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  1. Article ; Online: Impact of TR 34 /L98H, TR 46 /Y121F/T289A and TR 53 Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

    Rose-Anne Lavergne / Marjorie Albassier / Jean-Benoît Hardouin / Carlos Alvarez-Moreno / Fabrice Pagniez / Florent Morio / Patrice Le Pape / Isabelle Ourliac-Garnier

    Microorganisms, Vol 10, Iss 104, p

    2022  Volume 104

    Abstract: Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis. Azole resistance has emerged as a matter ... ...

    Abstract Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis. Azole resistance has emerged as a matter of concern but little is known about sterols biosynthesis in azole resistant Aspergillus fumigatus . Methods: We explored the sterol composition of 12 A. fumigatus isolates, including nine azole resistant isolates with TR 34 /L98H, TR 46 /Y121F/T289A or TR 53 alterations in the cyp51A gene and its promoter conferring azole resistance. Modifications in sterol composition were also investigated after exposure to two azole drugs, itraconazole and voriconazole. Results: Overall, under basal conditions, sterol compositions were qualitatively equivalent, whatever the alterations in the target of azole drugs with ergosterol as the main sterol detected. Azole exposure reduced ergosterol composition and the qualitative composition of sterols was similar in both susceptible and resistant isolates. Interestingly TR 53 strains behaved differently than other strains. Conclusions: Elucidating sterol composition in azole-susceptible and resistant isolates is of interest for a better understanding of the mechanism of action of these drugs and the mechanism of resistance of fungi.
    Keywords Aspergillus fumigatus ; sterol ; ergosterol ; azole-resistance ; tandem repeat ; Biology (General) ; QH301-705.5
    Subject code 290
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Overcoming Drug Resistance in Advanced Prostate Cancer by Drug Repurposing

    Hisham F. Bahmad / Timothy Demus / Maya M. Moubarak / Darine Daher / Juan Carlos Alvarez Moreno / Francesca Polit / Olga Lopez / Ali Merhe / Wassim Abou-Kheir / Alan M. Nieder / Robert Poppiti / Yumna Omarzai

    Medical Sciences, Vol 10, Iss 15, p

    2022  Volume 15

    Abstract: Prostate cancer (PCa) is the second most common cancer in men. Common treatments include active surveillance, surgery, or radiation. Androgen deprivation therapy and chemotherapy are usually reserved for advanced disease or biochemical recurrence, such ... ...

    Abstract Prostate cancer (PCa) is the second most common cancer in men. Common treatments include active surveillance, surgery, or radiation. Androgen deprivation therapy and chemotherapy are usually reserved for advanced disease or biochemical recurrence, such as castration-resistant prostate cancer (CRPC), but they are not considered curative because PCa cells eventually develop drug resistance. The latter is achieved through various cellular mechanisms that ultimately circumvent the pharmaceutical’s mode of action. The need for novel therapeutic approaches is necessary under these circumstances. An alternative way to treat PCa is by repurposing of existing drugs that were initially intended for other conditions. By extrapolating the effects of previously approved drugs to the intracellular processes of PCa, treatment options will expand. In addition, drug repurposing is cost-effective and efficient because it utilizes drugs that have already demonstrated safety and efficacy. This review catalogues the drugs that can be repurposed for PCa in preclinical studies as well as clinical trials.
    Keywords drug repurposing ; androgen-deprivation therapy ; prostate cancer ; CRPC ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A One Health Perspective to Recognize Fusarium as Important in Clinical Practice

    Valeri Sáenz / Carlos Alvarez-Moreno / Patrice Le Pape / Silvia Restrepo / Josep Guarro / Adriana Marcela Celis Ramírez

    Journal of Fungi, Vol 6, Iss 235, p

    2020  Volume 235

    Abstract: Any strategy that proposes solutions to health-related problems recognizes that people, animals, and the environment are interconnected. Fusarium is an example of this interaction because it is capable of infecting plants, animals, and humans. This ... ...

    Abstract Any strategy that proposes solutions to health-related problems recognizes that people, animals, and the environment are interconnected. Fusarium is an example of this interaction because it is capable of infecting plants, animals, and humans. This review provides information on various aspects of these relations and proposes how to approach fusariosis with a One Health methodology (a multidisciplinary, and multisectoral approach that can address urgent, ongoing, or potential health threats to humans, animals, and the environment). Here, we give a framework to understand infection pathogenesis, through the epidemiological triad, and explain how the broad utilization of fungicides in agriculture may play a role in the treatment of human fusariosis. We assess how plumbing systems and hospital environments might play a role as a reservoir for animal and human infections. We explain the role of antifungal resistance mechanisms in both humans and agriculture. Our review emphasizes the importance of developing interdisciplinary research studies where aquatic animals, plants, and human disease interactions can be explored through coordination and collaborative actions.
    Keywords Fusarium ; One Health ; Biology (General) ; QH301-705.5
    Subject code 306
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Reporte de catorce casos de leptospirosis en un hospital universitario de IV nivel entre 2010 y 2012

    Gabriel Mosquera Klinger / Fernando Vela Lozada / Carlos Álvarez Moreno

    Revista Universitas Medica, Vol 55, Iss 1, Pp 93-

    2014  Volume 100

    Abstract: La leptospirosis es una enfermedad infecciosa aguda generalizada, provocada por espiroquetas del género Leptospira, caracterizada por una extensa vasculitis. Siempre debe considerarse entre los diagnósticos diferenciales de síndrome febril en nuestra ... ...

    Abstract La leptospirosis es una enfermedad infecciosa aguda generalizada, provocada por espiroquetas del género Leptospira, caracterizada por una extensa vasculitis. Siempre debe considerarse entre los diagnósticos diferenciales de síndrome febril en nuestra población. Se reporta una serie de catorce casos con clínica indicativa de leptospirosis, que presentó resultado positivo de serología para Leptospira spp., lo cual confirma el diagnóstico. Se describen las características demográficas en la población estudiada: fue más frecuente en población entre 20 y 35 años de edad. En el 35,7 % existía un antecedente de desplazamiento reciente a municipios del norte del departamento del Tolima y en el 14,2 %, a municipios del sur de Cundinamarca. El 71,4 % de los pacientes tuvo factores de riesgo para adquirir la infección. La mayoría de las consultas a urgencias se presentó siete días de iniciados los síntomas. En todos los pacientes hubo fiebre, cefalea, mialgias y artralgias, y en menor proporción, dolor abdominal y diarreas.
    Keywords Medicine ; R
    Language Spanish
    Publishing date 2014-01-01T00:00:00Z
    Publisher Pontificia Universidad Javeriana
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Multiple Fungicide-Driven Alterations in Azole-Resistant Aspergillus fumigatus, Colombia, 2015

    Patrice Le Pape / Rose-Anne Lavergne / Florent Morio / Carlos Alvarez-Moreno

    Emerging Infectious Diseases, Vol 22, Iss 1, Pp 156-

    2016  Volume 157

    Keywords Aspergillus fumigatus ; Colombia ; triazoles ; antimicrobial resistance ; fungal ; aspergillosis ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Citomegalovirus diseminado

    Gabriel Alonso Mosquera Klinger / Fredy Orlando Guevara Pulido / Carlos Álvarez Moreno

    Revista Universitas Medica, Vol 55, Iss 1, Pp 71-

    a propósito de un caso

    2014  Volume 75

    Abstract: El artículo presenta el caso de un hombre sin antecedentes previos de enfermedad, que consultó inicialmente por dolor abdominal. Se documentó colecistitis aguda, en la patología con hallazgos de citomegalovirus; adicionalmente, presentaba múltiples ... ...

    Abstract El artículo presenta el caso de un hombre sin antecedentes previos de enfermedad, que consultó inicialmente por dolor abdominal. Se documentó colecistitis aguda, en la patología con hallazgos de citomegalovirus; adicionalmente, presentaba múltiples manifestaciones: síntomas respiratorios, sangrado gastrointestinal y pancitopenia. Se documentó infección por VIH y muestras serológicas e histológicas de citomegalovirus. Se hace diagnóstico de citomegalovirus diseminado en el contexto de infección por VIH.
    Keywords Medicine ; R
    Language Spanish
    Publishing date 2014-01-01T00:00:00Z
    Publisher Pontificia Universidad Javeriana
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Uso de resúmenes de evidencia para informar el tratamiento farmacológico de personas con sospecha o diagnóstico de infección respiratoria por SARS-CoV-2/COVID-19

    Nancy Yomayusa González / Eduardo Low Padilla / Ilich de la Hoz Siegler / Kelly Chacón / Juan Acevedo Peña / Liliana Barrero Garzón / Alexander Barrera Barinas / Natalia Tolosa Pérez / Andrea Castillo Niuman / Fredy Guevara Pulido / Diana Castelblanco Cuevas / Carlos Pinzón Flórez / Fredy Mendivelso Duarte / Francy Cantor Cruz / Ana Castillo Gutiérrez / Olga Gómez Gómez / Adriana Ávila / Claudia Guevara / Carlos Álvarez Moreno /
    José Rojas Gambasica / Carlos Miguel Arbeláez Duque / Bibiana García Guarín / Martha Cárdenas Rodríguez / Sandra Robayo Rodríguez / Marcela Torres Castro

    Revista Colombiana de Nefrología, Vol 7, Iss 2, Pp 160-

    2020  Volume 182

    Abstract: Introducción: debido a la emergencia del coronavirus SARS-CoV-2 desde diciembre del 2019, se ha generado un gran volumen de producción científica, en algún caso incierta o controvertida especialmente en el manejo farmacológico de los pacientes con esta ... ...

    Abstract Introducción: debido a la emergencia del coronavirus SARS-CoV-2 desde diciembre del 2019, se ha generado un gran volumen de producción científica, en algún caso incierta o controvertida especialmente en el manejo farmacológico de los pacientes con esta infección; por lo tanto, se considera relevante buscar alternativas metodológicas para realizar su síntesis rigurosa, sistemática y de calidad, pero con menor tiempo de ejecución y menor costo. Objetivo: presentar la evidencia disponible respecto al manejo farmacológico de personas con sospecha o diagnóstico de infección respiratoria por SARS-CoV-2 (COVID-19) utilizando el método de revisiones sistemáticas rápidas (RS-R) en medicamentos poten- cialmente eficaces para su manejo. Metodología: se realizó una búsqueda sistemática y estructurada en Medline, Embase, Scopus, Cochrane Library, Clinical trials y Google Scholar en inglés. Los estudios incluidos fueron guías de práctica clínica, consensos, revisiones sistemáticas, metaanálisis, ensayos clínicos y otros estudios primarios. La búsqueda y extracción de datos se realizó por múltiples revisores, pero ninguna fue pareada. Resultados: dieciseis preguntas de interés clínico fueron resueltas, relacionadas con el uso en COVID-19 de lopinavir/ ritonavir, nelfinavir, oseltamivir, remdesivir, ribavirina, teicoplanina, umifenovir, favipiravir, tocilizumab, ivermectina y plasma convaleciente; también se evaluó el uso de medicamentos de soporte e incluidos en el manejo como la dexametasona, así como el uso concomitante de medicamentos que generaron dudas como son los AINES, los IECA y los ARA II. Conclusiones: los resúmenes de evidencia se muestran dentro del escenario de la pandemia como una buena alternativa metodológica para ofrecer información de calidad a corto plazo para los tomadores de decisiones
    Keywords covid-19 ; síndromerespiratorioagudograve ; tratamientofarmacológico ; antivirales ; sars-cov-2 ; Internal medicine ; RC31-1245 ; Diseases of the genitourinary system. Urology ; RC870-923
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Asociación Colombiana de Nefrología e Hipertensión Arterial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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