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Article: Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals

Carlson, Jeffrey M. / Janulewicz, Patricia A. / Kleinstreuer, Nicole C. / Heiger-Bernays, Wendy

Environmental science & technology. 2022 Apr. 21, v. 56, no. 9

2022

Abstract: Chemical-induced alteration of maternal thyroid hormone levels may increase the risk of adverse neurodevelopmental outcomes in offspring. US federal risk assessments rely almost exclusively on apical endpoints in animal models for deriving points of ... ...

Abstract	Chemical-induced alteration of maternal thyroid hormone levels may increase the risk of adverse neurodevelopmental outcomes in offspring. US federal risk assessments rely almost exclusively on apical endpoints in animal models for deriving points of departure (PODs). New approach methodologies (NAMs) such as high-throughput screening (HTS) and mechanistically informative in vitro human cell-based systems, combined with in vitro to in vivo extrapolation (IVIVE), supplement in vivo studies and provide an alternative approach to calculate/determine PODs. We examine how parameterization of IVIVE models impacts the comparison between IVIVE-derived equivalent administered doses (EADs) from thyroid-relevant in vitro assays and the POD values that serve as the basis for risk assessments. Pesticide chemicals with thyroid-based in vitro bioactivity data from the US Tox21 HTS program were included (n = 45). Depending on the model structure used for IVIVE analysis, up to 35 chemicals produced EAD values lower than the POD. A total of 10 chemicals produced EAD values higher than the POD regardless of the model structure. The relationship between IVIVE-derived EAD values and the in vivo-derived POD values is highly dependent on model parameterization. Here, we derive a range of potentially thyroid-relevant doses that incorporate uncertainty in modeling choices and in vitro assay data.
Keywords	bioactive properties ; environmental science ; humans ; in vitro to in vivo extrapolation ; pesticides ; progeny ; risk ; technology ; thyroid hormones ; toxicology ; uncertainty
Language	English
Dates of publication	2022-0421
Size	p. 5620-5631.
Publishing place	American Chemical Society
Document type	Article
ISSN	1520-5851
DOI	10.1021/acs.est.1c07143
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Seeing Snakes: An HIV Patient with Visual Hallucinations.

Meyer, Matthew J / Carlson, Jeffrey J / Lin, Doris

The American journal of medicine

2020 Volume 133, Issue 6, Page(s) 687–689

MeSH term(s)	AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/diagnostic imaging ; AIDS-Related Opportunistic Infections/psychology ; Hallucinations/etiology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Parietal Lobe/diagnostic imaging ; Parietal Lobe/pathology ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/pathology ; Tuberculoma, Intracranial/diagnosis ; Tuberculoma, Intracranial/diagnostic imaging ; Tuberculoma, Intracranial/etiology ; Tuberculoma, Intracranial/psychology
Language	English
Publishing date	2020-02-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2019.10.013
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Article ; Online: Stercoral Colitis: When Constipation is an Emergency.

Panneerselvam, Sugi / Carlson, Jeffrey J / Lin, Doris

The American journal of the medical sciences

2020 Volume 361, Issue 6, Page(s) e61–e62

MeSH term(s)	Adult ; Colitis/diagnostic imaging ; Colitis/etiology ; Colitis/surgery ; Constipation/diagnostic imaging ; Constipation/etiology ; Constipation/surgery ; Emergency Medical Services/methods ; Fecal Impaction/complications ; Fecal Impaction/diagnostic imaging ; Fecal Impaction/surgery ; Female ; Humans
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2020.11.013
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Article ; Online: Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals.

Carlson, Jeffrey M / Janulewicz, Patricia A / Kleinstreuer, Nicole C / Heiger-Bernays, Wendy

Environmental science & technology

2022 Volume 56, Issue 9, Page(s) 5620–5631

Abstract	Chemical-induced alteration of maternal thyroid hormone levels may increase the risk of adverse neurodevelopmental outcomes in offspring. US federal risk assessments rely almost exclusively on apical endpoints in animal models for deriving points of departure (PODs). New approach methodologies (NAMs) such as high-throughput screening (HTS) and mechanistically informative in vitro human cell-based systems, combined with in vitro to in vivo extrapolation (IVIVE), supplement in vivo studies and provide an alternative approach to calculate/determine PODs. We examine how parameterization of IVIVE models impacts the comparison between IVIVE-derived equivalent administered doses (EADs) from thyroid-relevant in vitro assays and the POD values that serve as the basis for risk assessments. Pesticide chemicals with thyroid-based in vitro bioactivity data from the US Tox21 HTS program were included (
MeSH term(s)	Animals ; High-Throughput Screening Assays/methods ; Pesticides/toxicity ; Risk Assessment/methods ; Thyroid Gland ; Uncertainty
Chemical Substances	Pesticides
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c07143
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Family burden, child disability, and the adjustment of mothers caring for children with epilepsy: Role of social support and coping.

Carlson, Jeffrey M / Miller, Paul A

Epilepsy & behavior : E&B

2017 Volume 68, Page(s) 168–173

Abstract: Purpose: This study was designed to contribute to the existing research on the coping behaviors, social support, and mental health outcomes in parents of children with epilepsy in the United States.: Methods: Participants included 152, predominantly ... ...

Abstract	Purpose: This study was designed to contribute to the existing research on the coping behaviors, social support, and mental health outcomes in parents of children with epilepsy in the United States. Methods: Participants included 152, predominantly Caucasian (89.5%), married (78.9%) women (95.4%). Via a web-based interface, mothers completed questionnaires assessing the impact of their child's disability on their family (i.e., severity of their child's disability, family burden, and personal stress), social resources (i.e., perceived social support), coping (i.e., emotion-focused and social support seeking), and adjustment (i.e., depression and anxiety). Results: After controlling for demographic variables, mediational analysis revealed that mothers' perceptions of the severity of their child's disability were associated with decreased perceived social support, which was then related to higher reported levels of depression and anxiety. Similarly, low levels of perceived social support partially mediated the relation between family burden and depression, anxiety, and stress. Finally, mothers' perceptions of the severity of their children's disability and family burden were unrelated to their reports of emotion-focused or social support seeking coping. However, their use of emotion-focused and social support seeking behaviors was related to lower levels of depression. Conclusion: Low levels of perceived social support may help to explain the mechanisms underlying the relation between mothers' perceptions of the severity of their child's disability and family burden on their mental health adjustment, such as depression and anxiety.
MeSH term(s)	Adaptation, Psychological ; Adult ; Anxiety/psychology ; Child ; Cost of Illness ; Depression/psychology ; Disabled Children ; Epilepsy ; Female ; Humans ; Male ; Mental Health ; Middle Aged ; Mothers/psychology ; Social Support
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2017.01.013
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Article ; Online: Zika virus prevention behaviors and knowledge among male partners of pregnant people and lack of condom use as a prevention behavior from the Zika en Embarazadas y Niños (ZEN) prospective cohort study, Colombia.

Sancken, Christina L / Tannis, Ayzsa / Amouzou, Sandra A / Burkel, Veronica / Carlson, Jeffrey M / Newton, Suzanne / Gilboa, Suzanne M / Gonzalez, Maritza / Valencia, Diana / Tong, Van T / Ospina, Martha

BMC research notes

2024 Volume 17, Issue 1, Page(s) 87

Abstract: Objective: Zika virus (ZIKV) infection in pregnancy can cause brain and eye abnormalities and neurodevelopmental sequelae. In the absence of medical countermeasures, behavioral interventions were recommended to prevent mosquito bites and sexual ... ...

Abstract	Objective: Zika virus (ZIKV) infection in pregnancy can cause brain and eye abnormalities and neurodevelopmental sequelae. In the absence of medical countermeasures, behavioral interventions were recommended to prevent mosquito bites and sexual transmission of ZIKV. This report uses data from the Zika en Embarazadas y Niños (ZEN) prospective cohort study in Colombia to describe the knowledge, attitudes, and behaviors (KAB) related to ZIKV prevention in male partners compared to those of their pregnant partners at study enrollment during February 2017-2018. Results: Most male partners reported wearing protective clothing such as long pants (97.6%) and long sleeves (72.8%), as well as covering ankles and feet (89.1%) to prevent ZIKV infection. When comparing the preventive behavior of condom use between male and pregnant partners, 26 pairs (10.0%) both responded that they performed the behavior. Overall, 25.1% of male partners and 18.9% of pregnant people reported any condom use during the three months before enrolling in ZEN. When comparing other preventive behaviors between male and pregnant partners, the behavior which was most frequently reported by both partners was wearing long pants (85.4%), and the least frequently reported by both partners was using condoms after finding out about a partner's pregnancy (3.4%).
MeSH term(s)	Pregnancy ; Female ; Humans ; Male ; Zika Virus ; Zika Virus Infection/prevention & control ; Condoms ; Colombia ; Prospective Studies ; Pregnancy Complications, Infectious/prevention & control
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-024-06702-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Lunar Dust Particles Blown By Lander Engine Exhaust in Rarefied and Compressible Flow

Lane, John E. / Metzger, Philip T. / Carlson, Jeffrey W.

2021

Abstract: Previously we presented a numerical model that predicts trajectories of lunar dust, soil, and gravel blown by the engine exhaust of a lunar lander. The model uses the gas density, velocity vector field, and temperature predicted by computational fluid ... ...

Abstract	Previously we presented a numerical model that predicts trajectories of lunar dust, soil, and gravel blown by the engine exhaust of a lunar lander. The model uses the gas density, velocity vector field, and temperature predicted by computational fluid dynamics (CFD) or Direct Simulation Monte Carlo (DSMC) simulations to compute the forces and accelerations acting on the regolith particles, one particle at a time (ignoring particle collisions until more advanced models are developed). Here we present significant improvements to the model, including the implementation of particle drag and lift formulas to account for the rarefaction and compressibility of the flow. It turns out that the drag force is reduced due to the rarefaction, but the lift is increased due to several effects such as particle rotation. A data matrix of particle sizes, engine thrusts (descent and ascent values for Altair), horizontal and vertical starting distances, and lander height above ground, have been tested using the latest version of the software. These results suggest that the previously reported 3 degree trajectory angle limit can be exceeded in several cases by as much as a factor of five. Particles that originate at a height of 1 cm above the surface from an outer crater rim can be propelled to angles of 5 degrees or more. Particles that start at 10 cm above the surface can be ejected with angles of up to 15 degrees. Mechanisms responsible for placing particles at starting heights above the surface may include the kinetics of horizontal collisions, as suggested by Discrete Element Method (DEM) simulations. We also present results showing the distance particles travel and their impact velocities. We then use the model to evaluate the effectiveness of berms or other methods to block the spray of soil at a lunar landing site. Comment: 9 pages, 6 figures
Keywords	Physics - Fluid Dynamics ; Astrophysics - Earth and Planetary Astrophysics
Subject code	621
Publishing date	2021-04-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pre-pregnancy body mass index and parent and teacher-reported behavioral outcomes among offspring in childhood.

Parker, Samantha E / Carlson, Jeffrey M / Kebede, Nehemiah / Werler, Martha M / Janulewicz, Patricia A

Neurotoxicology and teratology

2021 Volume 89, Page(s) 107049

Abstract: Objective: Pre-pregnancy obesity has been linked to childhood neurodevelopmental outcomes, including autism and attention-deficit hyperactivity disorder. The aim of our study was to examine the association between pre-pregnancy body mass index (BMI) and ...

Abstract	Objective: Pre-pregnancy obesity has been linked to childhood neurodevelopmental outcomes, including autism and attention-deficit hyperactivity disorder. The aim of our study was to examine the association between pre-pregnancy body mass index (BMI) and scores on behavioral scales according to both mother and teacher report. Methods: We conducted a longitudinal study of 469 mother-child pairs. Information on pre-pregnancy body mass index (BMI) was collected from standardized maternal interviews conducted after delivery and assessment of childhood behavioral problems was measured at 5-12 years of age according to maternal-report using the Child Behavior Checklist (CBCL) and teacher-report using the Teacher Report Form (TRF). Using normal pre-pregnancy BMI (18.5-24.9 kg/m Results: Pre-pregnancy obesity was associated with a mean increase in child's total behavior problem t-scores according to both mother and teacher report, after adjustment for confounders and weighted for loss to follow-up (MD: 0.7, 95% CI: -2.2, 3.6 on CBCL; MD: 3.1, 95% CI: 0.5, 5.7 on TRF), indicating poorer behavioral outcomes. Comparing the magnitude of associations between mother and teacher-report, mean differences for pre-pregnancy obesity and most behavioral problem scales were larger for teacher-reported outcomes than mother-reported outcomes. Pre-pregnancy obesity was associated with increased risks of externalizing behaviors in the clinical range regardless of informant (CBCL RR: 1.6, 95% CI: 0.8, 3.2 and TRF RR: 1.7, 95% CI: 0.8, 3.5). Pre-pregnancy obesity was also associated with increased risks of internalizing behaviors according to teacher-report (TRF RR: 2.6, 95% CI:1.5, 4.6). Conclusions: Pre-pregnancy obesity, compared to pre-pregnancy normal weight, is associated with generally higher scores on both mother and teacher reported childhood behavioral assessments, indicating an increased likelihood of behavioral problems.
MeSH term(s)	Body Mass Index ; Female ; Humans ; Longitudinal Studies ; Mothers ; Obesity/epidemiology ; Pregnancy ; Problem Behavior
Language	English
Publishing date	2021-11-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639165-5
ISSN	1872-9738 ; 0892-0362
ISSN (online)	1872-9738
ISSN	0892-0362
DOI	10.1016/j.ntt.2021.107049
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Article: Investigating discounting of discounts in an online context

Carlson, Jeffrey R / Kukar-Kinney, Monika

Journal of retailing and consumer services Vol. 41 , p. 153-160

the mediating effect of discount credibility and moderating effect of online daily deal promotions

2018 Volume 41, Page(s) 153–160

Author's details	Jeffrey R. Carlson, Monika Kukar-Kinney
Keywords	Discounting of discounts ; Price promotions ; Daily deals ; Discount credibility
Language	English
Publisher	Elsevier
Publishing place	Amsterdam [u.a.]
Document type	Article
ZDB-ID	1204385-0
ISSN	0969-6989
Database	ECONomics Information System

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Article ; Online: Pre-Delta, Delta, and Omicron Periods of the Coronavirus Disease 2019 (COVID-19) Pandemic and Health Outcomes During Delivery Hospitalization.

Carlson, Jeffrey / Simeone, Regina M / Ellington, Sascha / Galang, Romeo / DeSisto, Carla L / Fleming-Dutra, Katherine / Riley, Laura / Meaney-Delman, Dana / Tong, Van T

Obstetrics and gynecology

2023 Volume 143, Issue 1, Page(s) 131–138

Abstract: Objective: To examine the relationship between coronavirus disease 2019 (COVID-19) diagnosis at delivery and adverse maternal health and pregnancy outcomes during pre-Delta, Delta, and Omicron variant predominance, with a focus on the time period of ... ...

Abstract	Objective: To examine the relationship between coronavirus disease 2019 (COVID-19) diagnosis at delivery and adverse maternal health and pregnancy outcomes during pre-Delta, Delta, and Omicron variant predominance, with a focus on the time period of Omicron variant predominance. Methods: We conducted a cross-sectional observational study with data from delivery hospitalizations in the Premier Healthcare Database from February 2020 to August 2023. The pre-Delta (February 2020-June 2021), Delta (July 2021-December 2021), and Omicron (January 2022-August 2023) periods of variant predominance were examined. Exposure to COVID-19 was identified by having a diagnostic code for COVID-19 during the delivery hospitalization. Adjusted prevalence ratios (aPRs) were calculated to compare the risks of adverse maternal and pregnancy outcomes for women with and without COVID-19 diagnoses at the time of delivery for each variant period. Results: Among 2,990,973 women with delivery hospitalizations, 1.9% (n=56,618) had COVID-19 diagnoses noted at delivery admission discharge, including 26,053 during the Omicron period. Across all variant time periods, the prevalence of many adverse maternal and pregnancy outcomes during the delivery hospitalization was significantly higher for pregnant women with COVID-19 compared with pregnant women without COVID-19. In adjusted models, COVID-19 during the Omicron period was associated with significant increased risks for maternal sepsis (COVID-19: 0.4% vs no COVID-19: 0.1%; aPR 3.32, 95% CI, 2.70-4.08), acute respiratory distress syndrome (0.6% vs 0.1%; aPR 6.19, 95% CI, 5.26-7.29), shock (0.2% vs 0.1%; aPR 2.14, 95% CI, 1.62-2.84), renal failure (0.5% vs 0.2%; aPR 2.08, 95% CI, 1.73-2.49), intensive care unit admission (2.7% vs 1.7%; aPR 1.64, 95% CI, 1.52-1.77), mechanical ventilation (0.3% vs 0.1%; aPR 3.15, 95% CI, 2.52-3.93), in-hospital death (0.03% vs 0.01%; aPR 5.00, 95% CI, 2.30-10.90), stillbirth (0.7% vs 0.6%; aPR 1.17, 95% CI, 1.01-1.36), and preterm delivery (12.3% vs 9.6%; aPR 1.28, 95% CI, 1.24-1.33). Conclusion: Despite the possibility of some level of immunity due to previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, vaccination, or testing differences, risks of adverse outcomes associated with COVID-19 diagnosis at delivery remained elevated during the Omicron variant time period.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; COVID-19 Testing ; Cross-Sectional Studies ; Hospital Mortality ; Pandemics ; Hospitalization ; Outcome Assessment, Health Care ; Pregnancy Complications, Infectious/epidemiology
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000005449
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