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  1. Article ; Online: [No title information]

    Lønnee, Mads Fich / Carlsen, Esben Andreas / Hovind, Peter

    Ugeskrift for laeger

    2023  Volume 185, Issue 13

    Title translation Spondylitis kompliceret med septiske embolier i lunger og muskulatur.
    MeSH term(s) Humans ; Spondylitis ; Muscles ; Sepsis ; Lung
    Language Danish
    Publishing date 2023-03-31
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prospective Phase II Trial of [

    Carlsen, Esben Andreas / Loft, Mathias / Loft, Annika / Czyzewska, Dorota / Andreassen, Mikkel / Langer, Seppo W / Knigge, Ulrich / Kjaer, Andreas

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2022  Volume 64, Issue 2, Page(s) 252–259

    Abstract: ... Integrin ... ...

    Abstract Integrin α
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography/methods ; Gallium Radioisotopes ; Integrin alphaVbeta3/metabolism ; Endothelial Cells/metabolism ; Prospective Studies ; Oligopeptides ; Neuroendocrine Tumors/diagnostic imaging ; Liver Neoplasms
    Chemical Substances 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane ; Gallium Radioisotopes ; Integrin alphaVbeta3 ; Oligopeptides
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.264383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prospective Phase II Trial of Prognostication by

    Carlsen, Esben Andreas / Loft, Mathias / Loft, Annika / Berthelsen, Anne Kiil / Langer, Seppo W / Knigge, Ulrich / Kjaer, Andreas

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2022  Volume 63, Issue 9, Page(s) 1371–1377

    Abstract: The clinical course for patients with neuroendocrine neoplasms (NENs) ranges from indolent to highly aggressive. Noninvasive tools to improve prognostication and guide decisions on treatment are warranted. Expression of urokinase plasminogen activator ... ...

    Abstract The clinical course for patients with neuroendocrine neoplasms (NENs) ranges from indolent to highly aggressive. Noninvasive tools to improve prognostication and guide decisions on treatment are warranted. Expression of urokinase plasminogen activator receptor (uPAR) is present in many cancer types and associated with a poor outcome. Therefore, using an in-house-developed uPAR PET tracer [
    MeSH term(s) Gallium Radioisotopes ; Heterocyclic Compounds, 1-Ring ; Humans ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/pathology ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Prospective Studies ; Receptors, Urokinase Plasminogen Activator/metabolism
    Chemical Substances Gallium Radioisotopes ; Heterocyclic Compounds, 1-Ring ; Receptors, Urokinase Plasminogen Activator ; 1,4,7-triazacyclononane-N,N',N''-triacetic acid (56491-86-2)
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.263177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diagnostic Value of Preoperative uPAR-PET/CT in Regional Lymph Node Staging of Oral and Oropharyngeal Squamous Cell Carcinoma: A Prospective Phase II Trial.

    Lawaetz, Mads / Christensen, Anders / Juhl, Karina / Lelkaitis, Giedrius / Karnov, Kirstine / Carlsen, Esben Andreas / Charabi, Birgitte W / Loft, Annika / Czyzewska, Dorota / Buchwald, Christian von / Kjaer, Andreas

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 21

    Abstract: The detection of lymph node metastases is a major challenge in oral and oropharyngeal squamous cell carcinoma (OSCC and OPSCC). ...

    Abstract The detection of lymph node metastases is a major challenge in oral and oropharyngeal squamous cell carcinoma (OSCC and OPSCC).
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13213303
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  5. Article ; Online: Semiautomatic Tumor Delineation for Evaluation of

    Carlsen, Esben Andreas / Johnbeck, Camilla Bardram / Loft, Mathias / Pfeifer, Andreas / Oturai, Peter / Langer, Seppo W / Knigge, Ulrich / Ladefoged, Claes Nøhr / Kjaer, Andreas

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 62, Issue 11, Page(s) 1564–1570

    Abstract: Patients with neuroendocrine neoplasms (NENs) have heterogeneous somatostatin receptor expression, with highly differentiated lesions having higher expression. Receptor expression of the total tumor burden may be visualized by somatostatin receptor ... ...

    Abstract Patients with neuroendocrine neoplasms (NENs) have heterogeneous somatostatin receptor expression, with highly differentiated lesions having higher expression. Receptor expression of the total tumor burden may be visualized by somatostatin receptor imaging, such as with
    MeSH term(s) Adult ; Humans ; Middle Aged ; Neuroendocrine Tumors ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radionuclide Imaging ; Receptors, Somatostatin
    Chemical Substances Receptors, Somatostatin ; copper dotatate CU-64
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.258392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: First-in-Human Study of [

    Clausen, Malene Martini / Carlsen, Esben Andreas / Christensen, Camilla / Madsen, Jacob / Brandt-Larsen, Malene / Klausen, Thomas Levin / Holm, Søren / Loft, Annika / Berthelsen, Anne Kiil / Kroman, Niels / Knigge, Ulrich / Kjaer, Andreas

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: Arginine-Glycine-Aspartate (RGD)-recognizing cell surface integrins are involved in tumor growth, invasiveness/metastases, and angiogenesis, and are therefore an attractive treatment target in cancers. The subtype integrin ... ...

    Abstract Arginine-Glycine-Aspartate (RGD)-recognizing cell surface integrins are involved in tumor growth, invasiveness/metastases, and angiogenesis, and are therefore an attractive treatment target in cancers. The subtype integrin α
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12040851
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  7. Article: A convolutional neural network for total tumor segmentation in [

    Carlsen, Esben Andreas / Lindholm, Kristian / Hindsholm, Amalie / Gæde, Mathias / Ladefoged, Claes Nøhr / Loft, Mathias / Johnbeck, Camilla Bardram / Langer, Seppo Wang / Oturai, Peter / Knigge, Ulrich / Kjaer, Andreas / Andersen, Flemming Littrup

    EJNMMI research

    2022  Volume 12, Issue 1, Page(s) 30

    Abstract: Background: Segmentation of neuroendocrine neoplasms (NENs) in [: Results: Cross-validation training was used to generate models and an ensemble model. The ensemble model performed best overall with a lesion-wise dice of 0.850 and pixel-wise dice, ... ...

    Abstract Background: Segmentation of neuroendocrine neoplasms (NENs) in [
    Results: Cross-validation training was used to generate models and an ensemble model. The ensemble model performed best overall with a lesion-wise dice of 0.850 and pixel-wise dice, precision and sensitivity of 0.801, 0.786 and 0.872, respectively. Performance of the ensemble model was acceptable with some degree of manual adjustment in 35/41 (85%) patients. Final tumor segmentation could be obtained from the AI model with manual adjustments in 5 min versus 17 min for ground truth method, p < 0.01.
    Conclusion: We implemented and validated an AI model that achieved a high similarity with ground truth segmentation and resulted in faster tumor segmentation. With AI, total tumor segmentation may become feasible in the clinical routine.
    Language English
    Publishing date 2022-05-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-022-00901-2
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  8. Article ; Online: 64

    Carlsen, Esben Andreas / Johnbeck, Camilla Bardram / Binderup, Tina / Loft, Mathias / Pfeifer, Andreas / Mortensen, Jann / Oturai, Peter / Loft, Annika / Berthelsen, Anne Kiil / Langer, Seppo W / Knigge, Ulrich / Kjaer, Andreas

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 61, Issue 10, Page(s) 1491–1497

    Abstract: Overexpression of somatostatin receptors (SSTRs) in patients with neuroendocrine neoplasms (NENs) is used for both diagnosis and treatment. Receptor density may reflect tumor differentiation and thus be associated with prognosis. Noninvasive ... ...

    Abstract Overexpression of somatostatin receptors (SSTRs) in patients with neuroendocrine neoplasms (NENs) is used for both diagnosis and treatment. Receptor density may reflect tumor differentiation and thus be associated with prognosis. Noninvasive visualization and quantification of SSTR density is possible by SSTR imaging (SRI) using PET. Recently, we introduced
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/mortality ; Octreotide/analogs & derivatives ; Organometallic Compounds ; Positron Emission Tomography Computed Tomography/methods ; Progression-Free Survival ; Prospective Studies
    Chemical Substances 64Cu-DOTATATE ; Organometallic Compounds ; Octreotide (RWM8CCW8GP)
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.119.240143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study.

    Carlsen, Esben Andreas / Fazio, Nicola / Granberg, Dan / Grozinsky-Glasberg, Simona / Ahmadzadehfar, Hojjat / Grana, Chiara Maria / Zandee, Wouter T / Cwikla, Jaroslaw / Walter, Martin A / Oturai, Peter Sandor / Rinke, Anja / Weaver, Andrew / Frilling, Andrea / Gritti, Sara / Arveschoug, Anne Kirstine / Meirovitz, Amichay / Knigge, Ulrich / Sorbye, Halfdan

    Endocrine-related cancer

    2018  Volume 26, Issue 2, Page(s) 227–239

    Abstract: Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1-2 (G1-G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN G3) is largely unknown. ...

    Abstract Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1-2 (G1-G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN G3) is largely unknown. We therefore aimed to assess the benefits and side effects of PRRT in patients with GEP NEN G3. We performed a retrospective cohort study at 12 centers to assess the efficacy and toxicity of PRRT in patients with GEP NEN G3. Outcomes were response rate, disease control rate, progression-free survival (PFS), overall survival (OS) and toxicity. We included 149 patients (primary tumor: pancreatic n = 89, gastrointestinal n = 34, unknown n = 26). PRRT was first-line (n = 30), second-line (n = 62) or later-line treatment (n = 57). Of 114 patients evaluated, 1% had complete response, 41% partial response, 38% stable disease and 20% progressive disease. Of 104 patients with documented progressive disease before PRRT, disease control rate was 69%. The total cohort had median PFS of 14 months and OS of 29 months. Ki-67 21-54% (n = 125) vs Ki-67 ≥55% (n = 23): PFS 16 vs 6 months (P < 0.001) and OS 31 vs 9 months (P < 0.001). Well (n = 60) vs poorly differentiated NEN (n = 62): PFS 19 vs 8 months (P < 0.001) and OS 44 vs 19 months (P < 0.001). Grade 3-4 hematological or renal toxicity occurred in 17% of patients. This large multicenter cohort of patients with GEP NEN G3 treated with PRRT demonstrates promising response rates, disease control rates, PFS and OS as well as toxicity in patients with mainly progressive disease. Based on these results, PRRT may be considered for patients with GEP NEN G3.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Intestinal Neoplasms/diagnostic imaging ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/mortality ; Intestinal Neoplasms/radiotherapy ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/metabolism ; Neuroendocrine Tumors/mortality ; Neuroendocrine Tumors/radiotherapy ; Octreotide/adverse effects ; Octreotide/analogs & derivatives ; Octreotide/therapeutic use ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/radiotherapy ; Positron Emission Tomography Computed Tomography ; Radioisotopes/adverse effects ; Radioisotopes/therapeutic use ; Receptors, Peptide/metabolism ; Retrospective Studies ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/mortality ; Stomach Neoplasms/radiotherapy ; Treatment Outcome ; Young Adult
    Chemical Substances Radioisotopes ; Receptors, Peptide ; Octreotide (RWM8CCW8GP)
    Language English
    Publishing date 2018-12-11
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-18-0424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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