LIVIVO - Search results -

Search results

Result 1 - 9 of total 9

Search options

Article ; Online: Synthesis and evaluation of water-soluble imidazolium salt chitin with broad-spectrum antimicrobial activity and excellent biocompatibility for infected wound healing

Ma, Yongsheng / Xu, Shuyi / Yue, Pengpeng / Cao, Hankun / Zou, Yongkang / Wang, Lizhe / Long, Haitao / Wu, Shuangquan / Ye, Qifa

Carbohydrate Polymers. 2023 Apr., v. 306 p.120575-

2023

Abstract: Infections caused by bacteria have long constituted a major threat to human health and the economy. Therefore, there is an urgent need to design broad-spectrum antibacterial materials possessing good biocompatibility to treat such infections. Herein, ... ...

Abstract	Infections caused by bacteria have long constituted a major threat to human health and the economy. Therefore, there is an urgent need to design broad-spectrum antibacterial materials possessing good biocompatibility to treat such infections. Herein, inspired by the good biocompatibility of chitin and antibacterial properties of imidazolium salts, a polysaccharide-based material, imidazolium salt chitin (IMSC), was homogeneously prepared using a facile method with epichlorohydrin as a chemical crosslinker to combine chitin with imidazole to enhance Staphylococcus aureus (S. aureus)-infected wound healing. The characteristics, antimicrobial properties, and biosafety of IMSC were evaluated. The results demonstrated successful grafting of imidazole onto chitin. Furthermore, IMSC exhibited good water solubility, broad-spectrum antimicrobial activity, hemocompatibility, and biocompatibility. Moreover, IMSC enabled complete healing of S. aureus-infected wound in Sprague–Dawley rats within 15 days of application, thus demonstrating that IMSC could reduce wound inflammation and remarkably accelerate wound healing owing to its efficient antibacterial activity and ability to promote collagen deposition in and around the wound area. Therefore, this study provides a promising and potential therapeutic strategy for infected wound healing by synthesizing a water-soluble and broad-spectrum antimicrobial material exhibiting good biocompatibility.
Keywords	Staphylococcus aureus ; antibacterial properties ; biocompatibility ; biosafety ; chitin ; collagen ; epichlorohydrins ; human health ; imidazole ; inflammation ; therapeutics ; water solubility ; APTT ; ATCC ; C. albicans ; Calcein-AM ; CCK-8 ; DA ; DS ; ECH ; E. coli ; FTIR ; H&E ; IMSC ; IMSs ; NMR ; PBS ; PI ; PT ; QCS ; S. aureus ; SD ; SEM ; TEM ; TGA ; TT ; XPS ; XRD ; Imidazolium salt ; Antimicrobial activity ; Wound healing
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120575
Database	NAL-Catalogue (AGRICOLA)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: A novel ameliorated rat model of reversible obstructive jaundice.

Zou, Yongkang / Yue, Pengpeng / Cao, Hankun / Wu, Liqin / Xu, Li / Liu, Zhongzhong / Wu, Shuangquan / Ye, Qifa

Journal of Zhejiang University. Science. B

2023 Volume 24, Issue 4, Page(s) 345–351

Abstract: Obstructive jaundice is a common clinical symptom generally caused by bile duct stones, inflammatory hyperplasia, and tumors. It is characterized by hyperbilirubinemia and may trigger a variety of complications such as hypotension, kidney injury, ... ...

Title translation	一种新型改良式可逆性梗阻性黄疸大鼠模型的建立.
Abstract	Obstructive jaundice is a common clinical symptom generally caused by bile duct stones, inflammatory hyperplasia, and tumors. It is characterized by hyperbilirubinemia and may trigger a variety of complications such as hypotension, kidney injury, endotoxemia, multiple organ dysfunction syndrome, and even death (Pavlidis and Pavlidis, 2018; Liu et al., 2021). Relieving bile duct obstruction and providing adequate drainage have been considered as the most effective therapies for obstructive jaundice. However, it has not yet been established whether it is beneficial to treat affected patients by pre-operative biliary drainage (Blacker et al., 2021). Moreover, the pathophysiological changes or mechanisms associated with the reversal of organ function following the relief of bile-duct obstruction are unclear (Huang et al., 2004). Therefore, it is necessary to establish an experimental model of reversible obstructive jaundice to simulate biliary drainage in clinical practice.
MeSH term(s)	Animals ; Rats ; Jaundice, Obstructive/etiology ; Jaundice, Obstructive/surgery ; Disease Models, Animal
Language	Chinese
Publishing date	2023-03-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2247290-3
ISSN	1862-1783 ; 1673-1581
ISSN (online)	1862-1783
ISSN	1673-1581
DOI	10.1631/jzus.B2200421
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.

Yue, Pengpeng / Lv, Xiaoyan / You, Jian / Zou, Yongkang / Luo, Jun / Lu, Zhongshan / Cao, Hankun / Liu, Zhongzhong / Fan, Xiaoli / Ye, Qifa

Cellular & molecular biology letters

2023 Volume 28, Issue 1, Page(s) 55

Abstract: Background: Hepatic ischemia-reperfusion injury (IRI) in donation after cardiac death (DCD) donors is a major determinant of transplantation success. Endoplasmic reticulum (ER) stress plays a key role in hepatic IRI, with potential involvement of the ... ...

Abstract	Background: Hepatic ischemia-reperfusion injury (IRI) in donation after cardiac death (DCD) donors is a major determinant of transplantation success. Endoplasmic reticulum (ER) stress plays a key role in hepatic IRI, with potential involvement of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and the antiapoptotic protein hematopoietic-lineage substrate-1-associated protein X-1 (HAX1). In this study, we aimed to investigate the effects of hypothermic oxygenated perfusion (HOPE), an organ preservation modality, on ER stress and apoptosis during hepatic IRI in a DCD rat model. Methods: To investigate whether HOPE could improve IRI in DCD livers, levels of different related proteins were examined by western blotting and quantitative real-time polymerase chain reaction. Further expression analyses, immunohistochemical analyses, immunofluorescence staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, and transmission electron microscopy were conducted to analyze the effects of HOPE on ER stress and apoptosis. To clarify the role of the JAK2/STAT3 pathway and HAX1 in this process, AG490 inhibitor, JAX1 plasmid transfection, co-immunoprecipitation (CO-IP), and flow cytometry analyses were conducted. Results: HOPE reduced liver injury and inflammation while alleviating ER stress and apoptosis in the DCD rat model. Mechanistically, HOPE inhibited unfolded protein responses by activating the JAK2/STAT3 pathway, thus reducing ER stress and apoptosis. Moreover, the activated JAK2/STAT3 pathway upregulated HAX1, promoting the interaction between HAX1 and SERCA2b to maintain ER calcium homeostasis. Upregulated HAX1 also modulated ER stress and apoptosis by inhibiting the inositol-requiring enzyme 1 (IRE1) pathway. Conclusions: JAK2/STAT3-mediated upregulation of HAX1 during HOPE alleviates hepatic ER stress and apoptosis, indicating the JAK2/STAT3/HAX1 pathway as a potential target for IRI management during DCD liver transplantation.
MeSH term(s)	Animals ; Rats ; Janus Kinase 2 ; STAT3 Transcription Factor ; Liver ; Endoplasmic Reticulum Stress ; Perfusion
Chemical Substances	Janus Kinase 2 (EC 2.7.10.2) ; STAT3 Transcription Factor
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2108724-6
ISSN	1689-1392 ; 1689-1392
ISSN (online)	1689-1392
ISSN	1689-1392
DOI	10.1186/s11658-023-00466-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Biocompatible and biodegradable chitin-based hydrogels crosslinked by BDDE with excellent mechanical properties for effective prevention of postoperative peritoneal adhesion.

Zou, Yongkang / Yue, Pengpeng / Cao, Hankun / Wu, Liqin / Xu, Li / Liu, Zhongzhong / Wu, Shuangquan / Ye, Qifa

Carbohydrate polymers

2023 Volume 305, Page(s) 120543

Abstract: Postoperative peritoneal adhesions are common complications caused by abdominal and pelvic surgery, which seriously impact the quality of life of patients and impose additional financial burdens. Using of biomedical materials as physical barriers to ... ...

Abstract	Postoperative peritoneal adhesions are common complications caused by abdominal and pelvic surgery, which seriously impact the quality of life of patients and impose additional financial burdens. Using of biomedical materials as physical barriers to completely isolate the traumatic organ and injured tissue is an optimal strategy for preventing postoperative adhesions. However, the limited efficacy and difficulties in the complete degradation or integration of biomedical materials with living tissues restrict the application of these materials. In this study, novel chitin-based crosslinked hydrogels with appropriate mechanical properties and flexibilities were developed using a facile and green strategy. The developed hydrogels simultaneously exhibited excellent biocompatibilities and resistance to nonspecific protein adsorption and NIH/3T3 fibroblast adhesion. Furthermore, these hydrogels were biodegradable and could be completely integrated into the native extracellular matrix. The chitin-based crosslinked hydrogels also effectively inhibited postoperative peritoneal adhesions in rat models of adhesion and recurrence. Therefore, these novel chitin-based crosslinked hydrogels are excellent candidate physical barriers for the efficient prevention of postoperative peritoneal adhesions and provide a new anti-adhesion strategy for biomedical applications.
MeSH term(s)	Rats ; Animals ; Chitin/pharmacology ; Chitin/therapeutic use ; Hydrogels/pharmacology ; Quality of Life ; Peritoneum/pathology ; Biocompatible Materials/pharmacology ; Biocompatible Materials/therapeutic use ; Tissue Adhesions/prevention & control
Chemical Substances	Chitin (1398-61-4) ; Hydrogels ; Biocompatible Materials
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120543
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: High-strength, antibacterial, antioxidant, hemostatic, and biocompatible chitin/PEGDE-tannic acid hydrogels for wound healing.

Cao, Hankun / Xiang, Du / Zhou, Xin / Yue, Pengpeng / Zou, Yongkang / Zhong, Zibiao / Ma, Yongsheng / Wang, Lizhe / Wu, Shuangquan / Ye, Qifa

Carbohydrate polymers

2023 Volume 307, Page(s) 120609

Abstract: Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. ... ...

Abstract	Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. Herein, we fabricated novel multifunctional chitin/PEGDE-tannic acid (CPT) hydrogels through chemical- and physical-crosslinking strategies, using chitin as the base material, polyethylene glycol diglycidyl ether (PEGDE) and tannic acid (TA) as crosslinking agents, and 90 % ethanol as the regenerative bath. CPT hydrogels maintained a stable three-dimensional porous structure with suitable water contents and excellent biocompatibility. The mechanical properties of hydrogels were greatly improved (tensile stress up to 5.43 ± 1.14 MPa). Moreover, CPT hydrogels had good antibacterial, antioxidant, and hemostatic activities and could substantially promote wound healing in a rat model of full-thickness skin defect by regulating inflammatory responses and promoting collagen deposition and blood vessel formation. Therefore, this work provides a useful strategy to fabricate novel multifunctional CPT hydrogels with excellent mechanical, antibacterial, antioxidant, hemostatic, and biocompatible properties. CPT hydrogels could be promising candidates for wound healing.
MeSH term(s)	Rats ; Animals ; Hemostatics/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Wound Healing/physiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Chitin/pharmacology
Chemical Substances	Hemostatics ; Antioxidants ; Hydrogels ; Anti-Bacterial Agents ; Chitin (1398-61-4)
Language	English
Publishing date	2023-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120609
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: New Drainage Management Following Liver Transplant Results in Fewer Postoperative Hospital Days.

Wang, Lizhe / Liu, Zhongzhong / Cao, Hankun / Yue, Pengpeng / Ma, Yongsheng / Zhong, Zibiao / Zhou, Xin / Hu, Zhengbin / Ye, Shaojun / Ye, Qifa

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2023 Volume 21, Issue 9, Page(s) 749–755

Abstract: Objectives: Drain tube management after liver transplant is controversial. A new peritoneal drainage management protocol was developed to validate clinical characteristics, such as drain characteristics, postoperative complications, duration of ... ...

Abstract	Objectives: Drain tube management after liver transplant is controversial. A new peritoneal drainage management protocol was developed to validate clinical characteristics, such as drain characteristics, postoperative complications, duration of postoperative hospital stay, changes in albumin levels, and 30-day readmission rates. Materials and methods: Data from 183 consecutive patients who underwent deceased donor liver transplant at our institution between January 2019 and June 2022 were retrospectively analyzed. A new drain management protocol was implemented on August 1, 2021, which included early removal of the drain tube when the serum albumin level was >3 g/dL and nonchylous fluid drainage was <200 mL/day. Results: When we compared the traditional and new drain management protocol groups (n = 131 vs n = 52), the new management protocol group showed a decrease in the median duration of intraperitoneal drainage. In addition, the median length of postoperative hospital stay decreased from 33 to 27 days and serum albumin levels returned to normal faster at postoperative 3 weeks. No significant differences were found in postoperative hemorrhage, hematoma, hydrops abdominis, infections, biliary complications, orin the rate ofreinterventions and 30-day rehospitalizations. Conclusions: The new management protocol was associated with fewer postoperative hospital days and faster recovery than traditional management. Our findings may aid in the development of new drain policy recommendations based on preexisting risk factors.
MeSH term(s)	Humans ; Liver Transplantation/adverse effects ; Retrospective Studies ; Time Factors ; Living Donors ; Drainage/adverse effects ; Drainage/methods ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Length of Stay ; Serum Albumin ; Hospitals
Chemical Substances	Serum Albumin
Language	English
Publishing date	2023-10-26
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2023.0159
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6632: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synthesis and evaluation of water-soluble imidazolium salt chitin with broad-spectrum antimicrobial activity and excellent biocompatibility for infected wound healing.

Ma, Yongsheng / Xu, Shuyi / Yue, Pengpeng / Cao, Hankun / Zou, Yongkang / Wang, Lizhe / Long, Haitao / Wu, Shuangquan / Ye, Qifa

Carbohydrate polymers

2023 Volume 306, Page(s) 120575

Abstract	Infections caused by bacteria have long constituted a major threat to human health and the economy. Therefore, there is an urgent need to design broad-spectrum antibacterial materials possessing good biocompatibility to treat such infections. Herein, inspired by the good biocompatibility of chitin and antibacterial properties of imidazolium salts, a polysaccharide-based material, imidazolium salt chitin (IMSC), was homogeneously prepared using a facile method with epichlorohydrin as a chemical crosslinker to combine chitin with imidazole to enhance Staphylococcus aureus (S. aureus)-infected wound healing. The characteristics, antimicrobial properties, and biosafety of IMSC were evaluated. The results demonstrated successful grafting of imidazole onto chitin. Furthermore, IMSC exhibited good water solubility, broad-spectrum antimicrobial activity, hemocompatibility, and biocompatibility. Moreover, IMSC enabled complete healing of S. aureus-infected wound in Sprague-Dawley rats within 15 days of application, thus demonstrating that IMSC could reduce wound inflammation and remarkably accelerate wound healing owing to its efficient antibacterial activity and ability to promote collagen deposition in and around the wound area. Therefore, this study provides a promising and potential therapeutic strategy for infected wound healing by synthesizing a water-soluble and broad-spectrum antimicrobial material exhibiting good biocompatibility.
MeSH term(s)	Rats ; Animals ; Humans ; Staphylococcus aureus ; Rats, Sprague-Dawley ; Escherichia coli ; Wound Healing ; Anti-Infective Agents ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/chemistry ; Chitin/pharmacology ; Chitin/therapeutic use ; Chitin/chemistry ; Sodium Chloride ; Water/chemistry ; Wound Infection/drug therapy
Chemical Substances	Anti-Infective Agents ; Anti-Bacterial Agents ; Chitin (1398-61-4) ; Sodium Chloride (451W47IQ8X) ; Water (059QF0KO0R)
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120575
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Book ; Online: Adaptive Gradient Coding

Cao, Hankun / Yan, Qifa / Tang, Xiaohu / Han, Guojun

2020

Abstract: This paper focuses on mitigating the impact of stragglers in distributed learning system. Unlike the existing results designed for a fixed number of stragglers, we developed a new scheme called Adaptive Gradient Coding(AGC) with flexible tolerance of ... ...

Abstract	This paper focuses on mitigating the impact of stragglers in distributed learning system. Unlike the existing results designed for a fixed number of stragglers, we developed a new scheme called Adaptive Gradient Coding(AGC) with flexible tolerance of various number of stragglers. Our scheme gives an optimal tradeoff between computation load, straggler tolerance and communication cost. In particular, it allows to minimize the communication cost according to the real-time number of stragglers in the practical environments. Implementations on Amazon EC2 clusters using Python with mpi4py package verify the flexibility in several situations.
Keywords	Computer Science - Information Theory
Publishing date	2020-06-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.

Yue, Pengpeng / Chen, Biao / Lv, Xiaoyan / Zou, Yongkang / Cao, Hankun / Ma, Yongsheng / Wang, Lizhe / Liu, Zhongzhong / Zheng, Yiran / Duan, Bo / Wu, Shuangquan / Ye, Qifa

Macromolecular bioscience

2022 Volume 22, Issue 4, Page(s) e2100412

Abstract: Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease. Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility ... ...

Abstract	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease. Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials. In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres are successfully prepared. Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m
MeSH term(s)	Adsorption ; Animals ; Bilirubin ; Carbon/pharmacology ; Chitin/chemistry ; Chitin/pharmacology ; Humans ; Mice ; Microspheres ; Porosity ; Rabbits
Chemical Substances	Chitin (1398-61-4) ; Carbon (7440-44-0) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-01-22
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202100412
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito