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  1. AU="Carfagna, Charles S"
  2. AU="Chakraborti, Udipta"
  3. AU="Uson, Jesus"
  4. AU="Riotto, A W"
  5. AU="Candel, Bart Gj"
  6. AU="Brinken, Tatjana"
  7. AU="Korkmaz, Asli"

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  1. Artikel ; Online: Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.

    Rzigalinski, Beverly A / Carfagna, Charles S / Ehrich, Marion

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2016  Band 9, Heft 4

    Abstract: Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative ... ...

    Abstract Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative organs in the body, it is subject to some of the greatest levels of oxidative stress, particularly in neurodegenerative disease. Therefore, cerium oxide nanoparticles are currently being investigated for efficacy in several neurodegenerative disorders and have shown promising levels of neuroprotection. This review discusses the basis for cerium oxide nanoparticle use in neurodegenerative disease and its hypothesized mechanism of action. The review focuses on an up-to-date summary of in vivo work with cerium oxide nanoparticles in animal models of neurodegenerative disease. Additionally, we examine the current state of information regarding biodistribution, toxicity, and safety for cerium oxide nanoparticles at the in vivo level. Finally, we discuss future directions that are necessary if this nanopharmaceutical is to move up from the bench to the bedside. WIREs Nanomed Nanobiotechnol 2017, 9:e1444. doi: 10.1002/wnan.1444 For further resources related to this article, please visit the WIREs website.
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Cerium/pharmacology ; Humans ; Nanoparticles/chemistry ; Neurodegenerative Diseases/drug therapy ; Neuroprotection ; Oxidative Stress ; Tissue Distribution
    Chemische Substanzen Antioxidants ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
    Sprache Englisch
    Erscheinungsdatum 2016-11-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1444
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: {2,6-Bis[(2,6-diisopropyl-phosphan-yl)-oxy]-4-fluoro-phenyl-κ(3)P,C(1),P'}(1H-pyrazole-κN(2))nickel(II) hexa-fluoro-phosphate.

    Kwan, Man-Lung / Conry, Sara J / Carfagna, Charles S / Press, Loren P / Ozerov, Oleg V / Hoffman, Norris W / Sykora, Richard E

    Acta crystallographica. Section E, Structure reports online

    2012  Band 68, Heft Pt 10, Seite(n) m1282–3

    Abstract: The title compound, [Ni(C(18)H(30)FO(2)P(2))(C(3)H(4)N(2))]PF(6), was prepared by halide abstraction with TlPF(6) in the presence of CH(3)CN in CDCl(3) from the respective neutral pincer chlorido analogue followed by addition of pyrazole. The PO-C-OP ... ...

    Abstract The title compound, [Ni(C(18)H(30)FO(2)P(2))(C(3)H(4)N(2))]PF(6), was prepared by halide abstraction with TlPF(6) in the presence of CH(3)CN in CDCl(3) from the respective neutral pincer chlorido analogue followed by addition of pyrazole. The PO-C-OP pincer ligand acts in typical trans-P(2) tridentate fashion to generate a distorted square-planar nickel structure. The Ni-N(pyrazole) distance is 1.925 (2) Å and the plane of the pyrazole ligand is rotated 56.2 (1)° relative to the approximate square plane surrounding the Ni(II) center in which the pyrazole is bound to the Ni(II) atom through its sp(2)-hybridized N atom. This Ni-N distance is similar to bond lengths in the other reported Ni(II) pincer-ligand square-planar pyrazole complex structures; however, its dihedral angle is significantly larger than any of those for the latter set of pyrazole complexes.
    Sprache Englisch
    Erscheinungsdatum 2012-09-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368 ; 1600-5368
    ISSN (online) 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536812039207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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