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Article ; Online: Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis.

Fernandez-Carbonell, Cristina / Charvet, Leigh E / Krupp, Lauren B

2021 Volume 23, Issue 4, Page(s) 317–329

Abstract: Pediatric-onset multiple sclerosis (POMS), representing approximately 5% of all MS cases, affects the central nervous system during its ongoing development. POMS is most commonly diagnosed during adolescence but can occur in younger children as well. For ...

Abstract	Pediatric-onset multiple sclerosis (POMS), representing approximately 5% of all MS cases, affects the central nervous system during its ongoing development. POMS is most commonly diagnosed during adolescence but can occur in younger children as well. For pediatric patients with MS, it is critical to manage the full impact of the disease and monitor for any effects on school and social functioning. Disease management includes not only disease-modifying therapies but also strategies to optimize wellbeing. We review the interventions with the highest evidence of ability to improve the disease course and quality of life in POMS. High levels of vitamin D and a diet low in saturated fat are associated with lower relapse rates. Exercise ameliorates fatigue and sleep. Behavioral strategies for sleep hygiene and mood regulation can also improve fatigue and perceived health. POMS management should be addressed holistically, including assessing overall symptom burden as well as the psychological and functional impact of the disease.
MeSH term(s)	Adolescent ; Affect/physiology ; Antioxidants/administration & dosage ; Child ; Cognition/physiology ; Disease Management ; Exercise/physiology ; Exercise/psychology ; Fatigue/etiology ; Fatigue/psychology ; Fatigue/therapy ; Humans ; Longitudinal Studies ; Medical Marijuana/administration & dosage ; Multiple Sclerosis/complications ; Multiple Sclerosis/psychology ; Multiple Sclerosis/therapy ; Quality of Life/psychology ; Vitamin D/administration & dosage
Chemical Substances	Antioxidants ; Medical Marijuana ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-05-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1492748-2
ISSN	1179-2019 ; 1174-5878
ISSN (online)	1179-2019
ISSN	1174-5878
DOI	10.1007/s40272-021-00451-5
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Article: Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications.

Salete-Granado, Daniel / Carbonell, Cristina / Puertas-Miranda, David / Vega-Rodríguez, Víctor-José / García-Macia, Marina / Herrero, Ana Belén / Marcos, Miguel

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic liver disease (ALD). Autophagy ... ...

Abstract	Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic liver disease (ALD). Autophagy is a regulated dynamic process that sequesters damaged and excess cytoplasmic organelles for lysosomal degradation and may counteract the harmful effects of ROS-induced oxidative stress. These effects include hepatotoxicity, mitochondrial damage, steatosis, endoplasmic reticulum stress, inflammation, and iron overload. In liver diseases, particularly ALD, macroautophagy has been implicated as a protective mechanism in hepatocytes, although it does not appear to play the same role in stellate cells. Beyond the liver, autophagy may also mitigate the harmful effects of alcohol on other organs, thereby providing an additional layer of protection against ALD. This protective potential is further supported by studies showing that drugs that interact with autophagy, such as rapamycin, can prevent ALD development in animal models. This systematic review presents a comprehensive analysis of the literature, focusing on the role of autophagy in oxidative stress regulation, its involvement in organ-organ crosstalk relevant to ALD, and the potential of autophagy-targeting therapeutic strategies.
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071425
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Article ; Online: Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications

Salete-Granado, Daniel / Carbonell, Cristina / Puertas-Miranda, David / Vega-Rodríguez, Víctor-José / García-Macia, Marina / Herrero, Ana Belén / Marcos, Miguel

Antioxidants. 2023 July 14, v. 12, no. 7

2023

Abstract	Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic liver disease (ALD). Autophagy is a regulated dynamic process that sequesters damaged and excess cytoplasmic organelles for lysosomal degradation and may counteract the harmful effects of ROS-induced oxidative stress. These effects include hepatotoxicity, mitochondrial damage, steatosis, endoplasmic reticulum stress, inflammation, and iron overload. In liver diseases, particularly ALD, macroautophagy has been implicated as a protective mechanism in hepatocytes, although it does not appear to play the same role in stellate cells. Beyond the liver, autophagy may also mitigate the harmful effects of alcohol on other organs, thereby providing an additional layer of protection against ALD. This protective potential is further supported by studies showing that drugs that interact with autophagy, such as rapamycin, can prevent ALD development in animal models. This systematic review presents a comprehensive analysis of the literature, focusing on the role of autophagy in oxidative stress regulation, its involvement in organ–organ crosstalk relevant to ALD, and the potential of autophagy-targeting therapeutic strategies.
Keywords	alcohol drinking ; alcohols ; animals ; endoplasmic reticulum stress ; hepatocytes ; hepatotoxicity ; inflammation ; iron overload ; liver ; liver diseases ; macroautophagy ; metabolites ; mitochondria ; oxidative stress ; rapamycin ; reactive oxygen species ; systematic review ; therapeutics
Language	English
Dates of publication	2023-0714
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071425
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Article ; Online: Prevalence and treatment of fragility fractures in Spanish primary care: PREFRAOS study.

Martínez-Laguna, Daniel / Carbonell, Cristina / Bastida, José-Carlos / González, Milagros / Micó-Pérez, Rafael M / Vargas, Francisco / Balcells-Oliver, Mónica / Canals, Laura

Archives of osteoporosis

2022 Volume 17, Issue 1, Page(s) 93

Abstract: In Spanish primary care (PC), the prevalence of fragility fractures (FF) in subjects ≥ 70 years old is high, especially in women. One-third of subjects with an FF lacked osteoporosis (OP) diagnosis and >50% were not currently receiving OP medication. An ... ...

Abstract	In Spanish primary care (PC), the prevalence of fragility fractures (FF) in subjects ≥ 70 years old is high, especially in women. One-third of subjects with an FF lacked osteoporosis (OP) diagnosis and >50% were not currently receiving OP medication. An improvement of the FF management in this population is needed. Purpose: In Spanish PC, the prevalence of FF is high, especially in women. One-third of subjects with a FF lacked an OP diagnosis and more than half were not currently receiving OP medication. Several studies reported underdiagnosis/undertreatment of OP in PC among elderly subjects with FF. To date, no such data exist for Spain. The purpose is to estimate the prevalence of FF in the elderly population (≥ 70 years old) and to describe the characteristics, risk factors, comorbidities, and OP diagnosis and treatment rates of subjects with FF in Spanish PC centers. Methods: This is an observational, retrospective study in Spain consisting of two phases. Phase A included all subjects ≥ 70 years old listed in the center's medical records from November 2018 to March 2020. Phase B included subjects with FF and prior consultation at the center for any reason. Subjects were excluded only if they had previously participated in another study. Primary outcomes were prevalence of FF (phase A) and characteristics of subjects with at least one FF (phase B). Results: The overall prevalence of FF was 17.7% among subjects visiting medical centers for any reason (24.1% women vs. 8.0% men) (30 PC centers from 14 Spanish regions). Vertebral (5.1%) was the most prevalent fracture. Of 665 subjects in phase B, most (87%) were women and ≥ 80 years old (57%), suffered mainly major OP fracture (68%), and had multiple comorbidities (≥ 2, 89.2%). While two-thirds had OP diagnosis and 61.1% received OP medication anytime in the past, 56.8% were not currently receiving OP medication. Diagnosis and treatment rates were lower among men (43% and 38% vs. 70% and 65%, respectively). Conclusion: Prevalence of FF was high, especially in women. One-third of subjects lacked OP diagnosis and ≥ 50% were not receiving OP treatment; diagnosis and treatment gaps were larger among men. This reinforces the need to improve the management of FF in the elderly population. However, as PC centers participating in this study had high OP experience that have the potential to do better in terms of diagnosis and treatment, caution in the generalization of these data should be taken.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Osteoporosis/drug therapy ; Osteoporosis/epidemiology ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/therapy ; Prevalence ; Primary Health Care ; Retrospective Studies
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-022-01124-7
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Article ; Online: Prevalence and treatment of fragility fractures in Spanish primary care: PREFRAOS study

Martínez-Laguna, Daniel / Carbonell, Cristina / Bastida, José-Carlos / González, Milagros / Micó-Pérez, Rafael M. / Vargas, Francisco / Balcells-Oliver, Mónica / Canals, Laura

Arch Osteoporos. 2022 Dec., v. 17, no. 1, p. 93

2022 , Page(s) 93

Institution	on behalf of the PREFRAOS Group
Abstract	In Spanish primary care (PC), the prevalence of fragility fractures (FF) in subjects ≥ 70 years old is high, especially in women. One-third of subjects with an FF lacked osteoporosis (OP) diagnosis and >50% were not currently receiving OP medication. An improvement of the FF management in this population is needed. PURPOSE: In Spanish PC, the prevalence of FF is high, especially in women. One-third of subjects with a FF lacked an OP diagnosis and more than half were not currently receiving OP medication. Several studies reported underdiagnosis/undertreatment of OP in PC among elderly subjects with FF. To date, no such data exist for Spain. The purpose is to estimate the prevalence of FF in the elderly population (≥ 70 years old) and to describe the characteristics, risk factors, comorbidities, and OP diagnosis and treatment rates of subjects with FF in Spanish PC centers. METHODS: This is an observational, retrospective study in Spain consisting of two phases. Phase A included all subjects ≥ 70 years old listed in the center’s medical records from November 2018 to March 2020. Phase B included subjects with FF and prior consultation at the center for any reason. Subjects were excluded only if they had previously participated in another study. Primary outcomes were prevalence of FF (phase A) and characteristics of subjects with at least one FF (phase B). RESULTS: The overall prevalence of FF was 17.7% among subjects visiting medical centers for any reason (24.1% women vs. 8.0% men) (30 PC centers from 14 Spanish regions). Vertebral (5.1%) was the most prevalent fracture. Of 665 subjects in phase B, most (87%) were women and ≥ 80 years old (57%), suffered mainly major OP fracture (68%), and had multiple comorbidities (≥ 2, 89.2%). While two-thirds had OP diagnosis and 61.1% received OP medication anytime in the past, 56.8% were not currently receiving OP medication. Diagnosis and treatment rates were lower among men (43% and 38% vs. 70% and 65%, respectively). CONCLUSION: Prevalence of FF was high, especially in women. One-third of subjects lacked OP diagnosis and ≥ 50% were not receiving OP treatment; diagnosis and treatment gaps were larger among men. This reinforces the need to improve the management of FF in the elderly population. However, as PC centers participating in this study had high OP experience that have the potential to do better in terms of diagnosis and treatment, caution in the generalization of these data should be taken.
Keywords	drug therapy ; elderly ; osteoporosis ; retrospective studies ; risk ; Spain
Language	English
Dates of publication	2022-12
Size	p. 93
Publishing place	Springer London
Document type	Article ; Online
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-022-01124-7
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Article ; Online: Validation of gout diagnosis in electronic primary care medical records: A population-based study.

Pou, Maria A / Martinez-Laguna, Daniel / Estebanez, Jose L / Aivar, Meritxell / Gayarre, Raquel / Conesa, Angels / Hoyo, Jordi / Carbonell, Cristina / Reyes, Carlen / Diaz-Torne, Cesar

Joint bone spine

2023 Volume 90, Issue 6, Page(s) 105628

Abstract: Objective: The main objective of the study was to see the concordance between the diagnosis of gout recorded in primary care electronic medical records and the ACR/EULAR 2015 classification criteria.: Methods: A cross-sectional study was conducted ... ...

Abstract	Objective: The main objective of the study was to see the concordance between the diagnosis of gout recorded in primary care electronic medical records and the ACR/EULAR 2015 classification criteria. Methods: A cross-sectional study was conducted using electronic medicals records in 7 primary care centres of Barcelona. Patients' data to study clinical diagnose and management was gathered from the primary care electronic medical records of the Catalonian health institute (Institut Català de la Salut, ICS) and phone interview. Patients were considered to have gout if they scored 8 or more points on the EULAR/ACR 2015 classification criteria for gout. Results: In total, 70.9% of the patients with a gout diagnosis met ACR/EULAR 2015 criteria. Adding a hyperuricemia in a blood test in the EMR increased the percentage to 78.9%. 29.8% of the gout patients were not receiving urate-lowering therapy. 62.3% of the treated patients did not achieve the target uricemia (< 6mg/dL). Conclusions: The majority of gout patients from primary care electronic medical records fulfil ACR/EULAR gout criteria. This database can be used for observational studies. In most of the gout patients the urate target was not achieved.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Electronic Health Records ; Electronics ; Gout/diagnosis ; Gout/drug therapy ; Gout/epidemiology ; Gout Suppressants ; Primary Health Care ; Uric Acid
Chemical Substances	Gout Suppressants ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2023-08-25
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2023.105628
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Article ; Online: Clinical features of paediatric and adult autoimmune encephalitis: A multicenter sample.

Roliz, Annie / Shah, Yash / Morse, Anne / Troester, Matthew / Lynch, Rebecca / Pickle, Jacob / Karkare, Shefali / Fernandez-Carbonell, Cristina / Kothare, Sanjeev

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2021 Volume 30, Page(s) 82–87

Abstract: Background: Autoimmune encephalitis (AE) is a heterogeneous class of inflammatory diseases of the brain that can present with a wide spectrum of neuropsychiatric symptoms. Patients may be negative for CSF anti-neuronal antibodies, which can make the ... ...

Abstract	Background: Autoimmune encephalitis (AE) is a heterogeneous class of inflammatory diseases of the brain that can present with a wide spectrum of neuropsychiatric symptoms. Patients may be negative for CSF anti-neuronal antibodies, which can make the diagnosis of AE challenging. Distinguishing features between paediatric and adult patients with AE are not well characterized. Objective: Describe the clinical presentation, seizure type, EEG and sleep patterns in paediatric and adult patients with AE. Methods/design: Retrospective review of clinical data from paediatric and adult patients diagnosed with AE from three medical centers between 1/2008-12/2019. Results: We included 100 patients with AE, including 65 children. Median age at presentation was 14 years (1-88years). Fifty-five patients had positive CSF autoantibody results (NMDAR 36%, VGKC Ab 10%, anti-GAD65 4%, miscellaneous 3%), and 47 patients were autoantibody-negative. Paediatric patients were more likely to present with psychiatric symptoms, focal seizures and/or status epilepticus, and sleep disturbances compared to adult patients (p < 0.05). There was a higher incidence of NMDA-R encephalitis in children compared to adults. Conclusion: Paediatric patients with AE were more likely to present with psychiatric symptoms, sleep disturbances, focal seizures, and/or status epilepticus compared to adults (p < 0.05). Insomnia and hypersomnia are common sleep problems associated with AE that should be screened early in the diagnostic evaluation. Further studies can be performed to explore the relationship between sleep disturbances and long-term cognitive effects and the incidence of chronic epilepsy in this subset of patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autoimmune Diseases/complications ; Autoimmune Diseases/immunology ; Autoimmune Diseases/physiopathology ; Child ; Child, Preschool ; Encephalitis/complications ; Encephalitis/immunology ; Encephalitis/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2021-01-07
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2021.01.001
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Crimean-Congo Hemorrhagic Fever, Spain, 2013-2021.

Lorenzo Juanes, Helena Miriam / Carbonell, Cristina / Sendra, Begoña Febrer / López-Bernus, Amparo / Bahamonde, Alberto / Orfao, Alberto / Lista, Carmen Vieira / Ledesma, María Sánchez / Negredo, Ana Isabel / Rodríguez-Alonso, Beatriz / Bua, Beatriz Rey / Sánchez-Seco, María Paz / Muñoz Bellido, Juan Luis / Muro, Antonio / Belhassen-García, Moncef

Emerging infectious diseases

2023 Volume 29, Issue 2, Page(s) 252–259

Abstract: Crimean-Congo hemorrhagic fever (CCHF) is a viral infectious disease for which distribution of the main vector, Hyalomma spp. ticks, is expanding. We analyzed all 10 cases of CCHF diagnosed in Spain during 2013-2021; case-patient median age was 56.5 ... ...

Abstract	Crimean-Congo hemorrhagic fever (CCHF) is a viral infectious disease for which distribution of the main vector, Hyalomma spp. ticks, is expanding. We analyzed all 10 cases of CCHF diagnosed in Spain during 2013-2021; case-patient median age was 56.5 years, and 7 were men. We identified CCHF virus genotypes III and V. Six case-patients acquired the infection in urban areas. Sixty percent of patients were infected in summer and 40% in spring. Two patients met criteria for hemophagocytic syndrome. Seven patients survived. The epidemiologic pattern of CCHF in Spain is based on occasional cases with an elevated mortality rate. Genotype III and, to a less extent also genotype V, CCHF circulates in humans in a common geographic area in Spain. Those data suggest that the expansion pathways are complex and may change over time. Physicians should remain alert to the possibility of new CCHF cases.
MeSH term(s)	Animals ; Male ; Humans ; Middle Aged ; Female ; Hemorrhagic Fever, Crimean/diagnosis ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Spain/epidemiology ; Ticks ; Ixodidae
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2902.220677
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Article: Adverse Effects in Patients with Intellectual and Developmental Disabilities Hospitalized at the University Clinical Hospital.

Alonso-Sardón, Montserrat / Sáez-Lorenzo, María / Chamorro, Antonio Javier / Fernández-Martín, Luz Celia / Iglesias-de-Sena, Helena / González-Núñez, Verónica / Santos-Sánchez, José Ángel / Carbonell, Cristina / Lorenzo-Gómez, María Fernanda / Mirón-Canelo, José Antonio

Journal of personalized medicine

2022 Volume 12, Issue 11

Abstract: 1) Background: Providing the patient with the health care they need in a personalized and appropriate manner and without adverse effects (AEs) is a part of quality of care and patient safety. The aim of this applied research project was the assessment ... ...

Abstract	(1) Background: Providing the patient with the health care they need in a personalized and appropriate manner and without adverse effects (AEs) is a part of quality of care and patient safety. The aim of this applied research project was the assessment of AEs as a clinical risk in patients with high social vulnerability such as persons with intellectual and developmental disabilities (PwIDD). (2) Methods: A retrospective epidemiological cohort study was performed on exposed and unexposed groups (the control group) in order to estimate the incidence of AEs in PwIDDs and assess their importance for this category of patients. (3) Results: AEs were observed with a frequency of 30.4% (95% CI) in the PwIDD exposed group, with significant differences to the unexposed group (
Language	English
Publishing date	2022-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12111898
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Article ; Online: Increasing Incidence of mucormycosis in Spanish inpatients from 1997 to 2018.

Parra Fariñas, Raúl / Alonso-Sardón, Montserrat / Velasco-Tirado, Virginia / Pérez, Inmaculada Galindo / Carbonell, Cristina / Álvarez Artero, Elisa / Romero-Alegría, Ángela / Pardo-Lledías, Javier / Belhassen-García, Moncef

Mycoses

2022 Volume 65, Issue 3, Page(s) 344–353

Abstract: Background: Mucormycosis is a worldwide angio-invasive fungal infection that is associated with high morbidity and mortality. A few European studies have focused on the epidemiology.: Methodology: A retrospective longitudinal descriptive study was ... ...

Abstract	Background: Mucormycosis is a worldwide angio-invasive fungal infection that is associated with high morbidity and mortality. A few European studies have focused on the epidemiology. Methodology: A retrospective longitudinal descriptive study was performed with inpatients diagnosed with mucormycosis (ICD-9-CM, code 117.7, cases 1997-2015; and ICD-10, code B46, cases 2016-2018; along with length of hospital stay) in Spanish public hospitals between 1 January 1997 and 31 December 2018. Data were obtained from the Minimum Basic Data Set (CMBD in Spanish). Principal findings: A total of 962 patients were recorded; 665 were men. The mean age (±SD) was 55 ± 18.8 years. The annual incidence rate increased from 0.74 to 1.24 cases per million person-years. The lethality rate was 31.3%. Renal failure (41.6%) and haematological malignancy (36.3%) were the main factors involved. Conclusions: Mucormycosis is a rare infectious disease in Spain, but it has had a significantly increased incidence in the last two decades. Being an adult male and having diabetes, neoplasm or renal failure are the main factors associated. High mortality is usually associated mainly with haematological malignancy and renal failure. CMBD studies could be an efficient tool for assessing changes in the epidemiology of mucormycosis.
MeSH term(s)	Adult ; Aged ; Humans ; Incidence ; Inpatients ; Male ; Middle Aged ; Mucormycosis/diagnosis ; Retrospective Studies ; Spain/epidemiology
Language	English
Publishing date	2022-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13418
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