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Article ; Online: International Journal of Antimicrobial Agents Themed Section Issue: "Therapeutics of hepatitis viruses".

Colson, Philippe / Capobianchi, Maria R

International journal of antimicrobial agents

2018 Volume 56, Issue 1, Page(s) 105402

MeSH term(s)	Antiviral Agents/therapeutic use ; Hepatitis B/drug therapy ; Hepatitis C, Chronic/drug therapy ; Hepatitis E/drug therapy ; Hepatitis, Viral, Human/drug therapy ; Humans
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2018-03-21
Publishing country	Netherlands
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2018.03.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemic.

Agrati, Chiara / Carsetti, Rita / Bordoni, Veronica / Sacchi, Alessandra / Quintarelli, Concetta / Locatelli, Franco / Ippolito, Giuseppe / Capobianchi, Maria R

Immunology

2022 Volume 167, Issue 3, Page(s) 287–302

Abstract: The COVID-19 pandemic has represented an unprecedented challenge for the humanity, and scientists around the world provided a huge effort to elucidate critical aspects in the fight against the pathogen, useful in designing public health strategies, ... ...

Abstract	The COVID-19 pandemic has represented an unprecedented challenge for the humanity, and scientists around the world provided a huge effort to elucidate critical aspects in the fight against the pathogen, useful in designing public health strategies, vaccines and therapeutic approaches. One of the first pieces of evidence characterizing the SARS-CoV-2 infection has been its breadth of clinical presentation, ranging from asymptomatic to severe/deadly disease, and the indication of the key role played by the immune response in influencing disease severity. This review is aimed at summarizing what the SARS-CoV-2 infection taught us about the immune response, highlighting its features of a double-edged sword mediating both protective and pathogenic processes. We will discuss the protective role of soluble and cellular innate immunity and the detrimental power of a hyper-inflammation-shaped immune response, resulting in tissue injury and immunothrombotic events. We will review the importance of B- and T-cell immunity in reducing the clinical severity and their ability to cross-recognize viral variants.
MeSH term(s)	COVID-19 ; Humans ; Immunity ; Inflammation ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13564
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Article ; Online: About the origin of the first two Sars-CoV-2 infections in Italy: Inference not supported by appropriate sequence analysis.

Carletti, Fabrizio / Lalle, Eleonora / Messina, Francesco / Ippolito, Giuseppe / Capobianchi, Maria R

Journal of medical virology

2020 Volume 92, Issue 9, Page(s) 1404–1405

MeSH term(s)	COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sequence Analysis
Keywords	covid19
Language	English
Publishing date	2020-04-19
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25833
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Article ; Online: Asymptomatic individuals positive for anti-SARS-CoV-2 antibodies negative on molecular swab.

Antonelli, Guido / Anastasi, Emanuela / Ciprani, Fabrizio / Cabral, Rodolfo J Riveros / Ialongo, Cristiano / Capobianchi, Maria R / Turriziani, Ombretta / Angeloni, Antonio

The Lancet. Microbe

2021 Volume 2, Issue 5, Page(s) e178

MeSH term(s)	Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2/genetics
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2021-05-04
Publishing country	England
Document type	Letter
ISSN	2666-5247
ISSN (online)	2666-5247
DOI	10.1016/S2666-5247(21)00083-5
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Article ; Online: Differential Dynamics of SARS-CoV-2 Binding and Functional Antibodies upon BNT162b2 Vaccine: A 6-Month Follow-Up.

Matusali, Giulia / Sberna, Giuseppe / Meschi, Silvia / Gramigna, Giulia / Colavita, Francesca / Lapa, Daniele / Francalancia, Massimo / Bettini, Aurora / Capobianchi, Maria R / Puro, Vincenzo / Castilletti, Concetta / Vaia, Francesco / Bordi, Licia

Viruses

2022 Volume 14, Issue 2

Abstract: To investigate the dynamic association among binding and functional antibodies in health-care-workers receiving two doses of BNT162b2 mRNA COVID-19-vaccine, SARS-CoV-2 anti-RBD IgG, anti-Trimeric-S IgG, and neutralizing antibodies (Nabs) were measured in ...

Abstract	To investigate the dynamic association among binding and functional antibodies in health-care-workers receiving two doses of BNT162b2 mRNA COVID-19-vaccine, SARS-CoV-2 anti-RBD IgG, anti-Trimeric-S IgG, and neutralizing antibodies (Nabs) were measured in serum samples collected at 2 weeks, 3 months, and 6 months from full vaccination. Despite the high correlation, results for anti-RBD and anti-Trimeric S IgG were numerically different even after recalculation to BAU/mL following WHO standards indications. Moreover, after a peak response at 2 weeks, anti-RBD IgG levels showed a 4.5 and 13 fold decrease at 3 and 6 months, respectively, while the anti-Trimeric S IgG presented a less pronounced decay of 2.8 and 4.7 fold. Further different dynamics were observed for Nabs titers, resulting comparable at 3 and 6 months from vaccination. We also demonstrated that at NAbs titers ≥40, the area under the receiver operating characteristic curve and the optimal cutoff point decreased with time from vaccination for both anti-RBD and anti-Trimeric S IgG. The mutating relation among the anti-RBD IgG, anti-Trimeric S IgG, and neutralizing antibodies are indicative of antibody maturation upon vaccination. The lack of standardized laboratory procedures is one factor interfering with the definition of a correlate of protection from COVID-19.
MeSH term(s)	Adult ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antibodies, Viral/metabolism ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/immunology ; Binding Sites, Antibody ; COVID-19/immunology ; COVID-19/prevention & control ; Cohort Studies ; Female ; Follow-Up Studies ; Health Personnel/statistics & numerical data ; Humans ; Immunity, Humoral ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Kinetics ; Longitudinal Studies ; Male ; Middle Aged ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; Vaccination
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14020312
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Article: Differential Dynamics of SARS-CoV-2 Binding and Functional Antibodies upon BNT162b2 Vaccine: A 6-Month Follow-Up

Matusali, Giulia / Sberna, Giuseppe / Meschi, Silvia / Gramigna, Giulia / Colavita, Francesca / Lapa, Daniele / Francalancia, Massimo / Bettini, Aurora / Capobianchi, Maria R. / Puro, Vincenzo / Castilletti, Concetta / Vaia, Francesco / Bordi, Licia

Viruses. 2022 Feb. 02, v. 14, no. 2

2022

Abstract	To investigate the dynamic association among binding and functional antibodies in health-care-workers receiving two doses of BNT162b2 mRNA COVID-19-vaccine, SARS-CoV-2 anti-RBD IgG, anti-Trimeric-S IgG, and neutralizing antibodies (Nabs) were measured in serum samples collected at 2 weeks, 3 months, and 6 months from full vaccination. Despite the high correlation, results for anti-RBD and anti-Trimeric S IgG were numerically different even after recalculation to BAU/mL following WHO standards indications. Moreover, after a peak response at 2 weeks, anti-RBD IgG levels showed a 4.5 and 13 fold decrease at 3 and 6 months, respectively, while the anti-Trimeric S IgG presented a less pronounced decay of 2.8 and 4.7 fold. Further different dynamics were observed for Nabs titers, resulting comparable at 3 and 6 months from vaccination. We also demonstrated that at NAbs titers ≥40, the area under the receiver operating characteristic curve and the optimal cutoff point decreased with time from vaccination for both anti-RBD and anti-Trimeric S IgG. The mutating relation among the anti-RBD IgG, anti-Trimeric S IgG, and neutralizing antibodies are indicative of antibody maturation upon vaccination. The lack of standardized laboratory procedures is one factor interfering with the definition of a correlate of protection from COVID-19.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; blood serum ; vaccination ; vaccines
Language	English
Dates of publication	2022-0202
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14020312
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Performance of rapid tests in the management of dengue fever imported cases in Lazio, Italy 2014-2019.

Matusali, Giulia / Colavita, Francesca / Carletti, Fabrizio / Lalle, Eleonora / Bordi, Licia / Vairo, Francesco / Ippolito, Giuseppe / Capobianchi, Maria R / Castilletti, Concetta

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 99, Page(s) 193–198

Abstract: Background: In Italy, dengue virus is the most frequent agent of imported viral infections. The use of rapid diagnostic tests (RDTs) may be of help as a preliminary user-friendly quick assay to facilitate dengue diagnosis, as ordinary laboratory ... ...

Abstract	Background: In Italy, dengue virus is the most frequent agent of imported viral infections. The use of rapid diagnostic tests (RDTs) may be of help as a preliminary user-friendly quick assay to facilitate dengue diagnosis, as ordinary laboratory diagnosis of dengue fever may require special efforts in terms of tools availability, interpretation of results, and skilled personnel. The performance of RDTs, however, may vary according to different epidemiological and laboratory background. Methods: We reviewed five years of laboratory records of two dengue RDT results (Colorimetric SD-Bioline Dengue-Duo-RDT and Fluorimetric SD-Biosensor-STANDARD-F-Dengue-RDT), able to detect viral NS1 antigen and specific IgM and IgG. Diagnostic parameters were calculated using as reference the results of molecular (RT-PCR) and serological (immunofluorescence, IFA) tests. Overall performance, calculated considering the final case definition, was included in the accuracy assessment of RDTs. Results: The combined use of NS1 and IgM/IgG RDT for the detection of acute dengue cases resulted in an overall sensitivity and specificity of 87.2% and 97.9% for Colorimetric RDT, 96.2% and 96.2% for Fluorimetric RDT. NS1 was the most reliable marker of acute infection, while IgM resulted falsely positive in nine samples, including sera derived from 2 Zika and 4 non-arbovirus infected patients. Conclusions: The inclusion of RDT in the diagnostic algorithm is of undeniable help in the prompt management and surveillance of dengue infection in non-endemic areas. Confirmatory tests are, however, necessary to rule in or rule out dengue fever diagnosis.
MeSH term(s)	Adult ; Aged ; Colorimetry/methods ; Dengue/diagnosis ; Dengue/epidemiology ; Dengue/prevention & control ; Dengue Virus/immunology ; Female ; Humans ; Immunoglobulin M/blood ; Italy ; Male ; Middle Aged ; Reagent Kits, Diagnostic ; Retrospective Studies ; Sensitivity and Specificity ; Time Factors ; Zika Virus Infection
Chemical Substances	Immunoglobulin M ; Reagent Kits, Diagnostic
Language	English
Publishing date	2020-07-11
Publishing country	Canada
Document type	Evaluation Study ; Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.07.008
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Article: About the origin of the first two Sars-CoV-2 infections in Italy: inference not supported by appropriate sequence analysis

Carletti, Fabrizio / Lalle, Eleonora / Messina, Francesco / Ippolito, Giuseppe / Capobianchi, Maria R

J. med. virol

Abstract: In the 5th February 2020 issue of Journal of Medical Virology a paper was published by Giovannetti et al., entitled "The first two cases of 2019-nCoV in Italy: where they come from?"1 . In this paper a phylogenetic and evolutionary analysis was applied ... ...

Abstract	In the 5th February 2020 issue of Journal of Medical Virology a paper was published by Giovannetti et al., entitled "The first two cases of 2019-nCoV in Italy: where they come from?"1 . In this paper a phylogenetic and evolutionary analysis was applied to the virus identified in the first two subjects diagnosed in Italy with 2019-nCoV infection, recently renamed SARS-CoV-22 , two Chinese spouses arrived in Italy for tourism. The diagnosis was performed by the virology team under direction of Maria R. Capobianchi, at the National Institute of Infectious Diseases (INMI) in Rome, Italy, where the patients are currently hospitalized. This article is protected by copyright. All rights reserved.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #35037
Database	COVID19

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Article ; Online: About the origin of the first two Sars‐CoV‐2 infections in Italy

Carletti, Fabrizio / Lalle, Eleonora / Messina, Francesco / Ippolito, Giuseppe / Capobianchi, Maria R.

Journal of Medical Virology

Inference not supported by appropriate sequence analysis

2020 Volume 92, Issue 9, Page(s) 1404–1405

Keywords	Virology ; Infectious Diseases ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25833
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tropism of the Chikungunya Virus.

Matusali, Giulia / Colavita, Francesca / Bordi, Licia / Lalle, Eleonora / Ippolito, Giuseppe / Capobianchi, Maria R / Castilletti, Concetta

Viruses

2019 Volume 11, Issue 2

Abstract: Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus that displays a large cell and organ tropism, and causes a broad range of clinical symptoms in humans. It is maintained in nature through both urban and sylvatic cycles, involving mosquito ... ...

Abstract	Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus that displays a large cell and organ tropism, and causes a broad range of clinical symptoms in humans. It is maintained in nature through both urban and sylvatic cycles, involving mosquito vectors and human or vertebrate animal hosts. Although CHIKV was first isolated in 1953, its pathogenesis was only more extensively studied after its re-emergence in 2004. The unexpected spread of CHIKV to novel tropical and non-tropical areas, in some instances driven by newly competent vectors, evidenced the vulnerability of new territories to this infectious agent and its associated diseases. The comprehension of the exact CHIKV target cells and organs, mechanisms of pathogenesis, and spectrum of both competitive vectors and animal hosts is pivotal for the design of effective therapeutic strategies, vector control measures, and eradication actions.
MeSH term(s)	Aedes/virology ; Animals ; Chikungunya Fever/pathology ; Chikungunya Fever/transmission ; Chikungunya virus/pathogenicity ; Chikungunya virus/physiology ; Disease Vectors ; Host Microbial Interactions ; Humans ; Infectious Disease Transmission, Vertical ; Mice ; Mosquito Vectors/virology ; Viral Tropism
Language	English
Publishing date	2019-02-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v11020175
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