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  1. Article ; Online: Intermittent Normal Ventricular Conduction in Left Bundle Branch Block After TAVR.

    Cecchini, Edoardo / Massaro, Gianluca / Carbone, Vincenzo / Sangiorgi, Giuseppe

    JACC. Case reports

    2023  Volume 15, Page(s) 101865

    Abstract: In a patient who previously developed left bundle branch block after transcatheter aortic valve replacement, intermittent narrow QRS complexes were recorded on ambulatory electrocardiography monitoring. The peculiar distribution of wide and narrow QRS ... ...

    Abstract In a patient who previously developed left bundle branch block after transcatheter aortic valve replacement, intermittent narrow QRS complexes were recorded on ambulatory electrocardiography monitoring. The peculiar distribution of wide and narrow QRS complexes suggested the presence of a window of supernormality in the refractory period of a branch block that on other occasions exhibited the Wenckebach phenomenon. (
    Language English
    Publishing date 2023-05-06
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101865
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  2. Article ; Online: Reply to the editor--supernormal conduction or masked bundle branch block?

    Carbone, Vincenzo

    Heart rhythm

    2015  Volume 12, Issue 5, Page(s) e34–5

    MeSH term(s) Bundle-Branch Block/physiopathology ; Electrocardiography ; Heart Conduction System/physiopathology ; Humans ; Tachycardia, Supraventricular/physiopathology
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2015.01.030
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
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  3. Article ; Online: Supraventricular Tachycardia Following Mitral Valve Surgery.

    Carbone, Vincenzo / Carbone, Giovanni / Cassese, Antonio

    JAMA cardiology

    2022  Volume 7, Issue 10, Page(s) 1076–1078

    MeSH term(s) Humans ; Mitral Valve/surgery ; Tachycardia, Paroxysmal ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/etiology
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2022.2902
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  4. Article ; Online: Wolff-Parkinson-White pattern on alternate beats: What is the mechanism?

    Carbone, Vincenzo / Ferrara, Ferdinando / Cassese, Antonio / Carbone, Giovanni

    Journal of electrocardiology

    2021  Volume 66, Page(s) 12–15

    Abstract: The Holter electrocardiogram from an asymptomatic man shows intermittent preexcitation. At the lowest rates all the QRS complexes display a WPW pattern. As the rate increases, preexcitation fails to occur and all the QRS complexes become persistently ... ...

    Abstract The Holter electrocardiogram from an asymptomatic man shows intermittent preexcitation. At the lowest rates all the QRS complexes display a WPW pattern. As the rate increases, preexcitation fails to occur and all the QRS complexes become persistently narrow. With a further increase in sinus rate the WPW occurs on alternate beats and this alternation is maintained for a while. A careful analysis of the accessory pathway conduction in relation to sinus-cycle length and morphology of the prior beat strongly supports the supernormal conduction through the Kent bundle associated with linking as the key mechanism underlying the preexcitation on alternate beats.
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410286-1
    ISSN 1532-8430 ; 0022-0736
    ISSN (online) 1532-8430
    ISSN 0022-0736
    DOI 10.1016/j.jelectrocard.2021.02.008
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  5. Article ; Online: A novel mutation in IAA16 is associated with dicamba resistance in Chenopodium album.

    Ghanizadeh, Hossein / He, Lulu / Griffiths, Andrew G / Harrington, Kerry C / Carbone, Vincenzo / Wu, Haotian / Tian, Ke / Bo, Han / Xinhui, Duan

    Pest management science

    2024  

    Abstract: Background: Resistance to dicamba in Chenopodium album was first documented over a decade ago, however, the molecular basis of dicamba resistance in this species has not been elucidated. In this research, the resistance mechanism in a dicamba-resistant ... ...

    Abstract Background: Resistance to dicamba in Chenopodium album was first documented over a decade ago, however, the molecular basis of dicamba resistance in this species has not been elucidated. In this research, the resistance mechanism in a dicamba-resistant C. album phenotype was investigated using a transcriptomics (RNA-sequence) approach.
    Results: The dose-response assay showed that the resistant (R) phenotype was nearly 25-fold more resistant to dicamba than a susceptible (S) phenotype of C. album. Also, dicamba treatment significantly induced transcription of the known auxin-responsive genes, Gretchen Hagen 3 (GH3), small auxin-up RNAs (SAURs), and 1-aminocyclopropane-1-carboxylate synthase (ACS) genes in the susceptible phenotype. Comparing the transcripts of auxin TIR/AFB receptors and auxin/indole-3-acetic acid (AUX/IAA) proteins identified from C. album transcriptomic analysis revealed that the R phenotype contained a novel mutation at the first codon of the GWPPV degron motif of IAA16, resulting in an amino acid substitution of glycine (G) with aspartic acid (D). Sequencing the IAA16 gene in other R and S individuals further confirmed that all the R individuals contained the mutation.
    Conclusion: In this research, we describe the dicamba resistance mechanism in the only case of dicamba-resistant C. album reported to date. Prior work has shown that the dicamba resistance allele confers significant growth defects to the R phenotype investigated here, suggesting that dicamba-resistant C. album carrying this novel mutation in the IAA16 gene may not persist at high frequencies upon removal of dicamba application. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.8071
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    In stock of ZB MED Bonn / Germany

    Z 2731: Show issues

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  6. Article: Multi-Omic Profiling, Structural Characterization, and Potent Inhibitor Screening of Evasion-Related Proteins of a Parasitic Nematode,

    Palevich, Nikola / Maclean, Paul H / Carbone, Vincenzo / Jauregui, Ruy / Umair, Saleh

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: The emergence of drug-resistant parasitic nematodes in both humans and livestock calls for development of alternative and cost-effective control strategies. ... ...

    Abstract The emergence of drug-resistant parasitic nematodes in both humans and livestock calls for development of alternative and cost-effective control strategies. Barbervax
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020411
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  7. Article ; Online: On Yaglom's Law for the Interplanetary Proton Density and Temperature Fluctuations in Solar Wind Turbulence.

    Consolini, Giuseppe / Alberti, Tommaso / Carbone, Vincenzo

    Entropy (Basel, Switzerland)

    2020  Volume 22, Issue 12

    Abstract: In the past decades, there has been an increasing literature on the presence of an inertial energy cascade in interplanetary space plasma, being interpreted as the signature of Magnetohydrodynamic turbulence (MHD) for both fields and passive scalars. ... ...

    Abstract In the past decades, there has been an increasing literature on the presence of an inertial energy cascade in interplanetary space plasma, being interpreted as the signature of Magnetohydrodynamic turbulence (MHD) for both fields and passive scalars. Here, we investigate the passive scalar nature of the solar wind proton density and temperature by looking for scaling features in the mixed-scalar third-order structure functions using measurements on-board the Ulysses spacecraft during two different periods, i.e., an equatorial slow solar wind and a high-latitude fast solar wind, respectively. We find a linear scaling of the mixed third-order structure function as predicted by Yaglom's law for passive scalars in the case of slow solar wind, while the results for fast solar wind suggest that the mixed fourth-order structure function displays a linear scaling. A simple empirical explanation of the observed difference is proposed and discussed.
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e22121419
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  8. Article ; Online: A model for the geomagnetic field reversal rate and constraints on the heat flux variations at the core-mantle boundary.

    Carbone, Vincenzo / Alberti, Tommaso / Lepreti, Fabio / Vecchio, Antonio

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 13008

    Abstract: A striking feature of many natural magnetic fields generated by dynamo action is the occurrence of polarity reversals. Paleomagnetic measurements revealed that the Earth's magnetic field has been characterised by few hundred stochastic polarity switches ... ...

    Abstract A striking feature of many natural magnetic fields generated by dynamo action is the occurrence of polarity reversals. Paleomagnetic measurements revealed that the Earth's magnetic field has been characterised by few hundred stochastic polarity switches during its history. The rate of reversals changes in time, maybe obeying some underlying regular pattern. While chaotic dynamical systems can describe the short-term behaviour of the switches of the Earth's magnetic polarity, modelling the long-term variations of the reversal rate is somewhat problematic, as they occur on timescales of tens to hundreds of millions of years, of the order of mantle convection timescales. By investigating data of geomagnetic reversal rates, we find the presence of cycles with variable frequency and show that the transition towards periods where reversals do not occur for tens of million years (superchrons) can be described by a second-order phase transition that we interpret to be driven by variations of the heat flux at the core-mantle boundary (CMB). The model allows us to extract from the reversal sequence quantitative information on the susceptibility of the reversal rate caused by changes in the CMB heat flux amplitude, thus providing direct information on the deep inner layers of the Earth.
    Language English
    Publishing date 2020-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-69916-w
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  9. Article ; Online: Molecular and evolutionary basis for survival, its failure, and virulence factors of the zoonotic nematode Anisakis pegreffii.

    Trumbić, Željka / Hrabar, Jerko / Palevich, Nikola / Carbone, Vincenzo / Mladineo, Ivona

    Genomics

    2021  Volume 113, Issue 5, Page(s) 2891–2905

    Abstract: Parasitism is a highly successful life strategy and a driving force in genetic diversity that has evolved many times over. Accidental infections of non-targeted hosts represent an opportunity for lateral host switches and parasite niche expansion. ... ...

    Abstract Parasitism is a highly successful life strategy and a driving force in genetic diversity that has evolved many times over. Accidental infections of non-targeted hosts represent an opportunity for lateral host switches and parasite niche expansion. However, if directed toward organisms that are phylogenetically distant from parasite's natural host, such as humans, it may present a dead-end environment where the parasite fails to mature or is even killed by host immunity. One example are nematodes of Anisakidae family, genus Anisakis, that through evolution have lost the ability to propagate in terrestrial hosts, but can survive for a limited time in humans causing anisakiasis. To scrutinize versatility of Anisakis to infect an evolutionary-distant host, we performed transcriptomic profiling of larvae successfully migrating through the rat, a representative model of accidental human infection and compared it to that of larvae infecting an evolutionary-familiar, paratenic host (fish). In a homeothermic accidental host Anisakis upregulated ribosome-related genes, cell division, cuticle constituents, oxidative phosphorylation, in an unsuccessful attempt to molt to the next stage. In contrast, in the paratenic poikilothermic host where metabolic pathways were moderately upregulated or silenced, larvae prepared for dormancy by triggering autophagy and longevity pathways. Identified differences and the modelling of handful of shared transcripts, provide the first insights into evolution of larval nematode virulence, warranting their further investigation as potential drug therapy targets.
    MeSH term(s) Animals ; Anisakiasis/genetics ; Anisakiasis/parasitology ; Anisakis/genetics ; Fishes ; Larva/genetics ; Rats ; Virulence Factors/genetics
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2021-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2021.06.032
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    Zs.A 2367: Show issues Location:
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  10. Article ; Online: Accelerating Digitalization in Healthcare with the InSilicoTrials Cloud-Based Platform: Four Use Cases.

    Nicolò, Chiara / Sips, Fianne / Vaghi, Cristina / Baretta, Alessia / Carbone, Vincenzo / Emili, Luca / Bursi, Roberta

    Annals of biomedical engineering

    2022  Volume 51, Issue 1, Page(s) 125–136

    Abstract: The use of in silico trials is expected to play an increasingly important role in the development and regulatory evaluation of new medical products. Among the advantages that in silico approaches offer, is that they permit testing of drug candidates and ... ...

    Abstract The use of in silico trials is expected to play an increasingly important role in the development and regulatory evaluation of new medical products. Among the advantages that in silico approaches offer, is that they permit testing of drug candidates and new medical devices using virtual patients or computational emulations of preclinical experiments, allowing to refine, reduce or even replace time-consuming and costly benchtop/in vitro/ex vivo experiments as well as the involvement of animals and humans in in vivo studies. To facilitate and widen the adoption of in silico trials, InSilicoTrials Technologies has developed a cloud-based platform, hosting healthcare simulation tools for different bench, preclinical and clinical evaluations, and for diverse disease areas. This paper discusses four use cases of in silico trials performed using the InSilicoTrials.com platform. The first application illustrates how in silico approaches can improve the early preclinical assessment of drug-induced cardiotoxicity risks. The second use case is a virtual reproduction of a bench test for the safety assessment of transcatheter heart valve substitutes. The third and fourth use cases are examples of virtual patients generation to evaluate treatment effects in multiple sclerosis and prostate cancer patients, respectively.
    MeSH term(s) Animals ; Humans ; Cloud Computing ; Computer Simulation ; Delivery of Health Care
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-022-03052-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1018: Show issues Location:
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