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  1. AU="Capote, Ailem Rabasa"
  2. AU="Richier, Q"
  3. AU="Jamla, Monica"
  4. AU="Shimomura, Taizou"
  5. AU="Tampakakis, Emmanouil"
  6. AU="Tabares, Jeffrey V"

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  1. Artikel ; Online: Author Correction: Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity.

    Schrand, Brett / Clark, Emily / Levay, Agata / Capote, Ailem Rabasa / Martinez, Olivier / Brenneman, Randall / Castro, Iris / Gilboa, Eli

    Nature communications

    2021  Band 12, Heft 1, Seite(n) 6939

    Sprache Englisch
    Erscheinungsdatum 2021-11-22
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-25400-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity.

    Schrand, Brett / Clark, Emily / Levay, Agata / Capote, Ailem Rabasa / Martinez, Olivier / Brenneman, Randall / Castro, Iris / Gilboa, Eli

    Nature communications

    2018  Band 9, Heft 1, Seite(n) 3348

    Abstract: Uptake of tumor antigens by tumor-infiltrating dendritic cells is limiting step in the induction of tumor immunity, which can be mediated through Fc receptor (FcR) triggering by antibody-coated tumor cells. Here we describe an approach to potentiate ... ...

    Abstract Uptake of tumor antigens by tumor-infiltrating dendritic cells is limiting step in the induction of tumor immunity, which can be mediated through Fc receptor (FcR) triggering by antibody-coated tumor cells. Here we describe an approach to potentiate tumor immunity whereby hapten-specific polyclonal antibodies are recruited to tumors by coating tumor cells with the hapten. Vaccination of mice against dinitrophenol (DNP) followed by systemic administration of DNP targeted to tumors by conjugation to a VEGF or osteopontin aptamer elicits potent FcR dependent, T cell mediated, antitumor immunity. Recruitment of αGal-specific antibodies, the most abundant naturally occurring antibodies in human serum, inhibits tumor growth in mice treated with a VEGF aptamer-αGal hapten conjugate, and recruits antibodies from human serum to human tumor biopsies of distinct origin. Thus, treatment with αGal hapten conjugated to broad-spectrum tumor targeting ligands could enhance the susceptibility of a broad range of tumors to immune elimination.
    Mesh-Begriff(e) Animals ; Antibodies/metabolism ; Dinitrophenols/immunology ; Haptens/metabolism ; Humans ; Immunohistochemistry ; Immunotherapy ; Mice ; Mice, Inbred C57BL ; Osteopontin/metabolism ; Receptors, Fc/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemische Substanzen Antibodies ; Dinitrophenols ; Haptens ; Receptors, Fc ; Vascular Endothelial Growth Factor A ; Osteopontin (106441-73-0)
    Sprache Englisch
    Erscheinungsdatum 2018-08-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-05566-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: HER1-ECD vaccination dispenses with emulsification to elicit HER1-specific anti-proliferative effects.

    Alpízar, Yeranddy Aguiar / Ramírez, Belinda Sánchez / Fernández, Diana Rosa Hernández / Capote, Ailem Rabasa / Hidalgo, Greta Garrido / Rodríguez, Rolando Pérez / Molina, Luis Enrique Fernández

    Human vaccines

    2009  Band 5, Heft 3, Seite(n) 158–165

    Abstract: EGFR (HER1) highlights as one of the most relevant tumor associated antigen in epithelial malignant cells. Monoclonal antibodies and tyrosine kinase inhibitors against EGFR remain as the most advanced approaches in clinical trials. More recently, an ... ...

    Abstract EGFR (HER1) highlights as one of the most relevant tumor associated antigen in epithelial malignant cells. Monoclonal antibodies and tyrosine kinase inhibitors against EGFR remain as the most advanced approaches in clinical trials. More recently, an active immunotherapy using the HER1 extracellular domain (ECD) adjuvated in very small size proteoliposomes (VSSP) and emulsified in Montanide ISA-51 demonstrated its strength to inhibit tumor cell line proliferation by arresting cells in G(0)/G(1) stage and induction of apoptosis. In this study, we present a simpler HER1-ECD-based formulation, which is lacking the oily component Montanide ISA-51. Generated antibodies following non-emulsive formulation immunization recognized membrane EGFR; avoid EGF and TGFalpha coupling to EGFR leading to a marked abrogation of EGFR phosphorylation levels. Non-emulsive formulation also arrests cell cycle in G(0)/G(1) stage, demonstrating it preserves previous formulation quality in a newer and simpler formulation.
    Mesh-Begriff(e) Adjuvants, Immunologic/pharmacology ; Animals ; Antibodies, Neoplasm/blood ; Cancer Vaccines/immunology ; Cell Line ; ErbB Receptors/immunology ; Female ; Humans ; Immunization, Secondary/methods ; Liposomes/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL
    Chemische Substanzen Adjuvants, Immunologic ; Antibodies, Neoplasm ; Cancer Vaccines ; Liposomes ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2009-03-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1554-8619
    ISSN (online) 1554-8619
    DOI 10.4161/hv.5.3.7129
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine.

    Ramírez, Belinda Sánchez / Alpízar, Yeranddy Aguiar / Fernández, Diana Rosa Hernández / Hidalgo, Greta Garrido / Capote, Ailem Rabasa / Rodríguez, Rolando Pérez / Fernández, Luis Enrique

    Vaccine

    2008  Band 26, Heft 38, Seite(n) 4918–4926

    Abstract: Up to now clinical experiences focusing EGF receptor, an attractive target for cancer therapy, have been limited to passive therapies, suggesting that therapeutic cancer vaccines inducing anti-epidermal growth factor receptor (EGFR) antibodies could also ...

    Abstract Up to now clinical experiences focusing EGF receptor, an attractive target for cancer therapy, have been limited to passive therapies, suggesting that therapeutic cancer vaccines inducing anti-epidermal growth factor receptor (EGFR) antibodies could also work. Here, the humoral immune response induced in mice with a vaccine formulation containing the human EGFR-extracellular domain and very small-sized proteoliposomes (VSSP), a novel nanoparticulated adjuvant was assessed. In vaccinated mice sera average of the specific polyclonal antibodies (PAb) titers was 10(-5). Anti-EGFR PAb were able to bind EGFR+ tumor cell lines, expressing different levels of the molecule. Noteworthy, the presence of Cetuximab only partially inhibited the vaccine-induced antibodies binding to H125 cells. Anti-EGFR PAb abrogated ligands-dependent EGFR phosphorylation, provoking tumor cells apoptosis. The described EGFR-based vaccine might be a superior therapeutic approach for patients with EGFR+ tumors.
    Mesh-Begriff(e) Animals ; Antibodies/immunology ; Antibody Formation/drug effects ; Apoptosis/immunology ; Caco-2 Cells ; Cancer Vaccines/immunology ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Epidermal Growth Factor/antagonists & inhibitors ; Epidermal Growth Factor/metabolism ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Protein Binding/immunology ; Proteolipids ; Receptor, Epidermal Growth Factor/immunology ; Receptor, Epidermal Growth Factor/metabolism ; Transforming Growth Factor alpha/antagonists & inhibitors ; Transforming Growth Factor alpha/metabolism
    Chemische Substanzen Antibodies ; Cancer Vaccines ; Proteolipids ; Transforming Growth Factor alpha ; proteoliposomes ; Epidermal Growth Factor (62229-50-9) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2008-09-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2008.07.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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