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  1. AU="Caputo, Christina R"
  2. AU="Dupré, Caroline"
  3. AU="Eelco van Duinkerken"
  4. AU="Brumm, Henrik"
  5. AU=Kalligeros Markos
  6. AU="Oberholzer, Michael"
  7. AU="Phil B. Tsai"
  8. AU="Tallent, Melanie K"
  9. AU="Bajolle, Fanny"
  10. AU="El-Shafie, Sittana S"
  11. AU="Kammili, Nagamani"
  12. AU=Harholt Jesper

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  1. Artikel ; Online: HIV Outbreak Control With Effective Access to Care and Harm Reduction in North Carolina, 2017-2018.

    Samoff, Erika / Mobley, Victoria / Hudgins, Michelle / Cope, Anna Barry / Adams, Nicole Dzialowy / Caputo, Christina R / Dennis, Ann M / Billock, Rachael M / Crowley, Christy A / Clymore, Jacquelyn M / Foust, Evelyn

    American journal of public health

    2020  Band 110, Heft 3, Seite(n) 394–400

    Abstract: Objectives. ...

    Abstract Objectives.
    Mesh-Begriff(e) Adult ; Contact Tracing/methods ; Disease Outbreaks/prevention & control ; Female ; HIV/classification ; HIV/genetics ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Infections/transmission ; Harm Reduction ; Hepatitis B/epidemiology ; Hepatitis C/epidemiology ; Humans ; Male ; Middle Aged ; Needle-Exchange Programs ; North Carolina/epidemiology ; Substance Abuse, Intravenous
    Sprache Englisch
    Erscheinungsdatum 2020-01-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2019.305490
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers.

    Korstanje, Ron / Caputo, Christina R / Doty, Rosalinda A / Cook, Susan A / Bronson, Roderick T / Davisson, Muriel T / Miner, Jeffrey H

    Kidney international

    2014  Band 85, Heft 6, Seite(n) 1461–1468

    Abstract: A spontaneous mutation termed bilateral wasting kidneys (bwk) was identified in a colony of NONcNZO recombinant inbred mice. These mice exhibit a rapid increase of urinary albumin at an early age associated with glomerulosclerosis, interstitial nephritis, ...

    Abstract A spontaneous mutation termed bilateral wasting kidneys (bwk) was identified in a colony of NONcNZO recombinant inbred mice. These mice exhibit a rapid increase of urinary albumin at an early age associated with glomerulosclerosis, interstitial nephritis, and tubular atrophy. The mutation was mapped to a location on chromosome 1 containing the Col4a3 and Col4a4 genes, for which mutations in the human orthologs cause the hereditary nephritis Alport syndrome. DNA sequencing identified a G-to-A mutation in the conserved GT splice donor of Col4a4 intron 30, resulting in skipping of exon 30 but maintaining the mRNA reading frame. Protein analyses showed that mutant collagen α3α4α5(IV) trimers were secreted and incorporated into the glomerular basement membrane (GBM), but levels were low, and GBM lesions typical of Alport syndrome were observed. Moving the mutation into the more renal damage-prone DBA/2J and 129S1/SvImJ backgrounds revealed differences in albuminuria and its rate of increase, suggesting an interaction between the Col4a4 mutation and modifier genes. This novel mouse model of Alport syndrome is the only one shown to accumulate abnormal collagen α3α4α5(IV) in the GBM, as also found in a subset of Alport patients. These mice will be valuable for testing potential therapies, for understanding abnormal collagen IV structure and assembly, and for gaining better insights into the mechanisms leading to Alport syndrome, and to the variability in the age of onset and associated phenotypes.
    Mesh-Begriff(e) Albuminuria/genetics ; Albuminuria/metabolism ; Animals ; Autoantigens/genetics ; Autoantigens/metabolism ; Collagen Type IV/genetics ; Collagen Type IV/metabolism ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Glomerular Basement Membrane/metabolism ; Glomerular Basement Membrane/pathology ; Male ; Mice, 129 Strain ; Mice, Inbred DBA ; Mutation ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/metabolism ; Nephritis, Hereditary/pathology ; Phenotype ; Protein Multimerization ; RNA, Messenger/metabolism ; Time Factors
    Chemische Substanzen Autoantigens ; Col4a5 protein, mouse ; Collagen Type IV ; RNA, Messenger ; type IV collagen alpha3 chain
    Sprache Englisch
    Erscheinungsdatum 2014-02-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2013.493
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.

    Huang, Yuan / Caputo, Christina R / Noordmans, Gerda A / Yazdani, Saleh / Monteiro, Luiz Henrique / van den Born, Jaap / van Goor, Harry / Heeringa, Peter / Korstanje, Ron / Hillebrands, Jan-Luuk

    PloS one

    2014  Band 9, Heft 3, Seite(n) e91850

    Abstract: A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown. To identify genes associated with aging-related ... ...

    Abstract A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown. To identify genes associated with aging-related renal infiltration, we analyzed kidneys from aged mice (≥20 strains) for infiltrating leukocytes followed by Haplotype Association Mapping (HAM) analysis. Immunohistochemistry revealed CD45+ cell clusters (predominantly T and B cells) in perivascular areas coinciding with PNAd+ high endothelial venules and podoplanin+ lymph vessels indicative of tertiary lymphoid organs. Cumulative cluster size increased with age (analyzed at 6, 12 and 20 months). Based on the presence or absence of clusters in male and female mice at 20 months, HAM analysis revealed significant associations with loci on Chr1, Chr2, Chr8 and Chr14 in male mice, and with loci on Chr4, Chr7, Chr13 and Chr14 in female mice. Wisp2 (Chr2) showed the strongest association (P = 5.00×10(-137)) in male mice; Ctnnbip1 (P = 6.42×10(-267)) and Tnfrsf8 (P = 5.42×10(-245)) (both on Chr4) showed the strongest association in female mice. Both Wisp2 and Ctnnbip1 are part of the Wnt-signaling pathway and the encoded proteins were expressed within the tertiary lymphoid organs. In conclusion, this study revealed differential lymphocytic infiltration and tertiary lymphoid organ formation in aged mouse kidneys across different inbred mouse strains. HAM analysis identified candidate genes involved in the Wnt-signaling pathway that may be causally linked to tertiary lymphoid organ formation.
    Mesh-Begriff(e) Adaptor Proteins, Signal Transducing ; Aging/genetics ; Aging/immunology ; Aging/pathology ; Animals ; Female ; Genetic Association Studies ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Ki-1 Antigen/genetics ; Ki-1 Antigen/metabolism ; Kidney/immunology ; Kidney/metabolism ; Kidney/pathology ; Liver/immunology ; Liver/metabolism ; Liver/pathology ; Lymphatic Vessels/pathology ; Lymphoid Tissue/immunology ; Lymphoid Tissue/metabolism ; Lymphoid Tissue/pathology ; Male ; Mice ; Phenotype ; Polymorphism, Single Nucleotide ; Sex Factors
    Chemische Substanzen Adaptor Proteins, Signal Transducing ; CTNNBIP1 protein, human ; Intracellular Signaling Peptides and Proteins ; Ki-1 Antigen ; WISP-2 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2014-03-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0091850
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Uncovering genes and regulatory pathways related to urinary albumin excretion.

    Hageman, Rachael S / Leduc, Magalie S / Caputo, Christina R / Tsaih, Shirng-Wern / Churchill, Gary A / Korstanje, Ron

    Journal of the American Society of Nephrology : JASN

    2010  Band 22, Heft 1, Seite(n) 73–81

    Abstract: Identifying the genes underlying quantitative trait loci (QTL) for disease is difficult, mainly because of the low resolution of the approach and the complex genetics involved. However, recent advances in bioinformatics and the availability of genetic ... ...

    Abstract Identifying the genes underlying quantitative trait loci (QTL) for disease is difficult, mainly because of the low resolution of the approach and the complex genetics involved. However, recent advances in bioinformatics and the availability of genetic resources now make it possible to narrow the genetic intervals, test candidate genes, and define pathways affected by these QTL. In this study, we mapped three significant QTL and one suggestive QTL for an increased albumin-to-creatinine ratio on chromosomes (Chrs) 1, 4, 15, and 17, respectively, in a cross between the inbred MRL/MpJ and SM/J strains of mice. By combining data from several sources and by utilizing gene expression data, we identified Tlr12 as a likely candidate for the Chr 4 QTL. Through the mapping of 33,881 transcripts measured by microarray on kidney RNA from each of the 173 male F2 animals, we identified several downstream pathways associated with these QTL, including the glycan degradation, leukocyte migration, and antigen-presenting pathways. We demonstrate that by combining data from multiple sources, we can identify not only genes that are likely to be causal candidates for QTL but also the pathways through which these genes act to alter phenotypes. This combined approach provides valuable insights into the causes and consequences of renal disease.
    Mesh-Begriff(e) Albumins/metabolism ; Albuminuria/genetics ; Albuminuria/physiopathology ; Animals ; Cell Movement/physiology ; Creatinine/metabolism ; Female ; Leukocytes/cytology ; Leukocytes/physiology ; Male ; Mice ; Mice, Inbred Strains ; Models, Animal ; Polysaccharides/metabolism ; Quantitative Trait Loci/genetics ; Quantitative Trait Loci/physiology ; Signal Transduction/genetics ; Signal Transduction/physiology ; Toll-Like Receptors/genetics ; Toll-Like Receptors/physiology
    Chemische Substanzen Albumins ; Polysaccharides ; Tlr12 protein, mouse ; Toll-Like Receptors ; Creatinine (AYI8EX34EU)
    Sprache Englisch
    Erscheinungsdatum 2010-10-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2010050561
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene.

    Noordmans, Gerda A / Caputo, Christina R / Huang, Yuan / Sheehan, Susan M / Bulthuis, Marian / Heeringa, Peter / Hillebrands, Jan-Luuk / van Goor, Harry / Korstanje, Ron

    Journal of the American Society of Nephrology : JASN

    2013  Band 24, Heft 12, Seite(n) 1995–2001

    Abstract: Aging of the kidney is associated with renal damage, in particular mesangial matrix expansion (MME). Identifying the genes involved in this process will help to unravel the mechanisms of aging and aid in the design of novel therapeutic modalities aimed ... ...

    Abstract Aging of the kidney is associated with renal damage, in particular mesangial matrix expansion (MME). Identifying the genes involved in this process will help to unravel the mechanisms of aging and aid in the design of novel therapeutic modalities aimed at prevention and regression. In this study, structural changes in glomeruli of 24 inbred mouse strains were characterized in male mice at 6, 12, and 20 months of age. Haplotype association mapping was used to determine genetic loci associated with the presence of MME at 20 months. This analysis identified a significant association with a 200-kb haplotype block on chromosome 6 containing Far2. Sequencing revealed that mouse strains with MME contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without MME. Real-time PCR showed a two-fold increase in the expression of Far2 in the kidneys of strains with the insert, and subsequent experiments performed in vitro with luciferase reporter vectors showed that this sequence difference causes differential expression of Far2. Overexpression of Far2 in a mouse mesangial cell line induced upregulation of platelet activating factor and the fibrotic marker TGF-β. This upregulation of MME-promoting factors may result, in part, from the FAR2-catalyzed reduction of fatty acyl-coenzyme A to fatty alcohols, which are possible precursors of platelet activating factor. Overall, these data suggest the identification of a novel pathway involved in renal aging that may yield therapeutic targets for reducing MME.
    Mesh-Begriff(e) Aging/pathology ; Aging/physiology ; Aldehyde Oxidoreductases/genetics ; Animals ; Chromosome Mapping ; Haplotypes ; Kidney Glomerulus/pathology ; Kidney Glomerulus/physiology ; Male ; Mesangial Cells/pathology ; Mesangial Cells/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Inbred MRL lpr ; Mice, Inbred NOD ; Species Specificity
    Chemische Substanzen Aldehyde Oxidoreductases (EC 1.2.-) ; FAR2 protein, mouse (EC 1.2.1.84)
    Sprache Englisch
    Erscheinungsdatum 2013-09-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2012080838
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice

    Huang, Yuan / Caputo, Christina R. / Noordmans, Gerda A. / Yazdani, Saleh / Monteiro, Luiz Henrique / van den Born, Jaap / van Goor, Harry / Heeringa, Peter / Korstanje, Ron / Hillebrands, Jan-Luuk

    Huang , Y , Caputo , C R , Noordmans , G A , Yazdani , S , Monteiro , L H , van den Born , J , van Goor , H , Heeringa , P , Korstanje , R & Hillebrands , J-L 2014 , ' Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice ' , PLoS ONE , vol. 9 , no. 3 , e91850 . https://doi.org/10.1371/journal.pone.0091850 ; ISSN:1932-6203

    2014  

    Abstract: A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown. To identify genes associated with aging-related ... ...

    Abstract A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown. To identify genes associated with aging-related renal infiltration, we analyzed kidneys from aged mice (≥20 strains) for infiltrating leukocytes followed by Haplotype Association Mapping (HAM) analysis. Immunohistochemistry revealed CD45+ cell clusters (predominantly T and B cells) in perivascular areas coinciding with PNAd+ high endothelial venules and podoplanin+ lymph vessels indicative of tertiary lymphoid organs. Cumulative cluster size increased with age (analyzed at 6, 12 and 20 months). Based on the presence or absence of clusters in male and female mice at 20 months, HAM analysis revealed significant associations with loci on Chr1, Chr2, Chr8 and Chr14 in male mice, and with loci on Chr4, Chr7, Chr13 and Chr14 in female mice. Wisp2 (Chr2) showed the strongest association (P = 5.00×10(-137)) in male mice; Ctnnbip1 (P = 6.42×10(-267)) and Tnfrsf8 (P = 5.42×10(-245)) (both on Chr4) showed the strongest association in female mice. Both Wisp2 and Ctnnbip1 are part of the Wnt-signaling pathway and the encoded proteins were expressed within the tertiary lymphoid organs. In conclusion, this study revealed differential lymphocytic infiltration and tertiary lymphoid organ formation in aged mouse kidneys across different inbred mouse strains. HAM analysis identified candidate genes involved in the Wnt-signaling pathway that may be causally linked to tertiary lymphoid organ formation.
    Schlagwörter ENDOTHELIAL-CELLS ; CHRONIC REJECTION ; IMMUNE-RESPONSE ; HUMAN KIDNEY ; NEOGENESIS ; DISEASE ; EXPRESSION ; CD30 ; FAMILY ; TISSUE
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2014-03-17
    Erscheinungsland nl
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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