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  1. Article ; Online: Comparison of the accuracy of residents, senior physicians and surrogate decision-makers for predicting hospital mortality of critically ill patients.

    Carneiro, Bárbara Vieira / Crozatti, Lucas Lonardoni / Mendes, Pedro Vitale / Nassar Júnior, Antonio Paulo / Taniguchi, Leandro Utino

    Revista Brasileira de terapia intensiva

    2022  Volume 34, Issue 2, Page(s) 220–226

    Abstract: Objective: To compare the predictive performance of residents, senior intensive care unit physicians and surrogates early during intensive care unit stays and to evaluate whether different presentations of prognostic data (probability of survival versus ...

    Title translation Comparação da acurácia de residentes, médicos seniores e decisores substitutos na previsão da mortalidade hospitalar de pacientes críticos.
    Abstract Objective: To compare the predictive performance of residents, senior intensive care unit physicians and surrogates early during intensive care unit stays and to evaluate whether different presentations of prognostic data (probability of survival versus probability of death) influenced their performance.
    Methods: We questioned surrogates and physicians in charge of critically ill patients during the first 48 hours of intensive care unit admission on the patient's probability of hospital outcome. The question framing (i.e., probability of survival versus probability of death during hospitalization) was randomized. To evaluate the predictive performance, we compared the areas under the ROC curves (AUCs) for hospital outcome between surrogates and physicians' categories. We also stratified the results according to randomized question framing.
    Results: We interviewed surrogates and physicians on the hospital outcomes of 118 patients. The predictive performance of surrogate decisionmakers was significantly lower than that of physicians (AUC of 0.63 for surrogates, 0.82 for residents, 0.80 for intensive care unit fellows and 0.81 for intensive care unit senior physicians). There was no increase in predictive performance related to physicians' experience (i.e., senior physicians did not predict outcomes better than junior physicians). Surrogate decisionmakers worsened their prediction performance when they were asked about probability of death instead of probability of survival, but there was no difference for physicians.
    Conclusion: Different predictive performance was observed when comparing surrogate decision-makers and physicians, with no effect of experience on health care professionals' prediction. Question framing affected the predictive performance of surrogates but not of physicians.
    MeSH term(s) Critical Illness ; Decision Making ; Hospital Mortality ; Humans ; Intensive Care Units ; Physicians
    Language English
    Publishing date 2022-08-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2732162-9
    ISSN 1982-4335 ; 1982-4335
    ISSN (online) 1982-4335
    ISSN 1982-4335
    DOI 10.5935/0103-507X.20220019-pt
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of withholding early antibiotic therapy in nonseptic surgical patients with suspected nosocomial infection: a retrospective cohort analysis.

    Bassi, Estevão / Tomazini, Bruno Martins / Carneiro, Bárbara Vieira / Siqueira, Amanda Rodrigues de Oliveira / Siqueira, Sara Rodrigues de Oliveira / Guimarães, Thais / Novo, Fernando da Costa Ferreira / Utiyama, Edivaldo Massazo / Pelosi, Paolo / Malbouisson, Luiz Marcelo Sá

    Brazilian journal of anesthesiology (Elsevier)

    2023  

    Abstract: Background: Systemic inflammatory responses mimicking infectious complications are often present in surgical patients.: Methods: The objective was to assess the association between withholding early antimicrobial therapy while investigating ... ...

    Abstract Background: Systemic inflammatory responses mimicking infectious complications are often present in surgical patients.
    Methods: The objective was to assess the association between withholding early antimicrobial therapy while investigating alternative diagnoses and worse outcomes in nonseptic patients with suspected nosocomial infection in a retrospective cohort of critically ill surgical patients. The initiation of antibiotic therapy within 24 h of the suspicion of infection was defined as the Early Empirical Antibiotic strategy (EEA) group and the initiation after 24 h of suspicion or not prescribed was defined as the Conservative Antibiotic strategy (CA) group. Primary outcome was composite: death, sepsis, or septic shock within 14 days. Main exclusion criteria were sepsis or an evident source of infection at inclusion.
    Results: Three hundred and forty patients were eligible for inclusion (74% trauma patients). Age, sex, reason for hospital admission, SAPS3 score, SOFA score, and use of vasopressors or mechanical ventilation were not different between the groups. Within 14 days of inclusion, 100% (130/130) of EEA patients received antibiotics compared to 57% (120/210) of CA patients. After adjusting for confounding variables, there was no association between primary outcome and the groups. In a post hoc subgroup analysis including only patients with a posteriori confirmed infection (by microbiological cultures), delay in initiation of adequate antimicrobial therapy was independently associated with the primary outcome (Odds Ratio = 1.19 per day of delay; 95% CI 1.05-1.37).
    Conclusions: Withholding early empiric antibiotic therapy was not associated with progression of organ dysfunction within 14 days in nonseptic surgical patients with suspected nosocomial infection without an obvious source.
    Language English
    Publishing date 2023-03-23
    Publishing country Brazil
    Document type Journal Article
    ISSN 2352-2291
    ISSN (online) 2352-2291
    DOI 10.1016/j.bjane.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimization of conditions for apnea testing in a hypoxemic brain dead patient.

    Carneiro, Bárbara Vieira / Garcia, Guilherme Henrique / Isensee, Larissa Padrão / Besen, Bruno Adler Maccagnan Pinheiro

    Revista Brasileira de terapia intensiva

    2019  Volume 31, Issue 1, Page(s) 106–110

    Abstract: We report the case of a patient in whom brain death was suspected and associated with atelectasis and moderate to severe hypoxemia even though the patient was subjected to protective ventilation, a closed tracheal suction system, positive end-expiratory ... ...

    Title translation Otimização de condições para teste de apneia em paciente hipoxêmico com morte encefálica.
    Abstract We report the case of a patient in whom brain death was suspected and associated with atelectasis and moderate to severe hypoxemia even though the patient was subjected to protective ventilation, a closed tracheal suction system, positive end-expiratory pressure, and recruitment maneuvers. Faced with the failure to obtain an adequate partial pressure of oxygen for the apnea test, we elected to place the patient in a prone position, use higher positive end-expiratory pressure, perform a new recruitment maneuver, and ventilate with a higher tidal volume (8mL/kg) without exceeding the plateau pressure of 30cmH2O. The apnea test was performed with the patient in a prone position, with continuous positive airway pressure coupled with a T-piece. The delay in diagnosis was 10 hours, and organ donation was not possible due to circulatory arrest. This report demonstrates the difficulties in obtaining higher levels of the partial pressure of oxygen for the apnea test. The delays in the diagnosis of brain death and in the organ donation process are discussed, as well as potential strategies to optimize the partial pressure of oxygen to perform the apnea test according to the current recommendations.
    MeSH term(s) Apnea/diagnosis ; Brain Death/diagnosis ; Continuous Positive Airway Pressure ; Delayed Diagnosis ; Humans ; Hypoxia/complications ; Male ; Middle Aged ; Oxygen/blood ; Partial Pressure ; Prone Position ; Pulmonary Atelectasis/complications ; Tidal Volume
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2019-04-10
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2732162-9
    ISSN 1982-4335 ; 0103-507X
    ISSN (online) 1982-4335
    ISSN 0103-507X
    DOI 10.5935/0103-507X.20190015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19-associated coagulopathy and acute kidney injury in critically ill patients.

    Silva, Bruno Caldin da / Cordioli, Ricardo Luiz / Santos, Bento Fortunato Cardoso Dos / Guerra, João Carlos de Campos / Rodrigues, Roseny Dos Reis / Souza, Guilherme Martins de / Ashihara, Carolina / Midega, Thais Dias / Campos, Niklas Söderberg / Carneiro, Bárbara Vieira / Campos, Flávia Nunes Dias / Guimarães, Hélio Penna / Matos, Gustavo Faissol Janot de / Aranda, Valdir Fernandes de / Ferraz, Leonardo José Rolim / Corrêa, Thiago Domingos

    Einstein (Sao Paulo, Brazil)

    2023  Volume 21, Page(s) eAO0119

    Abstract: Objective: The incidence of thrombotic events and acute kidney injury is high in critically ill patients with COVID-19. We aimed to evaluate and compare the coagulation profiles of patients with COVID-19 developing acute kidney injury versus those who ... ...

    Abstract Objective: The incidence of thrombotic events and acute kidney injury is high in critically ill patients with COVID-19. We aimed to evaluate and compare the coagulation profiles of patients with COVID-19 developing acute kidney injury versus those who did not, during their intensive care unit stay.
    Methods: Conventional coagulation and platelet function tests, fibrinolysis, endogenous inhibitors of coagulation tests, and rotational thromboelastometry were conducted on days 0, 1, 3, 7, and 14 following intensive care unit admission.
    Results: Out of 30 patients included, 13 (43.4%) met the criteria for acute kidney injury. Comparing both groups, patients with acute kidney injury were older: 73 (60-84) versus 54 (47-64) years, p=0.027, and had a lower baseline glomerular filtration rate: 70 (51-81) versus 93 (83-106) mL/min/1.73m2, p=0.004. On day 1, D-dimer and fibrinogen levels were elevated but similar between groups: 1780 (1319-5517) versus 1794 (726-2324) ng/mL, p=0.145 and 608 (550-700) versus 642 (469-722) g/dL, p=0.95, respectively. Rotational thromboelastometry data were also similar between groups. However, antithrombin activity and protein C levels were lower in patients who developed acute kidney injury: 82 (75-92) versus 98 (90-116), p=0.028 and 70 (52-82) versus 88 (78-101) µ/mL, p=0.038, respectively. Mean protein C levels were lower in the group with acute kidney injury across multiple time points during their stay in the intensive care unit.
    Conclusion: Critically ill patients experiencing acute kidney injury exhibited lower endogenous anticoagulant levels. Further studies are needed to understand the role of natural anticoagulants in the pathophysiology of acute kidney injury within this population.
    MeSH term(s) Humans ; Critical Illness ; Protein C ; COVID-19/complications ; Blood Coagulation Disorders/etiology ; Acute Kidney Injury/etiology ; Anticoagulants
    Chemical Substances Protein C ; Anticoagulants
    Language English
    Publishing date 2023-09-15
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 2317-6385
    ISSN (online) 2317-6385
    ISSN 2317-6385
    DOI 10.31744/einstein_journal/2023AO0119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study.

    Corrêa, Thiago Domingos / Cordioli, Ricardo Luiz / Campos Guerra, João Carlos / Caldin da Silva, Bruno / Dos Reis Rodrigues, Roseny / de Souza, Guilherme Martins / Midega, Thais Dias / Campos, Niklas Söderberg / Carneiro, Bárbara Vieira / Campos, Flávia Nunes Dias / Guimarães, Hélio Penna / de Matos, Gustavo Faissol Janot / de Aranda, Valdir Fernandes / Rolim Ferraz, Leonardo José

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0243604

    Abstract: Background: Coagulation abnormalities in COVID-19 patients have not been addressed in depth.: Objective: To perform a longitudinal evaluation of coagulation profile of patients admitted to the ICU with COVID-19.: Methods: Conventional coagulation ... ...

    Abstract Background: Coagulation abnormalities in COVID-19 patients have not been addressed in depth.
    Objective: To perform a longitudinal evaluation of coagulation profile of patients admitted to the ICU with COVID-19.
    Methods: Conventional coagulation tests, rotational thromboelastometry (ROTEM), platelet function, fibrinolysis, antithrombin, protein C and S were measured at days 0, 1, 3, 7 and 14. Based on median total maximum SOFA score, patients were divided in two groups: SOFA ≤ 10 and SOFA > 10.
    Results: Thirty patients were studied. Some conventional coagulation tests, as aPTT, PT and INR remained unchanged during the study period, while alterations on others coagulation laboratory tests were detected. Fibrinogen levels were increased in both groups. ROTEM maximum clot firmness increased in both groups from Day 0 to Day 14. Moreover, ROTEM-FIBTEM maximum clot firmness was high in both groups, with a slight decrease from day 0 to day 14 in group SOFA ≤ 10 and a slight increase during the same period in group SOFA > 10. Fibrinolysis was low and decreased over time in all groups, with the most pronounced decrease observed in INTEM maximum lysis in group SOFA > 10. Also, D-dimer plasma levels were higher than normal reference range in both groups and free protein S plasma levels were low in both groups at baseline and increased over time, Finally, patients in group SOFA > 10 had lower plasminogen levels and Protein C ​​than patients with SOFA <10, which may represent less fibrinolysis activity during a state of hypercoagulability.
    Conclusion: COVID-19 patients have a pronounced hypercoagulability state, characterized by impaired endogenous anticoagulation and decreased fibrinolysis. The magnitude of coagulation abnormalities seems to correlate with the severity of organ dysfunction. The hypercoagulability state of COVID-19 patients was not only detected by ROTEM but it much more complex, where changes were observed on the fibrinolytic and endogenous anticoagulation system.
    MeSH term(s) Aged ; Aged, 80 and over ; Antithrombins/blood ; Blood Coagulation Tests ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/virology ; Female ; Fibrinolysis/physiology ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Platelet Function Tests/methods ; Protein C/metabolism ; Protein S/metabolism ; SARS-CoV-2/pathogenicity ; Thrombelastography/methods
    Chemical Substances Antithrombins ; Protein C ; Protein S
    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0243604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection.

    Corrêa, Thiago Domingos / Matos, Gustavo Faissol Janot de / Bravim, Bruno de Arruda / Cordioli, Ricardo Luiz / Garrido, Alejandra Del Pilar Gallardo / Assuncao, Murillo Santucci Cesar de / Barbas, Carmen Silvia Valente / Timenetsky, Karina Tavares / Rodrigues, Roseny Dos Reis / Guimarães, Hélio Penna / Rabello Filho, Roberto / Lomar, Frederico Polito / Scarin, Farah Christina de La Cruz / Batista, Carla Luciana / Pereira, Adriano José / Guerra, João Carlos de Campos / Carneiro, Bárbara Vieira / Nawa, Ricardo Kenji / Brandão, Rodrigo Martins

    Einstein (Sao Paulo, Brazil)

    2020  Volume 18, Page(s) eCE5931

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Critical Illness ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language Portuguese
    Publishing date 2020-08-05
    Publishing country Brazil
    Document type Journal Article ; Comment
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 1679-4508
    ISSN (online) 2317-6385
    ISSN 1679-4508
    DOI 10.31744/einstein_journal/2020ce5931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection

    Corrêa, Thiago Domingos / Matos, Gustavo Faissol Janot de / Bravim, Bruno de Arruda / Cordioli, Ricardo Luiz / Garrido, Alejandra del Pilar Gallardo / Assuncao, Murillo Santucci Cesar de / Barbas, Carmen Silvia Valente / Timenetsky, Karina Tavares / Rodrigues, Roseny dos Reis / Guimarães, Hélio Penna / Rabello Filho, Roberto / Lomar, Frederico Polito / Scarin, Farah Christina de La Cruz / Batista, Carla Luciana / Pereira, Adriano José / Guerra, João Carlos de Campos / Carneiro, Bárbara Vieira / Nawa, Ricardo Kenji / Brandão, Rodrigo Martins /
    Pesaro, Antônio Eduardo Pereira / Silva Júnior, Moacyr / Carvalho, Fabricio Rodrigues Torres de / Silva, Cilene Saghabi de Medeiros / Almeida, Ana Claudia Ferraz de / Franken, Marcelo / Pesavento, Marcele Liliane / Eid, Raquel Afonso Caserta / Ferraz, Leonardo José Rolim

    Einstein (São Paulo) v.18 2020

    2020  

    Abstract: ABSTRACT In December 2019, a series of patients with severe pneumonia were identified in Wuhan, Hubei province, China, who progressed to severe acute respiratory syndrome and acute respiratory distress syndrome. Subsequently, COVID-19 was attributed to a ...

    Abstract ABSTRACT In December 2019, a series of patients with severe pneumonia were identified in Wuhan, Hubei province, China, who progressed to severe acute respiratory syndrome and acute respiratory distress syndrome. Subsequently, COVID-19 was attributed to a new betacoronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approximately 20% of patients diagnosed as COVID-19 develop severe forms of the disease, including acute hypoxemic respiratory failure, severe acute respiratory syndrome, acute respiratory distress syndrome and acute renal failure and require intensive care. There is no randomized controlled clinical trial addressing potential therapies for patients with confirmed COVID-19 infection at the time of publishing these treatment recommendations. Therefore, these recommendations are based predominantly on the opinion of experts (level C of recommendation).
    Keywords Coronavirus ; COVID-19 ; Respiratory insufficiency ; Respiratory distress syndrome ; adult ; Intensive care units ; covid19
    Language English
    Publishing date 2020-01-01
    Publisher Instituto Israelita de Ensino e Pesquisa Albert Einstein
    Publishing country br
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Comment to

    Corrêa, Thiago Domingos / Matos, Gustavo Faissol Janot de / Bravim, Bruno de Arruda / Cordioli, Ricardo Luiz / Garrido, Alejandra del Pilar Gallardo / Assuncao, Murillo Santucci Cesar de / Barbas, Carmen Silvia Valente / Timenetsky, Karina Tavares / Rodrigues, Roseny dos Reis / Guimarães, Hélio Penna / Rabello Filho, Roberto / Lomar, Frederico Polito / Scarin, Farah Christina de La Cruz / Batista, Carla Luciana / Pereira, Adriano José / Guerra, João Carlos de Campos / Carneiro, Bárbara Vieira / Nawa, Ricardo Kenji / Brandão, Rodrigo Martins /
    Pesaro, Antônio Eduardo Pereira / Silva Júnior, Moacyr / Carvalho, Fabricio Rodrigues Torres de / Silva, Cilene Saghabi de Medeiros / Almeida, Ana Claudia Ferraz de / Franken, Marcelo / Pesavento, Marcele Liliane / Eid, Raquel Afonso Caserta / Ferraz, Leonardo José Rolim

    Einstein (São Paulo) v.18 2020

    Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-01-01
    Publisher Instituto Israelita de Ensino e Pesquisa Albert Einstein
    Publishing country br
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection.

    Corrêa, Thiago Domingos / Matos, Gustavo Faissol Janot de / Bravim, Bruno de Arruda / Cordioli, Ricardo Luiz / Garrido, Alejandra Del Pilar Gallardo / Assuncao, Murillo Santucci Cesar de / Barbas, Carmen Silvia Valente / Timenetsky, Karina Tavares / Rodrigues, Roseny Dos Reis / Guimarães, Hélio Penna / Rabello Filho, Roberto / Lomar, Frederico Polito / Scarin, Farah Christina de La Cruz / Batista, Carla Luciana / Pereira, Adriano José / Guerra, João Carlos de Campos / Carneiro, Bárbara Vieira / Nawa, Ricardo Kenji / Brandão, Rodrigo Martins /
    Pesaro, Antônio Eduardo Pereira / Silva Júnior, Moacyr / Carvalho, Fabricio Rodrigues Torres de / Silva, Cilene Saghabi de Medeiros / Almeida, Ana Claudia Ferraz de / Franken, Marcelo / Pesavento, Marcele Liliane / Eid, Raquel Afonso Caserta / Ferraz, Leonardo José Rolim

    Einstein (Sao Paulo, Brazil)

    2020  Volume 18, Page(s) eAE5793

    Abstract: In December 2019, a series of patients with severe pneumonia were identified in Wuhan, Hubei province, China, who progressed to severe acute respiratory syndrome and acute respiratory distress syndrome. Subsequently, COVID-19 was attributed to a new ... ...

    Abstract In December 2019, a series of patients with severe pneumonia were identified in Wuhan, Hubei province, China, who progressed to severe acute respiratory syndrome and acute respiratory distress syndrome. Subsequently, COVID-19 was attributed to a new betacoronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approximately 20% of patients diagnosed as COVID-19 develop severe forms of the disease, including acute hypoxemic respiratory failure, severe acute respiratory syndrome, acute respiratory distress syndrome and acute renal failure and require intensive care. There is no randomized controlled clinical trial addressing potential therapies for patients with confirmed COVID-19 infection at the time of publishing these treatment recommendations. Therefore, these recommendations are based predominantly on the opinion of experts (level C of recommendation).
    MeSH term(s) Betacoronavirus ; COVID-19 ; Checklist ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Critical Illness ; Humans ; Intensive Care Units/standards ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Respiration, Artificial/methods ; Respiration, Artificial/standards ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/therapy
    Keywords covid19
    Language Portuguese
    Publishing date 2020-06-03
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 1679-4508
    ISSN (online) 2317-6385
    ISSN 1679-4508
    DOI 10.31744/einstein_journal/2020AE5793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection

    Correa, Thiago Domingos / Janot de Matos, Gustavo Faissol / Bravim, Bruno de Arruda / Cordioli, Ricardo Luiz / Gallardo Garrido, Alejandra del Pilar / Cesar de Assuncao, Murillo Santucci / Valente Barbas, Carmen Silvia / Timenetsky, Karina Tavares / Rodrigues, Roseny dos Reis / Guimaraes, Helio Penna / Rabello Filho, Roberto / Lomar, Frederico Polito / de la Cruz Scarin, Farah Christina / Batista, Carla Luciana / Pereira, Adriano Jose / de Campos Guerra, Joao Carlos / Carneiro, Barbara Vieira / Nawa, Ricardo Kenji / Brandao, Rodrigo Martins /
    Pereira Pesaro, Antonio Eduardo / Silva Junior, Moacyr / Torres de Carvalho, Fabricio Rodrigues / de Medeiros Silva, Cilene Saghabi / Ferraz de Almeida, Ana Claudia / Franken, Marcelo / Pesavento, Marcele Liliane / Caserta Eid, Raquel Afonso / Rolim Ferraz, Leonardo Jose

    Einstein-Sao Paulo

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #732596
    Database COVID19

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