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Article: Editorial: Application of data mining in pharmaceutical research.

Bu, Qingting / Lyu, Jun / Zhao, Limei / Cao, Shiyi / Jia, Deyong / Pan, Zhenyu

2024 Volume 15, Page(s) 1388738

Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1388738
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Article ; Online: Association of changes in plant-based diet consumption with all-cause mortality among older adults in China: a prospective study from 2008 to 2019.

Huang, Shen / Lou, Yiling / Wang, Shiqi / You, Qiqi / Jiang, Qingqing / Cao, Shiyi

The journal of nutrition, health & aging

2024 Volume 28, Issue 2, Page(s) 100027

Abstract: Objectives: To examine the association of changes in plant-based diet consumption with all-cause mortality among older adults in China.: Design: Cohort study.: Setting: This cohort study of 11 years used data from the Chinese Longitudinal Healthy ... ...

Abstract	Objectives: To examine the association of changes in plant-based diet consumption with all-cause mortality among older adults in China. Design: Cohort study. Setting: This cohort study of 11 years used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a long-term, nationwide survey covering 23 provinces in China. Participants: A total of 7843 older participants aged ≥60 years were included in this study. Measurements: Changes in plant-based diets consumption (2008-2011) were assessed by 3 graded plant-based diet indices, including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). The main outcome was all-cause mortality. Multivariable-adjusted Cox proportional-hazards models were fitted to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of mortality for changes in PDI, hPDI, and uPDI. Results: A total of 7843 participants (mean [SD] age, 82.2 [10.9] years; 3588 [45.7%] men) were included in this study. During a median (IQR) of 9 (5-10) years of follow-up, 3749 deaths were documented. Compared with older adults whose plant-based diet indices were relatively stable, older adults with the greatest decrease (quintile 1) in PDI, hPDI, and uPDI had respectively 32% (95% CI, 19%-47%) higher, 21% (95% CI, 9%-33%) higher, and 10% (95% CI, 4%-21%) lower risk of death. Compared with older adults whose diet indices were relatively stable, older adults with the greatest increase (quintile 5) in uPDI had a 13% higher risk of death (95% CI, 1%-21%), while no significant associations of the increased PDI and hPDI with all-cause mortality were observed. Conclusion: Maintaining the consumption of overall and healthful plant-based diets, and decreasing the consumption of an unhealthful plant-based diet can be beneficial in preventing or delaying premature death among Chinese older adults.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Prospective Studies ; Cohort Studies ; Diet, Plant-Based ; China/epidemiology ; Diet, Healthy ; Diet
Language	English
Publishing date	2024-01-01
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2023.100027
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Article ; Online: Association of social isolation and loneliness with the risk of hypertension in middle aged and older adults: Findings from a national representative longitudinal survey.

Wang, Shiqi / Zhang, Hao / Lou, Yiling / You, Qiqi / Jiang, Qingqing / Cao, Shiyi

Journal of affective disorders

2024 Volume 349, Page(s) 577–582

Abstract: Background: Social isolation and loneliness have been proved to be associated with many adverse health outcomes, but their influence on hypertension remains unclear. This study aimed to assess the relationship of social isolation and loneliness with ... ...

Abstract	Background: Social isolation and loneliness have been proved to be associated with many adverse health outcomes, but their influence on hypertension remains unclear. This study aimed to assess the relationship of social isolation and loneliness with hypertension risk among middle-aged and older adults in China. Methods: We used data from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study. Participants were assessed for social isolation and loneliness at baseline, and hypertension was identified by self-report and blood pressure measurement at follow-up in 2015. Binary logistic regression analyses were conducted to assess the association of social isolation and loneliness with the risk of hypertension. Results: A total of 3711 residents were included. 13.7 % of the participants had high level of social isolation and 18.1 % felt lonely. During the four-year follow up period, 651 participants developed hypertension. People with high level of social isolation had an increased risk of hypertension (odds ratio [OR]: 1.40, 95 % confidence interval [CI]: 1.09-1.79). Similar results were found between social isolation score and hypertension risk (OR: 1.14, 95 % CI: 1.04-1.26). No significant association between loneliness and hypertension or any interaction effect of social isolation and loneliness on hypertension were observed. Limitations: Limited by the structure of questionnaire, some of the information was derived by self-report, which may lead to recalling bias. Conclusion: Social isolation, rather than loneliness was associated with hypertension for middle aged and older adults. Social support needs to be strengthened for hypertension prevention in community.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Loneliness ; Longitudinal Studies ; Social Isolation ; Social Support ; Hypertension/epidemiology
Language	English
Publishing date	2024-01-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.008
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Article: Response to Letter by Dr. Ajay Malhotra.

Yu, Xinyu / Cao, Shiyi

Journal of stroke

2020 Volume 22, Issue 3, Page(s) 421

Language	English
Publishing date	2020-09-29
Publishing country	Korea (South)
Document type	Journal Article ; Comment
ZDB-ID	2814366-8
ISSN	2287-6405 ; 2287-6391
ISSN (online)	2287-6405
ISSN	2287-6391
DOI	10.5853/jos.2020.02859
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Article ; Online: Chitosan/silk fibroin composite bilayer PCL nanofibrous mats for bone regeneration with enhanced antibacterial properties and improved osteogenic potential

Wang, Xiaoxuan / Peng, Yan / Wu, Yang / Cao, Shiyi / Deng, Hongbing / Cao, Zhengguo

International Journal of Biological Macromolecules. 2023 Mar., v. 230 p.123265-

2023

Abstract: In regenerative medicine and bone tissue engineering, various composite materials are enormously popular, but the final tissue restoration outcome is not always satisfactory. In this study, bilayer-deposited multifunctional nanofiber mats were ... ...

Abstract	In regenerative medicine and bone tissue engineering, various composite materials are enormously popular, but the final tissue restoration outcome is not always satisfactory. In this study, bilayer-deposited multifunctional nanofiber mats were successfully fabricated with an osteogenic side of silk fibroin/poly (ε-caprolactone) (referred to as SF/PCL) and an antibacterial side of poly (ε-caprolactone)/chitosan (referred to as PCL/CS). The PCL/CS-SF/PCL (referred to as PCSP) mats exhibited biocompatible properties, sufficient hydrophilicity and mechanical properties, as well as a higher breaking strength (3.6 MPa) than the monolayer of SF/PCL mats (1.5 MPa). The antibacterial side of PCSP mats (A-layer) demonstrated ideal antibacterial potency because the survival rate of Escherichia coli (E. coli) (approximately 25 %) and Staphylococcus aureus (S. aureus) (approximately 15 %) were both significantly lower. Subsequently, the plasmid encoding runt related transcription factor 2 (Runx2) was complexed with the osteogenic side of PCSP mats (O-layer) through polyethyleneimine (PEI), thereby enhancing both osteogenesis-related gene expression and the formation of mineralized nodules. Similarly, the implantation of PCSP+Runx2 mats effectively promoted bone tissue generation in vivo. These results indicated the excellent prospects of applying PCSP mats to bone regeneration with gene delivery.
Keywords	Escherichia coli ; Staphylococcus aureus ; bone formation ; bones ; chitosan ; fibroins ; gene expression ; gene transfer ; hydrophilicity ; medicine ; mineralization ; nanofibers ; plasmids ; polyethyleneimine ; survival rate ; transcription factors ; Double-layer ; Multifunctional ; Bone tissue engineering
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123265
Database	NAL-Catalogue (AGRICOLA)

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Article: Dynamic prediction of urban landscape pattern based on remote sensing image fusion

Cao, Shi-yi / Hu, Xi-jun

International journal of environmental technology and management

2021 Volume 24, Issue 1/2, Page(s) 18

Language	English
Document type	Article
ZDB-ID	2080011-3
ISSN	1466-2132
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Adherence to the Chinese Food Pagoda in the High-Risk Population of Non-communicable Diseases Aged 35-59 in Central China.

Jiang, Qingqing / You, Qiqi / Lou, Yiling / Wang, Shiqi / Cao, Shiyi

Frontiers in nutrition

2022 Volume 9, Page(s) 781963

Abstract: Objectives: A healthy dietary habit is essential for preventing non-communicable diseases (NCDs). We aimed to assess the adherence to the Chinese Food Pagoda (CFP) proposed in the Chinese Dietary Guidelines 2016 in the high-risk population of NCDs in ... ...

Abstract	Objectives: A healthy dietary habit is essential for preventing non-communicable diseases (NCDs). We aimed to assess the adherence to the Chinese Food Pagoda (CFP) proposed in the Chinese Dietary Guidelines 2016 in the high-risk population of NCDs in central China. Methods: A cross-sectional study was conducted in two large enterprises (totally 3,016 employees) from October to December 2019 in Hubei Province (central China). The high-risk population of NCDs was identified by physical examination, laboratory test and face-to-face questionnaire survey according to the Results: A total of 821 participants aged 35-59 years old with at least one high-risk factor of NCDs were enrolled in our study. Of them, 53.8% were daily smokers, 49.6% had elevated blood cholesterol, 31.4% were centrally obese, 23.3% had high normal blood pressure, and 3.5% had impaired fasting glucose. Significant disparity was detected in the high-risk population of NCDs between real food consumption and the CFP's recommendation ( Conclusion: Adherence to CFP in the high-risk population of NCDs appeared to be challenging. It is necessary to adopt dietary education campaign focusing on the high-risk population of NCDs to prevent or delay the occurrence of NCDs.
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.781963
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Article ; Online: Meta-analysis of the association between periodontal disease, periodontal treatment and carotid intima-media thickness.

Ding, Lifang / You, Qiqi / Jiang, Qingqing / Cao, Shiyi / Jiang, Shengjun

Journal of periodontal research

2022 Volume 57, Issue 4, Page(s) 690–697

Abstract: Periodontal disease is a major threat to oral health and would further contribute to systemic diseases without timely control. We aimed to evaluate the relation between periodontal disease, periodontal treatment and carotid intima-media thickness (CIMT) ... ...

Abstract	Periodontal disease is a major threat to oral health and would further contribute to systemic diseases without timely control. We aimed to evaluate the relation between periodontal disease, periodontal treatment and carotid intima-media thickness (CIMT) based on available epidemiological and clinical evidence. PubMed and Scopus were searched for relevant studies through May 2021. Observational studies reporting risk estimates with 95% confidence intervals (95% CIs) for the association between periodontal disease (including periodontitis and gingivitis) and risk of increased CIMT (defined as CIMT value that exceeded the cut-off value of clinical and prognostic significance), as well as interventional studies providing mean values with standard deviations of CIMT before and after periodontal intervention, were included. Random-effect models for meta-analysis were used to calculate the summary effect estimates with 95% CIs. A total of 406 citations were retrieved from electronic databases and 45 full-text articles were screened, leaving 11 articles using ultrasound to measure CIMT with 8744 participants included. Pooled results of seven cross-sectional studies involving 8558 participants indicated that compared to those without periodontitis, patients with periodontitis and those with severe periodontitis had an odds ratio of 1.42 (95% CI: 1.16, 1.75) and 1.70 (95% CI: 1.24, 2.33) for increased CIMT, respectively. Although publication bias was detected in these results, odds ratios corrected by the trim-and-fill method were still statistically significant. Results of four non-randomized controlled trials with 186 patients suggested that periodontal intervention may help reduce CIMT in patients with periodontal disease in the short term. Periodontitis, especially severe periodontitis, was significantly associated with the risk of increased CIMT. Periodontal intervention might help slow the progression of carotid intima-media thickening in patients with periodontal disease in the short term.
MeSH term(s)	Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Humans ; Periodontal Diseases/complications ; Periodontal Diseases/diagnostic imaging ; Periodontal Diseases/therapy ; Periodontitis/complications ; Risk Factors
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	390953-0
ISSN	1600-0765 ; 0022-3484
ISSN (online)	1600-0765
ISSN	0022-3484
DOI	10.1111/jre.13006
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Article: Association between neck circumference and diabetes mellitus: a systematic review and meta-analysis.

Li, Dandan / Zhao, Yuxin / Zhang, Lifang / You, Qiqi / Jiang, Qingqing / Yin, Xiaoxv / Cao, Shiyi

Diabetology & metabolic syndrome

2023 Volume 15, Issue 1, Page(s) 133

Abstract: Background: Despite that several original researchers have investigated the association between neck circumference (NC) and the risk of diabetes mellitus (DM), their results remain controversial. This review aimed to quantitatively determine the risk of ...

Abstract	Background: Despite that several original researchers have investigated the association between neck circumference (NC) and the risk of diabetes mellitus (DM), their results remain controversial. This review aimed to quantitatively determine the risk of DM in relation to the NC. Methods: We conducted a literature search of PubMed, Embase, and the Web of Science from these databases' inception through September 2022 to identify observational studies that examined the association between NC and the risk of DM. A meta-analysis of the random-effects model was applied to combine the results of the enrolled studies. Results: Sixteen observational studies involving 4,764 patients with DM and 26,159 participants were assessed. The pooled results revealed that NC was significantly associated with the risk of type 2 DM (T2DM) (OR = 2.17; 95% CI: 1.30-3.62) and gestational DM (GDM) (OR = 1.31; 95% CI: 1.17-1.48). Subgroup analysis revealed that after controlling for BMI, the relationship between the NC and T2DM remained statistically significant (OR = 1.94; 95% CI: 1.35-2.79). Moreover, the pooled OR of T2DM was found to be 1.16 (95% CI: 1.07-1.27) for an increment per each centimeter in the NC. Conclusions: Integrated epidemiological evidence supports the hypothesis that a greater NC is associated with an increased risk of T2DM and GDM.
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-023-01111-z
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Article ; Online: Effect of Qigong exercise on non-motor function and life quality in stroke patients: A systematic review and meta-analysis.

Lan, Yi / You, Qiqi / Jiang, Qingqing / Peng, Xiaoxiang / Cao, Shiyi / Sun, Jian

Brain and behavior

2023 Volume 13, Issue 11, Page(s) e3246

Abstract: Background: Qigong have a positive impact on the rehabilitation of motor function in stroke survivors, but there is no consensus on the effectiveness of Qigong on activities of daily living (ADL), neurological function, and life quality for patients ... ...

Abstract	Background: Qigong have a positive impact on the rehabilitation of motor function in stroke survivors, but there is no consensus on the effectiveness of Qigong on activities of daily living (ADL), neurological function, and life quality for patients with stroke. We aimed to quantitatively evaluate the effect of Qigong on non-motor function and life quality in stroke patients. Methods: Electronic literature searches were performed for randomized controlled trials on this topic using PubMed and China National Knowledge Infrastructure through August 2022. The primary outcome measures were the Barthel Index, neurological deficit score (NDS), and Stroke-Specific Quality of Life Scale (SSQLS). A random-effects model was used to calculate the pooled mean difference (MD) with 95% confidence interval (CI). RevMan 5.4 software was used for meta-analysis. Results: A total of 16 eligible randomized controlled trials with 1253 stroke patients were included. As indicated by the Barthel Index, Qigong was associated with the improvement in daily living activities of stroke patients (MD: 10.72, 95% CI: 5.88∼15.57). It was also found that Qigong was helpful in improving life quality (SSQLS, MD: 14.41, 95% CI: 5.56∼23.25) and reducing NDSs among them (NDS, MD: -4.56, 95% CI: -6.99∼-2.14). After sensitivity analysis, the effect of Qigong on these functions and life quality did not change significantly. By subgroup analysis of intervention duration, we found that long-term intervention (MD: 11.83, 95% CI: 2.80∼20.86) had a better effect on the improvement of daily living activities than short-term intervention (MD: 10.07, 95% CI: 6.15∼14.00) (p Conclusions: Pooled results suggested that Qigong had beneficial effects on ADL, neurological function, and life quality in stroke patients, which may provide an option for their rehabilitation.
MeSH term(s)	Humans ; Activities of Daily Living ; Qigong ; Quality of Life ; Stroke Rehabilitation/methods ; Stroke/therapy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3246
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