack statistical power.
    Areas covered: Registry-based Information regarding the epidemiology, clinical presentation, biochemical and imaging diagnosis, as well as therapeutic outcome and mortality in acromegaly is critically analyzed.
    Expert opinion: By gathering data from multiple centers in a specific Country, these registries generate important insights into the real-life behavior of this condition, that should be considered, both, in international consensus meetings and in the design of local, Country-specific diagnostic and therapeutic strategies.
    MeSH term(s) Humans ; Acromegaly/diagnosis ; Acromegaly/epidemiology ; Acromegaly/therapy ; Human Growth Hormone/therapeutic use ; Adenoma/diagnosis ; Adenoma/drug therapy ; Somatostatin/therapeutic use ; Treatment Outcome ; Registries ; Insulin-Like Growth Factor I ; Pituitary Neoplasms/drug therapy
    Chemical Substances Human Growth Hormone (12629-01-5) ; Somatostatin (51110-01-1) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2023.102856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mesenchymal stem cells induce an immunosuppressive microenvironment in pituitary tumors.

    Marrero-Rodriguez, Daniel / Cortes-Morales, Victor A / Cano-Zaragoza, Amayrani / Martinez-Mendoza, Florencia / Kerbel-Suton, Jacobo / Vela-Patiño, Sandra / Chavez-Santoscoy, Alejandra / Hinojosa-Alvarez, Silvia / Hernandez-Perez, Jesus / Gomez-Apo, Erick / Fajardo-Orduña, Guadalupe R / Taniguchi-Ponciano, Keiko / Montesinos, Juan Jose / Mercado, Moises

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Background: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been isolated from different tumors and they favor tumor cell growth, however, their role in ... ...

    Abstract Background: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been isolated from different tumors and they favor tumor cell growth, however, their role in pituitary tumors (PT) remains unknown. Herein we report the presence of MSCs in 2 ACTH-secreting PT causing Cushing disease (MCU), 2 nonfunctioning adenomas of gonadotrope differentiation (MNF) and 2 non tumoral pituitary glands (MS).
    Methods: We have analyzed their transcriptomic profiles by RNAseq and compared MSC in terms of their immunosuppressive effects against lymphoid T cell and macrophage populations by means of co-cultures and flow cytometry.
    Results: Our transcriptomic analysis revealed molecular differences between MSC derived from non-tumoral pituitaries and MSC derived from PT. Two distinct subpopulations of MSC, one displaying immunosuppressive properties and the other with increased pro-proliferative capabilities, regardless of their origin. MSC derived from ACTH- and nonfunctioning PT, but not those derived from non-tumoral glands significantly inhibited the proliferation of activated T cells, favored the generation of Tregs and promote M2 macrophage polarization. Such immunosuppressive effects were correlated with an upregulation of programmed death ligand 1 and intracellular expression of macrophage colony stimulating factor (M-CSF) and IL-10. Importantly, MSC derived from ACTH-PT showed a higher immunosuppressive potential than MSC isolated from nonfunctioning tumors.
    Conclusion: This study demonstrates the presence of at least two MSC subpopulations in the pituitary gland and suggests that immunosuppressive effects of MSC may have important implications in PT growth.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors.

    Marrero-Rodríguez, Daniel / Vela-Patiño, Sandra / Martinez-Mendoza, Florencia / Valenzuela-Perez, Alejandra / Peña-Martínez, Eduardo / Cano-Zaragoza, Amayrani / Kerbel, Jacobo / Andonegui-Elguera, Sergio / Glick-Betech, Shimon S / Hermoso-Mier, Karla X / Mercado-Medrez, Sophia / Moscona-Nissan, Alberto / Taniguchi-Ponciano, Keiko / Mercado, Moises

    Archives of medical research

    2023  Volume 54, Issue 8, Page(s) 102915

    Abstract: Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing ... ...

    Abstract Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing acromegaly-gigantism; ACTH-secreting corticotrophinomas causing Cushing disease (CD); and the rare TSH-secreting thyrotrophinomas that result in central hyperthyroidism. Nonfunctioning PT do not result in a hormonal hypersecretion syndrome and most of them are of gonadotrope differentiation; other non-functioning PT include null cell adenomas and silent ACTH-, GH- and PRL-adenomas. Less than 5% of PT occur in a familial or syndromic context whereby germline mutations of specific genes account for their molecular pathogenesis. In contrast, the more common sporadic PT do not result from a single molecular abnormality but rather emerge from several oncogenic events that culminate in an increased proliferation of pituitary cells, and in the case of functioning tumors, in a non-regulated hormonal hypersecretion. In recent years, important advances in the understanding of the molecular pathogenesis of PT have been made, including the genomic, transcriptomic, epigenetic, and proteomic characterization of these neoplasms. In this review, we summarize the available molecular information pertaining the oncogenesis of PT.
    MeSH term(s) Male ; Pregnancy ; Humans ; Female ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/pathology ; Proteomics ; Adenoma/genetics ; Adenoma/pathology ; Genomics ; Adrenocorticotropic Hormone/genetics ; Adrenocorticotropic Hormone/metabolism ; Gene Expression Profiling ; Epigenesis, Genetic
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2023.102915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The hallmarks of cancer… in pituitary tumors?

    Marrero-Rodríguez, Daniel / Taniguchi-Ponciano, Keiko / Kerbel, Jacobo / Cano-Zaragoza, Amayrani / Remba-Shapiro, Ilan / Silva-Román, Gloria / Vela-Patiño, Sandra / Andonegui-Elguera, Sergio / Valenzuela-Perez, Alejandra / Mercado, Moisés

    Reviews in endocrine & metabolic disorders

    2022  Volume 24, Issue 2, Page(s) 177–190

    Abstract: Over 20 years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation. This classical review, along with two revisions published in 2011 and 2022, has remain a classic of the ... ...

    Abstract Over 20 years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation. This classical review, along with two revisions published in 2011 and 2022, has remain a classic of the oncology literature. Since many of the addressed biological processes may apply to non-malignant tumorigenesis, we evaluated to what extent these hallmarks pertain to the development of pituitary adenomas.Some of the biological processes analyzed in this review include genome instability generated by somatic USP8 and GNAS mutations in Cushing's diseases and acromegaly respectively; non-mutational epigenetic reprograming through changes in methylation; induction of angiogenesis through alterations of VEGF gene expression; promotion of proliferative signals mediated by EGFR; evasion of growth suppression by disrupting cyclin dependent kinase inhibitors; avoidance of immune destruction; and the promotion of inflammation mediated by alteration of gene expression of immune check points. We also elaborate further on the existence of oncogene induced senescence in pituitary tumors. We conclude that a better understanding of these processes can help us dilucidated why pituitary tumors are so resistant to malignant transformation and can potentially contribute to the development of novel anticancer treatments.
    MeSH term(s) Humans ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/pathology ; Adenoma/pathology ; Mutation ; Acromegaly
    Language English
    Publishing date 2022-12-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-022-09777-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6069: Show issues Location:
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