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Article ; Online: Long-Term Outcomes in Severe Community-Acquired Pneumonia.

Carella, Francesco / Aliberti, Stefano / Stainer, Anna / Voza, Antonio / Blasi, Francesco

Seminars in respiratory and critical care medicine

2024 Volume 45, Issue 2, Page(s) 266–273

Abstract: Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological ... ...

Abstract	Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological impairment, due to persistent inflammation and hypoxemia, contribute to long-term outcomes in CAP, including mortality. Very few data are available in the specific population of sCAP. Multiple studies have reported variable 1-year mortality rates for patients with CAP up to 40.7%, with a clear influence by age, comorbidities, and disease severity. In terms of treatment, the potential protective role of macrolides in reducing mortality emphasizes the importance of appropriate empiric antibiotic therapy. This narrative review explores the growing interest in the literature focusing on the long-term implications of sCAP. Improved understanding of long-term outcomes in sCAP can facilitate targeted interventions and enhance posthospitalization care protocols.
MeSH term(s)	Humans ; Pneumonia/drug therapy ; Community-Acquired Infections/drug therapy ; Hospitalization
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0044-1781426
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Article: Long-Term Outcomes in Severe Community-Acquired Pneumonia

Carella, Francesco / Aliberti, Stefano / Stainer, Anna / Voza, Antonio / Blasi, Francesco

Seminars in Respiratory and Critical Care Medicine

(Severe community acquired pneumonia)

2024 Volume 45, Issue 02, Page(s) 266–273

Series title	Severe community acquired pneumonia
Abstract	Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological impairment, due to persistent inflammation and hypoxemia, contribute to long-term outcomes in CAP, including mortality. Very few data are available in the specific population of sCAP. Multiple studies have reported variable 1-year mortality rates for patients with CAP up to 40.7%, with a clear influence by age, comorbidities, and disease severity. In terms of treatment, the potential protective role of macrolides in reducing mortality emphasizes the importance of appropriate empiric antibiotic therapy. This narrative review explores the growing interest in the literature focusing on the long-term implications of sCAP. Improved understanding of long-term outcomes in sCAP can facilitate targeted interventions and enhance posthospitalization care protocols.
Keywords	severe community-acquired pneumonia ; long-term outcomes ; long-term mortality ; narrative review
Language	English
Publishing date	2024-02-23
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0044-1781426
Database	Thieme publisher's database

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Article: Increase in invasive group A streptococcal infections in Milan, Italy: a genomic and clinical characterization.

Mangioni, Davide / Fox, Valeria / Saltini, Paola / Lombardi, Andrea / Bussini, Linda / Carella, Francesco / Cariani, Lisa / Comelli, Agnese / Matinato, Caterina / Muscatello, Antonio / Teri, Antonio / Terranova, Leonardo / Cento, Valeria / Carloni, Sara / Bartoletti, Michele / Alteri, Claudia / Bandera, Alessandra

Frontiers in microbiology

2024 Volume 14, Page(s) 1287522

Abstract: Background: Group A Streptococcus (GAS) causes multiple clinical manifestations, including invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases during COVID-19 pandemic, in 2022 a sharp increase of GAS was reported ... ...

Abstract	Background: Group A Streptococcus (GAS) causes multiple clinical manifestations, including invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases during COVID-19 pandemic, in 2022 a sharp increase of GAS was reported globally. Methods: GAS strains collected in 09/2022-03/2023 in two university hospitals in Milan, Italy were retrospectively analyzed. Clinical/epidemiological data were combined with whole-genome sequencing to: (i) define resistome/virulome, (ii) identify putative transmission chains, (iii) explore associations between Results: Twenty-eight isolates were available, 19/28 (67.9%) from adults and 9/28 (32.1%) from pediatric population. The criteria for iGAS were met by 19/28 cases (67.9%), of which 11/19 (39.3%) met the further criteria for severe-iGAS. Pediatric cases were mainly non-invasive infections (8/9, 88.9%), adult cases were iGAS and severe-iGAS in 18/19 (94.7%) and 10/19 (52.6%), respectively. Thirteen Conclusions: This study showed that multiple
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1287522
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Article ; Online: Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis.

Cialdella, Pietro / Carella, Francesco

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

2012 Volume 8, Issue 3, Page(s) 66–68

Abstract: The objective of the study is to evaluate alterations of bone metabolism in adolescence and adult CF, determining the rate of osteoporosis, osteopenia and vertebral and non-vertebral fractures. We took into account the clinical case of a child who right ... ...

Abstract	The objective of the study is to evaluate alterations of bone metabolism in adolescence and adult CF, determining the rate of osteoporosis, osteopenia and vertebral and non-vertebral fractures. We took into account the clinical case of a child who right from the age of seven years has presented joint pain.The little girl was diagnosed with osteopenia taken with therapy of calcium and vitamin D; after few years despite treatment nephrocalcinosis and osteoporosis take over.It was examined a cohort of patients with cystic fibrosis of the southern Italy, 24 patients aged between 12 and 44 years, 12 females and 12 males with BMD assessment methods like dual energy X-rays (DXA) and calcaneal ultrasound densitometry in a few cases, ultrasonography was used jointly.From this case study we tried to establish the relationship between cystic fibrosis and osteoporosis etiopathogenetic, the adoptive therapy and the impact of therapies on patients.It was concluded that, given the high number of unrecognized patients with impaired bone mineralization, we must implement and integrate a more aggressive treatment with bisphosphonates and prevention programs that can combat the lifestyle and new eating habits of our young people that facilitate the loss of bone mass.
Language	English
Publishing date	2012-02-22
Publishing country	Italy
Document type	Case Reports
ZDB-ID	2660444-9
ISSN	1971-3266 ; 1724-8914
ISSN (online)	1971-3266
ISSN	1724-8914
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Article: Systematic Survey of

Mancini, Maria Emanuela / Alessiani, Alessandra / Donatiello, Adelia / Didonna, Antonella / D'Attoli, Luigi / Faleo, Simona / Occhiochiuso, Gilda / Carella, Francesco / Di Taranto, Pietro / Pace, Lorenzo / Rondinone, Valeria / Damato, Annita Maria / Coppola, Rosa / Pedarra, Carmine / Goffredo, Elisa

Microorganisms

2023 Volume 11, Issue 2

Abstract: The emergence of antimicrobial resistance (AMR) is increasingly common across the globe and aquatic ecosystems could be considered a reservoir of antibiotic-resistant bacteria. This study aimed to determine prevalence and antibiotic susceptibility of the ...

Abstract	The emergence of antimicrobial resistance (AMR) is increasingly common across the globe and aquatic ecosystems could be considered a reservoir of antibiotic-resistant bacteria. This study aimed to determine prevalence and antibiotic susceptibility of the potential pathogenic bacteria
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11020450
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Article ; Online: Ursodeoxycholic Acid Does Not Improve COVID-19 Outcome in Hospitalized Patients.

Colapietro, Francesca / Angelotti, Giovanni / Masetti, Chiara / Shiffer, Dana / Pugliese, Nicola / De Nicola, Stella / Carella, Francesco / Desai, Antonio / Ormas, Monica / Calatroni, Marta / Omodei, Paolo / Ciccarelli, Michele / Aliberti, Stefano / Reggiani, Francesco / Bartoletti, Michele / Cecconi, Maurizio / Lleo, Ana / Aghemo, Alessio / Voza, Antonio

Viruses

2023 Volume 15, Issue 8

Abstract: Ursodeoxycholic acid (UDCA) was demonstrated to reduce susceptibility to SARS-CoV-2 infection in vitro and improve infection course in chronic liver diseases. However, real-life evidence is lacking. We analyzed the impact of UDCA on COVID-19 outcomes in ... ...

Abstract	Ursodeoxycholic acid (UDCA) was demonstrated to reduce susceptibility to SARS-CoV-2 infection in vitro and improve infection course in chronic liver diseases. However, real-life evidence is lacking. We analyzed the impact of UDCA on COVID-19 outcomes in patients hospitalized in a tertiary center. Between January 2020 and January 2023, among 3847 patients consecutively hospitalized for COVID19, 57 (=UDCA group) were taking UDCA. The UDCA and the control groups (
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Ursodeoxycholic Acid/therapeutic use ; Diabetes Mellitus, Type 2 ; Vaccination
Chemical Substances	Ursodeoxycholic Acid (724L30Y2QR)
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15081738
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Article ; Online: Safety of allergen-specific immunotherapy in children.

De Filippo, Maria / Votto, Martina / Caminiti, Lucia / Panasiti, Ilenia / Carella, Francesco / De Castro, Giovanna / Landi, Massimo / Olcese, Roberta / Vernich, Mario / Marseglia, Gian Luigi / Ciprandi, Giorgio / Barberi, Salvatore

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2022 Volume 33 Suppl 27, Page(s) 27–30

Abstract: Allergic respiratory diseases, such as asthma and allergic rhinitis, are global health issues and have had an increasing prevalence in the last decades. Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic rhinitis and asthma, ...

Abstract	Allergic respiratory diseases, such as asthma and allergic rhinitis, are global health issues and have had an increasing prevalence in the last decades. Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic rhinitis and asthma, as it has a disease-modifying effect. AIT is generally administered by two routes: subcutaneous (SCIT) and sublingual immunotherapy (SLIT). Local side effects are common, but usually well-tolerated and self-limited. However, systemic side effects are rare, and associated with uncontrolled asthma and bronchial obstruction, or related to errors in administration. Physicians should constantly assess potential risk factors for not only reporting systemic reactions and fatalities but also implementing other therapies to improve AIT safety. This paper highlights recent evidence on local and systemic reactions related to SCIT and SLIT in children.
MeSH term(s)	Allergens ; Asthma ; Child ; Desensitization, Immunologic/adverse effects ; Humans ; Injections, Subcutaneous ; Rhinitis, Allergic ; Sublingual Immunotherapy
Chemical Substances	Allergens
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.13622
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Article ; Online: Omalizumab and allergen immunotherapy for respiratory allergies: A mini-review from the Allergen-Immunotherapy Committee of the Italian Society of Pediatric Allergy and Immunology (SIAIP).

Filippo, Maria De / Votto, Martina / Caminiti, Lucia / Carella, Francesco / Castro, Giovanna De / Landi, Massimo / Olcese, Roberta / Panasiti, Ilenia / Vernich, Mario / Barberi, Salvatore / Ciprandi, Giorgio / Marseglia, Gian Luigi

Allergologia et immunopathologia

2022 Volume 50, Issue 6, Page(s) 47–52

Abstract: Although currently approved to treat severe asthma and chronic spontaneous urticaria, omalizumab has also been an effective and safe add-on treatment for other allergic diseases. Namely, omalizumab has been proposed to be used as add-on therapy in ... ...

Abstract	Although currently approved to treat severe asthma and chronic spontaneous urticaria, omalizumab has also been an effective and safe add-on treatment for other allergic diseases. Namely, omalizumab has been proposed to be used as add-on therapy in patients with allergic rhinitis and asthma and undergoing specific allergen immunotherapy (AIT). AIT is the only treatment that modifies the natural history of IgE-mediated diseases. This brief review summarizes the available evidence and controversies on the efficacy and safety of omalizumab combined with specific AIT.
MeSH term(s)	Humans ; Child ; Omalizumab/therapeutic use ; Desensitization, Immunologic ; Rhinitis, Allergic/therapy ; Asthma/therapy ; Allergens/therapeutic use
Chemical Substances	Omalizumab (2P471X1Z11) ; Allergens
Language	English
Publishing date	2022-11-01
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v50i6.495
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Article ; Online: Eosinophilic gastrointestinal disorders and allergen immunotherapy: Lights and shadows.

Votto, Martina / De Filippo, Maria / Caminiti, Lucia / Carella, Francesco / de Castro, Giovanna / Landi, Massimo / Olcese, Roberta / Vernich, Mario / Marseglia, Gian Luigi / Ciprandi, Giorgio / Barberi, Salvatore

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2021 Volume 32, Issue 5, Page(s) 814–823

Abstract: Allergic diseases, such as IgE-mediated food allergy, asthma, and allergic rhinitis, are relevant health problems worldwide and show an increasing prevalence. Therapies for food allergies are food avoidance and the prompt administration of intramuscular ... ...

Abstract	Allergic diseases, such as IgE-mediated food allergy, asthma, and allergic rhinitis, are relevant health problems worldwide and show an increasing prevalence. Therapies for food allergies are food avoidance and the prompt administration of intramuscular epinephrine in anaphylaxis occurring after accidental exposure. However, allergen immunotherapy (AIT) is being investigated as a new potential tool for treating severe food allergies. Effective oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) induce desensitization and restore immune tolerance to the causal allergen. While immediate side effects are well known, the long-term effects of food AIT are still underestimated. In this regard, eosinophilic gastrointestinal disorders (EGIDs), mainly eosinophilic esophagitis, have been reported as putative complications of OIT for food allergy and sublingual immunotherapy (SLIT) for allergic asthma and rhinitis. Fortunately, these complications are usually reversible and the patient recovers after AIT discontinuation. This review summarizes current knowledge on the possible causative link between eosinophilic gastrointestinal disorders and AIT, highlighting recent evidence and controversies.
MeSH term(s)	Allergens ; Desensitization, Immunologic ; Enteritis ; Food Hypersensitivity/therapy ; Humans ; Sublingual Immunotherapy
Chemical Substances	Allergens
Language	English
Publishing date	2021-02-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.13458
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Article ; Online: Incidence and predictors of hepatocellular carcinoma in patients with autoimmune hepatitis.

Colapietro, Francesca / Maisonneuve, Patrick / Lytvyak, Ellina / Beuers, Ulrich / Verdonk, Robert C / van der Meer, Adriaan J / van Hoek, Bart / Kuiken, Sjoerd D / Brouwer, Johannes T / Muratori, Paolo / Aghemo, Alessio / Carella, Francesco / van den Berg, Ad P / Zachou, Kalliopi / Dalekos, George N / Di Zeo-Sánchez, Daniel E / Robles, Mercedes / Andrade, Raul J / Montano-Loza, Aldo J /

van den Brand, Floris F / Slooter, Charlotte D / Macedo, Guilherme / Liberal, Rodrigo / de Boer, Ynto S / Lleo, Ana

Journal of hepatology

2023 Volume 80, Issue 1, Page(s) 53–61

Abstract: Background and aims: Autoimmune hepatitis (AIH) is a rare chronic liver disease of unknown aetiology; the risk of hepatocellular carcinoma (HCC) remains unclear and risk factors are not well-defined. We aimed to investigate the risk of HCC across a ... ...

Abstract	Background and aims: Autoimmune hepatitis (AIH) is a rare chronic liver disease of unknown aetiology; the risk of hepatocellular carcinoma (HCC) remains unclear and risk factors are not well-defined. We aimed to investigate the risk of HCC across a multicentre AIH cohort and to identify predictive factors. Methods: We performed a retrospective, observational, multicentric study of patients included in the International Autoimmune Hepatitis Group Retrospective Registry. The assessed clinical outcomes were HCC development, liver transplantation, and death. Fine and Gray regression analysis stratified by centre was applied to determine the effects of individual covariates; the cumulative incidence of HCC was estimated using the competing risk method with death as a competing risk. Results: A total of 1,428 patients diagnosed with AIH from 1980 to 2020 from 22 eligible centres across Europe and Canada were included, with a median follow-up of 11.1 years (interquartile range 5.2-15.9). Two hundred and ninety-three (20.5%) patients had cirrhosis at diagnosis. During follow-up, 24 patients developed HCC (1.7%), an incidence rate of 1.44 cases/1,000 patient-years; the cumulative incidence of HCC increased over time (0.6% at 5 years, 0.9% at 10 years, 2.7% at 20 years, and 6.6% at 30 years of follow-up). Patients who developed cirrhosis during follow-up had a significantly higher incidence of HCC. The cumulative incidence of HCC was 2.6%, 4.6%, 5.6% and 6.6% at 5, 10, 15, and 20 years after the development of cirrhosis, respectively. Obesity (hazard ratio [HR] 2.94, p = 0.04), cirrhosis (HR 3.17, p = 0.01), and AIH/PSC variant syndrome (HR 5.18, p = 0.007) at baseline were independent risk factors for HCC development. Conclusions: HCC incidence in AIH is low even after cirrhosis development and is associated with risk factors including obesity, cirrhosis, and AIH/PSC variant syndrome. Impact and implications: The risk of developing hepatocellular carcinoma (HCC) in individuals with autoimmune hepatitis (AIH) seems to be lower than for other aetiologies of chronic liver disease. Yet, solid data for this specific patient group remain elusive, given that most of the existing evidence comes from small, single-centre studies. In our study, we found that HCC incidence in patients with AIH is low even after the onset of cirrhosis. Additionally, factors such as advanced age, obesity, cirrhosis, alcohol consumption, and the presence of the AIH/PSC variant syndrome at the time of AIH diagnosis are linked to a higher risk of HCC. Based on these findings, there seems to be merit in adopting a specialized HCC monitoring programme for patients with AIH based on their individual risk factors.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/diagnosis ; Hepatitis, Autoimmune/complications ; Hepatitis, Autoimmune/epidemiology ; Hepatitis, Autoimmune/diagnosis ; Incidence ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Liver Neoplasms/epidemiology ; Liver Neoplasms/etiology ; Liver Neoplasms/diagnosis ; Obesity/complications ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2023-10-05
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2023.09.010
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