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  1. Article ; Online: Coronavirus disease 2019 outcomes in heart transplant recipients: A large Australian cohort.

    Cherrett, Callum / Cao, Jacob / Adams, Cobi / Macdonald, Peter

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2023  Volume 43, Issue 2, Page(s) 346–349

    Abstract: Heart transplant recipients have been reported to be at a significantly elevated risk of poor outcomes from coronavirus disease 2019 (COVID-19) infection owing to their underlying comorbidities and immunosuppression. We conducted a single-center ... ...

    Abstract Heart transplant recipients have been reported to be at a significantly elevated risk of poor outcomes from coronavirus disease 2019 (COVID-19) infection owing to their underlying comorbidities and immunosuppression. We conducted a single-center retrospective cohort of all heart transplant recipients who were known to have contracted COVID-19 between January 2020 and September 2022. Electronic medical records were used to collect baseline demographics, vaccination status, COVID-19 treatment received, hospitalization data, and mortality. Our primary end point was mortality, and our secondary endpoint was hospitalization. Between January 2020 and September 2022, 132 heart transplant recipients at our single-center contracted COVID-19 infection. Our population had high rates of vaccination, with 124 patients (94%) having received at least 2 vaccines. We found significantly lower rates of mortality and hospitalization than had been previously reported earlier in the pandemic, with a mortality rate of 8/132 (6%) and hospitalization rate of 21/132 (16%).
    MeSH term(s) Humans ; COVID-19/therapy ; SARS-CoV-2 ; Retrospective Studies ; COVID-19 Drug Treatment ; Australia/epidemiology ; Heart Transplantation ; Transplant Recipients
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2023.09.007
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    Zs.A 2056: Show issues Location:
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  2. Article: The efficacy and cost-effectiveness of enoxaparin versus rivaroxaban in the prevention of venous thromboembolism following total hip or knee arthroplasty: A meta-analysis.

    Xu, Joshua / Chang, David / Chui, Juanita / Cao, Jacob / Negus, Jonathan

    Journal of orthopaedics

    2022  Volume 30, Page(s) 1–6

    Abstract: Introduction: Thromboprophylaxis following total hip and knee arthroplasty is variable across institutions, but commonly consists of enoxaparin, and more recently rivaroxaban. We aimed to analyze the current evidence on the efficacy, safety and cost- ... ...

    Abstract Introduction: Thromboprophylaxis following total hip and knee arthroplasty is variable across institutions, but commonly consists of enoxaparin, and more recently rivaroxaban. We aimed to analyze the current evidence on the efficacy, safety and cost-effectiveness of rivaroxaban versus enoxaparin for thromboprophylaxis following TKA or THA.
    Methods: This study was conducted according to PRISMA guidelines. Electronic database searches were performed using three databases from their dates of inception to June 2020. Relevant randomized controlled studies were identified, with data extracted and analyzed.
    Results: From eight studies, 13,384 patients were included, with 5700 undergoing TKA and 7684 undergoing THA. There were 6629 patients receiving rivaroxaban and 6755 patients receiving enoxaparin. From the total cohort, rivaroxaban was associated with significantly lower rates of major VTE (p = 0.009) and DVT (p < 0.001) when compared to enoxaparin. There was no significant difference in bleeding complications between rivaroxaban and enoxaparin groups (p = 0.14). Subgroup analysis of patients undergoing THA demonstrated that rivaroxaban reduced risk of major VTE (p = 0.002) and DVT (p = 0.01) with no significant differences in any other complications. For those undergoing TKA, rivaroxaban significantly reduced the risk of DVT (p < 0.001) but was associated with higher rates of post-operative blood transfusion (p = 0.03). Cost-analysis revealed that rivaroxaban was superior to enoxaparin, with the medication cost needed to prevent one DVT being $1081 and $432 less with rivaroxaban for THA and TKA respectively.
    Conclusions: Rivaroxaban may be a safe and cost-effective alternative to enoxaparin for routine thromboprophylaxis following total knee or hip arthroplasty.
    Language English
    Publishing date 2022-02-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2022.02.003
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  3. Article ; Online: COVID-19: getting to the heart of the matter.

    Wang, Nelson / Cao, Jacob / Lal, Sean

    European journal of heart failure

    2020  Volume 22, Issue 12, Page(s) 2216–2218

    MeSH term(s) COVID-19 ; Heart Failure ; Humans ; Incidence ; Prevalence ; Prognosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2007
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    Zs.A 5299: Show issues Location:
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  4. Article ; Online: Clinical Outcomes and Complications of Primary Fingertip Reconstruction Using a Reverse Homodigital Island Flap: A Systematic Review.

    Xu, Joshua / Cao, Jacob Y / Graham, David J / Lawson, Richard D / Sivakumar, Brahman S

    Hand (New York, N.Y.)

    2021  Volume 18, Issue 2, Page(s) 264–271

    Abstract: Background: Reverse homodigital island flaps (RHIFs) are increasingly used to reconstruct traumatic fingertip injuries, but there is limited evidence on the efficacy of this technique. We performed a systematic review of the literature to establish the ... ...

    Abstract Background: Reverse homodigital island flaps (RHIFs) are increasingly used to reconstruct traumatic fingertip injuries, but there is limited evidence on the efficacy of this technique. We performed a systematic review of the literature to establish the safety and functional outcomes of RHIF for traumatic fingertip injuries.
    Methods: Electronic searches were performed using 3 databases (PubMed, Ovid Medline, Cochrane CENTRAL) from their date of inception to April 2020. Relevant studies were required to report on complications and functional outcomes for patients undergoing RHIF for primary fingertip reconstruction. Data were extracted from included studies and analyzed.
    Results: Sixteen studies were included, which produced a total cohort of 459 patients with 495 fingertip injuries. The index and middle fingers were involved most frequently (34.6% and 34.1%, respectively), followed by the ring finger (22%), the little finger (6.7%), and the thumb (2.6%). The mean postoperative static and moving 2-point discrimination was 7.2 and 6.7 mm, respectively. The mean time to return to work was 8.4 weeks. The mean survivorship was 98.4%, with the pooled complication rate being 28%. The pooled complication rate of complete flap necrosis was 3.6%, of partial flap necrosis was 10.3%, of venous congestion was 14.6%, of pain or hypersensitivity was 11.5%, of wound infection was 7.2%, of flexion contractures was 6.3%, and of cold intolerance was 17.7%.
    Conclusions: Reverse homodigital island flaps can be performed safely with excellent outcomes. To minimize complications, care is taken during dissection and insetting, with extensive rehabilitation adhered to postoperatively. Prospective studies assessing outcomes of RHIF compared with other reconstruction techniques would be beneficial.
    MeSH term(s) Humans ; Prospective Studies ; Finger Injuries/surgery ; Surgical Flaps ; Fingers/surgery ; Necrosis
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2277325-3
    ISSN 1558-9455 ; 1558-9447
    ISSN (online) 1558-9455
    ISSN 1558-9447
    DOI 10.1177/15589447211003179
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    Zs.A 6820: Show issues Location:
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  6. Article ; Online: COVID ‐19

    Wang, Nelson / Cao, Jacob / Lal, Sean

    European Journal of Heart Failure ; ISSN 1388-9842 1879-0844

    getting to the heart of the matter

    2020  

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ejhf.2007
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID-19

    Wang, Nelson / Cao, Jacob / Lal, Sean

    Getting to the Heart of the Matter

    2020  

    Keywords COVID-19 ; Coronavirus ; covid19
    Language English
    Publishing date 2020-01-01
    Publishing country au
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Kinematic versus mechanical alignment for primary total knee replacement: A systematic review and meta-analysis.

    Xu, Joshua / Cao, Jacob Y / Luong, Jason K / Negus, Jonathan J

    Journal of orthopaedics

    2019  Volume 16, Issue 2, Page(s) 151–157

    Language English
    Publishing date 2019-02-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2019.02.008
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  9. Article: Comparison of outpatient versus inpatient total hip and knee arthroplasty: A systematic review and meta-analysis of complications.

    Xu, Joshua / Cao, Jacob Y / Chaggar, Gurpreet S / Negus, Jonathan J

    Journal of orthopaedics

    2019  Volume 17, Page(s) 38–43

    Abstract: Introduction: Patients undergoing TKA or THA have traditionally been managed post-operatively as inpatients. However, with current surgical techniques and pain management, there is evidence that outpatient joint arthroplasty can be safely performed in ... ...

    Abstract Introduction: Patients undergoing TKA or THA have traditionally been managed post-operatively as inpatients. However, with current surgical techniques and pain management, there is evidence that outpatient joint arthroplasty can be safely performed in selected patient. This systematic review and meta-analysis aimed to compare the post-operative complication rates of outpatient and inpatient TJA with subgroup analysis of TKA and THA.
    Methods: Electronic searches were performed using five databases from their date of inception to October 2018. Relevant studies were identified, with data extracted and meta-analyzed from the studies.
    Results: From seven included studies, 176,179 patients were inpatient TJA and 1613 were outpatient TJA. The outpatient and inpatient TJA cohorts had similar mean age and BMI, with a greater proportion of females in the inpatient group. For TJA we found no significant difference in total complications (P = 0.06), major complications (P = 0.59), readmissions (P = 0.60), DVT (P = 0.94), UTI (P = 0.50), pneumonia (P = 0.42) and wound complications (P = 0.50) between the outpatient and inpatient groups. However, there were fewer transfusions (P = 0.05) but increased reoperations (P = 0.02) in the outpatient TJA group. Subgroup analysis of TKA (P = 0.25) and THA (P = 0.39) also found no significant differences in total complications between the outpatient and inpatient groups.
    Conclusion: Outpatient TJA had comparable total complication rates to inpatient TJA. Along with that outpatient TJA can significantly reduce costs to healthcare systems but careful pre-operative patient selection is required to optimize outcomes. More quality randomized controlled trials with longer follow-up periods are needed to add to this body of evidence.
    Language English
    Publishing date 2019-08-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2019.08.022
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  10. Article ; Online: A comparison of aspirin against rivaroxaban for venous thromboembolism prophylaxis after hip or knee arthroplasty: A meta-analysis.

    Xu, Joshua / Kanagaratnam, Aran / Cao, Jacob Y / Chaggar, Gurpreet S / Bruce, Warwick

    Journal of orthopaedic surgery (Hong Kong)

    2020  Volume 28, Issue 1, Page(s) 2309499019896024

    Abstract: Purpose: Total knee arthroplasty (TKA) and total hip arthroplasty (THA) patients are at an elevated risk of post-operative venous thromboembolism (VTE). Newer thromboprophylactic agents such as rivaroxaban are increasingly used and effective in ... ...

    Abstract Purpose: Total knee arthroplasty (TKA) and total hip arthroplasty (THA) patients are at an elevated risk of post-operative venous thromboembolism (VTE). Newer thromboprophylactic agents such as rivaroxaban are increasingly used and effective in preventing thromboembolic events but may worsen bleeding risk. Recent studies have suggested that the more cost-effective aspirin may also be effective in preventing VTE. This systematic review and meta-analysis aimed to compare the efficacy of aspirin against rivaroxaban for the prevention of VTE following TKA and THA.
    Methods: Electronic searches were performed using five databases from their date of inception to August 2018. Relevant studies were identified, with data extracted and meta-analyzed from the studies.
    Results: Five studies were included, which consisted of 2257 in the aspirin group and 2337 in the rivaroxaban group. There were no differences between aspirin and rivaroxaban for either VTE (
    Conclusion: Aspirin was not significantly different to rivaroxaban for prevention of VTE or adverse events after TKA or THA. However, this study was limited by the significant heterogeneity of the included studies. More large randomized studies are needed to add to this body of evidence.
    MeSH term(s) Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Knee/adverse effects ; Aspirin/therapeutic use ; Factor Xa Inhibitors/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Humans ; Rivaroxaban/therapeutic use ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Factor Xa Inhibitors ; Fibrinolytic Agents ; Rivaroxaban (9NDF7JZ4M3) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-01-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1493368-8
    ISSN 2309-4990 ; 1022-5536
    ISSN (online) 2309-4990
    ISSN 1022-5536
    DOI 10.1177/2309499019896024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5104: Show issues Location:
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