LIVIVO - Search results -

Search results

Result 1 - 10 of total 12

Search options

Article: Rekindling Action Language: A Neuromodulatory Study on Parkinson's Disease Patients.

Suárez-García, Diana M A / Birba, Agustina / Zimerman, Máximo / Diazgranados, Jesús A / Lopes da Cunha, Pamela / Ibáñez, Agustín / Grisales-Cárdenas, Johan S / Cardona, Juan Felipe / García, Adolfo M

Brain sciences

2021 Volume 11, Issue 7

Abstract: Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson's disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be ... ...

Abstract	Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson's disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action-concept processing. On day 1, participants completed a picture-word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11070887
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases.

Birba, Agustina / Fittipaldi, Sol / Cediel Escobar, Judith C / Gonzalez Campo, Cecilia / Legaz, Agustina / Galiani, Agostina / Díaz Rivera, Mariano N / Martorell Caro, Miquel / Alifano, Florencia / Piña-Escudero, Stefanie D / Cardona, Juan Felipe / Neely, Alejandra / Forno, Gonzalo / Carpinella, Mariela / Slachevsky, Andrea / Serrano, Cecilia / Sedeño, Lucas / Ibáñez, Agustín / García, Adolfo M

Cerebral cortex (New York, N.Y. : 1991)

2022 Volume 32, Issue 16, Page(s) 3377–3391

Abstract: Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed ... ...

Abstract	Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson's disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer's disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action-text deficits related to the volume of action-observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social-text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer's disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.
MeSH term(s)	Alzheimer Disease/pathology ; Atrophy/pathology ; Biomarkers ; Brain ; Frontotemporal Dementia/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neurodegenerative Diseases/diagnostic imaging ; Neuropsychological Tests
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhab421
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3235: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach.

Bachli, M Belen / Sedeño, Lucas / Ochab, Jeremi K / Piguet, Olivier / Kumfor, Fiona / Reyes, Pablo / Torralva, Teresa / Roca, María / Cardona, Juan Felipe / Campo, Cecilia Gonzalez / Herrera, Eduar / Slachevsky, Andrea / Matallana, Diana / Manes, Facundo / García, Adolfo M / Ibáñez, Agustín / Chialvo, Dante R

NeuroImage

2019 Volume 208, Page(s) 116456

Abstract: Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for current clinical practice. Promisingly, current tools can be complemented by computational decision-support methods to objectively analyze multidimensional measures ...

Abstract	Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for current clinical practice. Promisingly, current tools can be complemented by computational decision-support methods to objectively analyze multidimensional measures and increase diagnostic confidence. Yet, widespread application of these tools cannot be recommended unless they are proven to perform consistently and reproducibly across samples from different countries. We implemented machine-learning algorithms to evaluate the prediction power of neurocognitive biomarkers (behavioral and imaging measures) for classifying two neurodegenerative conditions -Alzheimer Disease (AD) and behavioral variant frontotemporal dementia (bvFTD)- across three different countries (>200 participants). We use machine-learning tools integrating multimodal measures such as cognitive scores (executive functions and cognitive screening) and brain atrophy volume (voxel based morphometry from fronto-temporo-insular regions in bvFTD, and temporo-parietal regions in AD) to identify the most relevant features in predicting the incidence of the diseases. In the Country-1 cohort, predictions of AD and bvFTD became maximally improved upon inclusion of cognitive screenings outcomes combined with atrophy levels. Multimodal training data from this cohort allowed predicting both AD and bvFTD in the other two novel datasets from other countries with high accuracy (>90%), demonstrating the robustness of the approach as well as the differential specificity and reliability of behavioral and neural markers for each condition. In sum, this is the first study, across centers and countries, to validate the predictive power of cognitive signatures combined with atrophy levels for contrastive neurodegenerative conditions, validating a benchmark for future assessments of reliability and reproducibility.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Atrophy/pathology ; Biomarkers ; Executive Function/physiology ; Female ; Frontotemporal Dementia/diagnosis ; Frontotemporal Dementia/pathology ; Frontotemporal Dementia/physiopathology ; Humans ; Machine Learning ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Reproducibility of Results
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-12-10
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2019.116456
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

Order via subito

Details ▾

Article ; Online: Applauding with closed hands: neural signature of action-sentence compatibility effects.

Aravena, Pia / Hurtado, Esteban / Riveros, Rodrigo / Cardona, Juan Felipe / Manes, Facundo / Ibáñez, Agustín

PloS one

2010 Volume 5, Issue 7, Page(s) e11751

Abstract: Background: Behavioral studies have provided evidence for an action-sentence compatibility effect (ACE) that suggests a coupling of motor mechanisms and action-sentence comprehension. When both processes are concurrent, the action sentence primes the ... ...

Abstract	Background: Behavioral studies have provided evidence for an action-sentence compatibility effect (ACE) that suggests a coupling of motor mechanisms and action-sentence comprehension. When both processes are concurrent, the action sentence primes the actual movement, and simultaneously, the action affects comprehension. The aim of the present study was to investigate brain markers of bidirectional impact of language comprehension and motor processes. Methodology/principal findings: Participants listened to sentences describing an action that involved an open hand, a closed hand, or no manual action. Each participant was asked to press a button to indicate his/her understanding of the sentence. Each participant was assigned a hand-shape, either closed or open, which had to be used to activate the button. There were two groups (depending on the assigned hand-shape) and three categories (compatible, incompatible and neutral) defined according to the compatibility between the response and the sentence. ACEs were found in both groups. Brain markers of semantic processing exhibited an N400-like component around the Cz electrode position. This component distinguishes between compatible and incompatible, with a greater negative deflection for incompatible. Motor response elicited a motor potential (MP) and a re-afferent potential (RAP), which are both enhanced in the compatible condition. Conclusions/significance: The present findings provide the first ACE cortical measurements of semantic processing and the motor response. N400-like effects suggest that incompatibility with motor processes interferes in sentence comprehension in a semantic fashion. Modulation of motor potentials (MP and RAP) revealed a multimodal semantic facilitation of the motor response. Both results provide neural evidence of an action-sentence bidirectional relationship. Our results suggest that ACE is not an epiphenomenal post-sentence comprehension process. In contrast, motor-language integration occurring during the verb onset supports a genuine and ongoing brain motor-language interaction.
MeSH term(s)	Adolescent ; Adult ; Child ; Electroencephalography ; Evoked Potentials/physiology ; Female ; Humans ; Language ; Male ; Neurophysiology ; Reaction Time ; Semantics ; Speech Perception ; Young Adult
Language	English
Publishing date	2010-07-28
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0011751
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Does culture shape our understanding of others' thoughts and emotions? An investigation across 12 countries.

Quesque, François / Coutrot, Antoine / Cox, Sharon / de Souza, Leonardo Cruz / Baez, Sandra / Cardona, Juan Felipe / Mulet-Perreault, Hannah / Flanagan, Emma / Neely-Prado, Alejandra / Clarens, Maria Florencia / Cassimiro, Luciana / Musa, Gada / Kemp, Jennifer / Botzung, Anne / Philippi, Nathalie / Cosseddu, Maura / Trujillo-Llano, Catalina / Grisales-Cardenas, Johan Sebastián / Fittipaldi, Sol /

Magrath Guimet, Nahuel / Calandri, Ismael Luis / Crivelli, Lucia / Sedeno, Lucas / Garcia, Adolfo M / Moreno, Fermin / Indakoetxea, Begoña / Benussi, Alberto / Brandão Moura, Millena Vieira / Santamaria-Garcia, Hernando / Matallana, Diana / Pryanishnikova, Galina / Morozova, Anna / Iakovleva, Olga / Veryugina, Nadezda / Levin, Oleg / Zhao, Lina / Liang, Junhua / Duning, Thomas / Lebouvier, Thibaud / Pasquier, Florence / Huepe, David / Barandiaran, Myriam / Johnen, Andreas / Lyashenko, Elena / Allegri, Ricardo F / Borroni, Barbara / Blanc, Frederic / Wang, Fen / Yassuda, Mônica Sanches / Lillo, Patricia / Teixeira, Antônio Lúcio / Caramelli, Paulo / Hudon, Carol / Slachevsky, Andrea / Ibáñez, Agustin / Hornberger, Michael / Bertoux, Maxime

Neuropsychology

2022 Volume 36, Issue 7, Page(s) 664–682

Abstract: Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up, and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, ... ...

Abstract	Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up, and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global challenges that are mental health conditions. These initiatives commonly merge data across a diversity of populations and countries, while ignoring their specificity. Objective: In this context, we aimed to estimate the influence of participants' nationality on social cognition evaluation. This issue is of particular importance as most cognitive tasks are developed in highly specific contexts, not representative of that encountered by the world's population. Method: Through a large international study across 18 sites, neuropsychologists assessed core aspects of social cognition in 587 participants from 12 countries using traditional and widely used tasks. Results: Age, gender, and education were found to impact measures of mentalizing and emotion recognition. After controlling for these factors, differences between countries accounted for more than 20% of the variance on both measures. Importantly, it was possible to isolate participants' nationality from potential translation issues, which classically constitute a major limitation. Conclusions: Overall, these findings highlight the need for important methodological shifts to better represent social cognition in both fundamental research and clinical practice, especially within emerging international networks and consortia. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
MeSH term(s)	Cognition ; Educational Status ; Emotions ; Humans ; Mental Disorders ; Neuropsychology
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/neu0000817
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3002: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Time to Tango: expertise and contextual anticipation during action observation.

Amoruso, Lucía / Sedeño, Lucas / Huepe, David / Tomio, Ailin / Kamienkowski, Juan / Hurtado, Esteban / Cardona, Juan Felipe / Álvarez González, Miguel Ángel / Rieznik, Andrés / Sigman, Mariano / Manes, Facundo / Ibáñez, Agustín

NeuroImage

2014 Volume 98, Page(s) 366–385

Abstract: Predictive theories of action observation propose that we use our own motor system as a guide for anticipating and understanding other people's actions through the generation of context-based expectations. According to this view, people should be better ... ...

Abstract	Predictive theories of action observation propose that we use our own motor system as a guide for anticipating and understanding other people's actions through the generation of context-based expectations. According to this view, people should be better in predicting and interpreting those actions that are present in their own motor repertoire compared to those that are not. We recorded high-density event-related potentials (ERPs: P300, N400 and Slow Wave, SW) and source estimation in 80 subjects separated by their level of expertise (experts, beginners and naïves) as they observed realistic videos of Tango steps with different degrees of execution correctness. We also performed path analysis to infer causal relationships between ongoing anticipatory brain activity, evoked semantic responses, expertise measures and behavioral performance. We found that anticipatory activity, with sources in a fronto-parieto-occipital network, early discriminated between groups according to their level of expertise. Furthermore, this early activity significantly predicted subsequent semantic integration indexed by semantic responses (N400 and SW, sourced in temporal and motor regions) which also predicted motor expertise. In addition, motor expertise was a good predictor of behavioral performance. Our results show that neural and temporal dynamics underlying contextual action anticipation and comprehension can be interpreted in terms of successive levels of contextual prediction that are significantly modulated by subject's prior experience.
MeSH term(s)	Adult ; Anticipation, Psychological/physiology ; Brain/physiology ; Comprehension/physiology ; Dancing ; Electroencephalography ; Empathy/physiology ; Evoked Potentials ; Executive Function/physiology ; Female ; Humans ; Individuality ; Male ; Models, Neurological ; Motor Activity/physiology
Language	English
Publishing date	2014-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2014.05.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

Order via subito

Details ▾

Article ; Online: Attachment patterns trigger differential neural signature of emotional processing in adolescents.

Escobar, Maria Josefina / Rivera-Rei, Alvaro / Decety, Jean / Huepe, David / Cardona, Juan Felipe / Canales-Johnson, Andres / Sigman, Mariano / Mikulan, Ezequiel / Helgiu, Elena / Baez, Sandra / Manes, Facundo / Lopez, Vladimir / Ibañez, Agustín

PloS one

2013 Volume 8, Issue 8, Page(s) e70247

Abstract: Background: Research suggests that individuals with different attachment patterns process social information differently, especially in terms of facial emotion recognition. However, few studies have explored social information processes in adolescents. ... ...

Abstract	Background: Research suggests that individuals with different attachment patterns process social information differently, especially in terms of facial emotion recognition. However, few studies have explored social information processes in adolescents. This study examined the behavioral and ERP correlates of emotional processing in adolescents with different attachment orientations (insecure attachment group and secure attachment group; IAG and SAG, respectively). This study also explored the association of these correlates to individual neuropsychological profiles. Methodology/principal findings: We used a modified version of the dual valence task (DVT), in which participants classify stimuli (faces and words) according to emotional valence (positive or negative). Results showed that the IAG performed significantly worse than SAG on tests of executive function (EF attention, processing speed, visuospatial abilities and cognitive flexibility). In the behavioral DVT, the IAG presented lower performance and accuracy. The IAG also exhibited slower RTs for stimuli with negative valence. Compared to the SAG, the IAG showed a negative bias for faces; a larger P1 and attenuated N170 component over the right hemisphere was observed. A negative bias was also observed in the IAG for word stimuli, which was demonstrated by comparing the N170 amplitude of the IAG with the valence of the SAG. Finally, the amplitude of the N170 elicited by the facial stimuli correlated with EF in both groups (and negative valence with EF in the IAG). Conclusions/significance: Our results suggest that individuals with different attachment patterns process key emotional information and corresponding EF differently. This is evidenced by an early modulation of ERP components' amplitudes, which are correlated with behavioral and neuropsychological effects. In brief, attachments patterns appear to impact multiple domains, such as emotional processing and EFs.
MeSH term(s)	Adolescent ; Child ; Electroencephalography ; Emotions/physiology ; Female ; Humans ; Male ; Neurons/metabolism ; Neurons/physiology ; Recognition, Psychology/physiology ; Social Behavior
Language	English
Publishing date	2013-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0070247
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science.

Ibanez, Agustin / Yokoyama, Jennifer S / Possin, Katherine L / Matallana, Diana / Lopera, Francisco / Nitrini, Ricardo / Takada, Leonel T / Custodio, Nilton / Sosa Ortiz, Ana Luisa / Avila-Funes, José Alberto / Behrens, Maria Isabel / Slachevsky, Andrea / Myers, Richard M / Cochran, J Nicholas / Brusco, Luis Ignacio / Bruno, Martin A / Brucki, Sonia M D / Pina-Escudero, Stefanie Danielle / Okada de Oliveira, Maira /

Donnelly Kehoe, Patricio / Garcia, Adolfo M / Cardona, Juan Felipe / Santamaria-Garcia, Hernando / Moguilner, Sebastian / Duran-Aniotz, Claudia / Tagliazucchi, Enzo / Maito, Marcelo / Longoria Ibarrola, Erika Mariana / Pintado-Caipa, Maritza / Godoy, Maria Eugenia / Bakman, Vera / Javandel, Shireen / Kosik, Kenneth S / Valcour, Victor / Miller, Bruce L

Frontiers in neurology

2021 Volume 12, Page(s) 631722

Abstract: Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. ... ...

Abstract	Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.631722
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Tracking the Cognitive, Social, and Neuroanatomical Profile in Early Neurodegeneration: Type III Cockayne Syndrome.

Baez, Sandra / Couto, Blas / Herrera, Eduar / Bocanegra, Yamile / Trujillo-Orrego, Natalia / Madrigal-Zapata, Lucia / Cardona, Juan Felipe / Manes, Facundo / Ibanez, Agustin / Villegas, Andres

Frontiers in aging neuroscience

2013 Volume 5, Page(s) 80

Abstract: Cockayne syndrome (CS) is an autosomal recessive disease associated with premature aging, progressive multiorgan degeneration, and nervous system abnormalities including cerebral and cerebellar atrophy, brain calcifications, and white matter ... ...

Abstract	Cockayne syndrome (CS) is an autosomal recessive disease associated with premature aging, progressive multiorgan degeneration, and nervous system abnormalities including cerebral and cerebellar atrophy, brain calcifications, and white matter abnormalities. Although several clinical descriptions of CS patients have reported developmental delay and cognitive impairment with relative preservation of social skills, no previous studies have carried out a comprehensive neuropsychological and social cognition assessment. Furthermore, no previous research in individuals with CS has examined the relationship between brain atrophy and performance on neuropsychological and social cognition tests. This study describes the case of an atypical late-onset type III CS patient who exceeds the mean life expectancy of individuals with this pathology. The patient and a group of healthy controls underwent a comprehensive assessment that included multiple neuropsychological and social cognition (emotion recognition, theory of mind, and empathy) tasks. In addition, we compared the pattern of atrophy in the patient to controls and to its concordance with ERCC8 gene expression in a healthy brain. The results showed memory, language, and executive deficits that contrast with the relative preservation of social cognition skills. The cognitive profile of the patient was consistent with his pattern of global cerebral and cerebellar loss of gray matter volume (frontal structures, bilateral cerebellum, basal ganglia, temporal lobe, and occipito-temporal/occipito-parietal regions), which in turn was anatomically consistent with the ERCC8 gene expression level in a healthy donor's brain. The study of exceptional cases, such as the one described here, is fundamental to elucidating the processes that affect the brain in premature aging diseases, and such studies provide an important source of information for understanding the problems associated with normal and pathological aging.
Language	English
Publishing date	2013-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2013.00080
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Action-verb processing in Parkinson's disease: new pathways for motor-language coupling.

Cardona, Juan Felipe / Gershanik, Oscar / Gelormini-Lezama, Carlos / Houck, Alexander Lee / Cardona, Sebastian / Kargieman, Lucila / Trujillo, Natalia / Arévalo, Analía / Amoruso, Lucia / Manes, Facundo / Ibáñez, Agustín

Brain structure & function

2013 Volume 218, Issue 6, Page(s) 1355–1373

Abstract: Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson's disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this ... ...

Abstract	Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson's disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical-subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action-perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.
MeSH term(s)	Brain Mapping ; Cerebrum/physiopathology ; Cognition/physiology ; Efferent Pathways/pathology ; Humans ; Language Disorders/etiology ; Language Disorders/pathology ; Models, Neurological ; Parkinson Disease/complications ; Parkinson Disease/pathology ; Semantics
Language	English
Publishing date	2013-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-013-0510-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ub I Zs.90: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito