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Article ; Online: Prevalence and Factors Associated with Olfactory Dysfunction in Individuals with COVID-19 in Brazil: A Study of 20,669 Cases from 2020 to 2021.

Souza, Carlos Dornels Freire de / Magalhães, Amanda Júlia de Arruda / Silva Nobre, Yasmin Vitória / Souza, Carlos Alberto / Nascimento, André Luis Oliveira do / Faria, Luísa Robalinho de / Bezerra-Santos, Márcio / Armstrong, Anderson da Costa / Nicácio, Jandir Mendonça / Gomes, Orlando Vieira / Carmo, Rodrigo Feliciano do

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

2024 Volume 33, Issue 2, Page(s) 164–172

Abstract: Objective: The aim of the study is to determine the prevalence and factors associated with olfactory dysfunction in individuals with COVID-19 in the first 2 years of the pandemic in Brazil.: Materials and methods: This is a prevalent study involving ... ...

Abstract	Objective: The aim of the study is to determine the prevalence and factors associated with olfactory dysfunction in individuals with COVID-19 in the first 2 years of the pandemic in Brazil. Materials and methods: This is a prevalent study involving the confirmed cases of COVID-19 recorded in the municipality between the years 2020 and 2021. Individuals symptomatic for COVID-19, with a positive laboratory result and aged 12 or older were included in this study. Measures of central tendency and dispersion were used in the description of continuous variables and frequency was used for categorical variables. The Shapiro-Wilk test was used to evaluate data distribution. Results: Data from 20,669 individuals were analyzed. The prevalence of olfactory disorders was 17.9% and increased from 11.5% to 21.9% between 2020 and 2021. A female gender predominance was observed among individuals who reported anosmia, with 61.1% (n = 564) in 2020 and 61.7% (n = 1,713) in 2021. On the other hand, the median age of individuals with olfactory disorders was lower than that of the group without disorders (35 [IQR 27-46] vs. 39 [IQR 29-50]; p < 0.001). Smell disturbances were present in 18.2% (n = 3,634) of patients who recovered and in 7.1% (n = 38) of those who died. Furthermore, in 2021, a prevalence rate of 30.6% for olfactory disorders was linked to obesity as a comorbidity. Conclusion: The prevalence of olfactory disorders was lower compared to other studies, with cough and fever being negatively related to olfactory dysfunction and headache, coryza, and taste disorders being positively related. Obesity was the only associated comorbidity.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	645108-1
ISSN	1423-0151 ; 1011-7571
ISSN (online)	1423-0151
ISSN	1011-7571
DOI	10.1159/000536191
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Article ; Online: Blood parasite load by qPCR as therapeutic monitoring in visceral leishmaniasis patients in Brazil: a case series study.

Aquino, Samuel Ricarte de / Diniz, Lucyo Flávio Bezerra / Nunes, Sávio Luiz Pereira / Silva, Roberta Lane de Oliveira / Gouveia, Gisele Veneroni / Gouveia, João José Simoni / Sales, Kamila Gaudêncio da Silva / Dantas-Torres, Filipe / Carmo, Rodrigo Feliciano do

Revista da Sociedade Brasileira de Medicina Tropical

2023 Volume 56

Abstract: Background: This study aimed to describe the kinetics of Leishmania parasite load determined using kinetoplast DNA (kDNA)-based quantitative polymerase chain reaction (qPCR) in visceral leishmaniasis (VL) patients.: Methods: Parasite load in blood ... ...

Abstract	Background: This study aimed to describe the kinetics of Leishmania parasite load determined using kinetoplast DNA (kDNA)-based quantitative polymerase chain reaction (qPCR) in visceral leishmaniasis (VL) patients. Methods: Parasite load in blood was assessed by qPCR at five time points, up to 12 months post-diagnosis. Sixteen patients were followed up. Results: A significant reduction in the parasite load was observed after treatment (P < 0.0001). One patient had an increased parasite load 3 months post-treatment and relapsed clinically at month six. Conclusions: We have described the use of kDNA-based qPCR in the post-treatment follow-up of VL cases.
MeSH term(s)	Humans ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/parasitology ; DNA, Kinetoplast/genetics ; Brazil ; Leishmania/genetics ; Parasite Load
Chemical Substances	DNA, Kinetoplast
Language	English
Publishing date	2023-03-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0456-2022
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Article ; Online: Urbanization and cardiovascular health among Indigenous groups in Brazil.

Armstrong, Anderson da Costa / de Souza, Carlos Dornels Freire / Santos, Juracy Marques Dos / Carmo, Rodrigo Feliciano do / Armstrong, Dinani Matoso Fialho de Oliveira / Pereira, Vanessa Cardoso / Ladeia, Ana Marice / Correia, Luis Claudio Lemos / Barral-Netto, Manoel / Lima, Joao Augusto Costa

Communications medicine

2023 Volume 3, Issue 1, Page(s) 17

Abstract: Background: We described the prevalence of cardiovascular risk factors in groups of Brazilian Indigenous people at different degrees of urbanization.: Methods: The Project of Atherosclerosis among Indigenous populations (Projeto de Aterosclerose em ... ...

Abstract	Background: We described the prevalence of cardiovascular risk factors in groups of Brazilian Indigenous people at different degrees of urbanization. Methods: The Project of Atherosclerosis among Indigenous populations (Projeto de Aterosclerose em Indígenas; PAI) is a cross-sectional study conducted in Northeast Brazil between August 2016-June 2017. It included three populations: Fulni-ô Indigenous people (lowest degree of urbanization), Truká Indigenous people (greater urbanization), and a highly urbanized non-Indigenous local cohort (control group). Participants were assessed to register sociodemographic, anthropometric, as well as clinical and laboratory-derived cardiovascular (CV) risk parameters. Age-adjusted prevalence of hypertension was also computed. Nonparametric tests were used for group comparisons. Results: Here we included 999 participants, with a predominance of females in all three groups (68.3% Control group, 65.0% Fulni-ô indigenous group, and 60.1% Truká indigenous group). Obesity was present in 45.6% of the urban non-Indigenous population, 37.7% Truká and in 27.6% Fulni-ô participants. The prevalence of hypertension was 29.1% (n = 297) with lower prevalence in the less urbanized Fulni-ô people (Fulni-ô - 18.2%; Truká - 33.9%; and Control - 33.8%; p < 0.001). In the elderly male population, the prevalence of hypertension was 18.7% in the Fulni-ô, 45.8% in the Truká, and 54.5% in the control group. Of the 342 participants that self-reported hypertension, 37.5% (n = 68) showed uncontrolled blood pressure (BP). Uncontrolled BP was more prevalent among Truká people when compared to Fulni-ô people and non-Indigenous participants (45.4%, 22.9%, and 40.7%, respectively; p < 0.001). Conclusions: We found a higher cardiovascular risk in communities with a higher degree of urbanization, suggesting that living in towns and cities may have a negative impact on these aspects of cardiovascular health.
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-023-00239-3
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Article ; Online: Oral health of an indigenous population in northeastern Brazil: a cross-sectional Study of the Fulni-ô ethnic group.

Koike, Bruna Del Vechio / Valões, Rosangela Maria Pereira / Cazal, Claudia / Pereira, Vanessa Cardoso / Fraga, Carlos Alberto de Carvalho / Carmo, Rodrigo Feliciano do / Pereira, Meireane Firmino / Guimarães, Manoel Pereira / Souza, Carlos Dornels Freire de / Armstrong, Anderson da Costa

Sao Paulo medical journal = Revista paulista de medicina

2023 Volume 142, Issue 1, Page(s) e2022355

Abstract: Background: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil.: Objectives: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group ... ...

Abstract	Background: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. Objectives: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. Design and setting: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. Methods: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student's t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. Results: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. Conclusions: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases.
MeSH term(s)	Male ; Female ; Humans ; Ethnicity ; Cross-Sectional Studies ; Oral Health ; Brazil/epidemiology ; Indigenous Peoples ; Prevalence
Language	English
Publishing date	2023-07-31
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1203171-9
ISSN	1806-9460 ; 1516-3180 ; 0035-0362
ISSN (online)	1806-9460
ISSN	1516-3180 ; 0035-0362
DOI	10.1590/1516-3180.2022.0355.R1.10042023
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Article ; Online: Epidemiology of human visceral leishmaniasis in the urban centers of the lower-middle São Francisco Valley, Brazilian semiarid region.

Diniz, Lucyo Flávio Bezerra / Souza, Carlos Dornels Freire de / Carmo, Rodrigo Feliciano do

Revista da Sociedade Brasileira de Medicina Tropical

2018 Volume 51, Issue 4, Page(s) 461–466

Abstract: Introduction: Visceral leishmaniasis (VL) is a zoonosis caused by parasites of the Leishmania genus. VL is present in countries with tropical climates, being endemic in Brazil,, including the region of the lower-middle São Francisco Valley which ... ...

Abstract	Introduction: Visceral leishmaniasis (VL) is a zoonosis caused by parasites of the Leishmania genus. VL is present in countries with tropical climates, being endemic in Brazil,, including the region of the lower-middle São Francisco Valley which includes the urban centers of Petrolina (Pernambuco state) and Juazeiro (Bahia state). Methods: This retrospective and descriptive epidemiological study analyzed secondary data obtained from the mandatory visceral leishmaniasis notification forms of the Ministry of Health, which were compiled in the Information System for Notifiable Diseases (SINAN) database. We analyzed 181 autochthonous cases reported in the two aforementioned cities between 2010 and 2016. Data collection occurred in June 2017. Results: Of the 181 VL cases in the study area, 40.9% (n=74) occurred in Juazeiro and 59.1% (n=107) occurred in Petrolina. The average numbers of cases per year were 9.5 in Juazeiro and 14 in Petrolina; respectively, the incidence ranges were 2-8.6 cases and 2.8-6.1 cases per 100,000 inhabitants. Fever, weakness, weight loss, and pallor were the most commonly observed clinical manifestations. Coinfection with human immunodeficiency virus (HIV) was observed in 16.8% and 5.4% of cases in Petrolina and Juazeiro, respectively. The lethality rates were 2.8% and 5.4% in Petrolina and Juazeiro, respectively. Conclusions: Both cities had a high incidence of VL during the studied period. The findings of this study contribute to a better understanding of the behavior of VL during recent years and may help to direct regional disease control measures.
MeSH term(s)	Adolescent ; Adult ; Brazil/epidemiology ; Disease Notification ; Female ; Humans ; Incidence ; Leishmaniasis, Visceral/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Socioeconomic Factors ; Urban Population/statistics & numerical data ; Young Adult
Language	English
Publishing date	2018-08-31
Publishing country	Brazil
Document type	Comparative Study ; Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0074-2018
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Article ; Online: Urban mobility and COVID-19 in Brazil: Comparison between 2020 and 2021.

Armstrong, Anderson da Costa / Souza, Carlos Dornels Freire de / Santos, Márcio Bezerra / Santos, Lucas Gomes / Carmo, Rodrigo Feliciano do

Revista da Associacao Medica Brasileira (1992)

2021 Volume 67, Issue 9, Page(s) 1221–1225

Abstract: Objective: The aim of this study was to analyze and compare the indicators of urban mobility and the number of new cases of COVID-19 recorded daily between 2020 and 2021.: Methods: An observational study was carried out involving new cases of COVID- ... ...

Abstract	Objective: The aim of this study was to analyze and compare the indicators of urban mobility and the number of new cases of COVID-19 recorded daily between 2020 and 2021. Methods: An observational study was carried out involving new cases of COVID-19 registered daily in the state of Pernambuco, Brazil between March 12, 2020 and March 28, 2021 and six indicators of urban mobility. For analysis, the study was divided into two periods: the first was composed of 295 days and represents the year 2020 and the second was composed of 86 days and represents the year 2021. Spearman's non-parametric correlation was used. Results: In 2021, the greatest reductions in relation to the baseline were observed in parks (-29.0) and in retail and recreation areas (-28.7). However, these reductions were smaller than those observed in the previous year, indicating a greater circulation of people in 2021 when compared with mobility in 2020. In contrast, in residential areas, there was a reduction in the percentage change in relation to the previous year (11.2 in 2019 and 7.6 in 2021). In grocery and pharmacy, there was an increase 1.8 times greater than that observed in 2020 (9.1 in 2020 and 17.0 in 2021). It is also noteworthy that the daily average of new cases almost doubled in value (753.4 in 2020 and 1409.1 in 2021). Conclusion: More vigorous measures must be taken to adequately control the pandemic.
MeSH term(s)	Brazil ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-11-19
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20210570
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Article ; Online: COVID-19 in Brazil: spatial risk, social vulnerability, human development, clinical manifestations and predictors of mortality - a retrospective study with data from 59 695 individuals.

Baggio, Jussara Almeida Oliveira / Machado, Michael Ferreira / Carmo, Rodrigo Feliciano do / Armstrong, Anderson da Costa / Santos, Alan Dantas Dos / Souza, Carlos Dornels Freire de

Epidemiology and infection

2021 Volume 149, Page(s) e100

Abstract: Brazil ranks second in the number of confirmed cases of COVID-19 worldwide. In spite of this, coping measures differ throughout the national territory, as does the disease's impact on the population. This cross-sectional observational study, with 59 695 ... ...

Abstract	Brazil ranks second in the number of confirmed cases of COVID-19 worldwide. In spite of this, coping measures differ throughout the national territory, as does the disease's impact on the population. This cross-sectional observational study, with 59 695 cases of COVID-19 registered in the state of Alagoas between March and August 2020, analysed clinical-epidemiological variables, incidence rate, mortality rate, case fatality rate (CFR) and the social indicators municipal human development index (MHDI) and social vulnerability index (SVI). Moran statistics and regression models were applied. Logistic regression analysis was applied to determine the predictors of death. The incidence rate was 1788.7/100 000 inhabitants; mortality rate was 48.0/100 000 and CFR was 2.7%. The highest incidence rates were observed in municipalities with better human development (overall MHDI (I = 0.1668; p = 0.002), education MHDI (I = 0.1649; p = 0.002) and income MHDI (I = 0.1880; p = 0.005)) and higher social vulnerability (overall SVI (I = 0.0599; p = 0.033)). CFR was associated with higher social vulnerability (SVI human capital (I = 0.0858; p = 0.004) and SVI urban infrastructure (I = 0.0985; p = 0.040)). Of the analysed cases, 55.4% were female; 2/3 were Black or Brown and the median age was 41 years. Among deaths, most were male (919; 57.4%) and elderly (1171; 73.1%). The predictors of death were male sex, advanced age and the presence of comorbidities. In Alagoas, Brazil, the disease has undergone a process of interiorisation and caused more deaths in poorer municipalities. The presence of comorbidities and advanced age were predictors of death.
MeSH term(s)	Adult ; Aged ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/mortality ; Cross-Sectional Studies ; Databases, Factual ; Female ; Humans ; Incidence ; Logistic Models ; Male ; Middle Aged ; Registries ; Risk Factors ; Spatial Analysis ; Young Adult
Language	English
Publishing date	2021-04-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268821000935
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Article ; Online: Leprosy in the elderly population and the occurrence of physical disabilities: Is there cause for concern?

Matos, Thais Silva / Carmo, Rodrigo Feliciano do / Santos, Franklin Gerônimo Bispo / Souza, Carlos Dornels Freire de

Anais brasileiros de dermatologia

2019 Volume 94, Issue 2, Page(s) 243–245

MeSH term(s)	Aged ; Aged, 80 and over ; Aging ; Brazil/epidemiology ; Disabled Persons/statistics & numerical data ; Educational Status ; Female ; Humans ; Leprosy/complications ; Leprosy/epidemiology ; Male ; Middle Aged ; Sex Distribution
Language	English
Publishing date	2019-05-09
Publishing country	Spain
Document type	Letter
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1590/abd1806-4841.20198067
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Article: Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis

Nicacio, Jandir Mendonça / Gomes, Orlando Vieira / Carmo, Rodrigo Feliciano do / Nunes, Sávio Luiz Pereira / Rocha, José Roberto Coelho Ferreira / Souza, Carlos Dornels Freire de / Franca, Rafael Freitas de Oliveira / Khouri, Ricardo / Barral-Netto, Manoel / Armstrong, Anderson da Costa

Viruses. 2022 Sept. 08, v. 14, no. 9

2022

Abstract: Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential ... ...

Abstract	Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases with arboviruses, published up to March 2022. Relevant articles were selected and rated by two independent reviewers. Proportion meta-analysis was applied to assess the frequency-weighted mean of the cardiovascular findings. A total of 42 articles were selected (n = 76,678 individuals), with 17 manuscripts on dengue and 6 manuscripts on chikungunya undergoing meta-analysis. The global pooled incidence of cardiac events in dengue fever using a meta-analysis was 27.21% (95% CI 20.21–34.83; I² = 94%). The higher incidence of dengue-related myocarditis was found in the population younger than 20 years old (33.85%; 95% CI 0.00–89.20; I² = 99%). Considering the studies on chikungunya (n = 372), the global pooled incidence of cardiac involvement using a meta-analysis was 32.81% (95% CI 09.58–61.49, I² = 96%). Two Zika studies were included that examined cases of infection by vertical transmission in Brazil, finding everything from structural changes to changes in heart rate variability that increase the risk of sudden death. In conclusion, cardiac involvement in arboviruses is not uncommon, especially in dengue fever.
Keywords	arboviruses ; death ; dengue ; heart rate ; meta-analysis ; myocarditis ; risk ; systematic review ; Brazil
Language	English
Dates of publication	2022-0908
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14091988
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Article ; Online: Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis.

Viruses

2022 Volume 14, Issue 9

Abstract	Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases with arboviruses, published up to March 2022. Relevant articles were selected and rated by two independent reviewers. Proportion meta-analysis was applied to assess the frequency-weighted mean of the cardiovascular findings. A total of 42 articles were selected (
MeSH term(s)	Adult ; Arboviruses ; Chikungunya Fever/complications ; Chikungunya Fever/epidemiology ; Chikungunya virus/physiology ; Dengue ; Heart Diseases/complications ; Humans ; Young Adult ; Zika Virus/physiology ; Zika Virus Infection
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14091988
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