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  1. Book ; Online: Chapter Venere e Cupido di palazzo Pandolfini a Firenze: una scultura inedita di Chiarissimo Fancelli

    Cardini, Agnese

    (Studi e saggi)

    2020  

    Series title Studi e saggi
    Keywords Florentine sculpture ; Pandolfini Palace ; Venus ; Chiarissimo Fancelli
    Language 0|e
    Size 1 electronic resource (9 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021614803
    ISBN 9788855181815 ; 8855181815
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Modern morphometrics and the study of population differences: Good data behind clever analyses and cool pictures?

    Cardini, Andrea

    Anatomical record (Hoboken, N.J. : 2007)

    2020  Volume 303, Issue 11, Page(s) 2747–2765

    Abstract: The study of phenotypic variation in time and space is central to evolutionary biology. Modern geometric morphometrics is the leading family of methods for the quantitative analysis of biological forms. This set of techniques relies heavily on ... ...

    Abstract The study of phenotypic variation in time and space is central to evolutionary biology. Modern geometric morphometrics is the leading family of methods for the quantitative analysis of biological forms. This set of techniques relies heavily on technological innovation for data acquisition, often in the form of 2D or 3D digital images, and on powerful multivariate statistical tools for their analysis. However, neither the most sophisticated device for computerized imaging nor the best statistical test can produce accurate, robust and reproducible results, if it is not based on really good samples and an appropriate use of the 'measurements' extracted from the data. Using examples mostly from my own work on mammal craniofacial variation and museum specimens, I will show how easy it is to forget these most basic assumptions, while focusing heavily on analytical and visualization methods, and much less on the data that generate potentially powerful analyses and visually appealing diagrams.
    MeSH term(s) Animals ; Biological Evolution ; Biological Variation, Population ; Biometry ; Humans ; Phenotype
    Language English
    Publishing date 2020-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Corrigendum to "How flat can a horse be? Exploring 2D approximations of 3D crania in equids" [Zoology 139 (2020) 125746].

    Cardini, Andrea / Chiapelli, Marika

    Zoology (Jena, Germany)

    2021  Volume 148, Page(s) 125914

    Language English
    Publishing date 2021-04-10
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1191401-4
    ISSN 1873-2720 ; 0944-2006
    ISSN (online) 1873-2720
    ISSN 0944-2006
    DOI 10.1016/j.zool.2021.125914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: (with research data) Lost in the Other Half: Improving Accuracy in Geometric Morphometric Analyses of One Side of Bilaterally Symmetric Structures.

    Cardini, Andrea

    Systematic biology

    2016  Volume 65, Issue 6, Page(s) 1096–1106

    Abstract: Systematists and evolutionary biologists have widely adopted Procrustes-based geometric morphometrics for measuring size and shape in biology. Many structures, and in fact most animals, are bilaterally symmetric with an internal plane of symmetry (also ... ...

    Abstract Systematists and evolutionary biologists have widely adopted Procrustes-based geometric morphometrics for measuring size and shape in biology. Many structures, and in fact most animals, are bilaterally symmetric with an internal plane of symmetry (also called object symmetry). Often, when quantifying asymmetric variation is not an aim, only one or the other side is measured and analyzed. This approach has been used in hundreds of studies. Its implicit assumption is that the information on the other side is redundant and a single side will, therefore, produce results mirroring those one would have obtained from the analysis of the entire structure with all its left and right landmarks. However, the extent to which this assumption is met has, to my knowledge, never been explored. Using two example data sets, I will show that congruence may be high in analyses at a macroevolutionary level but much lower at a microevolutionary one, and inaccuracies might especially affect shape. I will discuss some of the other factors that may influence results and will suggest a simple expedient that can improve both the visualization and accuracy of shape analyses in one-side-only studies.
    MeSH term(s) Animal Structures/anatomy & histology ; Animals ; Biological Evolution ; Body Size ; Classification/methods ; Phylogeny
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1482572-7
    ISSN 1076-836X ; 1063-5157
    ISSN (online) 1076-836X
    ISSN 1063-5157
    DOI 10.1093/sysbio/syw043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: How flat can a horse be? Exploring 2D approximations of 3D crania in equids.

    Cardini, Andrea / Chiapelli, Marika

    Zoology (Jena, Germany)

    2020  Volume 139, Page(s) 125746

    Abstract: Quantitative analyses of morphological variation using geometric morphometrics are often performed on 2D photos of 3D structures. It is generally assumed that the error due to the flattening of the third dimension is negligible. However, despite hundreds ...

    Abstract Quantitative analyses of morphological variation using geometric morphometrics are often performed on 2D photos of 3D structures. It is generally assumed that the error due to the flattening of the third dimension is negligible. However, despite hundreds of 2D studies, few have actually tested this assumption and none has done it on large animals, such as those typically classified as megafauna. We explore this issue in living equids, focusing on ventral cranial variation at both micro- and macro-evolutionary levels. By comparing 2D and 3D data, we found that size is well approximated, whereas shape is more strongly impacted by 2D inaccuracies, as it is especially evident in intra-specific analyses. The 2D approximation improves when shape differences are larger, as in macroevolution, but even at this level precise inter-individual similarity relationships are altered. Despite this, main patterns of sex, species and allometric variation in 2D were the same as in 3D, thus suggesting that 2D may be a source of 'noise' that does not mask the main signal in the data. However, the picture that emerges from this and other recent studies on 2D approximation of 3D structures is complex and any generalization premature. Morphometricians should therefore test the appropriateness of 2D using preliminary investigations in relation to the specific study questions in their own samples. We discuss whether this might be feasible using a reduced landmark configuration and smaller samples, which would save time and money. In an exploratory analysis, we found that in equids results seem robust to sampling, but become less precise and, with fewer landmarks, may slightly overestimate 2D inaccuracies.
    MeSH term(s) Animals ; Equidae/anatomy & histology ; Female ; Male ; Skull/anatomy & histology ; Skull/diagnostic imaging ; Species Specificity
    Language English
    Publishing date 2020-01-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1191401-4
    ISSN 1873-2720 ; 0944-2006
    ISSN (online) 1873-2720
    ISSN 0944-2006
    DOI 10.1016/j.zool.2020.125746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Can morphotaxa be assessed with photographs? Estimating the accuracy of two-dimensional cranial geometric morphometrics for the study of threatened populations of African monkeys.

    Cardini, Andrea / de Jong, Yvonne A / Butynski, Thomas M

    Anatomical record (Hoboken, N.J. : 2007)

    2021  Volume 305, Issue 6, Page(s) 1402–1434

    Abstract: The classification of most mammalian orders and families is under debate and the number of species is likely greater than currently recognized. Improving taxonomic knowledge is crucial, as biodiversity is in rapid decline. Morphology is a source of ... ...

    Abstract The classification of most mammalian orders and families is under debate and the number of species is likely greater than currently recognized. Improving taxonomic knowledge is crucial, as biodiversity is in rapid decline. Morphology is a source of taxonomic knowledge, and geometric morphometrics applied to two dimensional (2D) photographs of anatomical structures is commonly employed for quantifying differences within and among lineages. Photographs are informative, easy to obtain, and low cost. 2D analyses, however, introduce a large source of measurement error when applied to crania and other highly three dimensional (3D) structures. To explore the potential of 2D analyses for assessing taxonomic diversity, we use patas monkeys (Erythrocebus), a genus of large, semi-terrestrial, African guenons, as a case study. By applying a range of tests to compare ventral views of adult crania measured both in 2D and 3D, we show that, despite inaccuracies accounting for up to one-fourth of individual shape differences, results in 2D almost perfectly mirror those in 3D. This apparent paradox might be explained by the small strength of covariation in the component of shape variance related to measurement error. A rigorous standardization of photographic settings and the choice of almost coplanar landmarks are likely to further improve the correspondence of 2D to 3D shapes. 2D geometric morphometrics is, thus, appropriate for taxonomic comparisons of patas ventral crania. Although it is too early to generalize, our results corroborate similar findings from previous research in mammals, and suggest that 2D shape analyses are an effective heuristic tool for morphological investigation of small differences.
    MeSH term(s) Animals ; Blacks ; Haplorhini ; Humans ; Mammals ; Skull/anatomy & histology ; Skull/diagnostic imaging
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Predicted and Measured Concentration of Pharmaceuticals in Surface Water of Areas with Increasing Anthropic Pressure: A Case Study in the Coastal Area of Central Italy

    Cardini, Alessio / Pellegrino, Elisa / Ercoli, Laura

    Water. 2021 Oct. 09, v. 13, no. 20

    2021  

    Abstract: This study investigated the occurrence of 12 pharmaceuticals (PhCs) in surface water in Central Italy, aiming to improve the estimation of the predicted environmental concentration (PEC) by normalizing the loads to the number of inhabitants of the ... ...

    Abstract This study investigated the occurrence of 12 pharmaceuticals (PhCs) in surface water in Central Italy, aiming to improve the estimation of the predicted environmental concentration (PEC) by normalizing the loads to the number of inhabitants of the drainage system in rural, periurban, and urban areas. We performed two sampling campaigns assessing the concentration of PhCs (measured environmental concentration (MEC)) in surface water and in effluent from a wastewater treatment plant. The reliability of PEC calculated by the refined formula was assessed and compared to the ratio obtained by the unrefined formula. MECs of diclofenac, estradiol, estrone, ibuprofen, metformin, naproxen, sulfamethoxazole, atenolol, carbamazepine, and dehydro-erythromycin were significantly higher in urban than in periurban and rural areas, and increases were 12-, 3600-, 256-, 33-, 18-, 120-, 10-, 5-, 2-, and 1-fold, respectively. Refinement of PEC improved estimation of PhC concentrations for all areas, especially for the urban one. The environmental risk was predicted as low for atenolol, carbamazepine, erythromycin, metformin, and naproxen; low/medium for diclofenac and ibuprofen; and high for clarithromycin, estradiol, estrone, and sulfamethoxazole. Overall, the highest risk was posed by PhCs in effluent, while a progressively decreasing risk was estimated for urban, periurban, and rural areas.
    Keywords anthropogenic activities ; case studies ; clarithromycin ; coasts ; diclofenac ; drainage systems ; estradiol ; estrone ; ibuprofen ; metformin ; risk ; sulfamethoxazole ; surface water ; wastewater treatment ; Italy
    Language English
    Dates of publication 2021-1009
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w13202807
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Author Correction: Larger mammals have longer faces because of size-related constraints on skull form.

    Cardini, Andrea / Polly, P David

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 4626

    Abstract: In Table 1 of this article, the descriptions of landmarks 14, 15, and 36 are incorrect. Landmarks 14 and 36 should read "Posterior extremity of occipital condyle along margin of foramen magnum" and landmark 15 should read "Opisthion". A correct version ... ...

    Abstract In Table 1 of this article, the descriptions of landmarks 14, 15, and 36 are incorrect. Landmarks 14 and 36 should read "Posterior extremity of occipital condyle along margin of foramen magnum" and landmark 15 should read "Opisthion". A correct version of Table 2 appears in the Author Correction associated with this article; the error has not been fixed in the original article.
    Language English
    Publishing date 2018-11-06
    Publishing country England
    Document type Published Erratum
    ISSN 2041-1723
    ISSN (online) 2041-1723
    DOI 10.1038/s41467-018-07156-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sexual differences in human cranial morphology: Is one sex more variable or one region more dimorphic?

    Milella, Marco / Franklin, Daniel / Belcastro, Maria Giovanna / Cardini, Andrea

    Anatomical record (Hoboken, N.J. : 2007)

    2021  Volume 304, Issue 12, Page(s) 2789–2810

    Abstract: The quantification of cranial sexual dimorphism (CSD) among modern humans is relevant in evolutionary studies of morphological variation and in a forensic context. Despite the abundance of quantitative studies of CSD, few have specifically examined intra- ...

    Abstract The quantification of cranial sexual dimorphism (CSD) among modern humans is relevant in evolutionary studies of morphological variation and in a forensic context. Despite the abundance of quantitative studies of CSD, few have specifically examined intra-sex variability. Here we quantify CSD in a geographically homogeneous sample of adult crania, which includes Italian individuals from the 19th and 20th centuries. Cranial morphology is described with 92 3D landmarks analyzed using Procrustean geometric morphometrics (PGMM). Size and shape variables are used to compare morphological variance between sexes in the whole cranium and four individual regions. The same variables, plus Procrustes form, are used to quantify average sex differences and explore classification accuracy. Our results indicate that: (a) as predicted by Wainer's rule, males present overall more variance in size and shape, albeit this is statistically significant only for total cranial size; (b) differences between sexes are dominated by size and to a lesser extent by Procrustes form; (c) shape only accounts for a minor proportion of variance; (d) the cranial base shows almost no dimorphism for shape; and (e) facial Procrustes form is the most accurate predictor of skeletal sex. Overall, this study suggests developmental factors underlying differences in CSD among cranial regions; stresses the need for population-specific models that describe craniofacial variation as the basis for models that facilitate the estimation of sex in unidentified skeletal remains; and provides one of the first confirmations of "Wainer's rule" in relation to sexual dimorphism in mammals specific to the human cranium.
    MeSH term(s) Female ; Humans ; Male ; Sex Characteristics ; Skull/anatomy & histology
    Language English
    Publishing date 2021-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Transcriptional Regulation of Genes Involved in Zinc Uptake, Sequestration and Redistribution Following Foliar Zinc Application to Medicago sativa

    Cardini, Alessio / Pellegrino, Elisa / White, Philip J / Mazzolai, Barbara / Mascherpa, Marco C / Ercoli, Laura

    Plants. 2021 Mar. 03, v. 10, no. 3

    2021  

    Abstract: Zinc (Zn) is an essential micronutrient for plants and animals, and Zn deficiency is a widespread problem for agricultural production. Although many studies have been performed on biofortification of staple crops with Zn, few studies have focused on ... ...

    Abstract Zinc (Zn) is an essential micronutrient for plants and animals, and Zn deficiency is a widespread problem for agricultural production. Although many studies have been performed on biofortification of staple crops with Zn, few studies have focused on forages. Here, the molecular mechanisms of Zn transport in alfalfa (Medicago sativa L.) were investigated following foliar Zn applications. Zinc uptake and redistribution between shoot and root were determined following application of six Zn doses to leaves. Twelve putative genes encoding proteins involved in Zn transport (MsZIP1-7, MsZIF1, MsMTP1, MsYSL1, MsHMA4, and MsNAS1) were identified and changes in their expression following Zn application were quantified using newly designed RT-qPCR assays. These assays are the first designed specifically for alfalfa and resulted in being more efficient than the ones already available for Medicago truncatula (i.e., MtZIP1-7 and MtMTP1). Shoot and root Zn concentration was increased following foliar Zn applications ≥ 0.1 mg plant⁻¹. Increased expression of MsZIP2, MsHMA4, and MsNAS1 in shoots, and of MsZIP2 and MsHMA4 in roots was observed with the largest Zn dose (10 mg Zn plant⁻¹). By contrast, MsZIP3 was downregulated in shoots at Zn doses ≥ 0.1 mg plant⁻¹. Three functional gene modules, involved in Zn uptake by cells, vacuolar Zn sequestration, and Zn redistribution within the plant, were identified. These results will inform genetic engineering strategies aimed at increasing the efficiency of crop Zn biofortification.
    Keywords Medicago sativa ; Medicago truncatula ; alfalfa ; biofortification ; genes ; transcription (genetics) ; vacuoles ; zinc
    Language English
    Dates of publication 2021-0303
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10030476
    Database NAL-Catalogue (AGRICOLA)

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