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  1. Article: Editorial: Type 2 diabetes and cancer: clinical and molecular interactions.

    Santorsola, Mariachiara / Caraglia, Michele / Ottaiano, Alessandro

    Frontiers in medicine

    2024  Volume 10, Page(s) 1345732

    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1345732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Multifaceted Insights into Innovative Approaches to Treating Colorectal Cancer Metastasis: From Emerging Biological Factors to Radiomics.

    Ottaiano, Alessandro / Circelli, Luisa / Santorsola, Mariachiara / Caraglia, Michele

    Cancers

    2023  Volume 15, Issue 18

    Abstract: We extend our appreciation to the authors who have made substantial contributions to the Special Issue focusing on "Colorectal Cancer Metastasis" [ ... ]. ...

    Abstract We extend our appreciation to the authors who have made substantial contributions to the Special Issue focusing on "Colorectal Cancer Metastasis" [...].
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15184644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bevacizumab-Induced Tumor Vasculature Normalization and Sequential Chemotherapy in Colorectal Cancer: An Interesting and Still Open Question.

    Ottaiano, Alessandro / Caraglia, Michele

    Frontiers in oncology

    2021  Volume 11, Page(s) 751986

    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.751986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A New Source of Heterogeneity in Comparative and Translational Clinical Trials: The "Border-Time" Bias.

    Santorsola, Mariachiara / Caraglia, Michele / Nasti, Guglielmo / Ottaiano, Alessandro

    Cancers

    2022  Volume 14, Issue 21

    Abstract: The use of target-oriented drugs is profoundly changing the anti-cancer treatments. This new and expanding therapeutic context relies on the translation of biomarkers expression (laboratory testing) into clinical practice (treatment). Progression-free ... ...

    Abstract The use of target-oriented drugs is profoundly changing the anti-cancer treatments. This new and expanding therapeutic context relies on the translation of biomarkers expression (laboratory testing) into clinical practice (treatment). Progression-free survival is a primary or co-primary endpoint in the large part of comparative clinical trials about biologic anti-cancer agents. Here, we describe the "border time" bias represented by specific time points and intervals that are an underestimated source of methodologic heterogeneity and can contribute to wrong evaluation of time-to-outcome. These issues are concentrated at the beginning (head: pre-screening and screening activities) and at the end (tail: modalities of disease reassessment) of the anti-cancer treatment and can represent a time-related bias. Reporting, and ideally shortening, the time spent in pre-screening and screening activities with synthetic and innovative methodological tools as well as more harmonized rules about timing of disease reassessment can contribute to reduce, or even prevent, this bias in clinical studies.
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Efficacy in randomised trials: the time matters.

    Ottaiano, Alessandro / Santorsola, Mariachiara / Caraglia, Michele / Nasti, Guglielmo

    The Lancet. Oncology

    2022  Volume 23, Issue 7, Page(s) 839–840

    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00187-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  6. Article ; Online: MGMT Promoter Methylation as a Target In Metastatic Colorectal Cancer: Rapid Turnover and Use of Folates Alter its Study-Letter.

    Ottaiano, Alessandro / Caraglia, Michele

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 13, Page(s) 3493–3494

    MeSH term(s) Capecitabine ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Humans ; Methylation ; Promoter Regions, Genetic ; Temozolomide ; Tumor Suppressor Proteins/genetics
    Chemical Substances Tumor Suppressor Proteins ; Capecitabine (6804DJ8Z9U) ; DNA Modification Methylases (EC 2.1.1.-) ; MGMT protein, human (EC 2.1.1.63) ; DNA Repair Enzymes (EC 6.5.1.-) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-3991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Initial tumour burden and hidden oligometastatic disease in phase 3 clinical trials.

    Ottaiano, Alessandro / Santorsola, Mariachiara / Caracò, Federica / Caraglia, Michele / Nasti, Guglielmo

    The Lancet. Oncology

    2022  Volume 23, Issue 4, Page(s) 452–454

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/pathology ; Clinical Trials, Phase III as Topic ; Humans ; Lung Neoplasms/pathology ; Tumor Burden
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00034-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  8. Article: Whole-genome analysis suggesting probiotic potential and safety properties of

    Tathode, Madhura S / Bonomo, Maria Grazia / Zappavigna, Silvia / Mang, Stefania Mirela / Bocchetti, Marco / Camele, Ippolito / Caraglia, Michele / Salzano, Giovanni

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1268216

    Abstract: Introduction: Many lactic acid bacteria (LAB) strains are currently gaining attention in the food industry and various biological applications because of their harmless and functional properties. Given the growing consumer demand for safe food, further ... ...

    Abstract Introduction: Many lactic acid bacteria (LAB) strains are currently gaining attention in the food industry and various biological applications because of their harmless and functional properties. Given the growing consumer demand for safe food, further research into potential probiotic bacteria is beneficial. Therefore, we aimed to characterize
    Methods: In this study, we analyzed the whole genome of the
    Results and discussion: The whole-genome assembly and functional annotations revealed many interesting characteristics of the DSPZPP1 strain. Sequencing raw reads were assembled into a draft genome of size 1,891,398 bp, with a G + C content of 37.3%. Functional annotation identified 1930 protein-encoding genes and 58 RNAs including tRNA, tmRNA, and 16S, 23S, and 5S rRNAs. The analysis shows the presence of genes that encode water-soluble B-group vitamins such as biotin, folate, coenzyme A, and riboflavin. Furthermore, the analysis revealed that the DSPZPP1 strain can synthesize class II bacteriocin, penocin A, adding importance to the food industry for bio-enriched food. The DSPZPP1 genome does not show the presence of plasmids, and no genes associated with antimicrobial resistance and virulence were found. In addition, two intact bacteriophages were identified. Importantly, the lowest probability value in pathogenicity analysis indicates that this strain is non-pathogenic to humans. 16 s rRNA-based phylogenetic analysis and comparative analysis based on ANI and Tetra reveal that the DSPZPP1 strain shares the closest evolutionary relationship with
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1268216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Tumor Dynamism Is the Dark Matter of the NGS Galaxy: How to Understand It?

    Ottaiano, Alessandro / Circelli, Luisa / Caraglia, Michele

    Cancers

    2021  Volume 13, Issue 21

    Abstract: Since its discovery, there has been a great enthusiasm around NGS (next generation sequencing) technology due to extensive (from restricted gene panels to entire genomes) and rapid (few hours) DNA sequencing [ ... ]. ...

    Abstract Since its discovery, there has been a great enthusiasm around NGS (next generation sequencing) technology due to extensive (from restricted gene panels to entire genomes) and rapid (few hours) DNA sequencing [...].
    Language English
    Publishing date 2021-10-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13215476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: The Treatment of RAS or BRAF Mutated Metastatic Colorectal Cancer: Challenges and Perspectives.

    Ottaiano, Alessandro / Berretta, Massimiliano / Von Arx, Claudia / Capozzi, Monica / Caraglia, Michele

    Frontiers in oncology

    2022  Volume 12, Page(s) 852445

    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.852445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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