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Article: Development and Validation of Pretreatment Serum Total Bilirubin as a Biomarker to Predict the Clinical Outcomes in Primary Central Nervous System Lymphoma: A Multicenter Cohort Study.

Cao, Jiazhen / Li, Shengjie / Li, Danhui / Hua, Wei / Guo, Lin / Xia, Zuguang

2023 Volume 15, Issue 18

Abstract: Primary central nervous system lymphoma (PCNSL) is a predominantly aggressive neoplasm isolated to the central nervous system or vitreoretinal space. Bilirubin is an important biomarker reflecting hepatic function and oxidative stress status that is ... ...

Abstract	Primary central nervous system lymphoma (PCNSL) is a predominantly aggressive neoplasm isolated to the central nervous system or vitreoretinal space. Bilirubin is an important biomarker reflecting hepatic function and oxidative stress status that is associated with the occurrence and development of various tumors. However, its prognostic role in PCNSL has yet to be evaluated. Therefore, we conducted a prospective-retrospective study to analyze the predictive value of serum total bilirubin (STB) in PCNSL patients. The association between the pretreatment STB and clinical outcomes in PCNSL was developed in the discovery cohort (retrospective [n = 44] and prospective [n = 45]) and validated in an independent retrospective cohort (n = 69). A generalized additive model, Kaplan-Meier curve, and Cox analysis were applied. In the discovery cohort, the STB showed a linear relationship with overall survival (OS,
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15184584
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Article ; Online: Auricular therapy for primary dysmenorrhea: A protocol for systematic review and meta-analysis of randomized controlled trials.

Yu, Qianhui / Cao, Jiazhen / Chen, Hongxiu / He, Jing / Wang, Xinyue / Liu, Renming / Li, Tie

Medicine

2023 Volume 102, Issue 13, Page(s) e33382

Abstract: Background: Primary dysmenorrhea (PD) is a common problem among women. It is defined as any degree of perceived cramping pain during menstruation without any evident pathology. Auricular therapy (AT), a widely used alternative medical treatment method ... ...

Abstract	Background: Primary dysmenorrhea (PD) is a common problem among women. It is defined as any degree of perceived cramping pain during menstruation without any evident pathology. Auricular therapy (AT), a widely used alternative medical treatment method as part of traditional Chinese acupuncture, lacks reliable evidence to support its safety and effectiveness for PD. We aimed to conduct a meta-analysis to investigate the efficacy and safety of AT in PD and to investigate possible factors impacting the particular efficacy of AT in PD by meta-regression. Methods: This protocol followed the PRISMA guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. The following 9 sources will be searched for randomized control trials of AT for PD: the Cochrane Central Register of Controlled Trials, PubMed, Medline, Embase, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure, Chinese Science and Technology Periodicals (VIP) database and WanFang Database from inception to January 1, 2023. Primary outcomes include visual rating scales and clinical efficacy rates, while secondary outcomes include endocrine hormone indicators related to PD and adverse events. Two reviewers will work independently on study selection, data extraction, and coding, including the risk of bias assessment in the included studies. While conducting a meta-analysis, Review Manager version 5.3 will be employed. Otherwise, a descriptive analysis will be performed. The results will be displayed as a risk ratio with 95% confidence intervals for dichotomous data as well as weight mean difference or standardized mean difference with 95% confidence intervals for continuous data. Results: This study's protocol will investigate the efficacy and safety of AT in the treatment of PD in a systematic way. Conclusion: This systematic evaluation will objectively and systematically assess the efficacy and safety of AT in PD based on the available evidence, as well as provides clinicians with evidence to support the treatment of the disease.
MeSH term(s)	Female ; Humans ; Dysmenorrhea/drug therapy ; Randomized Controlled Trials as Topic ; Systematic Reviews as Topic ; Meta-Analysis as Topic ; Acupuncture Therapy/methods ; Research Design
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033382
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Article ; Online: Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer.

Yan, Tianqing / Wang, Haozhe / Ma, Xiaolu / Cao, Jiazhen / Tong, Ying / Guo, Lin / Lu, Renquan

Biomarkers in medicine

2023 Volume 17, Issue 6, Page(s) 325–336

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial/diagnosis ; Ovarian Neoplasms/pathology ; Proteins/metabolism ; WAP Four-Disulfide Core Domain Protein 2 ; Neoplasms, Glandular and Epithelial/diagnosis ; Biomarkers, Tumor/metabolism ; Prognosis ; CA-125 Antigen ; Mucoproteins ; Oncogene Proteins
Chemical Substances	Proteins ; WAP Four-Disulfide Core Domain Protein 2 ; Biomarkers, Tumor ; CA-125 Antigen ; AGR2 protein, human ; Mucoproteins ; Oncogene Proteins
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2023-0178
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Article ; Online: Tailoring the Asymmetric Structure of NH2‐UiO‐66 Metal‐Organic Frameworks for Light‐promoted Selective and Efficient Gold Extraction and Separation

Cao, Jiazhen / Xu, Zhenmin / Chen, Yao / Li, Shuangjun / Jiang, Yue / Bai, Lele / Yu, Han / Li, Hexing / Bian, Zhenfeng

Angewandte Chemie International Edition. 2023 Apr. 24, v. 62, no. 18, p. e202302202

2023

Abstract: Designing adsorption materials with high adsorption capacities and selectivities is highly desirable for precious metal recovery. Desorption performance is also particularly crucial for subsequent precious metal recovery and adsorbent regeneration. ... ...

Abstract	Designing adsorption materials with high adsorption capacities and selectivities is highly desirable for precious metal recovery. Desorption performance is also particularly crucial for subsequent precious metal recovery and adsorbent regeneration. Herein, a metal–organic framework (MOF) material (NH₂‐UiO‐66) with an asymmetric electronic structure of the central zirconium oxygen cluster has an exceptional gold extraction capacity of 2.04 g g⁻¹ under light irradiation. The selectivity of NH₂‐UiO‐66 for gold ions is up to 98.8 % in the presence of interfering ions. Interestingly, the gold ions adsorbed on the surface of NH₂‐UiO‐66 spontaneously reduce in situ, undergo nucleation and growth and finally achieve the phase separation of high‐purity gold particles from NH₂‐UiO‐66. The desorption and separation efficiency of gold particles from the adsorbent surface reaches 89 %. Theoretical calculations indicate that ‐NH₂ functions as a dual donor of electrons and protons, and the asymmetric structure of NH₂‐UiO‐66 leads to energetically advantageous multinuclear gold capture and desorption. This adsorption material can greatly facilitate the recovery of gold from wastewater and can easily realize the recycling of the adsorbent.
Keywords	adsorbents ; adsorption ; coordination polymers ; desorption ; gold ; irradiation ; oxygen ; separation ; wastewater ; zirconium
Language	English
Dates of publication	2023-0424
Size	p. e202302202
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202302202
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Article ; Online: Application of fMRI techniques in the study of acupuncture for gynecological diseases: A review.

Liu, Renming / He, Min / Sun, Mengmeng / Wang, Lin / Cao, Jiazhen / Yu, Qianhui / Wang, Fuchun / Li, Tie

Medicine

2023 Volume 102, Issue 10, Page(s) e33268

Abstract: Acupuncture therapy, as a characteristic of Chinese medical therapy, has a long history and remarkable effect in the treatment of gynecological diseases, and so far, it has formed a complete treatment system, but its efficacy and mechanism of action ... ...

Abstract	Acupuncture therapy, as a characteristic of Chinese medical therapy, has a long history and remarkable effect in the treatment of gynecological diseases, and so far, it has formed a complete treatment system, but its efficacy and mechanism of action remain unclear. Functional magnetic resonance imaging, a visual technique, provides an objective basis for the study of acupuncture in the treatment of gynecological diseases. This paper summarizes the current status of acupuncture in the treatment of gynecological diseases and summarizes the progress of functional magnetic resonance imaging research related to acupuncture in the treatment of gynecological diseases in the past 10 years, mainly including the common types of gynecological diseases in acupuncture clinics, and the commonly used acupuncture points. This study is expected to provide literature support for subsequent research on the central mechanisms of acupuncture in the treatment of gynecological diseases.
MeSH term(s)	Female ; Humans ; Magnetic Resonance Imaging/methods ; Acupuncture Therapy ; Acupuncture ; Genital Diseases, Female ; Acupuncture Points ; Brain
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033268
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Article ; Online: TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability.

Meng, Xin / Cao, Jiazhen / Zheng, Hui / Ma, Xiaolu / Wang, Yanchun / Tong, Ying / Xie, Suhong / Lu, Renquan / Guo, Lin

Cancer medicine

2023 Volume 12, Issue 8, Page(s) 9738–9748

Abstract: Objective: Ovarian cancer (OC) is one of the fatal gynecologic malignancies. However, there are no effective prognostic or therapeutic indicators for OC. Herein, we aim to reveal the potential function of targeting protein for Xklp2 (TPX2) in OC ... ...

Abstract	Objective: Ovarian cancer (OC) is one of the fatal gynecologic malignancies. However, there are no effective prognostic or therapeutic indicators for OC. Herein, we aim to reveal the potential function of targeting protein for Xklp2 (TPX2) in OC progression. Methods: Immunohistochemical and bioinformatic analyses were used to evaluate the level of TPX2 in OC samples. Effects of TPX2 on cell proliferation, cell apoptosis and ROS production were evaluated in vivo and in vitro. Mass spectrometry, Co-IP and immunofluorescence assays were performed to identify and verify protein-protein interactions. Results: Our data showed that pathological overexpression (OE) of the TPX2 in OC could manifest a poor prognosis. Functional studies demonstrated that TPX2 silencing led to the suppression of cell proliferation in vitro and in vivo through an increase in reactive oxygen species (ROS) level and apoptosis, while TPX2 OE exhibited the opposite effect. Furthermore, by mass spectrometric analysis, we identified a novel interacting partner, Lamin A/C, for TPX2. Mechanistically, TPX2 regulated Lamin A/C's stability by modulating the level of phospho-Lamin A/C (Ser 22). Conclusion: Our findings thus suggest that TPX2 may be a promising therapeutic target for OC.
MeSH term(s)	Humans ; Female ; Lamin Type A/genetics ; Reactive Oxygen Species ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Cell Line, Tumor ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Cell Transformation, Neoplastic ; Cell Proliferation ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism
Chemical Substances	Lamin Type A ; Reactive Oxygen Species ; Nuclear Proteins ; Cell Cycle Proteins ; Microtubule-Associated Proteins ; TPX2 protein, human
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5683
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Article ; Online: Tailoring the Asymmetric Structure of NH

Cao, Jiazhen / Xu, Zhenmin / Chen, Yao / Li, Shuangjun / Jiang, Yue / Bai, Lele / Yu, Han / Li, Hexing / Bian, Zhenfeng

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 18, Page(s) e202302202

Abstract	Designing adsorption materials with high adsorption capacities and selectivities is highly desirable for precious metal recovery. Desorption performance is also particularly crucial for subsequent precious metal recovery and adsorbent regeneration. Herein, a metal-organic framework (MOF) material (NH
Language	English
Publishing date	2023-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202302202
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Article ; Online: Chinese patent medicine as a complementary and alternative therapy for type 2 diabetes mellitus: A scoping review.

Zheng, Hai-Zhu / Chang, Tian-Ying / Peng, Bo / Ma, Shi-Qi / Zhong, Zhen / Cao, Jia-Zhen / Yao, Lin / Li, Meng-Yuan / Wang, Hong-Feng / Liao, Xing

Complementary therapies in medicine

2024 Volume 80, Page(s) 103014

Abstract: Objective: This scoping review aims to document Chinese Patent Medicines (CPMs) for Type 2 Diabetes Mellitus, explore whether CPMs can improve patients' health outcomes, and set priorities in addressing research gaps in this area.: Methods: Following ...

Abstract	Objective: This scoping review aims to document Chinese Patent Medicines (CPMs) for Type 2 Diabetes Mellitus, explore whether CPMs can improve patients' health outcomes, and set priorities in addressing research gaps in this area. Methods: Following the framework of PRISMA-SCr, we proposed the research questions based on PICOS principle, and searched the CPMs for T2DM from three drug lists, followed by a systematic search of the literature in eight databases from their inception to June 22, 2023. Then, we developed the eligibility criteria and systematically reviewed the relevant studies, retained the studies about CPMs for T2DM, extracted the related data, and identified the differences across studies in structured charts. Results: A total of 25 types of CPMs were extracted from the three drug lists. Radix astragali appeared most frequently (19 times) among the herbal medicinal ingredients of CPMs. A total of 449 articles were included in the full-paper analysis ultimately, all of which were about 20 types of CPMs, and there were no related reports on the remaining five CPMs. Except about a quarter (25.39 %, 114/449) using CPMs alone, the remaining studies all involved the combination with oral hypoglycemics for T2DM. Biguanides are the most common drugs used in combination with CPMs (50.14 %, 168/335). Fasting plasma glucose (FPG) is the most frequently reported outcomes in efficacy evaluation (82.41 %, 370/449). Conclusion: There are a total of 25 types of CPMs currently available for T2DM patients. However, the volume of related evidence on these CPMs varies. It is necessary to standardize the combined use of CPMs and conventional medicine and select appropriate outcomes in future studies.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Nonprescription Drugs/therapeutic use ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional ; Complementary Therapies ; Chlorobenzenes ; Sulfides
Chemical Substances	Nonprescription Drugs ; 4-chlorophenyl methyl sulfide (123-09-1) ; Drugs, Chinese Herbal ; Chlorobenzenes ; Sulfides
Language	English
Publishing date	2024-01-04
Publishing country	Scotland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2024.103014
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Article ; Online: A novel CSN5/CRT O-GlcNAc/ER stress regulatory axis in platinum resistance of epithelial ovarian cancer.

Yan, Tianqing / Ma, Xiaolu / Zhou, Kaixia / Cao, Jiazhen / Tian, Yanan / Zheng, Hui / Tong, Ying / Xie, Suhong / Wang, Yanchun / Guo, Lin / Lu, Renquan

International journal of biological sciences

2024 Volume 20, Issue 4, Page(s) 1279–1296

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/genetics ; Platinum/therapeutic use ; Calreticulin/metabolism ; Calreticulin/therapeutic use ; Cell Line, Tumor ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; RNA
Chemical Substances	Platinum (49DFR088MY) ; Calreticulin ; RNA (63231-63-0)
Language	English
Publishing date	2024-01-27
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.89700
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: M-N3 Configuration on Boron Nitride Boosts Singlet Oxygen Generation via Peroxymonosulfate Activation for Selective Oxidation.

Zhen, Jianzheng / Sun, Jiahao / Xu, Xiangwei / Wu, Zenglong / Song, Wenkai / Ying, Yunzhan / Liang, Shikun / Miao, Lingshan / Cao, Jiazhen / Lv, Weiyang / Song, Changsheng / Yao, Yuyuan / Xing, Mingyang

Angewandte Chemie (International ed. in English)

2024 , Page(s) e202402669

Abstract: Singlet oxygen (1O2) is an essential reactive species responsible for selective oxidation of organic matter, especially in Fenton-like processes. However, due to the great limitations in synthesizing catalysts with well-defined active sites, the ... ...

Abstract	Singlet oxygen (1O2) is an essential reactive species responsible for selective oxidation of organic matter, especially in Fenton-like processes. However, due to the great limitations in synthesizing catalysts with well-defined active sites, the controllable production and practical application of 1O2 remain challenging. Herein, guided by theoretical simulations, a series of boron nitride-based single-atom catalysts (BvBN/M, M = Co, Fe, Cu, Ni and Mn) were synthesized to regulate 1O2 generation by activating peroxymonosulfate (PMS). All the fabricated BvBN/M catalysts with explicit M-N3 sites promoted the self-decomposition of the two PMS molecules to generate 1O2 with high selectivity, where BvBN/Co possessed moderate adsorption energy and d-band center exhibited superior catalytic activity. As an outcome, the BvBN/Co-PMS system coupled with membrane filtration technology could continuously transform aromatic alcohols to aldehydes with nearly 100% selectivity and conversion rate under mild conditions, suggesting the potential of this novel catalytic system for green organic synthesis.
Language	English
Publishing date	2024-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202402669
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