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  1. Article ; Online: Beyond Weight Loss: the Emerging Role of Incretin-Based Treatments in Cardiometabolic HFpEF.

    Capone, Federico / Nambiar, Natasha / Schiattarella, Gabriele G

    Current opinion in cardiology

    2024  Volume 39, Issue 3, Page(s) 148–153

    Abstract: Purpose of review: Incretin-based drugs are potent weight-lowering agents, emerging as potential breakthrough therapy for the treatment of obesity-related phenotype of heart failure with preserved ejection fraction (HFpEF). In this review article, we ... ...

    Abstract Purpose of review: Incretin-based drugs are potent weight-lowering agents, emerging as potential breakthrough therapy for the treatment of obesity-related phenotype of heart failure with preserved ejection fraction (HFpEF). In this review article, we will discuss the contribution of weight loss as part of the benefits of incretin-based medications in obese patients with HFpEF. Furthermore, we will describe the potential effects of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists on the heart, particularly in relation to HFpEF pathophysiology.
    Recent findings: In the STEP-HFpEF trial, the GLP-1 receptor agonist semaglutide significantly improved quality of life outcomes in obese HFpEF patients. Whether the beneficial effects of semaglutide in obese patients with HFpEF are merely a consequence of body weight reduction is unclear. Considering the availability of other weight loss strategies (e.g., caloric restriction, exercise training, bariatric surgery) to be used in obese HFpEF patients, answering this question is crucial to provide tailored therapeutic options in these subjects.
    Summary: Incretin-based drugs may represent a milestone in the treatment of obesity in HFpEF. Elucidating the contribution of weight loss in the overall benefit observed with these drugs is critical in the management of obese HFpEF patients, considering that other weight-lowering strategies are available and might represent potential alternative options for these patients.
    MeSH term(s) Humans ; Incretins/therapeutic use ; Heart Failure/drug therapy ; Quality of Life ; Stroke Volume/physiology ; Weight Loss/physiology ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide 1/therapeutic use ; Obesity/complications ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Incretins ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000001117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: I sistemi locali turistici in Italia

    Capone, Francesco

    2005  

    Abstract: Il turismo negli ultimi decenni è diventato una delle principali industrie delleconomia mondiale. In questo contesto, lo studio delle destinazioni turistiche si configura sempre più come un elemento critico per la competitività dei paesi a vocazione ... ...

    Abstract Il turismo negli ultimi decenni è diventato una delle principali industrie delleconomia mondiale. In questo contesto, lo studio delle destinazioni turistiche si configura sempre più come un elemento critico per la competitività dei paesi a vocazione turistica. Lobiettivo di questa ricerca è stato principalmente individuare quali sono i sistemi locali turistici in Italia ed in che modo competono tra di loro. Attraverso lapplicazione della metodologia Istat-Sforzi e le tecniche di Econometria Spaziale, il volume propone un ampio panorama di rappresentazione cartografiche delle destinazioni italiane ed elabora una proxi di analisi per misurare empiricamente le fonti di competitività di questi sistemi di impresa, concentrandosi in particolare sulla filiera turistica allargata e su reti di destinazioni
    Keywords Economic growth, development, planning
    Size 1 electronic resource (148 pages)
    Publisher Firenze University Press
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020678797
    ISBN 888453321X ; 9788884533210
    DOI 10.36253/88-8453-321-X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Cardiometabolic HFpEF: NASH of the Heart.

    Capone, Federico / Vettor, Roberto / Schiattarella, Gabriele G

    Circulation

    2023  Volume 147, Issue 6, Page(s) 451–453

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnosis ; Heart Failure/diagnosis ; Heart Failure/etiology ; Stroke Volume ; Liver ; Heart
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.062874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ensuring efficient development of personalized medicine by addressing regulatory needs: What role can research infrastructures play?

    Capone, Francesca / Morrow, David / Moretti, Franca

    The International journal of biological markers

    2023  Volume 38, Issue 2, Page(s) 77–80

    Abstract: Personalized Medicine is a novel medical practice that uses an individual's genetic profile to guide decisions made regarding the prevention, diagnosis, and treatment of disease. Knowledge of a patient's genetic profile is crucial to support doctors in ... ...

    Abstract Personalized Medicine is a novel medical practice that uses an individual's genetic profile to guide decisions made regarding the prevention, diagnosis, and treatment of disease. Knowledge of a patient's genetic profile is crucial to support doctors in selecting the proper therapy and administer it using the correct dose or regimen. Personalized Medicine is a great opportunity to turn the "one size fits all" approach to diagnostics, therapy, and prevention, into an individualized approach. In this paper we analyze the most recent achievements and regulatory challenges in Personalized Medicine and the role that research infrastructures can play in advancing its development.
    MeSH term(s) Humans ; Precision Medicine
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645113-5
    ISSN 1724-6008 ; 0393-6155
    ISSN (online) 1724-6008
    ISSN 0393-6155
    DOI 10.1177/03936155231179981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Turing patterns in a Leslie-Gower predator prey model

    Capone, Florinda / De Luca, Roberta / Torcicollo, Isabella

    2023  

    Abstract: A reaction-diffusion Leslie-Gower predator-prey model, incorporating the fear effect and prey refuge, with Beddington-DeAngelis functional response, is introduced. A qualitative analysis of the solutions of the model and the stability analysis of the ... ...

    Abstract A reaction-diffusion Leslie-Gower predator-prey model, incorporating the fear effect and prey refuge, with Beddington-DeAngelis functional response, is introduced. A qualitative analysis of the solutions of the model and the stability analysis of the coexistence equilibrium, are performed. Sufficient conditions guaranteeing the occurrence of Turing instability have been determined either in the case of self-diffusion or in the case of cross-diffusion. Different types of Turing patterns, representing a spatial redistribution of population in the environment, emerge for different values of the model parameters.
    Keywords Quantitative Biology - Populations and Evolution ; Mathematical Physics ; 35K57 ; 35B35 ; 92D25
    Publishing date 2023-02-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: New tools for shaping plasticity to enhance recovery after stroke.

    Motolese, Francesco / Capone, Fioravante / Di Lazzaro, Vincenzo

    Handbook of clinical neurology

    2021  Volume 184, Page(s) 299–315

    Abstract: Stroke is the second most common cause of death worldwide and its prevalence is projected to increase in the coming years in parallel with the increase of life expectancy. Despite the great improvements in the management of the acute phase of stroke, ... ...

    Abstract Stroke is the second most common cause of death worldwide and its prevalence is projected to increase in the coming years in parallel with the increase of life expectancy. Despite the great improvements in the management of the acute phase of stroke, some residual disability persists in most patients thus requiring rehabilitation. One third of patients do not reach the maximal recovery potential and different approaches have been explored with the aim to boost up recovery. In this regard, noninvasive brain stimulation techniques have been widely used to induce neuroplasticity phenomena. Different protocols of repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES) can induce short- and long-term changes of synaptic excitability and are promising tools for enhancing recovery in stroke patients. New options for neuromodulation are currently under investigation. They include: vagal nerve stimulation (VNS) that can be delivered invasively, with implanted stimulators and noninvasively with transcutaneous VNS (tVNS); and extremely low-frequency (1-300Hz) magnetic fields. This chapter will provide an overview on the new techniques that are used for neuroprotection and for enhancing recovery after stroke.
    MeSH term(s) Humans ; Neuronal Plasticity ; Recovery of Function ; Stroke/therapy ; Stroke Rehabilitation ; Transcranial Direct Current Stimulation ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2021-06-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-12-819410-2.00016-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials.

    Pozzilli, Valeria / Haggiag, Shalom / Di Filippo, Massimiliano / Capone, Fioravante / Di Lazzaro, Vincenzo / Tortorella, Carla / Gasperini, Claudio / Prosperini, Luca

    Journal of neurology, neurosurgery, and psychiatry

    2024  

    Abstract: Background: Seizures are reported to be more prevalent in individuals with multiple sclerosis (MS) compared with the general population. Existing data predominantly originate from population-based studies, which introduce variability in methodologies ... ...

    Abstract Background: Seizures are reported to be more prevalent in individuals with multiple sclerosis (MS) compared with the general population. Existing data predominantly originate from population-based studies, which introduce variability in methodologies and are vulnerable to selection and reporting biases.
    Methods: This meta-analysis aims to assess the incidence of seizures in patients participating in randomised clinical trials and to identify potential contributing factors. Data were extracted from 60 articles published from 1993 to 2022. The pooled effect size, representing the incidence rate of seizure events, was estimated using a random-effect model. Metaregression was employed to explore factors influencing the pooled effect size.
    Results: The meta-analysis included data from 53 535 patients and 120 seizure events in a median follow-up of 2 years. The pooled incidence rate of seizures was 68.0 per 100 000 patient-years, significantly higher than the general population rate of 34.6. Generalised tonic-clonic seizures were the most common type reported, although there was a high risk of misclassification for focal seizures with secondary generalisation. Disease progression, longer disease duration, higher disability levels and lower brain volume were associated with a higher incidence of seizures. Particularly, sphingosine-1-phosphate receptor (S1PR) modulators exhibited a 2.45-fold increased risk of seizures compared with placebo or comparators, with a risk difference of 20.5 events per 100 000 patient-years.
    Conclusions: Patients with MS face a nearly twofold higher seizure risk compared with the general population. This risk appears to be associated not only with disease burden but also with S1PR modulators. Our findings underscore epilepsy as a significant comorbidity in MS and emphasise the necessity for further research into its triggers, preventive measures and treatment strategies.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2023-332996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.93: Show issues Location:
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  8. Article ; Online: Adolescents with orofacial clefts: understanding their experiences.

    Gifalli, Marina / Antonio, Camila Trettene / Aparecida Pezzato da Silva, Verônica / Aroteia Capone, Francine / Capelato Prado, Priscila / Trettene, Armando Dos Santos

    Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

    2024  Volume 42, Page(s) e2023131

    Abstract: Objective: To understand the experience of young people with orofacial clefts regarding life as an adolescent.: Methods: Descriptive, qualitative study, developed in a Brazilian public and tertiary hospital, a reference center in the care of patients ...

    Abstract Objective: To understand the experience of young people with orofacial clefts regarding life as an adolescent.
    Methods: Descriptive, qualitative study, developed in a Brazilian public and tertiary hospital, a reference center in the care of patients with craniofacial anomalies and related syndromes, between February and April 2019. The sample was defined by theoretical saturation. The following inclusion criteria were established: age between ten and 19 years old and having previously operated on orofacial cleft (lip and/or palate). Individuals with fissure associated with syndromes or other malformations were excluded. Data collection was performed through semi-structured interviews, which were audio recorded and transcribed in full. The trigger element was: how has it been for you to experience your adolescence? For the construction of the results, content analysis was used in the thematic modality.
    Results: Seventeen adolescents participated. From the speeches, three categories were revealed: interacting socially, feeling supported, and experiencing and facing prejudice.
    Conclusions: The biopsychosocial and conflicting complexity that adolescents with orofacial clefts experience was noticed, as well as the importance of receiving support and establishing modalities of situational coping.
    MeSH term(s) Humans ; Cleft Palate/psychology ; Cleft Lip/psychology ; Adolescent ; Female ; Male ; Qualitative Research ; Child ; Young Adult ; Adaptation, Psychological ; Brazil ; Interviews as Topic
    Language English
    Publishing date 2024-05-06
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2560228-7
    ISSN 1984-0462 ; 1984-0462
    ISSN (online) 1984-0462
    ISSN 1984-0462
    DOI 10.1590/1984-0462/2024/42/2023131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Atrial fibrillation detection through the modified Microlife blood pressure monitor in patients with cryptogenic stroke: a pilot study.

    Galli, Mattia / Falato, Emma / Capone, Fioravante / DI Lazzaro, Vincenzo

    Minerva cardiology and angiology

    2022  Volume 71, Issue 5, Page(s) 606–607

    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Pilot Projects ; Blood Pressure Monitors ; Heart Rate ; Ischemic Stroke
    Language English
    Publishing date 2022-10-18
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3059238-0
    ISSN 2724-5772
    ISSN (online) 2724-5772
    DOI 10.23736/S2724-5683.22.06070-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Do tourist clusters boost hotels' performance?

    Capone, Francesco

    Tourist clusters, destinations and competitiveness : theoretical issues and empirical evidences , p. 103-123

    resilience in a crisis period in Italy

    2016  , Page(s) 103–123

    Author's details Francesco Capone
    Keywords Tourismuswirtschaft ; Hotellerie ; Italien
    Language English
    Publisher Routledge
    Publishing place London
    Document type Article
    ISBN 978-1-138-89169-2 ; 1-138-89169-X
    Database ECONomics Information System

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