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Article: Exploring the Interrelationships between Public Health, Fiscal Decentralization, and Local Government Debt in China.

Cao, Mingyao / Duan, Keyi / Cao, Mingyu / Ibrahim, Haslindar

2023 Volume 11, Issue 14

Abstract: This paper investigates the interrelationships among local government debt, fiscal decentralization, and public health. The investigation begins by constructing a theoretical model to analyze the inherent connections between these variables. Subsequently, ...

Abstract	This paper investigates the interrelationships among local government debt, fiscal decentralization, and public health. The investigation begins by constructing a theoretical model to analyze the inherent connections between these variables. Subsequently, an empirical analysis is conducted using data from China between 2015 and 2021. The findings demonstrate a bidirectional relationship between fiscal decentralization, local government debt, and public health. Specifically, it is observed that an increase in local government debt has adverse effects on both fiscal decentralization and public health, while fiscal decentralization has a positive impact on public health. These insights are consistently validated through rigorous regression methodologies, affirming the robustness and significance of these relationships.
Language	English
Publishing date	2023-07-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11142103
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Article ; Online: Total Synthesis of the Racemate of Laurolitsine.

Cao, Mingyu / Wang, Yiming / Zhang, Yong / Zhang, Caiyun / Chen, Niangen / Zhang, Xiaopo

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 3

Abstract: The total synthesis of laurolitsine was achieved for the first time. This reaction was accomplished in 14 steps with a 2.3% yield (this was calculated using 3-hydroxy-4-methoxybenzaldehyde as the starting material) starting from two simple materials, 3- ... ...

Abstract	The total synthesis of laurolitsine was achieved for the first time. This reaction was accomplished in 14 steps with a 2.3% yield (this was calculated using 3-hydroxy-4-methoxybenzaldehyde as the starting material) starting from two simple materials, 3-hydroxy-4-methoxybenzaldehyde and 2-(3-hydroxy-4-methoxyphenyl)acetic acid, and the longest linear sequence consisted of 11 steps. The key steps included an electrophilic addition reaction in which a nitro group was reduced to an amino group using lithium tetrahydroaluminum and a Pd-catalyzed direct biaryl coupling reaction. In this paper, many of the experimental steps were optimized, and an innovative postprocessing method in which 2-(3-(benzyloxy)-4-methoxyphenyl)ethanamine is salted with oxalic acid was proposed.
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29030745
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Article: The effects of vitamin D on all-cause mortality in different diseases: an evidence-map and umbrella review of 116 randomized controlled trials.

Cao, Mingyu / He, Chunrong / Gong, Matthew / Wu, Song / He, Jinshen

Frontiers in nutrition

2023 Volume 10, Page(s) 1132528

Abstract: Purpose: To conduct a solid evidence by synthesizing meta-analyses and updated RCTs about the effects of vitamin D on all-cause mortality in different health conditions.: Methods: Data sources: Pubmed, Embase, Web of Science, the Cochrane Library, ... ...

Abstract	Purpose: To conduct a solid evidence by synthesizing meta-analyses and updated RCTs about the effects of vitamin D on all-cause mortality in different health conditions. Methods: Data sources: Pubmed, Embase, Web of Science, the Cochrane Library, Google Scholar from inception until 25th April, 2022. Study selection: English-language, meta-analyses and updated RCTs assessing the relationships between vitamin D and all-cause mortality. Data synthesis: Information of study characteristics, mortality, supplementation were extracted, estimating with fixed-effects model. A Measurement Tool to Assess Systematic Reviews, Grading of Recommendations Assessment, Development and Evaluation, and funnel plot was used to assess risk of bias. Main outcomes: All-cause mortality, cancer mortality, cardiovascular disease mortality. Results: In total of 27 meta-analyses and 19 updated RCTs were selected, with a total of 116 RCTs and 149, 865 participants. Evidence confirms that vitamin D reduces respiratory cancer mortality (RR, 0.56 [95%CI, 0.33 to 0.96]). All-cause mortality is decreased in patients with COVID-19 (RR, 0.54[95%CI, 0.33 to 0.88]) and liver diseases (RR, 0.64 [95%CI, 0.50 to 0.81]), especially in liver cirrhosis (RR, 0.63 [95%CI, 0.50 to 0.81]). As for other health conditions, such as the general health, chronic kidney disease, critical illness, cardiovascular diseases, musculoskeletal diseases, sepsis, type 2 diabetes, no significant association was found between vitamin D and all-cause mortality. Conclusions: Vitamin D may reduce respiratory cancer mortality in respiratory cancer patients and all-cause mortality in COVID-19 and liver disorders' patients. No benefits showed in all-cause mortality after vitamin D intervention among other health conditions. The hypothesis of reduced mortality with vitamin D still requires exploration. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=252921, identifier: CRD42021252921.
Language	English
Publishing date	2023-06-22
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1132528
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Article ; Online: Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs <i>via</i> the Wnt/β-catenin Signaling Pathways.

Cao, Mingyu / Hu, Yabin / Zhang, Yukun / Xie, Jiang / Xie, Zengru

Protein and peptide letters

2022 Volume 29, Issue 10, Page(s) 851–858

Abstract: Objective: This study aimed to evaluate the combination of SDF-1 and KLD-12 to form self-assembling polypeptide and its effect on osteogenic differentiation.: Methods: ELISA assay was performed to detect whether KLD-12 composite SDF-1 self-assembled ... ...

Abstract	Objective: This study aimed to evaluate the combination of SDF-1 and KLD-12 to form self-assembling polypeptide and its effect on osteogenic differentiation. Methods: ELISA assay was performed to detect whether KLD-12 composite SDF-1 self-assembled polypeptide was successfully prepared. BMSCs were isolated and characterized by Flow cytometry. MTT assays, Calcein-AM/PI fluorescence staining, and Glycosaminoglycans (GAGs) measurement were carried out to detect cell viability after cells exposed to KLD-12 composite SDF-1 selfassembled polypeptide. The migration of cells induced by KLD-12 composite SDF-1 selfassembled polypeptide was also examined by transwell assay and Immunoblot. Osteogenic differentiation of cells stimulated with KLD-12 composite SDF-1 self-assembled polypeptide was analyzed by Immunoblot, Alizarin Red Staining, and Alkaline Phosphatase activity. Additionally, immunoblot and immunofluorescence assays were performed to investigate the effects of the polypeptide on the Wnt/β-catenin pathway. Results: KLD-12 composite SDF-1 self-assembled polypeptide was successfully prepared and identified. In addition, we isolated and characterized mouse mesenchymal stem BMSCs. Our data further revealed that KLD-12 combined with SDF-1 self-assembled polypeptide improved the survival of BMSCs and promoted cell migration. Moreover, the self-assembled polypeptide induced osteogenic differentiation of BMSCs. Mechanically, we found that the self-assembled polypeptide activated the Wnt/β-catenin pathway, therefore promoting the differentiation and migration of BMSCs. Conclusion: Our proposed treatment can potentially be effective for bone defects.
MeSH term(s)	Animals ; Mice ; beta Catenin/metabolism ; beta Catenin/pharmacology ; Cell Differentiation ; Cells, Cultured ; Mesenchymal Stem Cells ; Osteogenesis ; Peptides/pharmacology ; Peptides/metabolism ; Wnt Signaling Pathway ; Chemokine CXCL12/metabolism ; Cell Movement
Chemical Substances	beta Catenin ; Peptides ; KLD-12 polypeptide ; Chemokine CXCL12
Language	English
Publishing date	2022-09-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/0929866529666220822124627
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Article: NLR value and IL-18 level and their clinical significance in patients with deep vein thrombosis after receiving the surgery for spinal degeneration.

Zhang, Yukun / Cao, Mingyu / Ren, Jun

American journal of translational research

2021 Volume 13, Issue 6, Page(s) 7156–7163

Abstract: Objective: To investigate the value of the neutrophil-to-lymphocyte ratio (NLR) and Interleukin 18 (IL-18) level in patients with deep vein thrombosis after receiving surgery for spinal degeneration; and we explore their significance in clinical ... ...

Abstract	Objective: To investigate the value of the neutrophil-to-lymphocyte ratio (NLR) and Interleukin 18 (IL-18) level in patients with deep vein thrombosis after receiving surgery for spinal degeneration; and we explore their significance in clinical practice. Methods: This study was conducted in 296 patients who were treated in our hospital for spinal degeneration. After surgery, these patients were followed up for 1 month. After performing the color Doppler ultrasound examination, patients were divided into the thrombus group (n = 72) and the non-thrombus group (n = 224) based on the occurrence of deep vein thrombosis. Baseline data, NLR values and IL-18 levels before surgery, and at 1, 3, 5, and 7 days after surgery were compared between the two groups. Logistic regression analysis was implemented to analyze the risk factors for postoperative deep vein thrombosis. Patients in the thrombosis group were allocated to the mild, moderate, and severe group on the basis of the degree of thrombosis. NLR values and IL-18 levels at 3 days after surgery were compared among the three groups. The correlations between both NLR value and IL-18 level and the severity of deep vein thrombosis were analyzed with Pearson correlation. Receiver operating characteristic curve was used to assess the clinical value of NLR value and IL-18 level at 3 days after surgery in predicting postoperative deep vein thrombosis. Results: There were significant differences concerning age, the history of diabetes, and obesity between the two groups (all P<0.05). NLR values and IL-18 levels in both groups after surgery were increased when compared with before surgery (all P<0.01). In addition, NLR values and IL-18 levels reached a peak at 3 days after surgery. Compared with the non-thrombus group, NLR values and IL-18 levels in the thrombus group at 1, 3, 5, and 7 days after surgery were increased (all P<0.01). NLR value and IL-18 level in the thrombosis group at 3 days after surgery were increased with a worsened degree of thrombosis. In other words, both NLR value and IL-18 level were positively correlated with the degree of deep vein thrombosis. The results of logistic regression analysis displayed that age ≥60 years old, body mass index ≥23 kg/m Conclusion: Compared with the non-thrombus group, NLR value and IL-18 level in the thrombosis group after receiving surgery for spinal degeneration are significantly increased. In addition, the more severe the thrombosis is, the higher the NLR value and IL-18 level at 3 days after surgery. Therefore, NLR value and IL-18 level at 3 days after surgery have certain clinical value in predicting postoperative deep vein thrombosis and prognosis.
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Two new aporphine alkaloids with glucose consumption increasing activity from Cassytha filiformis

Huang, Zibao / Cao, Mingyu / Wang, Ruiqi / Zhang, Yong / Zhang, Xiaopo / Dong, Lin / Zhang, Caiyun

Phytochemical Society of Europe Phytochemistry letters. 2022 Oct., v. 51

2022

Abstract: Two new aporphine alkaloids, named precassythine (1) and (+)− 6S-ocotecine-N-oxide (2), were isolated from Cassytha filiformis. The new structures were elucidated by applying various spectroscopic techniques, including 1D-, ²D NMR and HRESIMS. The ... ...

Abstract	Two new aporphine alkaloids, named precassythine (1) and (+)− 6S-ocotecine-N-oxide (2), were isolated from Cassytha filiformis. The new structures were elucidated by applying various spectroscopic techniques, including 1D-, ²D NMR and HRESIMS. The absolute configurations of 1 and 2 were determined by calculated electronic circular dichroism (ECD). Both compounds were evaluated for their effects on glucose consumption on HL-7702 cells at different concentrations. The results showed that the two new compounds significantly increased glucose consumption.
Keywords	Cassytha filiformis ; circular dichroism spectroscopy ; glucose ; plant biochemistry
Language	English
Dates of publication	2022-10
Size	p. 23-27.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1874-3900
DOI	10.1016/j.phytol.2022.06.013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New aphidicolane diterpenoids with glucose consumption promoting and cell viability enhancing activities from Scoparia dulcis.

Dong, Lin / Chen, Mimi / Huang, Zibao / Cao, Mingyu / Zhang, Yong / Sun, Wanying / Liu, Chenpeng / Zhang, Caiyun / Zhang, Shouwen / Zhang, Xiaopo

Fitoterapia

2023 Volume 166, Page(s) 105438

Abstract: Two new aphidicolane diterpenoids, termed Scopadulinol A (1) and B (2), were obtained from whole plants of Scoparia dulcis. Their structures were elucidated by applying various spectroscopic techniques, including 1D- and 2D-NMR and HR-ESI-MS. The ... ...

Abstract	Two new aphidicolane diterpenoids, termed Scopadulinol A (1) and B (2), were obtained from whole plants of Scoparia dulcis. Their structures were elucidated by applying various spectroscopic techniques, including 1D- and 2D-NMR and HR-ESI-MS. The absolute configurations of 1 and 2 were determined by applying the calculated electronic circular dichroism (ECD). In addition, both compounds were tested for their effects on glucose consumption in HL-7702 cells and on palmitic acid (PA) induced viability in MIN6 cells at different concentrations. The results showed that they significantly promoted glucose consumption and attenuated the PA-induced decrease of cell viability. Additionally, 2 was tested to determine whether it could activate AMP-activated protein kinase (AMPK), but it showed no such effect at the tested dosage. These results indicated that the new compounds might promote glucose consumption through other pathways but not by activating AMPK. Collectively, we highlighted the isolation of two new aphidicolane diterpenoids from S. dulcis and found that they could promote glucose consumption and attenuate PA-induced decrease of cell viability.
MeSH term(s)	Glucose ; Scoparia/chemistry ; Cell Survival ; AMP-Activated Protein Kinases ; Molecular Structure ; Diterpenes/pharmacology ; Diterpenes/chemistry
Chemical Substances	Glucose (IY9XDZ35W2) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Diterpenes
Language	English
Publishing date	2023-01-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105438
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Article ; Online: Serum galectin-3 concentrations in patients with ankylosing spondylitis.

Cao, Ming-Yu / Wang, Jiang / Gao, Xiao-Liang / Hu, Ya-Bin

Journal of clinical laboratory analysis

2019 Volume 33, Issue 6, Page(s) e22914

Abstract: Objective: The aim of our study was to assess potential correlations between serum galectin-3 concentrations and Ankylosing Spondylitis Disease Activity (ASDAS) index in patients with ankylosing spondylitis (AS).: Methods: A total of 112 patients ... ...

Abstract	Objective: The aim of our study was to assess potential correlations between serum galectin-3 concentrations and Ankylosing Spondylitis Disease Activity (ASDAS) index in patients with ankylosing spondylitis (AS). Methods: A total of 112 patients with AS were included, and 130 healthy subjects were considered as controls. We collected the detailed medical history, and ASDAS index was used to assess the disease severity in patients with AS. Results: The serum galectin concentrations were higher in AS patients compared to the health groups (14.1 ± 9.6 vs 9.2 ± 3.7, P < 0.001). The correlation analysis showed that serum galectin concentrations were significantly positively correlated with C-reactive protein and erythrocyte sedimentation rate (r = 0.369, P < 0.001; r = 0.240, P = 0.011). In addition, the positively correlation of serum galectin-3 with global pain index (r = 0.238, P = 0.011) was observed in AS patients. A significant positively correlation between serum galectin and ASDAS index in AS patients was found (r = 0.367; P < 0.001). In multiple linear regression analysis, the results indicated that increased serum galectin still was correlated with ASDAS index (r = 0.322, P < 0.001) in patients with AS. Conclusions: Serum galectin concentrations were found to be correlated with ASDAS index in patients with AS.
MeSH term(s)	Adult ; Biomarkers/blood ; Blood Sedimentation ; C-Reactive Protein/analysis ; Case-Control Studies ; Female ; Galectin 3/blood ; Humans ; Linear Models ; Male ; Spondylitis, Ankylosing/blood ; Spondylitis, Ankylosing/etiology
Chemical Substances	Biomarkers ; Galectin 3 ; LGALS3 protein, human ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.22914
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Article ; Online: A neural network-based joint learning approach for biomedical entity and relation extraction from biomedical literature.

Luo, Ling / Yang, Zhihao / Cao, Mingyu / Wang, Lei / Zhang, Yin / Lin, Hongfei

Journal of biomedical informatics

2020 Volume 103, Page(s) 103384

Abstract: Recently joint modeling methods of entity and relation exhibit more promising results than traditional pipelined methods in general domain. However, they are inappropriate for the biomedical domain due to numerous overlapping relations in biomedical text. ...

Abstract	Recently joint modeling methods of entity and relation exhibit more promising results than traditional pipelined methods in general domain. However, they are inappropriate for the biomedical domain due to numerous overlapping relations in biomedical text. To alleviate the problem, we propose a neural network-based joint learning approach for biomedical entity and relation extraction. In this approach, a novel tagging scheme that takes into account overlapping relations is proposed. Then the Att-BiLSTM-CRF model is built to jointly extract the entities and their relations with our extraction rules. Moreover, the contextualized ELMo representations pre-trained on biomedical text are used to further improve the performance. Experimental results on biomedical corpora show that our method can significantly improve the performance of overlapping relation extraction and achieves the state-of-the-art performance.
MeSH term(s)	Data Mining ; Neural Networks, Computer ; Publications ; Research Design
Language	English
Publishing date	2020-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2057141-0
ISSN	1532-0480 ; 1532-0464
ISSN (online)	1532-0480
ISSN	1532-0464
DOI	10.1016/j.jbi.2020.103384
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Article ; Online: Ilizarov bone transport to treat infected nonunion of long bones: a multicenter retrospective cohort study.

Xie, Jiang / Zhao, Guobin / Yasheng, Tayierjiang / Chen, Hongtao / Amuti, Nuermaimaiti / Maimaitirexiati, Muhetaer / Yibulayinmu, Abulaitijiang / Cao, Mingyu / Yusufu, Aihemaitijiang

The Journal of international medical research

2021 Volume 49, Issue 3, Page(s) 3000605211002701

Abstract: Objective: To examine the efficacy and safety of Ilizarov bone transport in the treatment of infected nonunion of long bones.: Methods: Patients who underwent Ilizarov bone transport for treatment of bone nonunion with chronic osteomyelitis in the ... ...

Abstract	Objective: To examine the efficacy and safety of Ilizarov bone transport in the treatment of infected nonunion of long bones. Methods: Patients who underwent Ilizarov bone transport for treatment of bone nonunion with chronic osteomyelitis in the three largest regional orthopedic trauma centers in China from July 2013 to July 2018 were retrospectively examined. Treatment results were evaluated with Paley's criteria for bone healing and functional assessment. Results: In total, 189 patients were treated during the study period. The study population comprised 135 male and 54 female patients with an average age of 37.5 years (range, 11-61 years). The patients were followed up for at least 24 months. According to Paley's criteria for bone healing and functional assessment, the bone healing results were excellent in 115 (61%) patients, good in 31 (16%), fair in 21 (11%), and poor in 22 (12%). The functional evaluation results were excellent in 76 (40%) patients, good in 65 (34%), fair in 22 (11%), poor in 26 (14%). Conclusion: Infected nonunion of long bones can be effectively and safely treated with Ilizarov bone transport.
MeSH term(s)	Adult ; China ; Female ; Fractures, Ununited/surgery ; Humans ; Ilizarov Technique ; Male ; Osteomyelitis/drug therapy ; Osteomyelitis/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605211002701
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