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Article ; Online: Anorectic effect of COR659 in a rat model of overeating.

Maccioni, Paola / Mugnaini, Claudia / Carai, Mauro A M / Gessa, Gian Luigi / Corelli, Federico / Colombo, Giancarlo

2023 Volume 34, Issue 7, Page(s) 437–442

Abstract: COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that ... ...

Abstract	COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The present study was designed to assess whether the ability of COR659 to diminish these addictive-like, food-motivated behaviours extended to a rat model of overeating palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour feeding session with highly palatable, calorie-rich Danish butter cookies. Even though satiated, rats overconsumed cookies. COR659 (0, 2.5, 5, and 10 mg/kg, i.p.) was administered before the start of the cookie-feeding session. Treatment with all 3 doses of COR659 produced a substantial decrease in intake of cookies and calories from cookies. These results extend the anorectic profile of COR659 to overconsumption of a highly palatable food and intake of large amounts of unnecessary calories.
MeSH term(s)	Animals ; Rats ; Appetite Depressants ; Drug Inverse Agonism ; Food ; Behavior, Addictive ; Hyperphagia
Chemical Substances	Appetite Depressants
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1027374-8
ISSN	1473-5849 ; 0955-8810
ISSN (online)	1473-5849
ISSN	0955-8810
DOI	10.1097/FBP.0000000000000751
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Article ; Online: Blockade of the GABAB receptor suppressed alcohol self-administration in rats: an effect similar to that produced by GABAB receptor activation.

Maccioni, Paola / Lorrai, Irene / Carai, Mauro A M / Gessa, Gian Luigi / Colombo, Giancarlo

Behavioural pharmacology

2022 Volume 33, Issue 1, Page(s) 51–60

Abstract: Literature data suggest that activation and blockade of the GABAB receptor may produce similar effects on several reward-related behaviours. Accordingly, the present study was designed to investigate whether treatment with the GABAB receptor antagonist, ... ...

Abstract	Literature data suggest that activation and blockade of the GABAB receptor may produce similar effects on several reward-related behaviours. Accordingly, the present study was designed to investigate whether treatment with the GABAB receptor antagonist, SCH 50911, reproduced the suppressing effect of the GABAB receptor agonist, baclofen, and several positive allosteric modulators of the GABAB receptor on operant oral alcohol self-administration in rats. To this end, Sardinian alcohol-preferring (sP) rats were trained to lever-respond for alcohol (15% v/v) under the fixed ratio (FR) 4 (FR4) schedule of reinforcement. Once lever-responding had stabilized, rats were exposed to test sessions preceded by treatment with SCH 50911 (0, 25, 50, and 100 mg/kg; i.p.). Two independent experiments were conducted, differing solely in the set of rats used. Selectivity of SCH 50911 effect on alcohol self-administration was assessed by evaluating the effect of SCH 50911 (0, 25, 50, and 100 mg/kg; i.p.) on self-administration of a sucrose solution (0.7% w/v) in sP rats exposed to the FR4 schedule. In both 'alcohol' experiments, treatment with SCH 50911 reduced lever-responding for alcohol and amount of self-administered alcohol. SCH 50911 effect was characterized by large interindividual variability, with several instances of dose-unrelated reductions, and frequent occurrence of complete suppression of lever-responding for alcohol. Similar data were collected in the 'sucrose' experiment. These results extend to alcohol self-administration with the notion that activation and blockade of GABAB receptor may produce unidirectional effects on reward-related behaviours; these similarities are discussed in terms of differential contribution of pre- and postsynaptic GABAB receptors.
MeSH term(s)	Alcohol Drinking/metabolism ; Alcohol Drinking/psychology ; Animals ; Baclofen/pharmacology ; Behavior, Animal/drug effects ; Dose-Response Relationship, Drug ; GABA-B Receptor Agonists/pharmacology ; GABA-B Receptor Antagonists/pharmacology ; Models, Animal ; Morpholines/pharmacology ; Rats ; Receptors, GABA-B/metabolism ; Reinforcement, Psychology ; Self Administration/psychology
Chemical Substances	(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid ; GABA-B Receptor Agonists ; GABA-B Receptor Antagonists ; Morpholines ; Receptors, GABA-B ; Baclofen (H789N3FKE8)
Language	English
Publishing date	2022-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1027374-8
ISSN	1473-5849 ; 0955-8810
ISSN (online)	1473-5849
ISSN	0955-8810
DOI	10.1097/FBP.0000000000000668
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Article ; Online: Environmental enrichment augments binge-like alcohol drinking in Sardinian alcohol-preferring rats.

Maccioni, Paola / Somenzi, Laura Regonini / Lobina, Carla / Carai, Mauro A M / Gessa, Gian Luigi / Colombo, Giancarlo

Alcohol (Fayetteville, N.Y.)

2022 Volume 105, Page(s) 1–7

Abstract: Exposure of Sardinian alcohol-preferring (sP) rats to an enriched environment (EE) reduced different aspects of operant alcohol self-administration. The present study was aimed at expanding investigation of the effect of EE exposure upon a model of binge ...

Abstract	Exposure of Sardinian alcohol-preferring (sP) rats to an enriched environment (EE) reduced different aspects of operant alcohol self-administration. The present study was aimed at expanding investigation of the effect of EE exposure upon a model of binge drinking composed of daily 1-h drinking sessions with unpredictable access to multiple alcohol concentrations; binge-like alcohol intakes were observed when the drinking session occurred at the last hours of the dark phase of the light/dark cycle. Starting from postnatal day (PND) 21, male sP rats were kept under three different housing conditions: impoverished environment (IE; single housing with no environmental enrichment); standard environment (SE; 3 rats/cage and no environmental enrichment); EE (6 rats/cage and multiple elements of environmental enrichment). From PND 69, rats were exposed daily to a 1-hour drinking session under the 4-bottle "alcohol (10%, 20%, and 30%, v/v) vs. water" choice regimen, during the dark phase, and with timing of alcohol exposure changed each day. In all three rat groups (IE, SE, and EE), alcohol intake increased progressively as the drinking session moved from the first to last hours of the dark phase. The slope of the regression line was steeper in EE than IE and SE rats, suggestive of higher intakes of alcohol in EE than IE and SE rats when the drinking session occurred over the last hours of the dark phase. These results are discussed hypothesizing that the stressful attributes of alcohol expectation were potentiated by the increased "emotionality" that rats living in a comfortable environment (i.e., EE) may experience when facing new, challenging events or environments. Blood alcohol levels, assessed at the end of a final drinking session occurring at the 12th hour of the dark phase, did not differ among the three rat groups and averaged approximately 150 mg%, confirming that this experimental procedure may generate intoxicating levels of alcohol drinking in sP rats.
MeSH term(s)	Male ; Rats ; Animals ; Alcohol Drinking
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	605912-0
ISSN	1873-6823 ; 0741-8329
ISSN (online)	1873-6823
ISSN	0741-8329
DOI	10.1016/j.alcohol.2022.09.003
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Article: Analgesic properties of a food grade lecithin delivery system of Zingiber officinale and Acmella oleracea standardized extracts in rats

Lobina, Carla / Sau, Roberta / Fara, Federica / Maccioni, Paola / Carai, Mauro A. M. / Colombo, Giancarlo

Natural product research. 2021 Sept. 17, v. 35, no. 18

2021

Abstract: This study investigated whether (i) the 5:1 combination of standardized extracts of Zingiber officinale and Acmella oleracea is endowed with analgesic effects and (ii) the phospholipid-based formulation of Zingiber officinale and Acmella oleracea ... ...

Abstract	This study investigated whether (i) the 5:1 combination of standardized extracts of Zingiber officinale and Acmella oleracea is endowed with analgesic effects and (ii) the phospholipid-based formulation of Zingiber officinale and Acmella oleracea extracts (ZAP) potentiated the analgesic effects of the plain extract combination (PEC). To this end, rats were exposed to acute pain (Tail Flick test) and chronic, inflammatory pain [Von Frey monofilament test and Randall–Selitto paw pressure test in rats treated intraplantarily with complete Freund's adjuvant (CFA)]. The plain combination of per se ineffective doses of the two extracts produced analgesic effects in healthy rats. ZAP was more potent and effective than the corresponding doses of PEC. ZAP also produced analgesic effects in CFA-treated rats. Studies are now warranted to assess whether the analgesic properties of ZAP may generalize to humans.
Keywords	Zingiber officinale ; analgesics ; lecithins ; pain ; research ; tail flick test ; vaccine adjuvants
Language	English
Dates of publication	2021-0917
Size	p. 3078-3082.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2019.1680667
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Reducing Effect of Cannabidiol on Alcohol Self-Administration in Sardinian Alcohol-Preferring Rats.

Maccioni, Paola / Bratzu, Jessica / Carai, Mauro A M / Colombo, Giancarlo / Gessa, Gian Luigi

Cannabis and cannabinoid research

2021 Volume 7, Issue 2, Page(s) 161–169

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Animals ; Cannabidiol/pharmacology ; Ethanol/pharmacology ; Humans ; Male ; Plant Breeding ; Rats ; Rats, Wistar ; Self Administration
Chemical Substances	Cannabidiol (19GBJ60SN5) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2867624-5
ISSN	2378-8763 ; 2578-5125
ISSN (online)	2378-8763
ISSN	2578-5125
DOI	10.1089/can.2020.0132
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Article: Exposure to an enriched environment reduces alcohol self-administration in Sardinian alcohol-preferring rats

Maccioni, Paola / Bratzu, Jessica / Lobina, Carla / Acciaro, Carla / Corrias, Gianluigi / Capra, Alessandro / Carai, Mauro A.M. / Agabio, Roberta / Muntoni, Anna Lisa / Gessa, Gian Luigi / Colombo, Giancarlo

Physiology & behavior. 2022 May 15, v. 249

2022

Abstract: Living in an enriched environment (EE) produces a notable impact on several rodent behaviors, including those motivated by drugs of abuse. This picture is somewhat less clear when referring to alcohol-motivated behaviors. With the intent of contributing ... ...

Abstract	Living in an enriched environment (EE) produces a notable impact on several rodent behaviors, including those motivated by drugs of abuse. This picture is somewhat less clear when referring to alcohol-motivated behaviors. With the intent of contributing to this research field with data from one of the few rat lines selectively bred for excessive alcohol consumption, the present study investigated the effect of EE on operant oral alcohol self-administration in Sardinian alcohol-preferring (sP) rats. Starting from Postnatal Day (PND) 21, male sP rats were kept under 3 different housing conditions: impoverished environment (IE; single housing in shoebox-like cages with no environmental enrichment); standard environment (SE; small colony cages with 3 rats and no environmental enrichment); EE (large colony cages with 6 rats and multiple elements of environmental enrichment, including 2 floors, ladders, maze, running wheels, and shelter). From PND 60, rats were exposed to different phases of shaping and training of alcohol self-administration. IE, SE, and EE rats were then compared under (i) fixed ratio (FR) 4 (FR4) schedule of alcohol reinforcement for 20 daily sessions and (ii) progressive ratio (PR) schedule of alcohol reinforcement in a final single session. Acquisition of the lever-responding task (shaping) was slower in EE than IE and SE rats, as the likely consequence of a “devaluation” of the novel stimuli provided by the operant chamber in comparison to those to which EE rats were continuously exposed in their homecage or an alteration, induced by EE, of the rat “emotionality” state when facing the novel environment represented by the operant chamber. Training of alcohol self-administration was slower in EE than IE rats, with SE rats displaying intermediate values. A similar ranking order (IE>SE>EE) was also observed in number of lever-responses for alcohol, amount of self-administered alcohol, and breakpoint for alcohol under FR4 and PR schedules of reinforcement. These data suggest that living in a complex environment reduced the reinforcing and motivational properties of alcohol in sP rats. These results are interpreted in terms of the reinforcing and motivational properties of the main components of EE (i.e., social interactions, physical activities, exploration, novelty) substituting, at least partially, for those of alcohol.
Keywords	alcohol drinking ; alcohols ; environmental enrichment ; males ; rats
Language	English
Dates of publication	2022-0515
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2022.113771
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analgesic properties of a food grade lecithin delivery system of

Lobina, Carla / Sau, Roberta / Fara, Federica / Maccioni, Paola / Carai, Mauro A M / Colombo, Giancarlo

Natural product research

2019 Volume 35, Issue 18, Page(s) 3078–3082

Abstract: This study investigated whether (i) the 5:1 combination of standardized extracts ... ...

Abstract	This study investigated whether (i) the 5:1 combination of standardized extracts of
MeSH term(s)	Acute Pain/drug therapy ; Analgesics/isolation & purification ; Analgesics/pharmacology ; Animals ; Asteraceae/chemistry ; Drug Delivery Systems ; Zingiber officinale/chemistry ; Lecithins/chemistry ; Plant Extracts/pharmacology ; Rats
Chemical Substances	Analgesics ; Lecithins ; Plant Extracts
Language	English
Publishing date	2019-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2019.1680667
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Article ; Online: Exposure to an enriched environment reduces alcohol self-administration in Sardinian alcohol-preferring rats.

Maccioni, Paola / Bratzu, Jessica / Lobina, Carla / Acciaro, Carla / Corrias, Gianluigi / Capra, Alessandro / Carai, Mauro A M / Agabio, Roberta / Muntoni, Anna Lisa / Gessa, Gian Luigi / Colombo, Giancarlo

Physiology & behavior

2022 Volume 249, Page(s) 113771

Abstract	Living in an enriched environment (EE) produces a notable impact on several rodent behaviors, including those motivated by drugs of abuse. This picture is somewhat less clear when referring to alcohol-motivated behaviors. With the intent of contributing to this research field with data from one of the few rat lines selectively bred for excessive alcohol consumption, the present study investigated the effect of EE on operant oral alcohol self-administration in Sardinian alcohol-preferring (sP) rats. Starting from Postnatal Day (PND) 21, male sP rats were kept under 3 different housing conditions: impoverished environment (IE; single housing in shoebox-like cages with no environmental enrichment); standard environment (SE; small colony cages with 3 rats and no environmental enrichment); EE (large colony cages with 6 rats and multiple elements of environmental enrichment, including 2 floors, ladders, maze, running wheels, and shelter). From PND 60, rats were exposed to different phases of shaping and training of alcohol self-administration. IE, SE, and EE rats were then compared under (i) fixed ratio (FR) 4 (FR4) schedule of alcohol reinforcement for 20 daily sessions and (ii) progressive ratio (PR) schedule of alcohol reinforcement in a final single session. Acquisition of the lever-responding task (shaping) was slower in EE than IE and SE rats, as the likely consequence of a "devaluation" of the novel stimuli provided by the operant chamber in comparison to those to which EE rats were continuously exposed in their homecage or an alteration, induced by EE, of the rat "emotionality" state when facing the novel environment represented by the operant chamber. Training of alcohol self-administration was slower in EE than IE rats, with SE rats displaying intermediate values. A similar ranking order (IE>SE>EE) was also observed in number of lever-responses for alcohol, amount of self-administered alcohol, and breakpoint for alcohol under FR4 and PR schedules of reinforcement. These data suggest that living in a complex environment reduced the reinforcing and motivational properties of alcohol in sP rats. These results are interpreted in terms of the reinforcing and motivational properties of the main components of EE (i.e., social interactions, physical activities, exploration, novelty) substituting, at least partially, for those of alcohol.
MeSH term(s)	Alcohol Drinking ; Animals ; Conditioning, Operant ; Ethanol ; Male ; Motivation ; Rats ; Reinforcement, Psychology ; Self Administration
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2022.113771
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Zs.A 747: Show issues

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Article ; Online: Suppression by γ-Hydroxybutyric Acid of "Alcohol Deprivation Effect" in Rats: Preclinical Evidence of its anti-Relapse Properties.

Colombo, Giancarlo / Carai, Mauro A M / Gessa, Gian Luigi

Frontiers in psychiatry

2012 Volume 3, Page(s) 95

Abstract: γ-Hydroxybutyric acid (GHB) reduces (a) alcohol intake and alcohol motivational properties in alcohol-preferring rats and (b) alcohol drinking and craving for alcohol in human alcoholics. The present study was designed to extend to relapse-like drinking ... ...

Abstract	γ-Hydroxybutyric acid (GHB) reduces (a) alcohol intake and alcohol motivational properties in alcohol-preferring rats and (b) alcohol drinking and craving for alcohol in human alcoholics. The present study was designed to extend to relapse-like drinking the capacity of GHB to suppress different alcohol-related behaviors in alcohol-preferring rats. The "alcohol deprivation effect," defined as the temporary increase in alcohol intake occurring in laboratory animals after a period of alcohol deprivation, was used as model of alcohol relapse. Acute administration of non-sedative doses of GHB (0, 100, 200, and 300 mg/kg, i.p.) resulted in the complete suppression of the extra-amount of alcohol consumed by Sardinian alcohol-preferring rats during the first hour of re-access to alcohol after a 14-day period of deprivation. These data demonstrate that GHB suppressed relapse-like drinking in a rat model of excessive alcohol consumption.
Language	English
Publishing date	2012-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640 ; 1664-0640
ISSN (online)	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2012.00095
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Article: Reducing Effect of Saikosaponin A, an Active Ingredient of

Maccioni, Paola / Fara, Federica / Gessa, Gian Luigi / Carai, Mauro A M / Chin, Young-Won / Lee, Jung Hwan / Kwon, Hak Cheol / Colombo, Giancarlo

Frontiers in psychiatry

2018 Volume 9, Page(s) 369

Abstract: Recent lines of experimental evidence have indicated that saikosaponin A (SSA)-a bioactive ingredient of the medicinal plant, ...

Abstract	Recent lines of experimental evidence have indicated that saikosaponin A (SSA)-a bioactive ingredient of the medicinal plant,
Language	English
Publishing date	2018-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2018.00369
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