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Artikel ; Online: High-fidelity porcine models of metabolic syndrome: a contemporary synthesis.

Cluzel, Gaston L / Ryan, Paul M / Herisson, Florence M / Caplice, Noel M

American journal of physiology. Endocrinology and metabolism

2022 Band 322, Heft 4, Seite(n) E366–E381

Abstract: This review aims to describe and compare porcine models of metabolic syndrome. This syndrome and its associated secondary comorbidities are set to become the greatest challenge to healthcare providers and policy makers in the coming century. However, an ... ...

Abstract	This review aims to describe and compare porcine models of metabolic syndrome. This syndrome and its associated secondary comorbidities are set to become the greatest challenge to healthcare providers and policy makers in the coming century. However, an incomplete understanding of the pathogenesis has left significant knowledge gaps in terms of efficacious therapeutics. To further our comprehension and, in turn, management of metabolic syndrome, appropriate high-fidelity models of the disease complex are of great importance. In this context, our review aims to assess the most promising porcine models of metabolic syndrome currently available for their similarity to the human phenotype. In addition, we aim to highlight the strengths and shortcomings of each model in an attempt to identify the most appropriate application of each. Although no porcine model perfectly recapitulates the human metabolic syndrome, several pose satisfactory approximations. The Ossabaw miniature swine in particular represents a highly translatable model that develops each of the core parameters of the syndrome with many of the associated secondary comorbidities. Future high-fidelity porcine models of metabolic syndrome need to focus on secondary sequelae replication, which may require extended induction period to reveal.
Mesh-Begriff(e)	Animals ; Disease Models, Animal ; Disease Progression ; Metabolic Syndrome/etiology ; Swine ; Swine, Miniature
Sprache	Englisch
Erscheinungsdatum	2022-02-28
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00413.2021
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Mesenchymal stromal cell derived CCL2 is required for accelerated wound healing.

Whelan, Derek S / Caplice, Noel M / Clover, Anthony J P

Scientific reports

2020 Band 10, Heft 1, Seite(n) 2642

Abstract: Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived CCL2 may be ...

Abstract	Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived CCL2 may be involved in the MSC therapeutic effect by facilitating macrophage repolarisation. To further delineate this mechanism, MSC isolated from CCL2 deficient mice (MSC-KO) were applied to excisional wounds in wild-type (WT) mice. CCL2 deficiency in MSC completely abrogated the therapeutic response compared to MSC-WT. MSC-KO were unable to repolarise macrophages to the same extent as WT and this was accompanied by a reduced angiogenesis and re-epithelialisation of the wounds at day 10. This study demonstrates that MSC derived CCL2 is required for MSC induced accelerated wound healing. The role of CCL2 in the interaction between MSC and Macrophages has not been previously demonstrated in accelerated wound healing. CCL2 has a potent effect on the ability to reduce the inflammatory response through local recruitment of macrophages. This research highlights CCL2 as a possible target for augmentation of MSC therapy to enhance therapeutic potential.
Mesh-Begriff(e)	Animals ; Cell Polarity ; Chemokine CCL2/metabolism ; Disease Models, Animal ; Female ; Immunity, Innate ; Immunomodulation ; Inflammation/pathology ; Lectins, C-Type/metabolism ; Macrophages/metabolism ; Mannose-Binding Lectins/metabolism ; Mesenchymal Stem Cells/metabolism ; Mice, Inbred C57BL ; Mice, Transgenic ; Neovascularization, Physiologic ; Re-Epithelialization ; Receptors, Cell Surface/metabolism ; Wound Healing
Chemische Substanzen	Chemokine CCL2 ; Lectins, C-Type ; Mannose-Binding Lectins ; Receptors, Cell Surface ; mannose receptor
Sprache	Englisch
Erscheinungsdatum	2020-02-14
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-59174-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

Ryan, Paul MacDaragh / Caplice, Noel M

Obesity (Silver Spring, Md.)

2020 Band 28, Heft 7, Seite(n) 1191–1194

Abstract: Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors ... ...

Abstract	Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors including hypertension, diabetes, and, more recently, obesity. This article posits new obesity-driven predictors of poor COVID-19 outcomes, over and above the more obvious extant risks associated with obesity, including cardiometabolic disease and hypoventilation syndrome in intensive care patients. This article also outlines a theoretical mechanistic framework whereby adipose tissue in individuals with obesity may act as a reservoir for more extensive viral spread, with increased shedding, immune activation, and cytokine amplification. This paper proposes studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in individuals with obesity and COVID-19. Finally, this paper underscores emerging therapeutic strategies that might benefit subsets of patients in which cytokine amplification is excessive and potentially fatal.
Mesh-Begriff(e)	Adipose Tissue/virology ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Cytokines/metabolism ; Humans ; Lymphocyte Activation/immunology ; Obesity/immunology ; Obesity/virology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2
Chemische Substanzen	Cytokines
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-05-31
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.22843
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation.

Cullen, Paul P / Tsui, Steven S / Caplice, Noel M / Hinchion, John A

Interactive cardiovascular and thoracic surgery

2021 Band 32, Heft 5, Seite(n) 683–694

Abstract: Objectives: The use of 'extended criteria' donor hearts and reconditioned hearts from donation after circulatory death has corresponded with an increase in primary graft dysfunction, with ischaemia-reperfusion injury being a major contributing factor in ...

Abstract	Objectives: The use of 'extended criteria' donor hearts and reconditioned hearts from donation after circulatory death has corresponded with an increase in primary graft dysfunction, with ischaemia-reperfusion injury being a major contributing factor in its pathogenesis. Limiting ischaemia-reperfusion injury through optimising donor heart preservation may significantly improve outcomes. We sought to review the literature to evaluate the evidence for this. Methods: A review of the published literature was performed to assess the potential impact of organ preservation optimisation on cardiac transplantation outcomes. Results: Ischaemia-reperfusion injury is a major factor in myocardial injury during transplantation with multiple potential therapeutic targets. Innate survival pathways have been identified, which can be mimicked with pharmacological conditioning. Although incompletely understood, discoveries in this domain have yielded extremely encouraging results with one of the most exciting prospects being the synergistic effect of selected agents. Ex situ heart perfusion is an additional promising adjunct. Conclusions: Cardiac transplantation presents a unique opportunity to perfuse the whole heart before, or immediately after, the onset of ischaemia, thus maximising the potential for global cardioprotection while limiting possible systemic side effects. While clinical translation in the setting of myocardial infarction has often been disappointing, cardiac transplantation may afford the opportunity for cardioprotection to finally deliver on its preclinical promise.
Mesh-Begriff(e)	Heart ; Heart Transplantation/adverse effects ; Humans ; Myocardial Infarction ; Organ Preservation ; Tissue Donors
Sprache	Englisch
Erscheinungsdatum	2021-04-23
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivaa333
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Role of vessel wall and bone marrow syndecan-4 in neointimal hyperplasia: the plot thickens.

Caplice, Noel M

Arteriosclerosis, thrombosis, and vascular biology

2011 Band 31, Heft 5, Seite(n) 952–953

Mesh-Begriff(e)	Animals ; Apoptosis ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Bone Marrow Transplantation ; Cell Movement ; Cell Proliferation ; Disease Models, Animal ; Femoral Artery/injuries ; Femoral Artery/metabolism ; Femoral Artery/pathology ; Hyperplasia ; Mice ; Muscle, Smooth, Vascular/injuries ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Signal Transduction ; Stem Cells/metabolism ; Stem Cells/pathology ; Syndecan-4/metabolism ; Tunica Intima/injuries ; Tunica Intima/metabolism ; Tunica Intima/pathology ; Vascular System Injuries/metabolism ; Vascular System Injuries/pathology
Chemische Substanzen	Sdc4 protein, mouse ; Syndecan-4
Sprache	Englisch
Erscheinungsdatum	2011-05
Erscheinungsland	United States
Dokumenttyp	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.111.225557
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Obesity and COVID-19: A Virchow's Triad for the 21st Century.

Vaughan, Carl J / Cronin, Heather / Ryan, Paul MacDaragh / Caplice, Noel M

Thrombosis and haemostasis

2020 Band 120, Heft 11, Seite(n) 1590–1593

Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-07-17
Erscheinungsland	Germany
Dokumenttyp	Letter ; Comment
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0040-1714216
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: COVID-19-Where Have All the STEMIs Gone?

Tanner, Richard / MacDaragh Ryan, Paul / Caplice, Noel M

The Canadian journal of cardiology

2020 Band 36, Heft 7, Seite(n) 1161.e9–1161.e10

Mesh-Begriff(e)	Angioplasty, Balloon, Coronary/methods ; Angioplasty, Balloon, Coronary/statistics & numerical data ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; Hospital Mortality/trends ; Humans ; Incidence ; Infection Control/methods ; Italy/epidemiology ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; Risk Assessment ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/therapy ; Survival Analysis
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-05-01
Erscheinungsland	England
Dokumenttyp	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2020.04.032
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Exploring the Gut Microbiota and Cardiovascular Disease.

Murphy, Kiera / O'Donovan, Aoife N / Caplice, Noel M / Ross, R Paul / Stanton, Catherine

Metabolites

2021 Band 11, Heft 8

Abstract: Cardiovascular disease (CVD) has been classified as one of the leading causes of morbidity and mortality worldwide. CVD risk factors include smoking, hypertension, dyslipidaemia, obesity, inflammation and diabetes. The gut microbiota can influence human ... ...

Abstract	Cardiovascular disease (CVD) has been classified as one of the leading causes of morbidity and mortality worldwide. CVD risk factors include smoking, hypertension, dyslipidaemia, obesity, inflammation and diabetes. The gut microbiota can influence human health through multiple interactions and community changes are associated with the development and progression of numerous disease states, including CVD. The gut microbiota are involved in the production of several metabolites, such as short-chain fatty acids (SCFAs), bile acids and trimethylamine-N-oxide (TMAO). These products of microbial metabolism are important modulatory factors and have been associated with an increased risk of CVD. Due to its association with CVD development, the gut microbiota has emerged as a target for therapeutic approaches. In this review, we summarise the current knowledge on the role of the gut microbiome in CVD development, and associated microbial communities, functions, and metabolic profiles. We also discuss CVD therapeutic interventions that target the gut microbiota such as probiotics and faecal microbiota transplantation.
Sprache	Englisch
Erscheinungsdatum	2021-07-29
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11080493
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

Ryan, Paul MacDaragh / Caplice, Noel M

Obesity (Silver Spring)

Abstract	Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors including hypertension, diabetes, and, more recently, obesity. This article posits new obesity-driven predictors of poor COVID-19 outcomes, over and above the more obvious extant risks associated with obesity, including cardiometabolic disease and hypoventilation syndrome in intensive care patients. This article also outlines a theoretical mechanistic framework whereby adipose tissue in individuals with obesity may act as a reservoir for more extensive viral spread, with increased shedding, immune activation, and cytokine amplification. This paper proposes studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in individuals with obesity and COVID-19. Finally, this paper underscores emerging therapeutic strategies that might benefit subsets of patients in which cytokine amplification is excessive and potentially fatal.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #525894
Datenquelle	COVID19

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Buch ; Artikel ; Online: Is adipose tissue a reservoir for viral spread, immune activation and cytokine amplification in COVID-19?

Ryan, Paul MacDaragh / Caplice, Noel M.

2020

Abstract: Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcome include advanced age, male gender, pre-existing cardiovascular disease and risk factors ... ...

Abstract	Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcome include advanced age, male gender, pre-existing cardiovascular disease and risk factors including hypertension, diabetes and more recently obesity. Herein, we posit new obesity-driven predictors of poor COVID-19 outcome, over and above the more obvious extant risks associated with obesity including cardiometabolic disease and hypoventilation syndrome in intensive care patients. We outline a theoretical mechanistic framework whereby adipose tissue in subjects with obesity may act as a reservoir for more extensive viral spread with increased shedding, immune activation and cytokine amplification. We propose studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in subjects with obesity and COVID-19. Finally, we underscore emerging therapeutic strategies that might benefit subsets of patients in which cytokine amplification is excessive and potentially fatal.
Schlagwörter	Obesity ; Poor COVID-19 outcome ; Adipose tissue ; Cytokine pathways ; Cytokine amplification ; covid19
Thema/Rubrik (Code)	610 ; 616
Sprache	Englisch
Erscheinungsdatum	2020-04-21
Verlag	John Wiley & Sons, Inc.
Erscheinungsland	ie
Dokumenttyp	Buch ; Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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