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Article ; Online: Enhanced systematic delivery of fluconazole-loaded biotin-glutathione functionalized chitosan-g-proline carrier into the infected retinitis treatment.

Guo, Qing / Li, Zheng / Cao, Fang

2024 Volume 24, Issue 1, Page(s) 48

Abstract: Background: The polymer-based facile and effective drug carrier approach was developed to treat superficial fungal infected retinopathy infections.: Methods: Here, biotin-glutathione (B-GHS) functionalized with chitosan grafted proline (CS-g-P) ... ...

Abstract	Background: The polymer-based facile and effective drug carrier approach was developed to treat superficial fungal infected retinopathy infections. Methods: Here, biotin-glutathione (B-GHS) functionalized with chitosan grafted proline (CS-g-P) moieties were fabricated with the loading of fluconazole (FLZ) for the treatment of retinopathy. FT-IR and XRD techniques were used to characterize chemical structural and phase changes of the prepared carriers The SEM results show that the sphere morphology with interconnection particle nature. Results: The particle diameter was found as ~ 6.5 and ~ 8.6 nm for CS-g-P/B-GHS and FLZ-loaded CS-g-P/B-GHS carriers, respectively. The negative surface charge was found as the values of CS-g-P/B-GHS and FLZ-loaded CS-g-P/B-GHS, such as -20.7 mV and - 32.2 mV, from zeta potential analysis. The in-vitro FLZ releases from the CS-g-P/B-GHS were investigated at pH 7.4 (PBS) as the tear fluid environment, and it was observed at 85.02% of FLZ release in 8 h reaction time. The sustained release was observed, leading to the necessity for prolonged therapeutic effects. The antifungal effect of the carrier was studied by the minimum inhibitory concentration (MIC) and the percentage inhibition of viable fungal count against Candida albicans, and it observed 81.02% of the zone of inhibition by the FLZ carrier. Conclusion: FLZ-loaded CS-g-P/B-GHS carrier could inhibit the biofilm formation in a concentration-dependent inhibition. Hence, A novel FLZ/B-GHS-CS-g-P carrier is a hopeful approach for effectively treating superficial fungal contaminations of the retina region.
MeSH term(s)	Humans ; Amino Acid Transport Systems, Neutral ; Antifungal Agents/pharmacology ; Biotin ; Chitosan ; Fluconazole/administration & dosage ; Retinal Diseases ; Retinitis/drug therapy ; Spectroscopy, Fourier Transform Infrared ; Mycoses/drug therapy
Chemical Substances	Amino Acid Transport Systems, Neutral ; Antifungal Agents ; Biotin (6SO6U10H04) ; Chitosan (9012-76-4) ; Fluconazole (8VZV102JFY) ; proline transport protein
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-024-03305-z
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Article: Disease burden based on gender and age and risk factors for stroke in China, 2019.

Guo, Yuxin / Jiang, Junhao / Cao, Fang / Yan, Junxia

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2024 Volume 48, Issue 8, Page(s) 1217–1224

Abstract: Objectives: Stroke has become the leading cause of death and disability among adults in China. This study aims to analyze the disease burden based on gender and age and the risk factors for stroke subtypes in China 2019, and to provide reference for ... ...

Title translation	2019年中国脑卒中性别和年龄别疾病负担及其危险因素.
Abstract	Objectives: Stroke has become the leading cause of death and disability among adults in China. This study aims to analyze the disease burden based on gender and age and the risk factors for stroke subtypes in China 2019, and to provide reference for targeted stroke prevention and control. Methods: Based on 2019 data of the Global Burden of Disease (GBD), the gender and age in patients with different stroke subtypes (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage) in China 2019 was described by using disability-adjusted life years (DALY), and attributable burden of related risk factors was analyzed. Results: In 2019, the burden of intracranial hemorrhage was the heaviest one in China, resulting in 22.210 6 million person years of DALY, following by ischemic stroke and subarachnoid hemorrhage, resulting in 21.393 9 and 2.344 7 million person years of DALY, respectively. Among them, except the 0-14 age group, the disease burden of different subtypes of stroke in men was higher than that in women. The disease burden of ischemic stroke was increased with age in both men and women, with the heaviest disease burden in ≥70 years group. The disease burden of intracranial hemorrhage and subarachnoid hemorrhage was the heaviest in males aged 50-69 years old, and in females aged ≥70 years and 50-69 years, respectively. Metabolic factors were the main risk factors in all ages of different stroke subtypes, and the most important risk factor was high systolic blood pressure. Other risk factors were different between men and women. Smoking, high body mass index, high low-density lipoprotein, and outdoor particulate matter pollution were the main risk factors for stroke in men, while high body mass index, outdoor particulate matter pollution, and high fasting blood glucose were the main risk factors of stroke in women. The main risk were different among different age groups. Conclusions: The burden and attributable risk factors for different stroke subtypes are discrepancy in different gender and age groups. Targeted interventions should be conducted in the future to reduce the burden of stroke.
MeSH term(s)	Male ; Adult ; Humans ; Female ; Infant, Newborn ; Infant ; Child, Preschool ; Child ; Adolescent ; Middle Aged ; Aged ; Subarachnoid Hemorrhage/epidemiology ; Quality-Adjusted Life Years ; Cost of Illness ; Stroke/epidemiology ; Stroke/etiology ; Risk Factors ; China/epidemiology ; Particulate Matter ; Ischemic Stroke ; Intracranial Hemorrhages/epidemiology ; Intracranial Hemorrhages/etiology
Chemical Substances	Particulate Matter
Language	Chinese
Publishing date	2024-03-19
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2023.220561
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Article: Dynamic Recrystallization Constitutive Model and Texture Evolution of Metastable β Titanium Alloy TB8 during Thermal Deformation.

Zhou, Chuankun / Cao, Fang / Yang, Zhirong / Rao, Weifeng

Materials (Basel, Switzerland)

2024 Volume 17, Issue 7

Abstract: The mechanical properties of metastable β-titanium alloys are highly susceptible during the thermal mechanical processing (TMP). In this process, the recrystallization process plays an important role in determining the microstructure and texture ... ...

Abstract	The mechanical properties of metastable β-titanium alloys are highly susceptible during the thermal mechanical processing (TMP). In this process, the recrystallization process plays an important role in determining the microstructure and texture evolution. The implementation of dynamic recrystallization (DRX), a process for achieving β-grain refinement, is considered of great significance for the improvement of the properties of metastable β-titanium alloys and their industrial production. Along these lines, in this work, an isothermal compression test of TB8 titanium alloy was carried out by using a Gleeble-3500 thermal simulator. As a result, the rheological stress behavior was analyzed, the thermal processing map was accurately established based on the stress-strain curve, and the optimal processing interval was determined. The DRX kinetic and the DRX grain size models were developed, on the basis of which a new DRX intrinsic model was established to improve the material parameters. Therefore, the actual situation in the working process could be better predicted. The microstructural evolution of TB8 titanium alloy during thermal deformation was comprehensively investigated using the electron backscatter diffraction (EBSD) technique. The obtained results demonstrate a close correlation between the diversity of DRX mechanisms in TB8 alloy and the distribution of dislocation density. Four microstructural textures during thermal deformation were identified, in which the cube texture of (001) <010> and the R-Gorss Nd texture of (110) <110> dominate. Due to the random orientation of the dynamically recrystallized grains, the strength of the R-Gorss Nd texture of (110) <110> increases with the increase in the volume fraction of DRX. On the contrary, it was verified that the dynamic recrystallization behavior has a significant weakening impact on the cube texture of (001) <010>.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17071572
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Article ; Online: PLA2G7, caloric restriction and cardiovascular aging.

Cao, Fang / Lee, Richard T

The journal of cardiovascular aging

2022 Volume 2, Issue 2

Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2768-5993
ISSN (online)	2768-5993
DOI	10.20517/jca.2022.08
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Article: Factors Influencing the Choice of Automated Peritoneal Dialysis Treatment by Patients Receiving Home Peritoneal Dialysis.

Cao, Fang / Hong, Fuyuan / Ruan, Yiping / Lin, Miao

Patient preference and adherence

2023 Volume 17, Page(s) 2797–2804

Abstract: Objective: This study was conducted to understand the influencing factors for home peritoneal dialysis patients choosing APD and to provide a scientific basis for improving the completion rate of APD treatment and the follow-up of peritoneal dialysis ... ...

Abstract	Objective: This study was conducted to understand the influencing factors for home peritoneal dialysis patients choosing APD and to provide a scientific basis for improving the completion rate of APD treatment and the follow-up of peritoneal dialysis patients. Methods: The study was a cross-sectional questionnaire-based study. A total of 588 patients on peritoneal dialysis were randomly selected from 6 regions in Fujian Province in southern China using a stratified cluster sampling method. Results: The mean age of the patients were 56.5 ± 14.73 years. In the univariate analysis, knowledge, user experience and family support were the factors that affected patients' choice of APD (all Conclusion: Patients' knowledge of APD, experience in application and family support were the main factors affecting the choice of APD as a treatment mode ( Relevance to clinical practice: This study provides scientific evidence for improving APD treatment completion rates and improving patient quality of life.
Language	English
Publishing date	2023-11-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S423443
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Article: Hepatic anastomosing hemangioma: description of a rare case and a literature analysis.

Cao, Fang / Ma, Tianshi / Lin, Chunmiao

Quantitative imaging in medicine and surgery

2023 Volume 13, Issue 9, Page(s) 6355–6362

Language	English
Publishing date	2023-08-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-485
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Article: Effect of Patient-Empowerment Interaction Model on Self-Management Ability of Peritoneal Dialysis Patients: A Randomized Controlled Trial.

Cao, Fang / Hong, Fuyuan / Ruan, Yiping / Lin, Miao

Patient preference and adherence

2023 Volume 17, Page(s) 873–881

Abstract: Objective: Patient empowerment can be achieved through the PBL model. The purpose of the present study was to evaluate the effectiveness and feasibility of patient empowerment through the PBL model in health continuing education of peritoneal dialysis ( ... ...

Abstract	Objective: Patient empowerment can be achieved through the PBL model. The purpose of the present study was to evaluate the effectiveness and feasibility of patient empowerment through the PBL model in health continuing education of peritoneal dialysis (PD) patients. Methods: From March 2017 to April 2017, a total of 94 participants were randomly assigned to the PBL group and the traditional group, with 47 patients in each group. Patients of the PBL group were divided into 5 study groups; and six PBL health education activities were held. The basic knowledge, self-management behavior, quality of life, anxiety, and depression were assessed among the traditional group and the PBL group. The average follow-up duration was 10.6±1.5 months. Results: Compared with patients in the traditional group, patients in the PBL group had higher scores of basic knowledges for PD (84.33±3.55 vs 91.19±3.07; Conclusion: The empowerment model of PBL health education can effectively improve the knowledge, skills and quality of life of PD patients. Relevance to clinical practice: The findings identified in this study will help to improve the quality of nursing care and health education for PD patients. Patient or public contribution: The study design involved patients on PD training. The knowledge and skills of PD and quality of life will improve after they participate the PBL health education activities.
Language	English
Publishing date	2023-03-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S402698
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Article ; Online: The Sympathetic-Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues.

Ren, Wenran / Hua, Meng / Cao, Fang / Zeng, Wenwen

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 11, Issue 8, Page(s) e2306128

Abstract: Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important ... ...

Abstract	Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additionally, the immune system has long been studied for its essential roles in metabolic health and diseases. In this review, the aim is to provide an overview of the current research progress on the sympathetic regulation of key metabolic organs, including the pancreas, liver, intestine, and adipose tissues. In particular, efforts are made to highlight the critical roles of the peripheral nervous system and its potential interplay with immune components. Overall, it is hoped to underscore the importance of studying metabolic organs from a comprehensive and interconnected perspective, which will provide valuable insights into the complex mechanisms underlying metabolic regulation and may lead to novel therapeutic strategies for metabolic diseases.
MeSH term(s)	Liver ; Pancreas ; Adipose Tissue ; Intestines
Language	English
Publishing date	2023-12-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202306128
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Article ; Online: Cutaneous nodular polyarteritis presenting as refractory ulcers on both lower extremities: A case report.

Cao, Fang / Zhang, Yongkang / Xu, Yongcheng / Cao, Yemin

Explore (New York, N.Y.)

2023 Volume 20, Issue 2, Page(s) 264–269

Abstract: Background: Cutaneous polyarteritis nodosa (cPAN) is a systemic disease that is limited to the skin. cPAN usually presents with cutaneous reticular cyanotic, erythematous and palpable nodules, and cutaneous ulcers.Research has indicated that the use of ... ...

Abstract	Background: Cutaneous polyarteritis nodosa (cPAN) is a systemic disease that is limited to the skin. cPAN usually presents with cutaneous reticular cyanotic, erythematous and palpable nodules, and cutaneous ulcers.Research has indicated that the use of hormones and immunosuppressive drugs can delay ulcer healing and associated neuropathy, and also elevate the risk of disease recurrence upon their reduction or withdrawal. Therefore, it is a necessary to find a safe and effective approach that minimize hormone side effects in ulcer treatment. Case presentation: The patient, a 48-year-old female of Han Chinese ethnicity, has suffered from recurrent erythema nodosum on both lower limbs for 8 years. The condition was aggravated by skin breakdown over the last 3 months. Despite multiple treatments, the patient's condition did not improve significantly, leading to the exploration of a combined approach of traditional Chinese and Western medicine. Following six months of combined traditional Chinese and Western medicine treatment, t the patient's newborn erythema and ulcers on both lower limbs did not reappear, and the ulcers gradually decreased in size and the erythema disappeared. The patient took the TCM regularly until April 15, 2023, when the ulcers were completely healed. Three months after the patient stopped taking TCM, the ulcers had completely healed with no recurrence, as observed during the follow-up visit on July 14th, 2023. Conclusion: Traditional Chinese Medicine Combined with Low-Dose Hormones May Effectively Treat Bilateral Lower Extremity Skin Ulcers Caused by Cutaneous Polyarteritis Nodosa.
MeSH term(s)	Female ; Infant, Newborn ; Humans ; Middle Aged ; Polyarteritis Nodosa/complications ; Polyarteritis Nodosa/drug therapy ; Ulcer ; Lower Extremity ; Erythema ; Hormones/therapeutic use
Chemical Substances	Hormones
Language	English
Publishing date	2023-09-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2183945-1
ISSN	1878-7541 ; 1550-8307
ISSN (online)	1878-7541
ISSN	1550-8307
DOI	10.1016/j.explore.2023.08.018
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Article ; Online: Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells.

Yu, Yunhu / Liu, Qian / Ran, Qishan / Cao, Fang

Cell biology international

2023 Volume 48, Issue 2, Page(s) 143–153

Abstract: Protein phosphatase magnesium-dependent 1B (PPM1B) functions as IKKβ phosphatases to terminate nuclear factor kappa B (NF-κB) signaling. NF-κB signaling was constitutively activated in glioma cells. At present, little is known about the role of PPM1B in ... ...

Abstract	Protein phosphatase magnesium-dependent 1B (PPM1B) functions as IKKβ phosphatases to terminate nuclear factor kappa B (NF-κB) signaling. NF-κB signaling was constitutively activated in glioma cells. At present, little is known about the role of PPM1B in glioma. In the current study, we found that the expression of PPM1B was reduced in glioma tissues and cells, and decreased expression of PPM1B was related to poor overall survival of patients. Overexpression of PPM1B inhibited the proliferation and promoted apoptosis of glioma cells. Moreover, PPM1B overexpression reduced the phosphorylation of IKKβ and inhibited the nuclear localization of NF-κBp65. PDTC, an inhibitor of NF-κB signaling, reversed PPM1B-knockdown-induced cell proliferation. Furthermore, overexpression of PPM1B enhanced the sensitivity of glioma cells to temozolomide. In vivo experiments showed that overexpression of PPM1B could inhibit tumor growth, improve the survival rate of nude mice, and enhance the sensitivity to temozolomide. In conclusion, PPM1B suppressed glioma cell proliferation and the IKKβ-NF-κB signaling pathway, and enhanced temozolomide sensitivity of glioma cells.
MeSH term(s)	Mice ; Animals ; Humans ; Temozolomide/pharmacology ; NF-kappa B/metabolism ; Magnesium ; I-kappa B Kinase/metabolism ; Drug Resistance, Neoplasm ; Mice, Nude ; Glioma/metabolism ; Phosphoprotein Phosphatases ; Cell Line, Tumor ; Cell Proliferation ; Apoptosis ; Protein Phosphatase 2C
Chemical Substances	Temozolomide (YF1K15M17Y) ; NF-kappa B ; Magnesium (I38ZP9992A) ; I-kappa B Kinase (EC 2.7.11.10) ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; PPM1B protein, human (EC 3.1.3.16) ; Protein Phosphatase 2C (EC 3.1.3.16)
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.12092
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