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Article ; Online: Accuracy of radiostereometric analysis using a motorized Roentgen system in a pilot study for clinical simulation.

Cao, Han

2022 Volume 111, Page(s) 103929

Abstract: Radiostereometric analysis (RSA) is routinely implemented with two paired Roentgen tubes for three-dimensional (3D) implant migration measurements. A conventional set-up of one stationary tube and one mobile could be time-consuming. Utilizing two ... ...

Abstract	Radiostereometric analysis (RSA) is routinely implemented with two paired Roentgen tubes for three-dimensional (3D) implant migration measurements. A conventional set-up of one stationary tube and one mobile could be time-consuming. Utilizing two customized ceiling-mounted tubes is normally associated with investment costs. Thus, a pilot set-up of a motorized system (single Roentgen source) for radiostereometric image acquisition may be a time-saving and space-efficient alternative. RSA using the motorized system is feasible in this study as a non-synchronized image acquisition technique, however, patient motion may occur and influence the assessment of implant migration. The phantom study aimed to assess accuracy of RSA using the motorized Roentgen system in this in vitro study. Accuracy values of translations and rotations were ±0.29 mm and ±0.48° for the single Roentgen source RSA set-up and ±0.26 mm and ±0.48° for the conventional RSA set-up. This study was also performed to simulate potential patient motion during exposure intervals between paired image acquisition. RSA using the motorized system is able to implement RSA with acceptable accuracy. In general, RSA with synchronized image acquisition is the gold standard to access in vivo implant migration with the highest accuracy. Patient motion exists in non-synchronized image acquisition techniques and results in RSA-related motion artifacts. Then we introduced what RSA-related motion artifacts are. The uniplanar calibration cage applied in the study has a few fiducial and control markers, and some of the markers were occluded in radiographs. Whereas, the number of markers in the calibration cage is correlated with accuracy of 3D implant reconstruction.
MeSH term(s)	Humans ; Radiostereometric Analysis/methods ; Pilot Projects ; Computer Simulation ; Phantoms, Imaging
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2022.103929
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Article ; Online: Time course from cochlear implant surgery to non-use for congenitally deaf recipients implanted as children over ten years ago.

Killan, Catherine / Cao, Han / Cordingley, Angela / Strachan, David

Frontiers in rehabilitation sciences

2023 Volume 4, Page(s) 1283109

Abstract: Objective: To determine the time-course from first cochlear implantation to non-use, to characterise non-users' receptive and expressive communication, and document known risk factors for inconsistent use, for congenitally deaf non-users of cochlear ... ...

Abstract	Objective: To determine the time-course from first cochlear implantation to non-use, to characterise non-users' receptive and expressive communication, and document known risk factors for inconsistent use, for congenitally deaf non-users of cochlear implants implanted as children at least ten years ago. Methods: Retrospective service evaluation. All congenitally deaf patients who received a first cochlear implant as children at least ten years ago at a regional service, and were currently non-users, were identified. They were characterised in terms of ages at implantation and non-use, known risk factors for inconsistent CI use or CI non-use, and outcome measures were the Meaningful Auditory Integration Scale (MAIS) and Meaningful Use of Speech Scale (MUSS) scores. Results: Seventeen patients met the inclusion criteria. They were implanted from 1990 to 2006. Median age at implantation was 4 years (range: 2-11), median age at non-use was 17 years (range: 9-31), and median duration of use was 8.5 years (range: 4-25). All used sign or gesture as their primary expressive and receptive communication modes. In addition, each child had at least one other known risk factor for inconsistent CI use. At 3 years post-implantation, mean Parent-rated MAIS scores were 76.5% ( Discussion: This cohort included cases where CI use was rejected following longer periods of time than previously reported, highlighting a need for long-term support, particularly around the ages of life transitions. Studies conducted when the earliest cohort of paediatric CI users were younger, and studies reliant on parent or patient reports, may under-estimate long-term non-use rates. No non-users were identified among congenitally-deaf children implanted 10-15 years ago. Further research is warranted to explore relationships between risk factors, including communication mode, and non-use to inform expectation setting and candidacy selection.
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6861
ISSN (online)	2673-6861
DOI	10.3389/fresc.2023.1283109
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Article ; Online: Bayesian approach for design and analysis of medical device trials in the era of modern clinical studies.

Cao, Han / Yao, Chen / Yuan, Ying

Medical review (2021)

2023 Volume 3, Issue 5, Page(s) 408–424

Abstract: Medical device technology develops rapidly, and the life cycle of a medical device is much shorter than drugs. It is necessary to evaluate the safety and effectiveness of a medical device in a timely manner to keep up with technology flux. Bayesian ... ...

Abstract	Medical device technology develops rapidly, and the life cycle of a medical device is much shorter than drugs. It is necessary to evaluate the safety and effectiveness of a medical device in a timely manner to keep up with technology flux. Bayesian methods provides an efficient approach to addressing this challenge. In this article, we review the characteristics of the Bayesian approach and some Bayesian designs that were commonly used in medical device regulatory setting, including Bayesian adaptive design, Bayesian diagnostic design, Bayesian multiregional design, and Bayesian label expansion study. We illustrate these designs with medical devices approved by the US Food and Drug Administration (FDA). We also review several innovative Bayesian information borrowing methods, and briefly discuss the challenges and future directions of the Bayesian application in medical device trials. Our objective is to promote the use of the Bayesian approach to accelerate the development of innovative medical devices and their accessibility to patients for effective disease diagnoses and treatments.
Language	English
Publishing date	2023-10-03
Publishing country	Germany
Document type	Journal Article
ISSN	2749-9642
ISSN (online)	2749-9642
DOI	10.1515/mr-2023-0026
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Article ; Online: Validation for the effect of intra-exposure patient motion on the assessment of radiostereometric implant migration in a tibial component phantom study.

Cao, Han / Zheng, Tiansheng / Jin, Zhengshuai

Orthopaedics & traumatology, surgery & research : OTSR

2023 Volume 110, Issue 2, Page(s) 103776

Abstract: Background: An increasing number of radiostereometry (RSA) research studies have long-term follow-up implant migration outcomes, which show ascending curves of implant migration with occasionally decreasing migration. After scrutinizing images and RSA ... ...

Abstract	Background: An increasing number of radiostereometry (RSA) research studies have long-term follow-up implant migration outcomes, which show ascending curves of implant migration with occasionally decreasing migration. After scrutinizing images and RSA scenes related to the alternating curves, we suppose that intra-exposure patient motion may contribute to that. The main purposes of this in vitro study were 1) to identify whether the patient motion in different directions could result in the inaccurate assessment of implant migration, and 2) to figure out which direction(s) accounted for the alternating curves. Hypothesis: It was hypothesized that the assessments of implant migration would be less precise and accurate than they could be when patient motion occurred, and such motion would contribute to the alternating curves of radiostereometric implant migration. Materials and methods: A customized phantom, assembled with a tibial component, was designed for simulating intra-exposure patient motion during follow-up RSA examinations. Two different Roentgen tubes were used as the current standard of radiology departments. Radiographs were acquired in a uniplanar technical arrangement. Two defined protocols were conducted: one is to simulate implant migration outcomes at post-op, the early stage (6months), and the later stage (2 to 10years) during the later stage, the other is to mimic patient motion by phantom motion in the medial-lateral (x), distal-proximal (y), and anterior-posterior (z) axes. Results: Phantom motion could result in the inaccurate assessment of implant migration, and translations along the medial-lateral (x) axis were the most influenced by patient motion. Motion along the medial-lateral (x) axis could account for the curves with decreasing migration. Discussion: Our assessments of implant migration may be less precise and accurate than they could be when intra-exposure patient motion occurs. We probably neglect the importance of 100% simultaneous exposures, and the influence of patient motion on RSA accuracy and data reliability, due to the difficulty in detecting patient (micro)motion. Electronically synchronized exposures of two paired Roentgen tubes are 100% simultaneous for image acquisition, and they are thus highly recommended for the assessment of implant migration in RSA. Type of study and level of proof: not applicable.
MeSH term(s)	Humans ; Radiostereometric Analysis ; Arthroplasty, Replacement, Knee/methods ; Reproducibility of Results ; Knee Prosthesis ; Tibia/diagnostic imaging ; Tibia/surgery
Language	English
Publishing date	2023-11-26
Publishing country	France
Document type	Journal Article
ISSN	1877-0568
ISSN (online)	1877-0568
DOI	10.1016/j.otsr.2023.103776
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Article ; Online: Groundwater vulnerability assessment of typical covered karst areas in northern China based on an improved COPK method

Cao, Han / Dong, Weihong / Chen, Huanliang / Wang, Ruiqing

Journal of Hydrology. 2023 Sept., v. 624 p.129904-

2023

Abstract: Karst in China is characterized by a wide distribution, diverse forms, well-developed features, and excellent preservation, making it a representative example on a global scale. The semi-arid karst in northern China, widely distributed in many provinces, ...

Abstract	Karst in China is characterized by a wide distribution, diverse forms, well-developed features, and excellent preservation, making it a representative example on a global scale. The semi-arid karst in northern China, widely distributed in many provinces, has unique hydrogeological features, including covered karst, weak karst development, thick aquifers, highly interconnected fissure network, and numerous karst springs, making it difficult to directly apply the COP method which is widely used in karst groundwater vulnerability assessment in this area. Additionally, the quality of the karst groundwater in many northern China cities is facing a threat in recent years, making it urgent to evaluate the vulnerability of the karst groundwater. This study aims to develop an improved COPK method for the covered karst groundwater vulnerability assessment modified from the widely used COP method, and to use it in the Baotu Spring basin in Jinan City, as a typical representative of the covered karst area in northern China. The assessment result by the improved COPK method shows that most of the study area exhibits moderate to low karst groundwater vulnerability, and the area with very high to high vulnerability is situated in the Middle Ordovician-Upper Cambrian Chaomidian Formation limestone exposed area. The above results by the improved COPK method are more consistent with the hydrogeological conditions than those by the original COP method. A comparison of nitrate contamination map to the groundwater vulnerability map reveals the more efficient performance of the improved COPK method compared to the original COP method in vulnerability assessment of the typical covered karst areas in northern China. This paper can provide a reference for karst groundwater vulnerability assessment of covered karst areas in northern China, as well as other countries and regions with similar hydrogeological conditions, which can provide valuable support for groundwater pollution control efforts.
Keywords	Cambrian period ; basins ; groundwater ; groundwater contamination ; karsts ; limestone ; nitrates ; pollution control ; risk assessment ; China ; Groundwater vulnerability assessment ; Covered karst areas ; COPK method
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2023.129904
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Article ; Online: Child-Sum EATree-LSTMs: enhanced attentive Child-Sum Tree-LSTMs for biomedical event extraction.

Wang, Lei / Cao, Han / Yuan, Liu / Guo, Xiaoxu / Cui, Yachao

BMC bioinformatics

2023 Volume 24, Issue 1, Page(s) 253

Abstract: Background: Tree-structured neural networks have shown promise in extracting lexical representations of sentence syntactic structures, particularly in the detection of event triggers using recursive neural networks.: Methods: In this study, we ... ...

Abstract	Background: Tree-structured neural networks have shown promise in extracting lexical representations of sentence syntactic structures, particularly in the detection of event triggers using recursive neural networks. Methods: In this study, we introduce an attention mechanism into Child-Sum Tree-LSTMs for the detection of biomedical event triggers. We incorporate previous researches on assigning attention weights to adjacent nodes and integrate this mechanism into Child-Sum Tree-LSTMs to improve the detection of event trigger words. We also address a limitation of shallow syntactic dependencies in Child-Sum Tree-LSTMs by integrating deep syntactic dependencies to enhance the effect of the attention mechanism. Results: Our proposed model, which integrates an enhanced attention mechanism into Tree-LSTM, shows the best performance for the MLEE and BioNLP'09 datasets. Moreover, our model outperforms almost all complex event categories for the BioNLP'09/11/13 test set. Conclusion: We evaluate the performance of our proposed model with the MLEE and BioNLP datasets and demonstrate the advantage of an enhanced attention mechanism in detecting biomedical event trigger words.
MeSH term(s)	Humans ; Data Mining ; Neural Networks, Computer
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-023-05336-7
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Article ; Online: Robust optical edge detection enabled by a twisted reflective q-plate.

Chen, Quanming / Cao, Han / Ouyang, Cheng / Shen, Yanchun / Hu, Wei

Optics letters

2023 Volume 48, Issue 23, Page(s) 6112–6115

Abstract: Optical edge detection significantly reduces the image information load and is highly sought after in instant image processing. Robustness to the wavelength and polarization of light as well as mechanical vibration is a key requirement for practical ... ...

Abstract	Optical edge detection significantly reduces the image information load and is highly sought after in instant image processing. Robustness to the wavelength and polarization of light as well as mechanical vibration is a key requirement for practical applications. Here, a robust optical edge detector is proposed and demonstrated based on a reflective twisted liquid crystal q-plate. The device is composed of a mirror and a 1.46-μm-thick liquid crystal layer with a twist angle of 69.2°. The backtracking of the light inside the twisted medium forms a mirror symmetric twisted design and thus leads to a broadband self-compensated spiral phase modulation. By this means, an optical edge detector with excellent wavelength and polarization independence is presented for both coherent and partially coherent light sources. Additionally, the reflective design makes the system more compact and stable. This work supplies a practical design for robust optical edge detection, which may upgrade existing image processing techniques.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.505845
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Article ; Online: Comparing the efficacy of salvage regimens for relapsed/refractory B-cell acute lymphoblastic leukaemia: a systematic review and network meta-analysis.

Cao, Han-Yu / Wan, Chao-Ling / Xue, Sheng-Li

Annals of hematology

2022

Abstract: The complete remission (CR) rate and overall survival (OS) of relapsed/refractory (R/R) B-cell acute lymphoblastic leukaemia (B-ALL) are not satisfactory. The available salvage regimens include standard chemotherapy, inotuzumab ozogamicin, blinatumomab ... ...

Abstract	The complete remission (CR) rate and overall survival (OS) of relapsed/refractory (R/R) B-cell acute lymphoblastic leukaemia (B-ALL) are not satisfactory. The available salvage regimens include standard chemotherapy, inotuzumab ozogamicin, blinatumomab and cluster of differentiation (CD)19 chimeric antigen receptor T cells (CAR T), and the NCCN guidelines recommend all of these therapies with no preference. Dual CD19/CD22 CAR T-cells have emerged as new treatments and have shown some efficacy, with high CR rates and preventing CD19-negative relapse. However, direct comparisons of the CR rate and long-term survival among the different salvage therapies are lacking. Databases including PubMed, Embase, Web of Science and Cochrane were searched from inception to January 31, 2022, for relevant studies. The outcomes of interest were complete remission/complete remission with incomplete haematologic recovery (CR/CRi) rates and 1-year overall survival (OS) rates. Odds ratios (ORs) were generated for binary outcomes, and the mean difference (MD) was generated for consecutive outcomes by network meta-analysis. CD19 CAR T-cells demonstrated a significantly better effect in improving the CR/CRi rate than blinatumomab (OR = 8.32, 95% CI: 1.18 to 58.44) and chemotherapy (OR = 16.4, 95% CI: 2.76 to 97.45). In terms of OS, CD19 CAR T-cells and dual CD19/CD22 CAR T-cells both had a higher 1-year OS rate than blinatumomab, inotuzumab ozogamicin and chemotherapy. There was no significant difference between CD19 CAR T-cells and dual CD19/CD22 CAR T-cells in terms of 1-year OS and CR/CRi rates. CD19 CAR T-cells are effective in inducing CR, and CD19 CAR T-cells and dual CD19/CD22 CAR T-cells show benefits for overall survival. More high-quality randomized controlled trials and longer follow-ups are needed to confirm and update the results of this analysis in the future.
Language	English
Publishing date	2022-11-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-022-05040-1
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Article ; Online: Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March.

Xia, Yuhan / Cao, Han / Zheng, Jie / Chen, Lihong

Frontiers in immunology

2022 Volume 13, Page(s) 927465

Abstract: Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy tends to increase after atopic dermatitis. The mechanism underlying the progression of allergic inflammation from the skin to gastrointestinal (GI) tract and airways ... ...

Abstract	Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy tends to increase after atopic dermatitis. The mechanism underlying the progression of allergic inflammation from the skin to gastrointestinal (GI) tract and airways has still remained elusive. Impaired skin barrier was proposed as a risk factor for allergic sensitization. Claudin-1 protein forms tight junctions and is highly expressed in the epithelium of the skin, airways, and GI tract, thus, the downregulation of claudin-1 expression level caused by CLDN-1 gene polymorphism can mediate common dysregulation of epithelial barrier function in these organs, potentially leading to allergic sensitization at various sites. Importantly, in patients with atopic dermatitis, asthma, and food allergy, claudin-1 expression level was significantly downregulated in the skin, bronchial and intestinal epithelium, respectively. Knockdown of claudin-1 expression level in mouse models of atopic dermatitis and allergic asthma exacerbated allergic inflammation, proving that downregulation of claudin-1 expression level contributes to the pathogenesis of allergic diseases. Therefore, we hypothesized that the tight junction dysfunction mediated by downregulation of claudin-1 expression level contributes to atopic march. Further validation with clinical data from patients with atopic march or mouse models of atopic march is needed. If this hypothesis can be fully confirmed, impaired claudin-1 expression level may be a risk factor and likely a diagnostic marker for atopic march. Claudin-1 may serve as a valuable target to slowdown or block the progression of atopic march.
MeSH term(s)	Animals ; Asthma/metabolism ; Claudin-1/genetics ; Claudin-1/metabolism ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Food Hypersensitivity/metabolism ; Inflammation/metabolism ; Mice ; Tight Junctions/metabolism
Chemical Substances	Claudin-1 ; Cldn1 protein, mouse
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.927465
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Article: Efficient removal of Pb(II) by UiO-66-NH2: A combined experimental and spectroscopic studies

Huang, Lintianyang / Cao, Han / Ma, Junzhou / Wang, Xiangxue

Environmental nanotechnology, monitoring & management. 2022 Dec., v. 18

2022

Abstract: In this work, UiO-66 and UiO-66-NH₂ materials were successfully synthesized by hydrothermal method and applied to remove Pb(II) from aqueous solution efficiently. Scanning electron microscopy (SEM), X-ray energy spectroscopy (XRD), and Fourier infrared ... ...

Abstract	In this work, UiO-66 and UiO-66-NH₂ materials were successfully synthesized by hydrothermal method and applied to remove Pb(II) from aqueous solution efficiently. Scanning electron microscopy (SEM), X-ray energy spectroscopy (XRD), and Fourier infrared spectroscopy (FTIR) characterizations proved that the prepared MOFs had abundant oxygen-containing functional groups and excellent physicochemical properties. The effects of solution conditions (pH, reaction time and temperature) on Pb(II) adsorption to the MOF materials were investigated systematically by batch experiments. The adsorption equilibrium reached within 80 min and was well simulated by the Pseudo-second-order kinetic model. The adsorption isotherms were fitted by Langmuir model well, which indicated that the removal of Pb(II) was a uniform adsorption process in a single molecular layer. The maximum adsorption capacity of UiO-66-NH₂ was 320.73 mg/g at pH = 6 and T = 328 K, which was much higher than that of UiO-66 (291.39 mg/g). The above analysis suggested that UiO-66-NH₂ had high adsorption capacity and could be used as a potential stockpile material for efficient removal of Pb(II) ions from industrial wastewater.
Keywords	X-radiation ; administrative management ; adsorption ; aqueous solutions ; electron microscopy ; energy ; hot water treatment ; industrial wastewater ; infrared spectroscopy ; kinetics ; nanotechnology ; pH ; sorption isotherms ; temperature
Language	English
Dates of publication	2022-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2821777-9
ISSN	2215-1532
ISSN	2215-1532
DOI	10.1016/j.enmm.2022.100741
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