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  1. Article ; Online: Subversion of a protein-microRNA signaling pathway by hepatitis C virus.

    Cao, Qian M / Sarnow, Peter

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 4, Page(s) e2220406120

    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Hepacivirus/genetics ; Hepacivirus/metabolism ; Hepatitis C ; Signal Transduction ; Hepatitis B virus/genetics ; Virus Replication
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2220406120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Condition-based opportunistic maintenance strategy for multi-component wind turbines by using stochastic differential equations.

    Su, Hongsheng / Cao, Qian / Li, Yuqi

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2390

    Abstract: The components of wind turbines are complex in structure and the working environment is harsh, which makes wind turbines face problems such as high failure rates and high maintenance costs. In this paper, the stochastic differential equation model has ... ...

    Abstract The components of wind turbines are complex in structure and the working environment is harsh, which makes wind turbines face problems such as high failure rates and high maintenance costs. In this paper, the stochastic differential equation model has been established for the harsh operating environment of wind turbines, and used Brownian motion to simulate random disturbances; aiming at the problem of high failure rate of wind turbines, based on Weibull distribution, a new model has been established by combining operating time and equipment state to calculate the failure rate; in the analysis of monitoring data, the Higher-Order Moment method and Bayesian method were used to solve the parameters. The opportunity maintenance threshold curve and preventive maintenance threshold curve were obtained by analyzing Time-Based Maintenance and Condition-Based Maintenance. Therefore, the Condition-Based Opportunistic Maintenance strategy was obtained. The effectiveness of the proposed method was finally verified by arithmetic examples.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51930-x
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  3. Article ; Online: A stochastic model of preventive maintenance strategies for wind turbine gearboxes considering the incomplete maintenance.

    Su, Hongsheng / Li, Yuqi / Cao, Qian

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5700

    Abstract: In contemporary large wind farms, the combination of condition-based maintenance (CBM) and time-based maintenance (TBM) has become a prevalent approach in preventive maintenance, which is an indispensable part to ensure the safe, stable and environmental ...

    Abstract In contemporary large wind farms, the combination of condition-based maintenance (CBM) and time-based maintenance (TBM) has become a prevalent approach in preventive maintenance, which is an indispensable part to ensure the safe, stable and environmental operation of equipment. However, the utilization of an inappropriate maintenance strategy may result in over-maintenance or under-maintenance, leading to unstable equipment operation. Furthermore, the majority of preventive maintenance involves replacement maintenance, which may have adverse effects on the performance of wind turbines with excessive maintenance time. Therefore, this paper takes the gearbox as a case study to introduce the incomplete maintenance parameters into the failure rate function to establish a state model based on the stochastic differential equation (SDE) and describing the state change of incomplete maintenance. And then simulating the state model of the gearbox and the joint preventive maintenance strategy of TBM and CBM through examples, resulting the time-based incomplete maintenance (TBIM) is proposed based on the TBM and the incomplete maintenance, and a new joint preventive maintenance strategy incorporating TBIM and CBM is proposed. Through developing the decision-making process of the maintenance strategy to optimize the inappropriate maintenance which including over-maintenance and under-maintenance and simulating the optimized preventive maintenance strategy to compare with that of TBM and CBM and verify the superiority and effectiveness of the proposed maintenance method.
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56436-0
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  4. Article ; Online: Primary pulmonary histiocytic sarcoma with high PD-L1 expression benefited from immunotherapy: A case report and bioinformatic analysis.

    Lin, Yuanjie / Cao, Qian / Hong, Aonan / Liang, Xiao

    The clinical respiratory journal

    2024  Volume 18, Issue 3, Page(s) e13741

    Abstract: Histiocytic sarcoma is an aggressive haematopoietic malignancy accounting for less than 1% of haematolymphoid neoplasms with a diagnosis based on morphology and immunophenotype of tissue biopsies with a very poor prognosis. Here, we report a 45-year-old ... ...

    Abstract Histiocytic sarcoma is an aggressive haematopoietic malignancy accounting for less than 1% of haematolymphoid neoplasms with a diagnosis based on morphology and immunophenotype of tissue biopsies with a very poor prognosis. Here, we report a 45-year-old man who was diagnosed with primary pulmonary histiocytic sarcoma with systemic metastases, with partial remission (PR) treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but it relapsed soon after therapy above. Tests demonstrated that TMB was 21 Muts/Mb PD-L1 expression was 90% positive, and the disease has been well-controlled over 3 years using immune checkpoint inhibitors (nivolumab and pembrolizumab). Bioinformatic pan-cancer analysis verified that there was the highest genetic alteration frequency of PD-L1 in which amplification accounted for the majority of sarcoma tumour samples. Following that, we found that the genetic alteration of PD-L1 was associated with poor prognosis in sarcoma patients in terms of overall survival (OS) (p = 1.51 × 10
    MeSH term(s) Male ; Humans ; Middle Aged ; Histiocytic Sarcoma/drug therapy ; Histiocytic Sarcoma/genetics ; B7-H1 Antigen/genetics ; Nivolumab/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Immunotherapy ; Sarcoma ; Computational Biology
    Chemical Substances B7-H1 Antigen ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: [Retracted] Cardioprotective effect of epigallocatechin‑3‑gallate against myocardial infarction in hypercholesterolemic rats.

    Zhong, Wei / Huan, Xiao-Dong / Cao, Qian / Yang, Jun

    Experimental and therapeutic medicine

    2024  Volume 27, Issue 3, Page(s) 108

    Abstract: This retracts the article DOI: 10.3892/etm.2014.2135.]. ...

    Abstract [This retracts the article DOI: 10.3892/etm.2014.2135.].
    Language English
    Publishing date 2024-01-22
    Publishing country Greece
    Document type Retraction of Publication
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2024.12396
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  6. Article ; Online: PEGylated AIEgens for dual sensing of ATP and H

    Wen, Shi-Lian / Lang, Wei / Li, Xue / Cao, Qian-Yong

    Talanta

    2024  Volume 271, Page(s) 125739

    Abstract: Fluorescent sensors have been widely applied for biosensing, but probes for both multiple analytes sensing and photodynamic therapy (PDT) effect are less reported. In this article, we reported three AIE-based probes anchored with different mass-weight ... ...

    Abstract Fluorescent sensors have been widely applied for biosensing, but probes for both multiple analytes sensing and photodynamic therapy (PDT) effect are less reported. In this article, we reported three AIE-based probes anchored with different mass-weight polyethylene glycol (PEG) tails, i.e., TPE-PEG160, TPE-PEG350, and TPE-PEG750, for both adenosine-5'-triphosphate (ATP) and hydrogen sulfide (H
    MeSH term(s) Humans ; Photochemotherapy ; Amides ; Polyethylene Glycols ; HeLa Cells ; Neoplasms/drug therapy
    Chemical Substances Amides ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Macrophage: Hidden Criminal in Therapy Resistance.

    Ding, Yimin / Cao, Qian / Yang, Wenjuan / Xu, Junjie / Xiao, Peng

    Journal of innate immunity

    2024  Volume 16, Issue 1, Page(s) 188–202

    Abstract: Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent years, emerging evidence suggests ...

    Abstract Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent years, emerging evidence suggests a connection between drug resistance and immune dysregulation.
    Summary: As a ubiquitously distributed, versatile innate immune cell, macrophages play essential roles in maintaining tissue homeostasis in a steady state. Nevertheless, it is becoming aware that macrophages undermine the action of therapeutic drugs across various disease types. Reprogramming macrophage function has been proven to be effective in restoring patient responsiveness to treatment. Herein, we comprehensively reviewed how macrophages respond to drugs and the mechanisms by which they contribute to treatment unresponsiveness in cancer, inflammatory diseases, and metabolic diseases. In addition, future prospects in macrophage-based combination therapy were discussed.
    Key messages: Targeting macrophages is a promising strategy for overcoming drug resistance in immune disorders.
    MeSH term(s) Humans ; Macrophages/immunology ; Animals ; Immunity, Innate ; Neoplasms/immunology ; Neoplasms/therapy ; Neoplasms/drug therapy ; Drug Resistance ; Inflammation/immunology ; Homeostasis
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000538212
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6727: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Targeting and functional effects of biomaterials-based nanoagents for acute pancreatitis treatment.

    Cai, Yujie / Cao, Qian / Li, Jiannan / Liu, Tongjun

    Frontiers in bioengineering and biotechnology

    2023  Volume 10, Page(s) 1122619

    Abstract: Acute pancreatitis (AP) is a severe life-threatening inflammatory disease showing primary characteristics of excessive inflammatory response and oxidative stress. Based on the pathophysiology of AP, several anti-inflammatory and anti-oxidative stress ... ...

    Abstract Acute pancreatitis (AP) is a severe life-threatening inflammatory disease showing primary characteristics of excessive inflammatory response and oxidative stress. Based on the pathophysiology of AP, several anti-inflammatory and anti-oxidative stress agents have been studied. However, the low accumulated concentrations and scattered biodistributions limit the application of these agents. With the development of nanotechnology, functional nanomaterials can improve the bioavailability of drugs and extend their half-life by reducing immunogenicity to achieve targeted drug delivery. The biomaterial-based carriers can mediate the passive or active delivery of drugs to the target site for improved therapeutic effects, such as anti-oxidation and anti-inflammation for AP treatment. Other biomaterials-based nanomedicine may exhibit different functions with/without targeting effects. In this review, we have summarized the targeting and functional effects of biomaterials-based nanoagents specifically for AP treatment.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1122619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Significance of Nuclear Factor-Kappa B (NF-κB) and Survivin in Breast Cancer and Their Association with Radiosensitivity and Prognosis.

    Cao, Qian / Ai, Xiu-Qing / Mushajiang, Munire

    Breast cancer (Dove Medical Press)

    2023  Volume 15, Page(s) 175–188

    Abstract: Purpose: Analyze the expression of NF-κB and survivin genes and mRNAs in breast cancer, and evaluate their impact on prognosis. Investigate their association with radiosensitivity in breast cancer.: Methods: The expression levels of NF-κB and ... ...

    Abstract Purpose: Analyze the expression of NF-κB and survivin genes and mRNAs in breast cancer, and evaluate their impact on prognosis. Investigate their association with radiosensitivity in breast cancer.
    Methods: The expression levels of NF-κB and survivin genes in breast cancer were analyzed by bioinformatics, NF-κB and survivin mRNA was verified by RTRCR, and their association with prognosis were assessed. Knockdown of survivin by siRNA was used to analyze its association with radiosensitivity in breast cancer.
    Results: The gene expression of NFKB1 and BIRC5 are differentially expressed in a variety of tumours and their corresponding normal tissue species. In breast cancer tissues, NFKB1 expression levels were reduced compared to normal tissue, while BIRC5 expression levels were increased (
    Conclusion: NF-κB and survivin interact at the gene and mRNA levels. Regulation of mRNA expression of NF-κB or survivin may help to improve the radiosensitivity of breast cancer cells, more experiments are needed to verify this in the future.
    Language English
    Publishing date 2023-03-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S399994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterization of mechanical stiffness using additive manufacturing and finite element analysis: potential tool for bone health assessment.

    Marupudi, Sriharsha / Cao, Qian / Samala, Ravi / Petrick, Nicholas

    3D printing in medicine

    2023  Volume 9, Issue 1, Page(s) 32

    Abstract: Background: Bone health and fracture risk are known to be correlated with stiffness. Both micro-finite element analysis (μFEA) and mechanical testing of additive manufactured phantoms are useful approaches for estimating mechanical properties of ... ...

    Abstract Background: Bone health and fracture risk are known to be correlated with stiffness. Both micro-finite element analysis (μFEA) and mechanical testing of additive manufactured phantoms are useful approaches for estimating mechanical properties of trabecular bone-like structures. However, it is unclear if measurements from the two approaches are consistent. The purpose of this work is to evaluate the agreement between stiffness measurements obtained from mechanical testing of additive manufactured trabecular bone phantoms and μFEA modeling. Agreement between the two methods would suggest 3D printing is a viable method for validation of μFEA modeling.
    Methods: A set of 20 lumbar vertebrae regions of interests were segmented and the corresponding trabecular bone phantoms were produced using selective laser sintering. The phantoms were mechanically tested in uniaxial compression to derive their stiffness values. The stiffness values were also derived from in silico simulation, where linear elastic μFEA was applied to simulate the same compression and boundary conditions. Bland-Altman analysis was used to evaluate agreement between the mechanical testing and μFEA simulation values. Additionally, we evaluated the fidelity of the 3D printed phantoms as well as the repeatability of the 3D printing and mechanical testing process.
    Results: We observed good agreement between the mechanically tested stiffness and μFEA stiffness, with R
    Conclusion: Overall, the level of agreement achieved between the mechanical stiffness and μFEA indicates that our μFEA methods may be acceptable for assessing bone mechanics of complex trabecular structures as part of an analysis of overall bone health.
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ISSN 2365-6271
    ISSN (online) 2365-6271
    DOI 10.1186/s41205-023-00197-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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