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Article ; Online: Erratum to: Stroke in patients with prosthetic valve endocarditis : Single-center cohort study in China.

Cao, G-F / Liu, W / Cao, L / Wang, Y

2019 Volume 45, Issue Suppl 1, Page(s) 78–79

Abstract: Erratum to:Herz 2019 https://doi.org/10.1007/s00059-019-4809-4 The original article has been corrected. The data given in Table 4 for patient No. 13 were wrong. Please find here the corrected Table.The authors and publisher apologize for this …. ...

Abstract	Erratum to:Herz 2019 https://doi.org/10.1007/s00059-019-4809-4 The original article has been corrected. The data given in Table 4 for patient No. 13 were wrong. Please find here the corrected Table.The authors and publisher apologize for this ….
Language	English
Publishing date	2019-05-22
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-019-4821-8
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Article ; Online: Stroke in patients with prosthetic valve endocarditis : Single-center cohort study in China.

Cao, G-F / Liu, W / Cao, L / Wang, Y

Herz

2019 Volume 45, Issue Suppl 1, Page(s) 72–77

Abstract: Background: This study summarizes the clinical features of stroke in patients with prosthetic valve endocarditis (PVE) in China.: Methods: The clinical data of PVE patients admitted to Beijing Anzhen Hospital from January 1997 to August 2018 were ... ...

Title translation	Schlaganfall bei Patienten mit Klappenprothesenendokarditis : Einzelzentrum-Kohortenstudie in China.
Abstract	Background: This study summarizes the clinical features of stroke in patients with prosthetic valve endocarditis (PVE) in China. Methods: The clinical data of PVE patients admitted to Beijing Anzhen Hospital from January 1997 to August 2018 were retrospectively analyzed. Results: In total, 62 patients with PVE were enrolled (45 males, 17 females). The patients' age ranged from 23 to 79 years (51.69 ± 15.01). Rheumatic heart disease (RHD) was the most common reason for valve replacement. Of the patients, 58 were found to have vegetations by echocardiography. Blood cultures revealed the most common pathogens to be Staphylococcus (12 cases) and fungal infections (n = 7); 18 (29.03%) patients had strokes. There were 12 cases of ischemic stroke, three cases of cerebral hemorrhage, one case of subarachnoid hemorrhage, and two cases of unclear etiology. The most commonly found clinical symptoms of stroke patients were hemiplegia (n = 10) and coma (n = 5). The five patients in coma died during hospitalization. The incidence of RHD, double valve replacement, atrial fibrillation, and mitral valve vegetation was significantly higher in the stroke group than in the non-stroke group (p = 0.045, 0.000, 0.033, and 0.045, respectively). Logistic regression analysis showed that the odds ratios (ORs) for RHD, double valve replacement, and fungal infection as risk factors of stroke were 7.26 (95% CI: 1.23-42.68), 25.60 (95%CI: 4.33-126.16), and 20.58 (95% CI: 2.13-198.82), respectively, and were statistically significant. Eight patients died during hospitalization and the in-hospital mortality was 12.90%. The OR for in-hospital mortality with concurrent stroke was 5.13 (95% CI: 1.08-24.46, p = 0.028). Conclusion: Stroke is a common complication in PVE that increases patient mortality. Rheumatic heart disease, double valve replacement, and fungal infection may be risk factors for patients with PVE complicated by stroke.
MeSH term(s)	Adult ; Aged ; China/epidemiology ; Cohort Studies ; Endocarditis/diagnosis ; Endocarditis/epidemiology ; Endocarditis, Bacterial ; Female ; Heart Valve Prosthesis/adverse effects ; Humans ; Male ; Middle Aged ; Prosthesis-Related Infections/epidemiology ; Retrospective Studies ; Stroke/diagnosis ; Stroke/epidemiology ; Young Adult
Language	English
Publishing date	2019-05-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-019-4809-4
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Article: Association of variants in FABP4, FASN, SCD, SREBP1 and TCAP genes with intramuscular fat, carcass traits and body size in Chinese Qinchuan cattle

Gao, Y.Y. / Cheng, G. / Cheng, Z.X. / Bao, C. / Yamada, T. / Cao, G.F. / Bao, S.Q. / Schreurs, N.M. / Zan, L.S. / Tong, B.

Meat science. 2022 Oct., v. 192

2022

Abstract: This study aimed to genotype the variants in FABP4, FASN, SCD, SREBP1 and TCAP genes, and to analyze their associations with intramuscular fat (IMF) content, carcass traits and body size in Chinese Qinchuan cattle (QC). The association studies showed ... ...

Abstract	This study aimed to genotype the variants in FABP4, FASN, SCD, SREBP1 and TCAP genes, and to analyze their associations with intramuscular fat (IMF) content, carcass traits and body size in Chinese Qinchuan cattle (QC). The association studies showed that the FABP4 c.220A > G polymorphism was significantly associated with ultrasound longissimus muscle depth (ULMD) and IMF, the FASN g.16024A > G polymorphism was significantly associated with ULMD and some body size traits, the SREBP1 84 bp indel was significantly associated with back fat thickness, ULMD and some body size traits. The frequencies of well-characterized A allele in FABP4 c.220A > G in Korean cattle (KOR) and Japanese Black cattle (JB), T allele in SCD g.8586C > T in KOR, SS genotype in SREBP1 84 bp indel in KOR and JB, DELDEL genotype in TCAP g.592-597CTGCAGinsdel in KOR were significantly higher than in Chinese cattle breeds. Thus, the associated four polymorphisms were expected to be genetic selection markers for meat quality, carcass traits and body size of QC.
Keywords	Wagyu ; alleles ; backfat ; body size ; cattle ; fat thickness ; genetic selection ; genotype ; intramuscular fat ; longissimus muscle ; meat quality ; ultrasonics
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2022.108882
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Article: [The clinical characteristics of stroke in young patients with cardiac myxoma].

Cao, G F / Bi, Q / Cao, L / Wang, C

Zhonghua nei ke za zhi

2017 Volume 56, Issue 4, Page(s) 263–267

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; Cardiac Surgical Procedures ; Cerebral Hemorrhage ; Cerebral Infarction/diagnosis ; Cerebral Infarction/etiology ; Embolism ; Female ; Heart Atria ; Heart Neoplasms/complications ; Heart Neoplasms/diagnosis ; Humans ; Incidence ; Male ; Middle Aged ; Myxoma/complications ; Myxoma/diagnosis ; Retrospective Studies ; Stroke/etiology ; Treatment Outcome
Language	Chinese
Publishing date	2017-04-01
Publishing country	China
Document type	Journal Article
ZDB-ID	754223-9
ISSN	0578-1426
ISSN	0578-1426
DOI	10.3760/cma.j.issn.0578-1426.2017.04.005
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Article ; Online: Downregulated FGFR3 Expression Inhibits In Vitro Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells of Mice with TBXT Gene Mutation.

Su, H / Yang, G / Yang, H X / Liu, M N / Li, X D / Chen, L / Li, Y / Wang, D Q / Ma, T / Song, Y L / Li, H J / Du, C G / Li, X H / Cao, G F

Bulletin of experimental biology and medicine

2023 Volume 174, Issue 4, Page(s) 578–584

Abstract: We studied the effect of fibroblast growth factor receptor 3 (FGFR3) inhibitor BGJ-398 on the differentiation of bone marrow mesenchymal stem cells (BM MSC) into osteoblasts in wild type (wt) mice and in animals with mutation in TBXT gene (mt) and ... ...

Abstract	We studied the effect of fibroblast growth factor receptor 3 (FGFR3) inhibitor BGJ-398 on the differentiation of bone marrow mesenchymal stem cells (BM MSC) into osteoblasts in wild type (wt) mice and in animals with mutation in TBXT gene (mt) and possible differences in the pluripotency of these cells. Cytology tests showed that the cultured BM MSC could differentiate into osteoblasts and adipocytes. The effect of different BGJ-398 concentrations on the expression of FGFR3, RUNX2, SMAD1, SMAD4, SMAD5, SMAD6, SMAD7, and SMAD8 were studied by quantitative reverse transcription PCR. The expression of RUNX2 protein was evaluated by Western blotting. BM MSC of mt and wt mice did not differ in pluripotency and expressed the same membrane marker antigens. BGJ-398 inhibitor reduced the expression of FGFR3 and RUNX2. In BM MSC from mt and wt mice have similar gene expression (and its changing) in FGFR3, RUNX2, SMAD1, SMAD4, SMAD5, SMAD6, SMAD7, and SMAD8 genes. Thus, our experiments confirmed the effect of decreased expression of FGFR3 on osteogenic differentiation of BM MSC from wt and mt mice. However, BM MSC from mt and wt mice did not differ in pluripotency and are an adequate model for laboratory research.
MeSH term(s)	Animals ; Mice ; Bone Marrow Cells ; Cell Differentiation/genetics ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Mesenchymal Stem Cells/metabolism ; Mutation ; Osteogenesis/genetics ; Receptor, Fibroblast Growth Factor, Type 3/genetics ; Receptor, Fibroblast Growth Factor, Type 3/metabolism
Chemical Substances	Core Binding Factor Alpha 1 Subunit ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1) ; infigratinib (A4055ME1VK)
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-023-05750-0
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Article ; Online: Association of variants in FABP4, FASN, SCD, SREBP1 and TCAP genes with intramuscular fat, carcass traits and body size in Chinese Qinchuan cattle.

Gao, Y Y / Cheng, G / Cheng, Z X / Bao, C / Yamada, T / Cao, G F / Bao, S Q / Schreurs, N M / Zan, L S / Tong, B

Meat science

2022 Volume 192, Page(s) 108882

Abstract	This study aimed to genotype the variants in FABP4, FASN, SCD, SREBP1 and TCAP genes, and to analyze their associations with intramuscular fat (IMF) content, carcass traits and body size in Chinese Qinchuan cattle (QC). The association studies showed that the FABP4 c.220A > G polymorphism was significantly associated with ultrasound longissimus muscle depth (ULMD) and IMF, the FASN g.16024A > G polymorphism was significantly associated with ULMD and some body size traits, the SREBP1 84 bp indel was significantly associated with back fat thickness, ULMD and some body size traits. The frequencies of well-characterized A allele in FABP4 c.220A > G in Korean cattle (KOR) and Japanese Black cattle (JB), T allele in SCD g.8586C > T in KOR, SS genotype in SREBP1 84 bp indel in KOR and JB, DELDEL genotype in TCAP g.592-597CTGCAGinsdel in KOR were significantly higher than in Chinese cattle breeds. Thus, the associated four polymorphisms were expected to be genetic selection markers for meat quality, carcass traits and body size of QC.
MeSH term(s)	Acetophenones ; Animals ; Body Size ; Cattle/genetics ; China ; Genetic Markers ; Genotype ; Meat/analysis ; Phenotype ; Polymorphism, Single Nucleotide
Chemical Substances	Acetophenones ; Genetic Markers ; 2,2,2',4'-tetrachloroacetophenone (O43MMI49GE)
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2022.108882
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Article: [Multidisciplinary treatment for generalized severe periodontitis with malocclusion: a case report].

Cai, X / Zhou, M Q / Tan, L / Cao, G F / Wang, X F / Chen, Z H / Chen, X P

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

2020 Volume 55, Issue 12, Page(s) 994–998

MeSH term(s)	Humans ; Malocclusion/therapy ; Periodontitis/therapy
Language	Chinese
Publishing date	2020-12-06
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	1027950-7
ISSN	1002-0098
ISSN	1002-0098
DOI	10.3760/cma.j.cn112144-20200604-00317
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Article ; Online: The detection of SAS1B in serum provides clues for early diagnosis of thyroid cancer.

Yang, H-X / Yang, Y / Li, X-D / Miao, X-M / Yang, C / Zhi, D-F / Su, H / Yang, G / Gao, J / Du, C-G / Li, H-J / Song, Y-L / Cao, G-F

European review for medical and pharmacological sciences

2021 Volume 25, Issue 3, Page(s) 1410–1424

Abstract: Objective: The incidence of thyroid cancer is rising globally. Most patients progress slowly, but some patients develop lymph node and distant metastasis earlier, and their prognosis is poor. Therefore, early diagnosis and warning of malignancy are very ...

Abstract	Objective: The incidence of thyroid cancer is rising globally. Most patients progress slowly, but some patients develop lymph node and distant metastasis earlier, and their prognosis is poor. Therefore, early diagnosis and warning of malignancy are very meaningful for such patients. SAS1B gene is a newly discovered protein expressed on the surface of mature egg cells and has metalloendopeptidase activity. We aimed at exploring whether SAS1B is involved in the occurrence of thyroid cancer, and at providing evidence for early diagnosis and targeted therapy of thyroid cancer. Patients and methods: In this study, a rabbit anti-human SAS1B polyclonal antibody was prepared by gene recombination technology. The indirect ELISA method was used to detect the SAS1B protein expression in the serum of 69 patients with thyroid cancer and 55 normal controls, and the relevant pathological factors were analyzed. Immunohistochemistry and PCR technology were used to investigate the expression levels of SAS1B protein and mRNA in 30 thyroid cancer tissues and 23 control thyroid tissues. Results: The titer of SAS1B recombinant antibody was 1:51200. The expression of SAS1B in the serum of patients with thyroid cancer was higher than that in the normal control group (p<0.01). The antibody had a good sensitivity in serum detection of cancer patients (p=0.008<0.01), the linear regression analysis result was that the expression of SAS1B gene was related to tumor envelope invasion and lymph node metastasis (p=0.003<0.01, p=0.003<0.01), and it was irrelevant to the patient's gender, age, tumor mass size, number of cancer foci, pathological stage, etc. (p>0.05). The results of immunohistochemistry showed that SAS1B protein was mainly located in the cytoplasm and membrane of thyroid cancer cells. The expression intensity in thyroid cancer tissues was higher than that in control tissues (p<0.05), but it was not expressed in normal thyroid tissues. Antibodies showed a good sensitivity that was used to detect thyroid cancer tissues (p=0.000<0.01). The results of ordinary PCR detection using thyroid cancer tissue and control thyroid tissue showed that the amplification products of the three domains (N-terminal, C-terminal and catalytic domain) of the SAS1B gene showed high expression in thyroid cancer tissue. q-PCR results showed that the expression of SAS1B gene in thyroid cancer and control thyroid tissue was higher than that in control group (p<0.05), and the genes of Aurora A and BARD1 related to centrosome replication and DNA replication forks protection during the proliferation were highly expressed in thyroid cancer tissue. The study results suggested that SAS1B was involved in the carcinogenesis of thyroid cancer. The Hum_mPLoc.2.0 software, PSORT Ⅱ software and UniProt software were used to predict that SAS1B protein had secretory protein properties. Conclusions: The above data indicate that the SAS1B gene is closely related to the process of thyroid cancer and can serve as a good tumor marker that can be used for early diagnosis and early warning of thyroid malignancy.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Metalloproteases/blood ; Metalloproteases/genetics ; Middle Aged ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/diagnosis
Chemical Substances	Metalloproteases (EC 3.4.-) ; ASTL protein, human (EC 3.4.24.21)
Language	English
Publishing date	2021-02-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202102_24849
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Article ; Online: FasL-induced apoptosis in bovine oocytes via the Bax signal.

Li, H-J / Wang, C-Y / Mi, Y / Du, C-G / Cao, G-F / Sun, X-C / Liu, D-J / Shorgan, B

Theriogenology

2013 Volume 80, Issue 3, Page(s) 248–255

Abstract: The factor associated suicide (Fas) and its ligand (FasL) signaling is an important regulatory pathway of apoptosis in mammalian follicles. However, whether apoptosis in bovine oocytes is regulated by the Fas-FasL signaling pathway remains unknown. In ... ...

Abstract	The factor associated suicide (Fas) and its ligand (FasL) signaling is an important regulatory pathway of apoptosis in mammalian follicles. However, whether apoptosis in bovine oocytes is regulated by the Fas-FasL signaling pathway remains unknown. In this study, localization of Fas and FasL in immature oocytes and FasL in cumulus cells were examined using immunofluorescence staining. In addition, exogenous FasL was added to an in vitro culture system to investigate apoptotic changes in bovine oocytes, using annexin-V and terminal uridine nick-end labeling staining, and real-time quantitative polymerase chain reaction. In this study, Fas was expressed in immature oocytes, whereas FasL was expressed in cumulus cells, but not in immature oocytes; annexin-V- and terminal uridine nick-end labeling-positive rates of oocytes treated with 2, 10, or 50 ng/mL FasL were higher than those of control oocytes (P < 0.05); and oocytes from the three treatment groups had higher expression levels of Fas and B cell lymphoma/leukemia-2 associated X than those in the control group (P < 0.05). Taken together, we concluded that the Fas-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B cell lymphoma/leukemia-2 associated X upregulation.
MeSH term(s)	Animals ; Annexin A5 ; Apoptosis ; Cattle ; Cumulus Cells/metabolism ; Fas Ligand Protein/genetics ; Fas Ligand Protein/metabolism ; Female ; Gene Expression Regulation ; In Situ Nick-End Labeling ; Oocytes/physiology ; Protein Transport ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/physiology ; Staining and Labeling ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Chemical Substances	Annexin A5 ; Fas Ligand Protein ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger ; bcl-2-Associated X Protein
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2013.04.002
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Article ; Audio / Video: Histological study of germ cells development and apoptosis in mongolian sheep fetal ovaries

Qi, A / Zhang, Z.P / Cao, G.F / Zhang, Y

Animal reproduction science. 2008 Jan. 15, v. 103, issue 1-2

2008

Abstract: Mammalian germ cells proliferate by mitosis and begin meiotic development in fetal ovaries. The aim of this study is to demonstrate the germ cell proliferation and apoptosis, and elucidated some of the key developmental events and stages in Mongolian ... ...

Abstract	Mammalian germ cells proliferate by mitosis and begin meiotic development in fetal ovaries. The aim of this study is to demonstrate the germ cell proliferation and apoptosis, and elucidated some of the key developmental events and stages in Mongolian sheep fetal ovaries. Fourty three pairs of sheep fetal ovaries at days 37-99 of gestation were collected from local slaughterhouse. Studies in histological structure of ovaries and germ cell apoptosis were achieved by employing light microscopy and terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL). Following fetal gestation age increasing, three key development events were detected: oogonia fleetly proliferated by mitosis and clustered at days 37-55 of gestation in ovarian cortex forming oogonia nest; the formation of ovigerous cords (OC) and disorganization took place at day 51-81, especially at days 63-66 more OC developed, and more germ cells in OC entered meiosis prophase; subsequently, with the OC disappeared, primordial follicles gradually prevailed from day 73 of gestation. Another observation was germ cells apoptosis and the number of apoptotic germ cells showed a peak from day 58 to day 73 (P <0.05) and germ cells in OC were prone to apoptosis. The study provides evidence about histological feature and germ cells apoptosis in sheep fetal ovaries.
Keywords	sheep ; animal reproduction ; fetus ; sexual development ; oogenesis ; ova ; cell biology ; cell proliferation ; apoptosis ; histology ; ovaries ; light microscopes ; microstructure ; ovarian follicles ; oogonia ; normal values
Language	English
Dates of publication	2008-0115
Size	p. 179-186.
Document type	Article ; Audio / Video
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2007.05.014
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