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  1. Article ; Online: The impact of long-term care insurance system on family care: Evidence from China.

    Cao, Siyuan / Xue, Huiyuan

    The International journal of health planning and management

    2023  Volume 38, Issue 5, Page(s) 1435–1452

    Abstract: Aims: The inconsistent findings on the impact of the long-term care insurance (LTCI) system on family care require us to extend our study horizon to more countries with LTCI system designs or market practices. China has explored the LTCI system through ... ...

    Abstract Aims: The inconsistent findings on the impact of the long-term care insurance (LTCI) system on family care require us to extend our study horizon to more countries with LTCI system designs or market practices. China has explored the LTCI system through pilot programs, which provide a quasi-natural experimental environment. This paper aims to examine how the LTCI system affects family care in China.
    Methods: We primarily employ the time-varying difference-in-differences method to perform regression analyses based on the panel data from the China Health and Retirement Longitudinal Study.
    Results: We discover a 7.2% rise in family care under the LTCI system. Specifically, the LTCI system is more likely to promote family care as the relatively primary care for disabled women, disabled people aged 60-74, and those who cannot fully take care of themselves. In addition, the formal care support policy of LTCI will crowd in both formal care and family care, and the crowding-in-effect on formal care may even obscure the crowding-in-effect on family care. The family care support policy of LTCI may encourage the policy-covered groups to take family care as their relatively primary care. It may also lengthen family care for those groups.
    Conclusions: The LTCI system has a crowding-in effect on family care. It can increase family care through cash payments or linking formal and informal care resources by providing formal community and home care.
    MeSH term(s) Humans ; Female ; Insurance, Long-Term Care ; Longitudinal Studies ; Home Care Services ; Long-Term Care ; China
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632786-2
    ISSN 1099-1751 ; 0749-6753
    ISSN (online) 1099-1751
    ISSN 0749-6753
    DOI 10.1002/hpm.3672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diabetic Ketoalkalosis: A Common Yet Easily Overlooked Alkalemic Variant of Diabetic Ketoacidosis Associated with Mixed Acid-Base Disorders.

    Cao, Siyuan / Cao, Shanjin

    The Journal of emergency medicine

    2023  Volume 64, Issue 3, Page(s) 282–288

    Abstract: Background: Diabetic ketoacidosis (DKA) is commonly complicated by mixed acid-base disorders. Therefore, patients with DKA can present with pH > 7.3 or bicarbonate > 18 mmol/L, which falls outside the values defined by the current traditional DKA ... ...

    Abstract Background: Diabetic ketoacidosis (DKA) is commonly complicated by mixed acid-base disorders. Therefore, patients with DKA can present with pH > 7.3 or bicarbonate > 18 mmol/L, which falls outside the values defined by the current traditional DKA criteria (pH ≤ 7.3 or bicarbonate ≤ 18 mmol/L).
    Objective: We aimed to study the spectrum of acid-base clinical presentations of DKA and the prevalence of diabetic ketoalkalosis.
    Methods: This study included all adult patients at a single institution admitted in 2018-2020 with diabetes, positive beta-hydroxybutyric acid, and increased anion gap ≥ 16 mmol/L. Mixed acid-base disorders were analyzed to determine the spectrum of presentation of DKA.
    Results: There were 259 encounters identified under the inclusion criteria. Acid-base analysis was available in 227 cases. Traditional acidemic DKA (pH ≤ 7.3), DKA with mild acidemia (7.3 < pH ≤ 7.4), and diabetic ketoalkalosis (pH > 7.4) account for 48.9% (111/227), 27.8% (63/227), and 23.3% (53/227) of cases, respectively. Of the 53 cases with diabetic ketoalkalosis, increased anion gap metabolic acidosis was present in all, and concurrent metabolic alkalosis, respiratory alkalosis, and respiratory acidosis were present in 47.2% (25/53), 81.1% (43/53), and 11.3% (6/53) encounters, respectively. In addition, 34.0% (18/53) of those with diabetic ketoalkalosis were found to have severe ketoacidosis, defined by beta-hydroxybutyric acid ≥ 3 mmol/L.
    Conclusions: DKA can present as traditional acidemic DKA, DKA with mild acidemia, and diabetic ketoalkalosis. Diabetic ketoalkalosis is a common yet easily overlooked alkalemic variant of DKA associated with mixed acid-base disorders, and a high proportion of these presentations have severe ketoacidosis and thus, require the same treatment as traditional DKA.
    MeSH term(s) Adult ; Humans ; Diabetic Ketoacidosis/drug therapy ; Bicarbonates/therapeutic use ; 3-Hydroxybutyric Acid/therapeutic use ; Alkalosis ; Acidosis ; Acid-Base Imbalance ; Diabetes Mellitus
    Chemical Substances Bicarbonates ; 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2022.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Wheel-Running Facilitates Phase Advances in Locomotor and Peripheral Circadian Rhythm in Social Jet Lag Model Mice.

    Oneda, Satoshi / Cao, Siyuan / Haraguchi, Atsushi / Sasaki, Hiroyuki / Shibata, Shigenobu

    Frontiers in physiology

    2022  Volume 13, Page(s) 821199

    Abstract: The circadian clock maintains our health by controlling physiological functions. Social jet lag is one factor that can disrupt the body clock. This is caused by the difference in sleeping hours between weekdays when we live according to social time and ... ...

    Abstract The circadian clock maintains our health by controlling physiological functions. Social jet lag is one factor that can disrupt the body clock. This is caused by the difference in sleeping hours between weekdays when we live according to social time and holidays when we live according to our body clock. The body clock can be altered by exercise, nutrition, and stress, and several studies have reported that these factors can be used to improve a disturbed body clock. Here we focused on exercise and examined whether continuous wheel-running could improve the disordered body clock in a mouse model that mimics social jet lag. The results showed that the wheel-running exercise group showed faster synchronization of the onset of activities on weekdays which had been delayed by social jet lag and the results were even more pronounced in the high-fat diet feeding condition. Also, when the expression rhythms of the clock genes were examined, they experienced a sudden time shift in the advance light condition or social jet lag condition, it was found that the wheel-running group had a higher ability to adapt to the advance direction. Thus, it is possible that the effective inclusion of exercise in human, especially those who eat high-fat foods, life can improve the disordered body clock in terms of social jet lag.
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.821199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Addition of montmorillonite to improve the barrier and wetting properties of chitosan-based coatings and the application on the preservation of Shatang mandarin

    Cao, Siyuan / Liu, Min / Zou, Lina / He, Yue / Ren, Dan / Wu, Xiyu / Xu, Dan

    Food packaging and shelf life. 2022 Sept., v. 33

    2022  

    Abstract: Montmorillonite (MMT) has been incorporated with chitosan/nanocrystal cellulose (NCC) coatings to improve the wettability of the solution on fruit surface and the barrier properties of the coating film formed, thereby improving the preservation effect on ...

    Abstract Montmorillonite (MMT) has been incorporated with chitosan/nanocrystal cellulose (NCC) coatings to improve the wettability of the solution on fruit surface and the barrier properties of the coating film formed, thereby improving the preservation effect on the fruit. Results showed that the addition of MMT reduced the moisture sensitivity of the standing films and improved the barrier properties towards water vapor and oxygen. The dispersive component of surface tension of the coating solution was greatly increased by adding 6% MMT resulting in the improved wettability of the coating solution on the fruit surface, which promoted the formation of a uniform coating film. When applied to Shatang mandarin, the composite coating containing 6% MMT showed the best performance to inhibit the decay, maintain the nutrients content, and delay the postharvest senescence, which proved the effectiveness of nanoparticles in improving the formation of uniform structure and barrier properties of the coating film.
    Keywords cellulose ; chitosan ; fruits ; montmorillonite ; nanocrystals ; oxygen ; shelf life ; surface tension ; water vapor ; wettability
    Language English
    Dates of publication 2022-09
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2214-2894
    DOI 10.1016/j.fpsl.2022.100889
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Euglena gracilis

    Ryan, Conn / Cao, Siyuan / Sekiguchi, Masataka / Haraguchi, Atsushi / Murata, Ako / Nakashima, Ayaka / Suzuki, Kengo / Shibata, Shigenobu

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1113118

    Abstract: Paramylon, a β-1,3-glucan storage polysaccharide derived ... ...

    Abstract Paramylon, a β-1,3-glucan storage polysaccharide derived from
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1113118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Iterative Deep Homography Estimation

    Cao, Si-Yuan / Hu, Jianxin / Sheng, Zehua / Shen, Hui-Liang

    2022  

    Abstract: We propose Iterative Homography Network, namely IHN, a new deep homography estimation architecture. Different from previous works that achieve iterative refinement by network cascading or untrainable IC-LK iterator, the iterator of IHN has tied weights ... ...

    Abstract We propose Iterative Homography Network, namely IHN, a new deep homography estimation architecture. Different from previous works that achieve iterative refinement by network cascading or untrainable IC-LK iterator, the iterator of IHN has tied weights and is completely trainable. IHN achieves state-of-the-art accuracy on several datasets including challenging scenes. We propose 2 versions of IHN: (1) IHN for static scenes, (2) IHN-mov for dynamic scenes with moving objects. Both versions can be arranged in 1-scale for efficiency or 2-scale for accuracy. We show that the basic 1-scale IHN already outperforms most of the existing methods. On a variety of datasets, the 2-scale IHN outperforms all competitors by a large gap. We introduce IHN-mov by producing an inlier mask to further improve the estimation accuracy of moving-objects scenes. We experimentally show that the iterative framework of IHN can achieve 95% error reduction while considerably saving network parameters. When processing sequential image pairs, IHN can achieve 32.7 fps, which is about 8x the speed of IC-LK iterator. Source code is available at https://github.com/imdumpl78/IHN.

    Comment: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR 2022)
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2022-03-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing

    Haraguchi, Atsushi / Yamazaki, Tomohiro / Ryan, Conn / Ito, Kaede / Sato, Shuhei / Tamura, Konomi / Sekiguchi, Masataka / Cao, Siyuan / Shibata, Shigenobu

    Journal of Functional Foods. 2022 Dec., v. 99 p.105307-

    2022  

    Abstract: The time-dependent effects of caffeine intake on physiological functions remain to be investigated, although various effects of caffeine on physiological functions have been document. Therefore, the present study investigated the optimal timing of ... ...

    Abstract The time-dependent effects of caffeine intake on physiological functions remain to be investigated, although various effects of caffeine on physiological functions have been document. Therefore, the present study investigated the optimal timing of caffeine intake to produce an efficient anti-obesity effect. We prepared a high-fat diet (HFD) or HFD supplemented with 0.03% caffeine (HFD-caf) and regulated twice-daily 8-hour time-restricted feeding. Male Institute of Cancer Research mice were divided into three groups: group fed HFD alone (control), group fed HFD-caf at the beginning of the active period (BF-caf), and group fed HFD-caf at the end of the active period (DN-caf). The BF-caf group (42.8 ± 1.5 g) showed lower body weight than the other groups (control, 49.7 ± 2.1 g; DN-caf, 47.1 ± 1.3 g), although the three groups showed similar HFD intake levels. Therefore, caffeine intake at the beginning of the active period suppressed HFD-induced body weight gain.
    Keywords anti-obesity effects ; body weight changes ; caffeine ; high fat diet ; males ; Anti-obesity effect ; Chrono-nutrition ; Circadian clock system ; Lipogenesis ; BF ; Bmal1 ; Clock ; CM mice ; DN ; EE ; EGCG ; FDR ; HDL cholesterol ; HFD ; HFD-caf ; HMG ; ICR mice ; LDL cholesterol ; TRF ; PDE ; Per1/2 ; RER ; RT-PCR ; SCN ; SEM ; WT ; ZT
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2022.105307
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Development of pH-responsive absorbent pad based on polyvinyl alcohol/agarose/anthocyanins for meat packaging and freshness indication

    He, Yue / Li, Baoxiang / Du, Jin / Cao, Siyuan / Liu, Min / Li, Xiaonan / Ren, Dan / Wu, Xiyu / Xu, Dan

    International journal of biological macromolecules. 2022 Mar. 15, v. 201

    2022  

    Abstract: Absorbent pads with antioxidant and pH-responsive color changing functions have been developed based on polyvinyl alcohol (PVA), agarose (AG), and purple sweet potato anthocyanins (PSPA), aiming for fresh keeping and freshness indication of meat. The ... ...

    Abstract Absorbent pads with antioxidant and pH-responsive color changing functions have been developed based on polyvinyl alcohol (PVA), agarose (AG), and purple sweet potato anthocyanins (PSPA), aiming for fresh keeping and freshness indication of meat. The effects of PSPA content on the structure, physical properties, and colorimetric response towards pH changing of pads were evaluated. The results showed that PSPA interacted with PVA and AG and influenced the crystallinity, thermal stability and micro-morphology of pads. The increase of the PSPA content from 3% to 12% improved the strength and DPPH radical scavenging activity of the pads, but reduced the swelling ratio. Significant color change of the pads was observed when pH increased from 3 to 10, and the pad containing 9% PSPA presented the most distinguishable color change with the change of pH. When applied as an absorbent pad for minced meat packaging, the pad indicated the real-time spoilage of the meat through obvious color change, and also extended the shelf life by at least 24 h. Therefore, the dual-functional pad shows great potential to be applied as a smart and active packaging for fresh meat, which would play an important role in ensuring food safety and improving food storage quality.
    Keywords absorbents ; agarose ; anthocyanins ; antioxidants ; color ; colorimetry ; crystal structure ; food safety ; food storage ; freshness ; meat ; minced meat ; pH ; polyvinyl alcohol ; raw meat ; shelf life ; spoilage ; sweet potatoes ; thermal stability
    Language English
    Dates of publication 2022-0315
    Size p. 203-215.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.12.171
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online: BEVPlace

    Luo, Lun / Zheng, Shuhang / Li, Yixuan / Fan, Yongzhi / Yu, Beinan / Cao, Siyuan / Shen, Huiliang

    Learning LiDAR-based Place Recognition using Bird's Eye View Images

    2023  

    Abstract: Place recognition is a key module for long-term SLAM systems. Current LiDAR-based place recognition methods are usually based on representations of point clouds such as unordered points or range images. These methods achieve high recall rates of ... ...

    Abstract Place recognition is a key module for long-term SLAM systems. Current LiDAR-based place recognition methods are usually based on representations of point clouds such as unordered points or range images. These methods achieve high recall rates of retrieval, but their performance may degrade in the case of view variation or scene changes. In this work, we explore the potential of a different representation in place recognition, i.e. bird's eye view (BEV) images. We observe that the structural contents of BEV images are less influenced by rotations and translations of point clouds. We validate that, without any delicate design, a simple VGGNet trained on BEV images achieves comparable performance with the state-of-the-art place recognition methods in scenes of slight viewpoint changes. For more robust place recognition, we design a rotation-invariant network called BEVPlace. We use group convolution to extract rotation-equivariant local features from the images and NetVLAD for global feature aggregation. In addition, we observe that the distance between BEV features is correlated with the geometry distance of point clouds. Based on the observation, we develop a method to estimate the position of the query cloud, extending the usage of place recognition. The experiments conducted on large-scale public datasets show that our method 1) achieves state-of-the-art performance in terms of recall rates, 2) is robust to view changes, 3) shows strong generalization ability, and 4) can estimate the positions of query point clouds. Source code will be made publicly available at https://github.com/zjuluolun/BEVPlace.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Robotics
    Subject code 006
    Publishing date 2023-02-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The pharmaceutical excipient PEG400 affect the absorption of baicalein in Caco-2 monolayer model by interacting with UDP-glucuronosyltransferases and efflux transport proteins.

    Cao, Siyuan / Zhang, Min / Yuan, Minyan / Yang, Dan / Zhao, Mei / Zhang, Shuo / Wang, Pengjiao / Zhang, Rongping / Gao, Xiuli

    Pharmacology research & perspectives

    2022  Volume 10, Issue 1, Page(s) e00928

    Abstract: The bioavailability of drugs is often related to intestinal metabolism and transport mechanisms. In previous studies, pharmaceutical excipients were recognized as inert substances in clinical safety evaluations. However, a large number of studies have ... ...

    Abstract The bioavailability of drugs is often related to intestinal metabolism and transport mechanisms. In previous studies, pharmaceutical excipients were recognized as inert substances in clinical safety evaluations. However, a large number of studies have shown that pharmaceutical excipients regulate the metabolism and transport of drugs in the body and improve the bioavailability. The pharmaceutical excipient polyethylene glycol 400 (PEG400) as a good solubilizer and surfactant has the potential to improve the bioavailability of drugs. The combined action of UDP-glucuronosyltransferases (UGTs) and efflux transport proteins is responsible for the intestinal disposition and poor bioavailability of baicalein. Our aim is to study the effect of PEG400 on the absorption of baicalein on the Caco-2 monolayer, and confirm the interaction of PEG400 with UGTs (UGT1A8 and UGT1A9) and efflux transports. We initially found that baicalein in the Caco-2 monolayer would be metabolized into glucuronide conjugates BG and B6G under the action of UGT1A8 and UGT1A9 on the endoplasmic reticulum membrane, and then mainly excreted to different sides by acting of MRP and BCRP. The addition of PEG400 significantly accelerated the metabolism of B in Caco-2 cells and increased the penetration of BG and B6G. Furthermore, PEG400 also significantly decreased the efflux ratio of BG and B6G, which was the evidence of the interaction with the efflux transporters. In the in vitro intestinal microsome regeneration system, low concentration PEG400 decreased the K
    MeSH term(s) Antioxidants/administration & dosage ; Antioxidants/pharmacokinetics ; Biological Availability ; Biological Transport ; Caco-2 Cells ; Excipients/pharmacology ; Flavanones/administration & dosage ; Flavanones/pharmacokinetics ; Glucuronosyltransferase/metabolism ; Humans ; Intestinal Absorption ; Membrane Transport Proteins/metabolism ; Microsomes/metabolism ; Polyethylene Glycols/pharmacology ; UDP-Glucuronosyltransferase 1A9/metabolism
    Chemical Substances Antioxidants ; Excipients ; Flavanones ; Membrane Transport Proteins ; UGT1A9 protein, human ; Polyethylene Glycols (3WJQ0SDW1A) ; baicalein (49QAH60606) ; polyethylene glycol 400 (B697894SGQ) ; Glucuronosyltransferase (EC 2.4.1.17) ; UDP-Glucuronosyltransferase 1A9 (EC 2.4.1.17) ; UDP-glucuronosyltransferase, UGT1A8 (EC 2.4.1.17)
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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