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  1. Article: A pharmacokinetic analysis of amisulpride in adult Chinese patients with schizophrenia: Impact of creatinine clearance.

    Liu, Wei / Zhou, Jingqi / Cao, Minjuan / Zhang, Fangming / Sun, Xiaoming

    International journal of clinical pharmacology and therapeutics

    2023  

    Abstract: Objective: To develop a stable population pharmacokinetic (PPK) model of amisulpride and to investigate the effects of covariates on the pharmacokinetic parameters in adult Chinese patients with schizophrenia.: Materials and methods: This ... ...

    Abstract Objective: To develop a stable population pharmacokinetic (PPK) model of amisulpride and to investigate the effects of covariates on the pharmacokinetic parameters in adult Chinese patients with schizophrenia.
    Materials and methods: This retrospective study was carried out using 168 serum samples from 88 patients collected during routine clinical monitoring. Covariates recorded included demographic parameters (gender, age, weight), clinical parameters (serum creatinine, creatinine clearance), and intake of co-medications. The amisulpride PPK model was established using a nonlinear mixed effects modeling (NONMEM) approach. Goodness-of-fit (GOF) plots, bootstrap validation (1,000 runs), and normalized prediction distribution error (NPDE) were used in the evaluation of the final model.
    Results: A one-compartment model with first-order absorption and elimination was developed. The population estimates for apparent clearance (CL/F) and apparent volume of distribution (V/F) were 32.6 L/h and 391 L, respectively. Estimated creatinine clearance (eCLcr) was a significant covariate for CL/F. The established model was: CL/F = 32.6 × (eCLcr/114.3)0.485 (L/h). The stability of the model was confirmed using GOF plots, bootstrap, and NPDE.
    Conclusion: Creatinine clearance is a major covariate which is positively correlated with CL/F. Therefore, additional dose adjustments of amisulpride may be required on the basis of eCLcr. An ethnic difference may exist in the pharmacokinetics of amisulpride, but further research is needed in order to confirm this possibility. The PPK model of amisulpride for adult Chinese schizophrenic patients established here using NONMEM, is potentially an important tool for individualizing drug dosage and therapeutic drug monitoring.
    Language English
    Publishing date 2023-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124384-6
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    DOI 10.5414/CP204334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: ZnO nanoparticle-decorated two-dimensional titanium carbide with enhanced supercapacitive performance

    Wang, Fen / Cao, Minjuan / Qin, Yi / Zhu, Jianfeng / Wang, Lei / Tang, Yi

    RSC advances. 2016 Sept. 16, v. 6, no. 92

    2016  

    Abstract: In this work, a sandwich-like structure of ZnO nanoparticle-decorated two-dimensional Ti3C2 has been synthesized by the direct precipitation method and a subsequent heat-treatment process. During the synthesis procedure, ZnO nanoparticles are uniformly ... ...

    Abstract In this work, a sandwich-like structure of ZnO nanoparticle-decorated two-dimensional Ti3C2 has been synthesized by the direct precipitation method and a subsequent heat-treatment process. During the synthesis procedure, ZnO nanoparticles are uniformly distributed on the surface and interlayer of Ti3C2 sheets, which effectively prevents the restacking of Ti3C2 sheets and forms a sandwich-like structure. Serving as a supercapacitor electrode, the electrochemical performances of the as-prepared Ti3C2/ZnO were characterized by cyclic voltammetry, galvanostatic charge–discharge measurements and electrochemical impedance spectroscopy. These results show that the as-synthesized Ti3C2/ZnO delivers an improved specific capacitance of 120 F g−1 at 2 mV s−1 and excellent cycling stability with the capacitance retained at 85% after 10 000 cycles at 5 A g−1. The good electrochemical performances of Ti3C2/ZnO indicate that this metal oxide/two-dimensional layered nanocomposite has promising potential in supercapacitor applications.
    Keywords capacitance ; dielectric spectroscopy ; electrochemistry ; electrodes ; heat treatment ; nanocomposites ; nanoparticles ; titanium ; zinc oxide
    Language English
    Dates of publication 2016-0916
    Size p. 88934-88942.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c6ra15384d
    Database NAL-Catalogue (AGRICOLA)

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