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Article ; Online: Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway.

Wang, Zhiyuan / Han, Bin / Qi, Jianjiao / Cao, Xuelei / Gu, Huali / Sun, Jinping

2024 Volume 189, Page(s) 112407

Abstract: Vascular cognitive impairment (VCI) has become a common disease-causing cognitive deficit in humans, second only to Alzheimer's Disease (AD). Chuanzhitongluo capsule (CZTL) is a Traditional Chinese Medicine (TCM) preparation known for its effective ... ...

Abstract	Vascular cognitive impairment (VCI) has become a common disease-causing cognitive deficit in humans, second only to Alzheimer's Disease (AD). Chuanzhitongluo capsule (CZTL) is a Traditional Chinese Medicine (TCM) preparation known for its effective protection against cerebral ischemia. However, its potential to ameliorate VCI remains unclear. This study aimed to investigate the cognitive improvement effects of CZTL in a mouse model of VCI. Chronic cerebral hypoperfusion (CCH) was induced in mice by bilateral common carotid artery stenosis (BCAS) to simulate the pathological changes associated with VCI. Spatial learning and memory abilities were assessed using the Morris Water Maze (MWM). RNA sequencing (RNA-Seq) was employed to identify differentially expressed genes (DEGs) in the hippocampus. Levels of inflammatory factors were measured through enzyme-linked immunosorbent assay (ELISA), while immunofluorescence (IF) determined the expression intensity of target proteins. Western Blot (WB) confirmed the final action pathway. Results indicated that CZTL significantly improved the spatial learning and memory abilities of CCH mice, along with alterations in gene expression profiles in the hippocampus. It also reduced neuroinflammation in the hippocampus and upregulated the choline acetyltransferase (ChAT) and α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR), which are in synaptic plasticity and neuronal development. Moreover, CZTL inhibited the NF-κB signaling pathway. In conclusion, CZTL may alleviate neuroinflammation induced by CCH and improve cognitive impairment in CCH mice by regulating the cholinergic anti-inflammatory pathway (CAIP) involving ChAT/α7nAChR/NF-κB.
MeSH term(s)	Humans ; Mice ; Animals ; NF-kappa B/metabolism ; Neuroinflammatory Diseases ; Neuroimmunomodulation ; alpha7 Nicotinic Acetylcholine Receptor ; Cognitive Dysfunction/complications ; Brain Ischemia/drug therapy ; Carotid Stenosis/complications ; Carotid Stenosis/drug therapy
Chemical Substances	NF-kappa B ; alpha7 Nicotinic Acetylcholine Receptor
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2024.112407
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Article ; Online: Selective degradation of PL2L60 by metabolic stresses‑induced autophagy suppresses multi‑cancer growth.

Sun, Lei / Hui, Fu / Tang, Gao-Yan / Shen, Hai-Lian / Cao, Xue-Lei / Gao, Jian-Xin / Li, Lin-Feng

Oncology reports

2024 Volume 51, Issue 3

Abstract: It has been reported that PL2L60 proteins, a product ... ...

Abstract	It has been reported that PL2L60 proteins, a product of
MeSH term(s)	Humans ; RNA, Small Interfering/metabolism ; Neoplasms ; Hypoxia/metabolism ; Apoptosis ; Autophagy ; Stress, Physiological ; RNA, Messenger ; Argonaute Proteins/metabolism
Chemical Substances	RNA, Small Interfering ; RNA, Messenger ; PIWIL2 protein, human ; Argonaute Proteins
Language	English
Publishing date	2024-01-12
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2024.8700
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Zs.A 4213: Show issues

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Article ; Online: Curcumin suppresses tumorigenesis by ferroptosis in breast cancer.

Cao, Xuelei / Li, Yao / Wang, Yongbin / Yu, Tao / Zhu, Chao / Zhang, Xuezhi / Guan, Jialiang

PloS one

2022 Volume 17, Issue 1, Page(s) e0261370

Abstract: Breast cancer (BC) is one of the most common malignant tumors found in females. Previous studies have demonstrated that curcumin, which is a type of polyphenol compound extracted from Curcuma longa underground rhizome, is able to inhibit the survival of ... ...

Abstract	Breast cancer (BC) is one of the most common malignant tumors found in females. Previous studies have demonstrated that curcumin, which is a type of polyphenol compound extracted from Curcuma longa underground rhizome, is able to inhibit the survival of cancer cells. However, the functional role and mechanism of curcumin in BC are still unclear. The Cell Counting Kit-8 assay was performed to examine the effects of curcumin on cell viability in the BC cell lines MDA-MB-453 and MCF-7. The levels of lipid reactive oxygen species (ROS), malondialdehyde (MDA) production, and intracellular Fe2+ were determined to assess the effects of curcumin on cell ferroptosis. Western blot analysis was also carried out to detect the protein levels. Finally, the antitumorigenic effect of curcumin on BC was identified in a xenograft tumor model. In the present study, the results indicated that curcumin could dose-dependently suppress the viability of both MDA-MB-453 and MCF-7 cells. Further studies revealed that curcumin facilitated solute carrier family 1 member 5 (SLC1A5)-mediated ferroptosis in both MDA-MB-453 and MCF-7 cells by enhancing lipid ROS levels, lipid peroxidation end-product MDA accumulation, and intracellular Fe2+ levels. In vivo experiments demonstrated that curcumin could significantly hamper tumor growth. Collectively, the results demonstrated that curcumin exhibited antitumorigenic activity in BC by promoting SLC1A5-mediated ferroptosis, which suggests its use as a potential therapeutic agent for the treatment of BC.
MeSH term(s)	Breast Neoplasms
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0261370
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Article ; Online: Identification of Serum Biomarkers in Patients with Alzheimer's Disease by 2D-DIGE Proteomics.

Zhang, Xuezhi / Yu, Wenwen / Cao, Xuelei / Wang, Yongbin / Zhu, Chao / Guan, Jialiang

Gerontology

2022 Volume 68, Issue 6, Page(s) 686–698

Abstract: Aim: The aim of this study is to identify potential serum biomarkers of Alzheimer's disease (AD) for early diagnosis and to evaluate these markers on a large cohort.: Methods: We performed two-dimensional difference gel electrophoresis to compare the ...

Abstract	Aim: The aim of this study is to identify potential serum biomarkers of Alzheimer's disease (AD) for early diagnosis and to evaluate these markers on a large cohort. Methods: We performed two-dimensional difference gel electrophoresis to compare the serum of AD patients and normal controls. Western blot or enzyme-linked immunosorbent assay (ELISA) was used to identify the expression levels of proteins. Results: In this study, a total of 13 differentially expressed proteins were identified. Among them, 2 proteins (inter-alpha-trypsin inhibitor heavy chain H4 [ITI-H4], Apolipoprotein A-IV) were validated by Western blot and 4 proteins (Cofilin 2, Tetranectin, Zinc-alpha-2-glycoprotein [AZGP1], Alpha-1-microglobulin/bikunin precursor [AMBP]) were validated by ELISA, respectively. Western blot results showed that the full size of the ITI-H4 protein was increased, while a fragment of ITI-H4 was decreased in AD patients. In contrast, 1 fragment of Apo A-IV was mainly found in control group and rare to be detected in AD patients. On the other hand, ELISA results showed that Cofilin 2, Tetranectin, AZGP1, and AMBP were significantly increased in AD patients, and Cofilin 2 is strongly correlated with the Mini-Mental State Examination scores of the AD patients. Serum Cofilin 2 was unchanged in Parkinson disease patients as compared to the control group, indicating a specific correlation of serum Cofilin 2 with AD. Moreover, Cofilin 2 was increased in both the serum and brain tissue in the APP/PS1 transgenic mice. Conclusion: Our study identified several potential serum biomarkers of AD, including: ITI-H4, ApoA-IV, Cofilin 2, Tetranectin, AZGP1, and AMBP. Cofilin 2 was upregulated in different AD animal models and might play important roles in AD pathology.
MeSH term(s)	Alzheimer Disease/diagnosis ; Animals ; Biomarkers ; Cofilin 2 ; Humans ; Mice ; Proteomics/methods ; Two-Dimensional Difference Gel Electrophoresis
Chemical Substances	Biomarkers ; Cofilin 2
Language	English
Publishing date	2022-01-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193798-4
ISSN	1423-0003 ; 0304-324X
ISSN (online)	1423-0003
ISSN	0304-324X
DOI	10.1159/000520961
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Article ; Online: Clinical application of amplification-based versus amplification-free metagenomic next-generation sequencing test in infectious diseases.

Wang, Zhe-Ying / Li, Lu-Lu / Cao, Xue-Lei / Li, Ping / Du, Jian / Zou, Ming-Jin / Wang, Li-Li

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1138174

Abstract: Background: Recently, metagenomic next-generation sequencing (mNGS) has been used in the diagnosis of infectious diseases (IDs) as an emerging and powerful tool. However, whether the complicated methodological variation in mNGS detections makes a ... ...

Abstract	Background: Recently, metagenomic next-generation sequencing (mNGS) has been used in the diagnosis of infectious diseases (IDs) as an emerging and powerful tool. However, whether the complicated methodological variation in mNGS detections makes a difference in their clinical performance is still unknown. Here we conducted a method study on the clinical application of mNGS tests in the DNA detection of IDs. Methods: We analyzed the effect of several potential factors in the whole process of mNGS for DNA detection on microorganism identification in 98 samples of suspected ID patients by amplification-based mNGS. The amplification-based and amplification-free mNGS tests were successfully performed in 41 samples. Then we compared the clinical application of the two mNGS methods in the DNA detection of IDs. Results: We found that a higher concentration of extracted nucleic acid was more conducive to detecting microorganisms. Other potential factors, such as read depth and proportion of human reads, might not be attributed to microorganism identification. The concordance rate of amplification-based and amplification-free mNGS results was 80.5% (33/41) in the patients with suspected IDs. Amplification-based mNGS showed approximately 16.7% higher sensitivity than amplification-free mNGS. However, 4 cases with causative pathogens only detected by amplification-based mNGS were finally proved false-positive. In addition, empirical antibiotic treatments were adjusted in 18 patients following mNGS testing with unexpected pathogens. Conclusions: Amplification-based and amplification-free mNGS tests showed their specific advantages and disadvantages in the diagnosis of IDs. The clinical application of mNGS still needs more exploration from a methodological perspective. With advanced technology and standardized procedure, mNGS will play a promising role in the diagnosis of IDs and help guide the use of antibiotics.
MeSH term(s)	Humans ; Communicable Diseases/diagnosis ; High-Throughput Nucleotide Sequencing ; Anti-Bacterial Agents ; Metagenome ; Metagenomics ; DNA ; Sensitivity and Specificity
Chemical Substances	Anti-Bacterial Agents ; DNA (9007-49-2)
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1138174
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Article ; Online: Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort.

Yang, Xiaorong / Zhao, Shaohua / Wang, Shaohua / Cao, Xuelei / Xu, Yue / Yan, Meichen / Pang, Mingmin / Yi, Fan / Wang, Hao

BMC medicine

2023 Volume 21, Issue 1, Page(s) 76

Abstract: Background: The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various ... ...

Abstract	Background: The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various indicators of systemic inflammation and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia in the UK Biobank cohort. Methods: After excluding ineligible participants, a total of 478,524 eligible individuals (46.75% male, aged 40-69 years) were enrolled in the study to assess the association between systemic inflammatory indicators and each type of arrhythmia. Results: After covariates were fully adjusted, CRP levels were found to have an essentially linear positive correlation with the risk of various arrhythmias; neutrophil count, monocyte count, and NLR showed a non-linear positive correlation; and lymphocyte count, SII, PLR, and LMR showed a U-shaped association. VA showed the strongest association with systemic inflammation indicators, and it was followed sequentially by AF and bradyarrhythmia. Conclusions: Multiple systemic inflammatory indicators showed strong associations with the onset of AF, VA, and bradyarrhythmia, of which the latter two have been rarely studied. Active systemic inflammation management might have favorable effects in reducing the arrhythmia burden and further randomized controlled studies are needed.
MeSH term(s)	Male ; Humans ; Female ; Bradycardia ; Biological Specimen Banks ; Arrhythmias, Cardiac/epidemiology ; Inflammation/epidemiology ; United Kingdom/epidemiology
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-023-02770-5
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Article ; Online: A Novel Pharmacological Approach to Enhance the Integrity and Accelerate Restitution of the Intestinal Epithelial Barrier.

Cao, Xuelei / Sun, Lei / Lechuga, Susana / Naydenov, Nayden G / Feygin, Alex / Ivanov, Andrei I

Inflammatory bowel diseases

2020 Volume 26, Issue 9, Page(s) 1340–1352

Abstract: Background: Disruption of the gut barrier is an essential mechanism of inflammatory bowel diseases (IBDs) contributing to the development of mucosal inflammation. A hallmark of barrier disruption is the disassembly of epithelial adherens junctions (AJs) ...

Abstract	Background: Disruption of the gut barrier is an essential mechanism of inflammatory bowel diseases (IBDs) contributing to the development of mucosal inflammation. A hallmark of barrier disruption is the disassembly of epithelial adherens junctions (AJs) driven by decreased expression of a major AJ protein, E-cadherin. A group of isoxazole compounds, such as E-cadherin-upregulator (ECU) and ML327, were previously shown to stimulate E-cadherin expression in poorly differentiated human cancer cells. This study was designed to examine whether these isoxazole compounds can enhance and protect model intestinal epithelial barriers in vitro. Methods: The study was conducted using T84, SK-CO15, and HT-29 human colonic epithelial cell monolayers. Disruption of the epithelial barrier was induced by pro-inflammatory cytokines, tumor necrosis factor-α, and interferon-γ. Barrier integrity and epithelial junction assembly was examined using different permeability assays, immunofluorescence labeling, and confocal microscopy. Epithelial restitution was analyzed using a scratch wound healing assay. Results: E-cadherin-upregulator and ML327 treatment of intestinal epithelial cell monolayers resulted in several barrier-protective effects, including reduced steady-state epithelial permeability, inhibition of cytokine-induced barrier disruption and junction disassembly, and acceleration of epithelial wound healing. Surprisingly, these effects were not due to upregulation of E-cadherin expression but were mediated by multiple mechanisms including inhibition of junction protein endocytosis, attenuation of cytokine-induced apoptosis, and activation of promigratory Src and AKT signaling. Conclusions: Our data highlight ECU and ML327 as promising compounds for developing new therapeutic strategies to protect the integrity and accelerate the restitution of the intestinal epithelial barrier in IBD and other inflammatory disorders.
MeSH term(s)	Adherens Junctions/metabolism ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Membrane Permeability/drug effects ; Colon/cytology ; Epithelial Cells/metabolism ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Intestinal Mucosa/drug effects ; Isoxazoles/pharmacology ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Signal Transduction/drug effects ; Up-Regulation/drug effects
Chemical Substances	Cadherins ; Isoxazoles ; ML327 compound ; Niacinamide (25X51I8RD4)
Language	English
Publishing date	2020-02-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izaa063
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Article: Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats.

Qin, Qiaoji / Lin, Nan / Huang, Huan / Zhang, Xuezhi / Cao, Xuelei / Wang, Yongbin / Li, Peng

Diabetes, metabolic syndrome and obesity : targets and therapy

2019 Volume 12, Page(s) 1091–1103

Abstract: Background and purpose: ...

Abstract	Background and purpose:
Language	English
Publishing date	2019-07-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S208989
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Article ; Online: A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling.

Sun, Lei / Cao, Xuelei / Lechuga, Susana / Feygin, Alex / Naydenov, Nayden G / Ivanov, Andrei I

Cells

2019 Volume 9, Issue 1

Abstract: Septins are GTP-binding proteins that self-assemble into high-order cytoskeletal structures, filaments, and rings. The septin cytoskeleton has a number of cellular functions, including regulation of cytokinesis, cell migration, vesicle trafficking, and ... ...

Abstract	Septins are GTP-binding proteins that self-assemble into high-order cytoskeletal structures, filaments, and rings. The septin cytoskeleton has a number of cellular functions, including regulation of cytokinesis, cell migration, vesicle trafficking, and receptor signaling. A plant cytokinin, forchlorfenuron (FCF), interacts with septin subunits, resulting in the altered organization of the septin cytoskeleton. Although FCF has been extensively used to examine the roles of septins in various cellular processes, its specificity, and possible off-target effects in vertebrate systems, has not been investigated. In the present study, we demonstrate that FCF inhibits spontaneous, as well as hepatocyte growth factor-induced, migration of HT-29 and DU145 human epithelial cells. Additionally, FCF increases paracellular permeability of HT-29 cell monolayers. These inhibitory effects of FCF persist in epithelial cells where the septin cytoskeleton has been disassembled by either CRISPR/Cas9-mediated knockout or siRNA-mediated knockdown of septin 7, insinuating off-target effects of FCF. Biochemical analysis reveals that FCF-dependent inhibition of the motility of control and septin-depleted cells is accompanied by decreased expression of the c-Jun transcription factor and inhibited ERK activity. The described off-target effects of FCF strongly suggests that caution is warranted while using this compound to examine the biological functions of septins in cellular systems and model organisms.
MeSH term(s)	Cell Line ; Cell Movement/drug effects ; Cell Movement/genetics ; Cytoskeleton/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Fluorescent Antibody Technique ; Gene Expression Regulation/drug effects ; Gene Knockdown Techniques ; Humans ; Permeability/drug effects ; Phenylurea Compounds/pharmacology ; Pyridines/pharmacology ; Septins/antagonists & inhibitors ; Septins/genetics ; Septins/metabolism ; Signal Transduction/drug effects
Chemical Substances	Phenylurea Compounds ; Pyridines ; Septins (EC 3.6.1.-) ; N-(2-chloro-4-pyridyl)-N'-phenylurea (K62IP7463J)
Language	English
Publishing date	2019-12-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9010084
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Article: Corrigendum: A Dual-Circular RNA Signature as a Non-invasive Diagnostic Biomarker for Gastric Cancer.

Han, Li / Zhang, Xiaoying / Wang, Aimin / Ji, Yang / Cao, Xuelei / Qin, Qiaoji / Yu, Tao / Huang, Huan / Yin, Lei

Frontiers in oncology

2020 Volume 10, Page(s) 1704

Abstract: This corrects the article DOI: 10.3389/fonc.2020.00184.]. ...

Abstract	[This corrects the article DOI: 10.3389/fonc.2020.00184.].
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.01704
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