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  1. Article ; Online: Dual Antiplatelet Therapy with 3

    Scudiero, Fernando / Canonico, Mario E / Sanna, Giuseppe D / Dossi, Filippo / Silverio, Angelo / Galasso, Gennaro / Esposito, Giovanni / Porto, Italo / Parodi, Guido

    Cardiovascular drugs and therapy

    2022  Volume 37, Issue 4, Page(s) 695–703

    Abstract: Purpose: This study aims to assess the association between body mass index (BMI) and platelet reactivity in STEMI patients treated with oral 3: Methods: Overall, 429 STEMI patients were enrolled in this study. Patients were divided into two groups ... ...

    Abstract Purpose: This study aims to assess the association between body mass index (BMI) and platelet reactivity in STEMI patients treated with oral 3
    Methods: Overall, 429 STEMI patients were enrolled in this study. Patients were divided into two groups according to BMI (BMI < 25 vs ≥ 25 kg/m
    Results: After propensity score matching, patients with BMI ≥ 25 had similar values of baseline platelet reactivity, while they had higher level of platelet reactivity at 1 and 2 h after the LD and higher rate of HRPT. Furthermore, multivariate analysis demonstrated that BMI ≥ 25 was an independent predictor of HTPR at 2 h (OR 2.01, p = .009). Conversely, starting from 4 h after the LD, platelet reactivity values and HRPT rates were comparable among the two study groups.
    Conclusions: A BMI ≥ 25 kg/m
    MeSH term(s) Humans ; Platelet Aggregation Inhibitors ; Ticagrelor ; Prasugrel Hydrochloride/adverse effects ; Body Mass Index ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/drug therapy ; Blood Platelets ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC) ; Prasugrel Hydrochloride (G89JQ59I13) ; Purinergic P2Y Receptor Antagonists
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-022-07322-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cangrelor-supported primary percutaneous coronary intervention in a patient with cardiogenic shock due to left main acute occlusion.

    Siciliano, Roberta / Canonico, Mario E / Talanas, Giuseppe / Saba, Pier S / Parodi, Guido

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2020  Volume 21, Issue 8, Page(s) 616–617

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Coronary Occlusion/complications ; Coronary Occlusion/diagnosis ; Coronary Occlusion/therapy ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Platelet Aggregation Inhibitors/therapeutic use ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Adenosine Monophosphate (415SHH325A) ; cangrelor (6AQ1Y404U7)
    Language English
    Publishing date 2020-05-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000000996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Platelet inhibition with orodispersible ticagrelor in acute coronary syndromes according to morphine use: the TASTER study final results.

    Parodi, Guido / Dossi, Filippo / Raccis, Mario / Talanas, Giuseppe / Mura, Enrico / Siciliano, Roberta / Guarino, Simona / Marini, Alessandro / Franca, Paolo / Saba, Pier Sergio / Sanna, Giuseppe D / Canonico, Mario E

    European heart journal. Cardiovascular pharmacotherapy

    2023  Volume 9, Issue 8, Page(s) 692–700

    Abstract: Aim: To date, it is still unknown whether orodispersible tablet (ODT) ticagrelor might represent a suitable way to reach a proper antiaggregation in acute coronary syndrome (ACS) patients receiving morphine. Aim of the present study was to evaluate ... ...

    Abstract Aim: To date, it is still unknown whether orodispersible tablet (ODT) ticagrelor might represent a suitable way to reach a proper antiaggregation in acute coronary syndrome (ACS) patients receiving morphine. Aim of the present study was to evaluate platelet inhibition with 180 mg ticagrelor loading dose (LD) administered as ODT compared with standard coated tablet ticagrelor formulation in ACS patients undergoing percutaneous coronary intervention (PCI) according to morphine use.
    Methods and results: One-hundred and 30 patients presenting with STEMI or very high-risk NSTE-ACS were randomly assigned to receive ODT or standard ticagrelor LD. Potential morphine-ticagrelor interaction was assessed by stratified randomization according to morphine use. Platelet reactivity was evaluated by Platelet Reactivity Units (PRU) VerifyNow™ 1, 2, 4, and 6 h after ticagrelor LD. The primary endpoint was residual platelet reactivity 1 h after LD across the two ticagrelor formulation and according to morphine use. Safety endpoints were major bleedings and other in-hospital ticagrelor administration-related adverse events. One hour after LD, PRU median value was higher in morphine-treated patients (N = 32) as compared with patients not receiving morphine (N = 98; PRU = 187 [70-217]) vs. 73 [7-187]; P = 0.012). In patients with morphine, 1-h PRU values were similar between study groups (192 [114-236] vs. 173 [16-215] in ODT and standard tablet ticagrelor, respectively). Similarly, in patients without morphine, 1-h PRU values were not significantly different between study groups (69 [8-152] vs. 110 [6-193] in ODT and standard tablet ticagrelor, respectively). Platelet reactivity appeared similar in the 2 study arms at 2, 4, and 6 h after LD. No significant difference was observed among patients with or without morphine regarding in-hospital adverse events or drug side-effects, even if a reinfarction due to acute stent thrombosis was observed in a patient treated with morphine.
    Conclusions: There was no difference between ODT and standard ticagrelor tablets in terms of post-LD residual platelet reactivity, percentage of platelet inhibition or safety regardless to morphine use.
    MeSH term(s) Humans ; Ticagrelor/adverse effects ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Platelet Aggregation Inhibitors/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Adenosine/adverse effects ; Tablets ; Morphine Derivatives
    Chemical Substances Ticagrelor (GLH0314RVC) ; Platelet Aggregation Inhibitors ; Adenosine (K72T3FS567) ; Tablets ; Morphine Derivatives
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvad061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of glucose-6-phosphate dehydrogenase deficiency on the severity of coronary atherosclerosis in patients with acute coronary syndromes.

    Sanna, Giuseppe D / Canonico, Mario E / Siciliano, Roberta / Guarino, Simona / Montereggi, Francesco / Ponti, Enrico / Corda, Giulia / Talanas, Giuseppe / Parodi, Guido

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2021  Volume 22, Issue 11, Page(s) 813–817

    Abstract: Aims: The impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency on coronary atherosclerosis has not been clearly investigated so far. We aimed to assess the effects of G6PD deficiency on the extent and complexity of coronary atherosclerosis in a ...

    Abstract Aims: The impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency on coronary atherosclerosis has not been clearly investigated so far. We aimed to assess the effects of G6PD deficiency on the extent and complexity of coronary atherosclerosis in a large unselected cohort of consecutive patients with acute coronary syndromes (ACS).
    Methods: We studied 623 consecutive patients presenting with ACS and undergoing coronary angiography and percutaneous coronary intervention (PCI). G6PD activity was quantitatively measured in all individuals using a biochemical assay based on the G6PD/6GPD ratio in erythrocytes. Individuals were defined as deficient when the ratio was less than 0.80. The severity and complexity of coronary atherosclerosis were assessed by SYNTAX score at baseline angiography.
    Results: Fifty-six patients (9%) showed G6PD deficiency. Severe (i.e. enzymatic activity < 0.10) G6PD deficiency was detected in 33 (5.3%) individuals, mainly of male sex (n = 32). Overall, the cardiovascular risk profile was similar between patients with G6PD deficiency and controls. Patients with G6PD deficiency showed similar severity and complexity of coronary atherosclerosis as compared to control patients; accordingly, the SYNTAX score (15 vs. 14.5, P = 0.90, respectively, in G6PD-deficent patients and controls), and all its components were similar between deficient individuals and controls. The only independent predictor of a SYNTAX score of more than 22 was patients' age (odds ratio 1.035, 95% confidence interval 1.018-1.051; P < 0.001).
    Conclusion: G6PD deficiency does not impact on the extent and complexity of coronary atherosclerosis assessed by coronary angiography in patents presenting with ACS.
    MeSH term(s) Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/physiopathology ; Acute Coronary Syndrome/therapy ; Aged ; Cohort Studies ; Coronary Angiography ; Coronary Artery Disease/complications ; Coronary Artery Disease/physiopathology ; Cross-Sectional Studies ; Female ; Glucosephosphate Dehydrogenase/blood ; Glucosephosphate Dehydrogenase Deficiency/complications ; Glucosephosphate Dehydrogenase Deficiency/epidemiology ; Humans ; Logistic Models ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Severity of Illness Index
    Chemical Substances Glucosephosphate Dehydrogenase (EC 1.1.1.49)
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interrelation between midwall mechanics and longitudinal strain in newly diagnosed and never-treated hypertensive patients without clinically defined hypertrophy.

    Lembo, Maria / Santoro, Ciro / Sorrentino, Regina / Canonico, Mario E / Fazio, Valeria / Trimarco, Bruno / Tadic, Marijana / Galderisi, Maurizio / Esposito, Roberta

    Journal of hypertension

    2021  Volume 38, Issue 2, Page(s) 295–302

    Abstract: Background: In hypertensive patients, an impairment of midwall myocardial mechanics was described in presence of left ventricular (LV) concentric geometry. Under these circumstances, also LV longitudinal dysfunction was found.: Purpose: Our aim was ... ...

    Abstract Background: In hypertensive patients, an impairment of midwall myocardial mechanics was described in presence of left ventricular (LV) concentric geometry. Under these circumstances, also LV longitudinal dysfunction was found.
    Purpose: Our aim was to evaluate longitudinal and circumferential systolic function and correlations between these two functional components in newly diagnosed hypertensive patients without clinically defined LV hypertrophy (LVH). One hundred and thirty-eight newly diagnosed, never-treated hypertensive patients without LVH and a control group of 105 healthy normotensive individuals underwent two-dimensional and speckle tracking echocardiography. Global longitudinal strain (GLS) was derived (in absolute value) and midwall fractional shortening (MFS) computed. In addition, the hypertensive population was divided into two groups according to GLS: normal GLS (≥20%, n = 94) and reduced GLS (<20%, n = 44).
    Results: Hypertensive patients had lower MFS (P < 0.001) and GLS (P < 0.0001) than healthy controls. By dividing hypertensive patients according to GLS thresholds of normalcy, MFS was lower in patients with GLS less than 20% (P < 0.0001) while no significant difference was found in LV geometry, ejection fraction and diastolic parameters in comparison with patients with GLS at least 20%. In the pooled hypertensive population, GLS resulted positively related to MFS (r = 0.33, P < 0.0001). By a multiple linear regression analysis, after adjusting for female sex, age, BMI, circumferential end-systolic stress, average e', ejection fraction and relative wall thickness, MFS remained independently associated with GLS (β = 0.222, P < 0.005).
    Conclusion: In newly diagnosed and never-treated hypertensive patients without LVH, an early LV systolic dysfunction is testified by the reduction of both MFS and GLS. These two parameters resulted independently associated after adjusting for several confounders.
    MeSH term(s) Adult ; Blood Pressure/physiology ; Echocardiography/methods ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Male ; Middle Aged ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2021-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002257
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  6. Article ; Online: Echocardiographic Longitudinal Strain Analysis in Heart Failure: Real Usefulness for Clinical Management Beyond Diagnostic Value and Prognostic Correlations? A Comprehensive Review.

    Sanna, Giuseppe D / Canonico, Mario E / Santoro, Ciro / Esposito, Roberta / Masia, Stefano L / Galderisi, Maurizio / Parodi, Guido / Nihoyannopoulos, Petros

    Current heart failure reports

    2021  Volume 18, Issue 5, Page(s) 290–303

    Abstract: Heart failure (HF) is a highly prevalent clinical syndrome characterized by considerable phenotypic heterogeneity. The traditional classification based on left ventricular ejection fraction (LVEF) is widely accepted by the guidelines and represents the ... ...

    Abstract Heart failure (HF) is a highly prevalent clinical syndrome characterized by considerable phenotypic heterogeneity. The traditional classification based on left ventricular ejection fraction (LVEF) is widely accepted by the guidelines and represents the grounds for patient enrollment in clinical trials, even though it shows several limitations. Ejection fraction (EF) is affected by preload, afterload, and contractility, it being problematic to express LV function in several conditions, such as HF with preserved EF (HFpEF), valvular heart disease, and subclinical HF, and in athletes. Over the last two decades, developments in diagnostic techniques have provided useful tools to overcome EF limitations. Strain imaging analysis (particularly global longitudinal strain (GLS)) has emerged as a useful echocardiographic technique in patients with HF, as it is able to simultaneously supply information on both systolic and diastolic functions, depending on cardiac anatomy and physiology/pathophysiology. The use of GLS has proved helpful in terms of diagnostic performance and prognostic value in several HF studies. Universally accepted cutoff values and variability across vendors remain an area to be fully explored, hence limiting routine application of this technique in clinical practice. In the present review, the current role of GLS in the diagnosis and management of patients with HF will be discussed. We describe, by critical analysis of the pros and cons, various clinical settings in HF, and how the appropriate use and interpretation of GLS can provide important clues.
    MeSH term(s) Echocardiography ; Heart Failure/diagnostic imaging ; Heart Failure/therapy ; Humans ; Prognosis ; Stroke Volume ; Ventricular Dysfunction, Left ; Ventricular Function, Left
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-021-00530-1
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  7. Article ; Online: Prevalence, clinical and instrumental features of left bundle branch block-induced cardiomyopathy: the CLIMB registry.

    Sanna, Giuseppe D / De Bellis, Annamaria / Zecchin, Massimo / Beccu, Eleonora / Carta, Patrizia / Moccia, Eleonora / Canonico, Mario E / Parodi, Guido / Sinagra, Gianfranco / Merlo, Marco

    ESC heart failure

    2021  Volume 8, Issue 6, Page(s) 5589–5593

    Abstract: Aims: Although increasingly recognized as a distinct pathological entity, left bundle branch block-induced cardiomyopathy (LBBB-ICMP) is not included among the possible aetiologies of acquired dilated cardiomyopathies (DCM). While diagnostic criteria ... ...

    Abstract Aims: Although increasingly recognized as a distinct pathological entity, left bundle branch block-induced cardiomyopathy (LBBB-ICMP) is not included among the possible aetiologies of acquired dilated cardiomyopathies (DCM). While diagnostic criteria have been proposed, its recognition remains principally retrospective, in the presence of clinical and instrumental red flags. We aimed to assess the prevalence and clinical and instrumental features of LBBB-ICMP in a large cohort of patients with DCM.
    Methods and results: We analysed a cohort of 242 DCM patients from a two-centre registry. Inclusion criteria were age > 18, non-ischaemic or non-valvular DCM, and LBBB on electrocardiogram. LBBB-ICMP was defined according to previously proposed diagnostic criteria: (i) neither family history nor clinically identifiable potential causes for DCM; (ii) negative genetic testing; (iii) echocardiographic features including non-severe chamber dilation, normal absolute and relative wall thickness, marked dyssynchrony, and normal right ventricular function; and (iv) absence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR). From the entire cohort, we identified 30 subjects (similar in terms of New York Heart Association class I or II in 80% vs. 75%, P = 0.56; QRS width of 150 ± 22 vs. 151 ± 24 ms, P = 0.82; and cardiac remodelling of baseline end-diastolic diameter 66 ± 8 vs. 65 ± 10 mm, P = 0.53) with a comprehensive dataset including CMR and genetic testing, required to verify the presence of the diagnostic criteria proposed for LBBB-ICMP. The main characteristics of this subgroup were 73% males, age 45 ± 13 years, left ventricular ejection fraction (LVEF) 30 ± 10%, LGE in 38% of patients, and QRS complex of 150 ± 22 ms. Patients were under guideline-directed medical therapy, and 57% of them were treated with cardiac resynchronization therapy (CRT). Two patients (6.67%, 50% males, age 53 ± 13 years) fulfilled the diagnostic criteria proposed for LBBB-ICMP. After a follow-up of 44 (12-76) months, LVEF was normal and QRS width significantly reduced (from 154 ± 25 to 116 ± 52 ms) in patients with LBBB-ICMP. Both patients were under optimal medical treatment, and one was implanted with CRT-D. Neither of the two patients experienced death, malignant ventricular arrhythmia, or heart failure hospitalization at follow-up.
    Conclusions: Left bundle branch block-induced cardiomyopathy emerges as a distinct pathological entity, promptly identifiable in a minority but not negligible proportion of patients with newly diagnosed DCM and LBBB, using a series of diagnostic criteria including CMR and genetic testing. Further studies are needed to better elucidate the clinical course of LBBB-ICMP.
    MeSH term(s) Adult ; Aged ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/epidemiology ; Bundle-Branch Block/etiology ; Cardiomyopathies/diagnosis ; Cardiomyopathies/epidemiology ; Cardiomyopathies/etiology ; Contrast Media ; Female ; Gadolinium ; Humans ; Male ; Middle Aged ; Prevalence ; Registries ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2021-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13568
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  8. Article ; Online: Not-high before-treatment platelet reactivity in patients with STEMI: prevalence, clinical characteristics, response to therapy and outcomes.

    Canonico, Mario E / Sanna, Giuseppe D / Siciliano, Roberta / Guarino, Simona / Bellandi, Benedetta / Scudiero, Fernando / Saba, Pier Sergio / Esposito, Giovanni / Alexopoulos, Dimitrios / Parodi, Guido

    Platelets

    2021  Volume 33, Issue 3, Page(s) 390–397

    Abstract: Platelet reactivity (PR) has been indicated as a pathophysiological key element for ST-Elevation Myocardial Infarction (STEMI) development. Patients with not-high before-treatment platelet reactivity (NHPR) have been poorly studied so far. The aim of ... ...

    Abstract Platelet reactivity (PR) has been indicated as a pathophysiological key element for ST-Elevation Myocardial Infarction (STEMI) development. Patients with not-high before-treatment platelet reactivity (NHPR) have been poorly studied so far. The aim of this study is to investigate the prevalence, clinical characteristics, response to therapy and outcomes of baseline prior to treatment NHPR among patients with STEMI undergoing primary PCI.We analyzed the data from 358 STEMI patients with assessment of PR by VerifyNow before P2Y
    MeSH term(s) Blood Platelets/metabolism ; Female ; Humans ; Male ; Middle Aged ; Precision Medicine/methods ; Prevalence ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/physiopathology ; Treatment Outcome
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2021.1915973
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  9. Article ; Online: Orodispersible Ticagrelor in Acute Coronary Syndromes: The TASTER Study.

    Parodi, Guido / Talanas, Giuseppe / Mura, Enrico / Canonico, Mario E / Siciliano, Roberta / Guarino, Simona / Marini, Alessandro / Dossi, Filippo / Franca, Paolo / Raccis, Mario / Saba, Pier Sergio / Sanna, Giuseppe D

    Journal of the American College of Cardiology

    2021  Volume 78, Issue 3, Page(s) 292–294

    MeSH term(s) Acute Coronary Syndrome/drug therapy ; Administration, Oral ; Aged ; Dose-Response Relationship, Drug ; Drug Compounding/methods ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors ; Ticagrelor/administration & dosage ; Ticagrelor/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.05.015
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  10. Article ; Online: Platelet Reactivity in Hepatitis C Virus-Infected Patients on Dual Antiplatelet Therapy for Acute Coronary Syndrome.

    Scudiero, Fernando / Valenti, Renato / Marcucci, Rossella / Sanna, Giuseppe D / Gori, Anna Maria / Migliorini, Angela / Vitale, Raffaele / Giusti, Betti / De Vito, Elena / Corda, Giulia / Paniccia, Rita / Zirolia, Davide / Canonico, Mario E / Parodi, Guido

    Journal of the American Heart Association

    2020  Volume 9, Issue 18, Page(s) e016441

    Abstract: Background Coronary artery disease (CAD) has been recognized as a serious and potentially life-threatening complication of Hepatitis C Virus (HCV) infection. High on-treatment platelet reactivity has been associated with high risk of ischemic events in ... ...

    Abstract Background Coronary artery disease (CAD) has been recognized as a serious and potentially life-threatening complication of Hepatitis C Virus (HCV) infection. High on-treatment platelet reactivity has been associated with high risk of ischemic events in patients with CAD, but data regarding the association with HCV infection are still lacking. This post hoc analysis aims to assess high on-treatment platelet reactivity, severity of CAD, and long-term outcomes of patients with acute coronary syndrome (ACS) who were infected with HCV. Methods and Results Patients with ACS who were infected with HCV (n=47) were matched to patients with ACS and without HCV (n=137) for age, sex, diabetes mellitus, hypertension, and renal function. HCV-infected patients with ACS had higher levels of platelet reactivity (ADP
    MeSH term(s) Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/drug therapy ; Aged ; Aspirin/administration & dosage ; Aspirin/therapeutic use ; Clopidogrel/administration & dosage ; Clopidogrel/therapeutic use ; Drug Therapy, Combination ; Female ; Hepacivirus ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/complications ; Humans ; Male ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016441
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