LIVIVO - Search results -

Search results

Result 1 - 10 of total 48

Search options

Article ; Online: Proposal for antimicrobial therapy stewardship of lower respiratory tract infection in mechanically-ventilated patients based upon the Biofire® Filmarray® Pneumonia Plus panel results.

Clari, Mª Ángeles / Carbonell, Nieves / Albert, Eliseo / Navarro, David

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 8, Page(s) 521–523

MeSH term(s)	Humans ; Respiration, Artificial ; Respiratory Tract Infections/drug therapy ; Bacteria ; Pneumonia ; Anti-Infective Agents
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2023-10-15
Publishing country	Spain
Document type	Case Reports ; Letter
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2023.04.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Initial SARS-CoV-2 RNA load in nasopharyngeal specimens is not associated with severity and midterm resolution of pneumonia in COVID-19 patients.

Costa, Rosa / Signes-Costa, Jaime / Olea, Beatriz / Tarraso, Julia / Carbonell, Nieves / Blasco, María Luisa / Navarro, David

The Journal of infection

2022 Volume 85, Issue 6, Page(s) 702–769

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; RNA, Viral/genetics ; Nasopharynx ; COVID-19 Testing ; Viral Load
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.10.031
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 48: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Biofire® Filmarray® Pneumonia Plus panel for management of lower respiratory tract infection in mechanically-ventilated patients in the COVID-19 era: a diagnostic and cost-benefit evaluation.

Ferrer, Josep / Clari, María Ángeles / Giménez, Estela / Carbonell, Nieves / Torres, Ignacio / Blasco, María Luisa / Albert, Eliseo / Navarro, David

Diagnostic microbiology and infectious disease

2022 Volume 105, Issue 2, Page(s) 115847

Abstract: We assessed the diagnostic performance of the Biofire® Filmarray® Pneumonia Plus panel (FA-PP) compared to standard culture in Intensive Care Unit patients with suspected ventilator-associated lower respiratory tract infection in the COVID-19 era. We ... ...

Abstract	We assessed the diagnostic performance of the Biofire® Filmarray® Pneumonia Plus panel (FA-PP) compared to standard culture in Intensive Care Unit patients with suspected ventilator-associated lower respiratory tract infection in the COVID-19 era. We determined whether its implementation in routine diagnostic algorithms would be cost-beneficial from a hospital perspective. Of 163 specimens, 96 (59%) returned negative results with FA-PP and conventional culture, and 29 specimens (17.8%) were positive with both diagnostic methods and yielded concordant qualitative bacterial identification/isolation. Thirty-nine specimens (23.9%) gave discordant results (positive via FA-PP and negative via culture). Real-life adjustments of empirical antimicrobial therapy (EAT) after FA-PP results resulted in additional costs beyond EAT alone of 1868.7 €. Adequate EAT adjustments upon FA-PP results would have resulted in a saving of 6675.8 €. In conclusion, the data presented supports the potential utility of FA-PP for early EAT adjustment in patients with ventilator-associated lower respiratory tract infection.
MeSH term(s)	Humans ; Bacteria ; COVID-19 ; Respiration, Artificial ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/microbiology ; Anti-Infective Agents ; COVID-19 Testing
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115847
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1845: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: May it help to predict clinical outcomes?

Forqué, Lorena / Albert, Eliseo / Giménez, Estela / Torres, Ignacio / Carbonell, Nieves / Ferreres, José / Blasco, María Luisa / Navarro, David

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2022 Volume 148, Page(s) 105082

Abstract: Background: Torque teno virus (TTV) DNA load in plasma directly associates with the net state of immunosuppression and inflammation in different clinical settings, including transplantation and chronic inflammatory diseases.: Objectives: We ... ...

Abstract	Background: Torque teno virus (TTV) DNA load in plasma directly associates with the net state of immunosuppression and inflammation in different clinical settings, including transplantation and chronic inflammatory diseases. Objectives: We investigated whether plasma TTV DNA load may predict the occurrence of certain infectious events and overall mortality in critically ill COVID-19 patients. Patients and methods: 50 patients (median age, 65.5 years) were recruited. TTV DNA load was quantitated in serial plasma specimens by real-time PCR. Serum levels of interleukin-6, C-reactive protein, ferritin, lactate dehydrogenase, Gamma-Glutamyl Transferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST) and absolute lymphocyte counts (ALC) in paired specimens were available. Nosocomial bloodstream infections and ventilator-associated pneumonia and overall mortality were the clinical outcomes. Results: TTV DNA was detected in 38 patients (76%). A weak inverse correlation (Rho=-0.28; P = 0.004) was observed between TTV DNA loads and ALC. No direct correlation was found between TTV DNA load and serum levels of any of the above biomarkers. Patients with detectable TTV DNA had an increased risk of subsequently developing infectious events (HR 9.28; 95% CI, 1.29-69.5; P = 0.03). A trend (P = 0.05) towards higher TTV DNA area under a curve between days 7 and 17 after ICU admission (AUC Conclusion: Our findings suggested that plasma TTV DNA load monitoring may be helpful for predicting the occurrence of severe nosocomial infections and mortality in critically ill COVID-19 patients.
MeSH term(s)	Aged ; COVID-19 ; Critical Illness ; DNA Virus Infections ; DNA, Viral ; Humans ; SARS-CoV-2 ; Torque teno virus/genetics ; Viral Load
Chemical Substances	DNA, Viral
Language	English
Publishing date	2022-01-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2022.105082
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3790: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients.

Beltrán-García, Jesús / Casabó-Vallés, Germán / Osca-Verdegal, Rebeca / Navarrete-López, Paula / Rodriguez-Gimillo, María / Nacher-Sendra, Elena / Ferrando-Sánchez, Carolina / García-López, Eva / Pallardó, Federico V / Carbonell, Nieves / Mena-Mollá, Salvador / García-Giménez, José Luis

Frontiers in immunology

2024 Volume 14, Page(s) 1333705

Abstract: Introduction: Sepsis patients experience a complex interplay of host pro- and anti-inflammatory processes which compromise the clinical outcome. Despite considering the latest clinical and scientific research, our comprehension of the immunosuppressive ... ...

Abstract	Introduction: Sepsis patients experience a complex interplay of host pro- and anti-inflammatory processes which compromise the clinical outcome. Despite considering the latest clinical and scientific research, our comprehension of the immunosuppressive events in septic episodes remains incomplete. Additionally, a lack of data exists regarding the role of epigenetics in modulating immunosuppression, subsequently impacting patient survival. Methods: To advance the current understanding of the mechanisms underlying immunosuppression, in this study we explored the dynamics of DNA methylation using the Infinium Methylation EPIC v1.0 BeadChip Kit in leukocytes from patients suffering from sepsis, septic shock, and critically ill patients as controls, within the first 24 h after admission in the Intensive Care Unit of a tertiary hospital. Results and discussion: Employing two distinct analysis approaches (DMRcate and mCSEA) in comparing septic shock and critically ill patients, we identified 1,256 differentially methylated regions (DMRs) intricately linked to critical immune system pathways. The examination of the top 100 differentially methylated positions (DMPs) between septic shock and critically ill patients facilitated a clear demarcation among the three patient groups. Notably, the top 6,657 DMPs exhibited associations with organ dysfunction and lactate levels. Among the individual genes displaying significant differential methylation, IL10, TREM1, IL1B, and TNFAIP8 emerged with the most pronounced methylation alterations across the diverse patient groups when subjected to DNA bisulfite pyrosequencing analysis. These findings underscore the dynamic nature of DNA methylation profiles, highlighting the most pronounced alterations in patients with septic shock, and revealing their close association with the disease.
MeSH term(s)	Humans ; Shock, Septic/genetics ; Epigenome ; Critical Illness ; Sepsis/genetics ; Sepsis/diagnosis ; Phenotype ; Leukocytes ; Immunosuppression Therapy
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1333705
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation.

Cánovas-Cervera, Irene / Nacher-Sendra, Elena / Osca-Verdegal, Rebeca / Dolz-Andrés, Enric / Beltrán-García, Jesús / Rodríguez-Gimillo, María / Ferrando-Sánchez, Carolina / Carbonell, Nieves / García-Giménez, José Luis

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are ... ...

Abstract	Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further studied. Specifically, the relationship between the coagulation cascade and non-coding RNAs should be established. In this review, microRNAs, long non-coding RNAs, and circular RNAs are studied in relation to DIC. Specifically, the axis between these non-coding RNAs and the corresponding affected pathway has been identified, including inflammation, alteration of the coagulation cascade, and endothelial damage. The main affected pathway identified is PI3K/AKT/mTOR axis, where several ncRNAs participate in its regulation, including miR-122-5p which is sponged by circ_0005963, ciRS-122, and circPTN, and miR-19a-3p which is modulated by circ_0000096 and circ_0063425. Additionally, both miR-223 and miR-24 were found to affect the PI3K/AKT pathway and were regulated by lncGAS5 and lncKCNQ1OT1, respectively. Thus, this work provides a useful pipeline of inter-connected ncRNAs that future research on their impact on DIC can further explore.
MeSH term(s)	Humans ; Disseminated Intravascular Coagulation/genetics ; Proto-Oncogene Proteins c-akt ; Phosphatidylinositol 3-Kinases ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Biomarkers ; Sepsis/complications ; Sepsis/genetics ; Inflammation/genetics
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032582
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Update on the management of intra-abdominal Candida infections.

Calabuig, Eva / Camarena, Juan J / Carbonell, Nieves

Revista iberoamericana de micologia

2017 Volume 34, Issue 3, Page(s) 127–129

Language	English
Publishing date	2017-07
Publishing country	Spain
Document type	Journal Article
ISSN	2173-9188
ISSN (online)	2173-9188
DOI	10.1016/j.riam.2017.02.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Multicentre study of cefiderocol for treatment of Gram-negative bacteria infections in critically ill patients.

Balandín, Bárbara / Pintado, Vicente / Pérez-Pedrero, María José / Martínez-Sagasti, Fernando / Sancho-González, Milagros / Soriano-Cuesta, Cruz / Gesso, Cristina Martín-Dal / Chicot, Marta / de Luna, Rafael Ruiz / Asensio-Martín, María José / Catalan, Mercedes / Díaz-Díaz, Juan José / Carbonell, Nieves / Iranzo, Reyes / Royuela, Ana / Ballesteros, Daniel

International journal of antimicrobial agents

2024 Volume 63, Issue 5, Page(s) 107121

MeSH term(s)	Humans ; Critical Illness ; Anti-Bacterial Agents/therapeutic use ; Cefiderocol ; Cephalosporins/therapeutic use ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Male ; Middle Aged ; Aged ; Female ; Gram-Negative Bacteria/drug effects ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Cefiderocol (SZ34OMG6E8) ; Cephalosporins
Language	English
Publishing date	2024-02-24
Publishing country	Netherlands
Document type	Letter ; Multicenter Study
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107121
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients.

García-Giménez, José Luis / García-López, Eva / Mena-Mollá, Salvador / Beltrán-García, Jesús / Osca-Verdegal, Rebeca / Nacher-Sendra, Elena / Aguado-Velasco, Carmen / Casabó-Vallés, Germán / Romá-Mateo, Carlos / Rodriguez-Gimillo, María / Antúnez, Oreto / Ferreres, José / Pallardó, Federico V / Carbonell, Nieves

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 344

Abstract: Background: As leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern. Proactive biomarker identification in patients with sepsis suspicion at any time remains a daunting challenge ...

Abstract	Background: As leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern. Proactive biomarker identification in patients with sepsis suspicion at any time remains a daunting challenge for hospitals. Despite great progress in the understanding of clinical and molecular aspects of sepsis, its definition, diagnosis, and treatment remain challenging, highlighting a need for new biomarkers with potential to improve critically ill patient management. In this study we validate a quantitative mass spectrometry method to measure circulating histone levels in plasma samples for the diagnosis and prognosis of sepsis and septic shock patients. Methods: We used the mass spectrometry technique of multiple reaction monitoring to quantify circulating histones H2B and H3 in plasma from a monocenter cohort of critically ill patients admitted to an Intensive Care Unit (ICU) and evaluated its performance for the diagnosis and prognosis of sepsis and septic shock (SS). Results: Our results highlight the potential of our test for early diagnosis of sepsis and SS. H2B levels above 121.40 ng/mL (IQR 446.70) were indicative of SS. The value of blood circulating histones to identify a subset of SS patients in a more severe stage with associated organ failure was also tested, revealing circulating levels of histones H2B above 435.61 ng/ml (IQR 2407.10) and H3 above 300.61 ng/ml (IQR 912.77) in septic shock patients with organ failure requiring invasive organ support therapies. Importantly, we found levels of H2B and H3 above 400.44 ng/mL (IQR 1335.54) and 258.25 (IQR 470.44), respectively in those patients who debut with disseminated intravascular coagulation (DIC). Finally, a receiver operating characteristic curve (ROC curve) demonstrated the prognostic value of circulating histone H3 to predict fatal outcomes and found for histone H3 an area under the curve (AUC) of 0.720 (CI 0.546-0.895) p < 0.016 on a positive test cut-off point at 486.84 ng/mL, showing a sensitivity of 66.7% and specificity of 73.9%. Conclusions: Circulating histones analyzed by MS can be used to diagnose SS and identify patients at high risk of suffering DIC and fatal outcome.
MeSH term(s)	Humans ; Histones ; Shock, Septic ; Critical Illness ; Prognosis ; Early Diagnosis ; Sepsis ; Mass Spectrometry
Chemical Substances	Histones
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04197-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: "CAPA in Progress": A New Real-Life Approach for the Management of Critically Ill COVID-19 Patients.

Carbonell, Nieves / Alcaráz, María Jesús / Serrano-Lázaro, Ainhoa / Rodríguez-Gimillo, María / Sánchez Ramos, David / Ros, Francisco / Ferrer, Josep / Blasco, María Luisa / Navarro, David / Clari, María Ángeles

Biomedicines

2022 Volume 10, Issue 7

Abstract: 1) Background: COVID-19-associated pulmonary aspergillosis (CAPA) has worsened the prognosis of patients with pneumonia and acute respiratory distress syndrome admitted to the intensive care unit (ICU). The lack of specific diagnosis criteria is an ... ...

Abstract	(1) Background: COVID-19-associated pulmonary aspergillosis (CAPA) has worsened the prognosis of patients with pneumonia and acute respiratory distress syndrome admitted to the intensive care unit (ICU). The lack of specific diagnosis criteria is an obstacle to the timely initiation of appropriate antifungal therapy. Tracheal aspirate (TA) has been employed under special pandemic conditions. Galactomannan (GM) antigens are released during active fungal growth. (2) Methods: We proposed the term "CAPA in progress" (CAPA-IP) for diagnosis at an earlier stage by GM testing on TA in a specific population admitted to ICU presenting with clinical deterioration. A GM threshold ≥0.5 was set as the mycological inclusion criterion. This was followed by a pre-emptive short-course antifungal. (3) Results: We prospectively enrolled 200 ICU patients with COVID-19. Of these, 164 patients (82%) initially required invasive mechanical ventilation and GM was tested in TA in 93 patients. A subset of 19 patients (11.5%) fulfilled the CAPA-IP criteria at a median of 9 days after ICU admittance. The median GM value was 3.25 ± 2.82. CAPA-IP cases showed significantly higher ICU mortality [52.6% (10/19) vs. 34.5% (50/145),
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10071683
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito