Article: Model predictive control of depth of anaesthesia: guidelines for controller configuration.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2009 Volume 2008, Page(s) 5822–5825
Abstract: The paper presents a feasibility study on the use of Model based Predictive control (MPC) to regulate the level of Depth of Anaesthesia (DoA) when measured by the BIS index. Pharmacokinetic/pharmacodynamic nonlinear models of DoA when Propofol and ... ...
Abstract | The paper presents a feasibility study on the use of Model based Predictive control (MPC) to regulate the level of Depth of Anaesthesia (DoA) when measured by the BIS index. Pharmacokinetic/pharmacodynamic nonlinear models of DoA when Propofol and Remifentanil are used as hypnotic and analgesic drugs are linearized around the desired working point for DoA in order to obtain a linear state-space model coupled with an extra integrator to include integral action in the control. This state-space model is then used in a MPC algorithm. The main contribution of the paper consists in the characterization of the influence of the different design parameters in the MPC performance when controlling DoA. |
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MeSH term(s) | Algorithms ; Anesthesia/methods ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Therapy, Computer-Assisted/methods ; Drug Therapy, Computer-Assisted/standards ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/blood ; Hypnotics and Sedatives/pharmacokinetics ; Models, Biological ; Practice Guidelines as Topic |
Chemical Substances | Hypnotics and Sedatives |
Language | English |
Publishing date | 2009-01-21 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 2375-7477 |
ISSN | 2375-7477 |
DOI | 10.1109/IEMBS.2008.4650538 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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