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  1. Article ; Online: Lipopolysaccharide regulation of antiinflammatory tristetraprolin family and proinflammatory gene expression in mouse macrophages.

    Cao, Heping

    BMC research notes

    2024  Volume 17, Issue 1, Page(s) 82

    Abstract: Objective: Tristetraprolin (TTP/ZFP36) family proteins exhibit antiinflammatory effects by destabilizing proinflammatory mRNAs. Previous studies showed that bacterial endotoxin lipopolysaccharides (LPS) stimulated TTP and tumor necrosis factor (TNF) ... ...

    Abstract Objective: Tristetraprolin (TTP/ZFP36) family proteins exhibit antiinflammatory effects by destabilizing proinflammatory mRNAs. Previous studies showed that bacterial endotoxin lipopolysaccharides (LPS) stimulated TTP and tumor necrosis factor (TNF) gene expression, but less was known about LPS effects on TTP homologues and other proinflammatory gene expression in macrophages. The objective was to investigate LPS regulation of TTP family gene and TTP-targeted gene expression in mouse RAW264.7 macrophages using much higher concentrations of LPS and much longer treatment time than previous studies.
    Results: MTT assay showed that LPS was not toxic to the cells under LPS treatment up to 1000 ng/mL for 2-24 h. LPS mildly affected the soluble protein content in the cells. qPCR assay showed that LPS stimulated TTP mRNA rapidly but not sustainably with 40, 10, and 3 fold of the DMSO control after 2, 8 and 24 h treatment, respectively. Immunoblotting confirmed qPCR results on LPS stimulation of TTP gene expression in the mouse macrophages. LPS exhibited minimal effects on ZFP36L1, ZFP36L2 and ZFP36L3 mRNA levels. LPS increased mRNA levels of TNF, COX2, GM-CSF, INFγ and IL12b up to 311, 418, 11, 9 and 4 fold, respectively. This study demonstrated that LPS did not affect macrophage viability, dramatically increased antiinflammatory TTP gene expression as well as proinflammatory TNF and COX2 gene expression but had only mild effects on TTP homologues and other proinflammatory cytokine gene expression in the mouse macrophages.
    MeSH term(s) Mice ; Animals ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Tristetraprolin/genetics ; Tristetraprolin/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Macrophages/metabolism ; Anti-Inflammatory Agents/pharmacology ; Gene Expression ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Gene Expression Regulation
    Chemical Substances Lipopolysaccharides ; Tristetraprolin ; Cyclooxygenase 2 (EC 1.14.99.1) ; Anti-Inflammatory Agents ; RNA, Messenger ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-024-06743-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Measures of human functional connectome as intermediate phenotypes for schizophrenia

    Cao, Hengyi

    optimization for methods and application in imaging genetics

    2015  

    Author's details vorgelegt von Hengyi Cao
    Language English
    Size III, 120, iii, Illustrationen
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2015
    HBZ-ID HT019176359
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 E 1854 order for loan Magazin

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  3. Article: Analyzing Chinese parents' and teachers' perception of play, children's emotional needs and therapy: implications for seeking help.

    Cao, Huiting

    Frontiers in psychology

    2023  Volume 14, Page(s) 1219901

    Abstract: Introduction: Before going through play therapy with children, parents' consent is usually needed. Thus, Parents' perception of play therapy can be a very important variable that influences the extent to which children are exposed to play therapy. ... ...

    Abstract Introduction: Before going through play therapy with children, parents' consent is usually needed. Thus, Parents' perception of play therapy can be a very important variable that influences the extent to which children are exposed to play therapy. Previous research has demonstrated the significant influence of social-cultural factors on people's perceptions of play therapy. This may in turn influence parents' decision about whether their children will participate in play therapy. This study explores the factors that influence Chinese parents' decisions on their children's engagement in play therapy from a social-cultural perspective.
    Methods: This small-scale research includes the following: a questionnaire with 16 parents; three one-to-one semi-structured interviews with three parents; and one focus group with 3 teachers.
    Results: The results showed that Chinese parents' perceptions of therapy are mostly negative, which may reduce the desire of parents to let their children become involved with play therapy. The children's academic stress and the parents' economic pressures indicate a barrier for families to commit time and money to play therapy. Parents' confidence in their ability to recognize children's emotions, their lack of knowledge about play therapy, and the process of obtaining help from mental health services for children could be another barriers preventing engagement with play therapy.
    Discussions: Even though the research is conducted with a very limited sample size and the results cannot represent the wider population, this research provides some insights into this issue that can be explored in detail in future research, to re-evaluate the results and form a more concrete theory within a wider population in China.
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1219901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bacterial endotoxin lipopolysaccharides regulate gene expression in human colon cancer cells.

    Cao, Heping

    BMC research notes

    2023  Volume 16, Issue 1, Page(s) 216

    Abstract: Objective: Lipopolysaccharide (LPS) is a major cell wall component of gram-negative bacteria. Colon bacteria contribute to LPS which promotes colon cancer metastasis. The objective of this study was to survey the effect of LPS on cell viability and gene ...

    Abstract Objective: Lipopolysaccharide (LPS) is a major cell wall component of gram-negative bacteria. Colon bacteria contribute to LPS which promotes colon cancer metastasis. The objective of this study was to survey the effect of LPS on cell viability and gene expression of 55 molecular targets in human colon cancer cells.
    Results: LPS did not affect the viability of COLO 225 cells under the culture conditions but affected the expression of a number of genes important in inflammatory responses and cancer development. LPS increased TTP family, GLUT family and DGAT1 mRNA levels but decreased DGAT2a and DGAT2b expression in the human colon cancer cells. LPS also increased COX2, CXCL1, ELK1, ICAM1, TNFSF10 and ZFAND5 but decreased BCL2L1, CYP19A1 and E2F1 mRNA levels in the colon cancer cells. These data suggest that LPS has profound effects on gene expression in human colon cancer cells.
    MeSH term(s) Humans ; Lipopolysaccharides/pharmacology ; Endotoxins ; Colonic Neoplasms/genetics ; Gene Expression
    Chemical Substances Lipopolysaccharides ; Endotoxins
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-023-06506-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial for the Special Issue on Micro-Electromechanical System Inertial Devices.

    Cao, Huiliang

    Micromachines

    2023  Volume 14, Issue 12

    Abstract: Micro-electromechanical systems (MEMS) are miniature systems comprising micro-mechanical sensors, actuators, and microelectronic circuits [ ... ]. ...

    Abstract Micro-electromechanical systems (MEMS) are miniature systems comprising micro-mechanical sensors, actuators, and microelectronic circuits [...].
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14122134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial for the Special Issue on Plant Polyphenols in the Immune and Inflammatory Responses.

    Cao, Heping

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: Inflammation and associated immune diseases have placed a heavy burden on health care systems [ ... ]. ...

    Abstract Inflammation and associated immune diseases have placed a heavy burden on health care systems [...].
    MeSH term(s) Humans ; Polyphenols/pharmacology ; Inflammation ; Plants
    Chemical Substances Polyphenols
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Entrepreneurship education-infiltrated computer-aided instruction system for college Music Majors using convolutional neural network.

    Cao, Hong

    Frontiers in psychology

    2022  Volume 13, Page(s) 900195

    Abstract: The purpose is to improve the teaching and learning efficiency of college Innovation and Entrepreneurship Education (IEE). Firstly, from the perspective of aesthetic education, this work designs the teacher and student sides of the Computer-aided ... ...

    Abstract The purpose is to improve the teaching and learning efficiency of college Innovation and Entrepreneurship Education (IEE). Firstly, from the perspective of aesthetic education, this work designs the teacher and student sides of the Computer-aided Instruction (CAI) system. Secondly, the CAI model is implemented based on the weight sharing and local perception of the Convolutional Neural Network (CNN). Finally, the performance of the CNN-based CAI model is tested. Meanwhile, it analyses students' IEE experience under the proposed CAI model through a case study of Music Majors from Xi'an Conservatory of Music. The experimental data show that the CNN-based CAI model can respond quickly and stably when users access different functional modules, such as webpage browsing. The proposed CAI model increases students' entrepreneurial interest, skills, and knowledge by 55.62, 57.32, and 72.12%, respectively. Students' entrepreneurial practice ability has been improved by over 50.00%; such an increase in entrepreneurial practice ability has also shown individual differences. Thus, the proposed Music Majors-oriented IEE-infiltrated CAI model based on CNN improves students' entrepreneurial practice ability and reflects the positive experience of Music Majors on IEE. The finding provides references for the step-by-step identification of the CNN-based CAI model and has certain guiding significance for analyzing the effect of college IEE.
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.900195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Accuracy of radiostereometric analysis using a motorized Roentgen system in a pilot study for clinical simulation.

    Cao, Han

    Medical engineering & physics

    2022  Volume 111, Page(s) 103929

    Abstract: Radiostereometric analysis (RSA) is routinely implemented with two paired Roentgen tubes for three-dimensional (3D) implant migration measurements. A conventional set-up of one stationary tube and one mobile could be time-consuming. Utilizing two ... ...

    Abstract Radiostereometric analysis (RSA) is routinely implemented with two paired Roentgen tubes for three-dimensional (3D) implant migration measurements. A conventional set-up of one stationary tube and one mobile could be time-consuming. Utilizing two customized ceiling-mounted tubes is normally associated with investment costs. Thus, a pilot set-up of a motorized system (single Roentgen source) for radiostereometric image acquisition may be a time-saving and space-efficient alternative. RSA using the motorized system is feasible in this study as a non-synchronized image acquisition technique, however, patient motion may occur and influence the assessment of implant migration. The phantom study aimed to assess accuracy of RSA using the motorized Roentgen system in this in vitro study. Accuracy values of translations and rotations were ±0.29 mm and ±0.48° for the single Roentgen source RSA set-up and ±0.26 mm and ±0.48° for the conventional RSA set-up. This study was also performed to simulate potential patient motion during exposure intervals between paired image acquisition. RSA using the motorized system is able to implement RSA with acceptable accuracy. In general, RSA with synchronized image acquisition is the gold standard to access in vivo implant migration with the highest accuracy. Patient motion exists in non-synchronized image acquisition techniques and results in RSA-related motion artifacts. Then we introduced what RSA-related motion artifacts are. The uniplanar calibration cage applied in the study has a few fiducial and control markers, and some of the markers were occluded in radiographs. Whereas, the number of markers in the calibration cage is correlated with accuracy of 3D implant reconstruction.
    MeSH term(s) Humans ; Radiostereometric Analysis/methods ; Pilot Projects ; Computer Simulation ; Phantoms, Imaging
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2022.103929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2231: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Prefrontal-cerebellar dynamics during post-success and post-error cognitive controls in major psychiatric disorders.

    Cao, Hengyi

    Psychological medicine

    2022  Volume 53, Issue 11, Page(s) 4915–4922

    Abstract: Background: Difficulty in cognitive adjustment after a conflict or error is a hallmark for many psychiatric disorders, yet the underlying neural correlates are not fully understood. We have previously shown that post-success and post-error cognitive ... ...

    Abstract Background: Difficulty in cognitive adjustment after a conflict or error is a hallmark for many psychiatric disorders, yet the underlying neural correlates are not fully understood. We have previously shown that post-success and post-error cognitive controls are associated with distinct mechanisms particularly related to the prefrontal-cerebellar circuit, raising the possibility that altered dynamic interactions in this circuit may underlie mental illness.
    Methods: This study included 136 patients with three diagnosed disorders [48 schizophrenia (SZ), 49 bipolar disorder (BD), 39 attention deficit hyperactivity disorder (ADHD)] and 89 healthy controls who completed a stop-signal task during fMRI scans. Brain activations for concurrent, post-success, and post-error cognitive controls were analyzed and compared between groups. Dynamic causal modeling was applied to investigate prefrontal-cerebellar effective connectivity patterns during post-success and post-error processing.
    Results: No significant group differences were observed for brain activations and overall effective connectivity structures during post-success and post-error conditions. However, significant group differences were shown for the modulational effect on top-down connectivity from the prefrontal cortex to the cerebellum during post-error trials (
    Conclusions: These findings suggest that patients with SZ and ADHD are associated with insufficient neural modulation on the prefrontal-cerebellar circuit during post-success and post-error cognitive processing, a phenomenon that may underlie cognitive deficits in these disorders.
    MeSH term(s) Humans ; Brain Mapping ; Brain ; Cerebellum/diagnostic imaging ; Prefrontal Cortex/diagnostic imaging ; Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Magnetic Resonance Imaging ; Cognition
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291722001829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Application of Smart Wearable Fitness Equipment and Smart Health Management Based on the Improved Algorithm.

    Cao, Haibo

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 1654460

    Abstract: IoT technology has scientific, advanced, and practical characteristics in wearable fitness equipment and artificial intelligence health management. On this basis, this paper discusses the intelligent health management system based on IoT technology. By ... ...

    Abstract IoT technology has scientific, advanced, and practical characteristics in wearable fitness equipment and artificial intelligence health management. On this basis, this paper discusses the intelligent health management system based on IoT technology. By building an IoT health management system, the design principles and algorithm design of wearable fitness equipment are introduced around the device, and various noises that affect the accuracy of the equipment and how to better filter out various noises are also analyzed. The authors selected cloud service platforms and also investigated and analyzed the application prospects of wearable fitness equipment in the community. From the perspective of real-time monitoring, scientific management, and intelligent decision-making, we ensure high-quality, standardized, scientific, efficient, and accurate wearable fitness equipment applications and intelligent health management. In addition to simply viewing IoT technology as an information dissemination platform, IoT technology can also expand many other functions. According to the survey results of this article, 90% of people will use the APP with the function of sports and fitness in social media. One of the most concerned issues in the current society is the application of social media in national fitness activities.
    MeSH term(s) Algorithms ; Artificial Intelligence ; Cloud Computing ; Humans ; Technology ; Wearable Electronic Devices
    Language English
    Publishing date 2022-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/1654460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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