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  1. Article: Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome.

    Pospišil, Mladen / Car, Haris / Elveđi-Gašparović, Vesna / Beader, Nataša / Herljević, Zoran / Bedenić, Branka

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous ... ...

    Abstract Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. Antibiotic resistance patterns and therapy outcome were also determined. The patients' data obtained revealed that the prevalence of recent surgical procedures, solid organ tumors, metabolic diseases, kidney and liver failure, and hematological malignancies do not differ between resistant and susceptible isolates of AmpC-producing Enterobacterales. Furthermore, no difference was reported in mortality rates. Regarding antibiotic resistance, 34.52% of isolates were confirmed to be resistant (AmpC hyperproduction, ESBL, or carbapenemase). More than one in five AmpC hyperproducers were reported amid
    Language English
    Publishing date 2023-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12091125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic.

    Bedenić, Branka / Luxner, Josefa / Car, Haris / Sardelić, Sanda / Bogdan, Maja / Varda-Brkić, Dijana / Šuto, Sandra / Grisold, Andrea / Beader, Nataša / Zarfel, Gernot

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Resistance to carbapenems ... ...

    Abstract Resistance to carbapenems in
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12050677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FALSE POSITIVE PHENOTYPIC DETECTION OF METALLO-BETA-LACTAMASES IN

    Bedenić, Branka / Ladavac, Ranko / Vranić-Ladavac, Mirna / Barišić, Nada / Karčić, Natalie / Sreter, Katherina Bernadette / Mihaljević, Slobodan / Bielen, Luka / Car, Haris / Beader, Nataša

    Acta clinica Croatica

    2019  Volume 58, Issue 1, Page(s) 113–118

    Abstract: Phenotypic detection of metallo-β-lactamases (MBLs) ... ...

    Abstract Phenotypic detection of metallo-β-lactamases (MBLs) in
    MeSH term(s) Acinetobacter baumannii/isolation & purification ; Bacterial Proteins/isolation & purification ; Drug Resistance, Multiple, Bacterial ; Genotyping Techniques/methods ; Humans ; Metals/metabolism ; Microbial Sensitivity Tests/methods ; Phenotype ; beta-Lactamases/isolation & purification
    Chemical Substances Bacterial Proteins ; Metals ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; oxacillinase (EC 3.5.2.6)
    Language English
    Publishing date 2019-03-06
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1478635-7
    ISSN 1333-9451 ; 0353-9466
    ISSN (online) 1333-9451
    ISSN 0353-9466
    DOI 10.20471/acc.2019.58.01.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5057: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms.

    Bedenić, Branka / Car, Haris / Slačanac, Domagoj / Sviben, Mario / Čačić, Marko / Lukić-Grlić, Amarela / Benčić, Ana / Šijak, Dorotea / Tripković, Marko / Beader, Nataša

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2018  Volume 24, Issue 12, Page(s) 1016–1019

    Abstract: Aim: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases; combinations of two metallo-β-lactamases (MBL) ...

    Abstract Aim: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases; combinations of two metallo-β-lactamases (MBL) or MBL with OXA-48. Colistin-resistant strain positive for OXA-48 was also included in the study.
    Methods: The antibiotic susceptibility was tested by broth microdilution method. Synergy was tested by chequerboard, time-kill and 2-well method. PAE was determined by viable counting.
    Results: The chequerboard analysis revealed synergy for colistin combination with meropenem in all isolates with FICI values ranging from 0.12 to 0.24. FICI values for combinations with vancomycin were below 0.5 indicating synergy in two out of four isolates. K. pneumoniae 609815 positive for OXA-48 and colistin resistant showed the most pronounced and consistent synergy effect with meropenem in both chequerboard and time-kill method. Synergy effect in time-kill curves, was observed for K pneumoniae 145846 with two MBLs and colistin resistant K. pneumoniae 609815 positive for OXA-48, with both combinations including meropenem and vancomycin. Colistin alone exhibited short postantibiotic effect (PAE) against all tested isolates. Meropenem markedly prolonged the PAE in two isolates in contrast to vancomycin which did not demonstrate significant effect on the duration of PAE.
    Conclusions: The synergy effect and the duration of PAE was strain and antibiotic dependent but not related to the resistance gene content.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Colistin/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Synergism ; Enterobacter cloacae/drug effects ; Enterobacter cloacae/enzymology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/enzymology ; Meropenem/pharmacology ; Microbial Sensitivity Tests ; Vancomycin/pharmacology ; beta-Lactam Resistance/drug effects ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; beta-Lactamases (EC 3.5.2.6) ; Meropenem (FV9J3JU8B1) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2018-07-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2018.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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