LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article: The alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells

Ferreira Azevedo, L. / Masiero, Mauro Miguel / Cherkaoui, S. / Hornos Carneiro, M.F. / Barbosa Jr, F. / Zamboni, N.

Food and chemical toxicology. 2022 Sept., v. 167

2022

Abstract: Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chemicals that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat ... ...

Abstract	Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chemicals that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat pancreatic β-cells that could impair energy homeostasis regulation. We assessed the effects on growth, proliferation, and viability of hepatocarcinoma (HepG2) and insulinoma (INS-1E) cells exposed to either BPA or BPS in a full range concentration between 0.001 and 100 μM. Both the dose and duration of exposure caused a differential response on growth and viability of both cells. Effects were more pronounced on HepG2, as these cells exhibited non-linear dose-responses following exposure to xenobiotics. For INS-1E, effect was observed only at the highest concentration. In addition, we profiled their intracellular state by untargeted metabolomics at 24, 48, and 72 h of exposure. This analysis revealed time- and dose-dependently molecular changes for HepG2 and INS-1E that were similar between BPA and BPS. Both increased levels of inflammatory mediators, such as metabolites pertaining to linolenic and linoleic acid metabolic pathway. In summary, this study shows that BPS also disrupts molecular functions in cells that regulate energy homeostasis, displaying similar but less pronounced responses than BPA.
Keywords	biochemical pathways ; energy ; energy metabolism ; glucose ; hepatoma ; homeostasis ; humans ; linoleic acid ; liver ; metabolites ; metabolomics ; phenotype ; plasticizers ; toxicology ; viability ; xenobiotics
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113266
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4035: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells.

Ferreira Azevedo, L / Masiero, Mauro Miguel / Cherkaoui, S / Hornos Carneiro, M F / Barbosa, F / Zamboni, N

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 167, Page(s) 113266

Abstract	Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chemicals that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat pancreatic β-cells that could impair energy homeostasis regulation. We assessed the effects on growth, proliferation, and viability of hepatocarcinoma (HepG2) and insulinoma (INS-1E) cells exposed to either BPA or BPS in a full range concentration between 0.001 and 100 μM. Both the dose and duration of exposure caused a differential response on growth and viability of both cells. Effects were more pronounced on HepG2, as these cells exhibited non-linear dose-responses following exposure to xenobiotics. For INS-1E, effect was observed only at the highest concentration. In addition, we profiled their intracellular state by untargeted metabolomics at 24, 48, and 72 h of exposure. This analysis revealed time- and dose-dependently molecular changes for HepG2 and INS-1E that were similar between BPA and BPS. Both increased levels of inflammatory mediators, such as metabolites pertaining to linolenic and linoleic acid metabolic pathway. In summary, this study shows that BPS also disrupts molecular functions in cells that regulate energy homeostasis, displaying similar but less pronounced responses than BPA.
MeSH term(s)	Animals ; Benzhydryl Compounds/chemistry ; Benzhydryl Compounds/toxicity ; Endocrine Disruptors/chemistry ; Endocrine Disruptors/toxicity ; Glucose ; Humans ; Metabolomics ; Plasticizers ; Rats ; Sulfones
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Plasticizers ; Sulfones ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113266
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 529: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Coffee biotechnology and its application in genetic transformation

Carneiro, M.F

Euphytica : Netherlands journal of plant breeding. 1997. v. 96 (1)

1997

Keywords	Coffea ; genetic transformation ; biotechnology ; tissue culture ; somatic embryogenesis ; androgenesis ; protoplasts
Language	English
Size	p. 167-172.
Document type	Article
Note	Paper presented at the EUCARPIA meeting on Tropical Crop Breeding held March 11-15, 1996, Montpellier, France.
ZDB-ID	216568-5
ISSN	0014-2336
ISSN	0014-2336
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 905: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Microsporogenesis and anther culture in carob tree (Ceratonia siliqua L.)

Custodio, L / Carneiro, M.F / Romano, A

Scientia horticulturae 2005 Mar. 15, v. 104, issue 1

2005

Keywords	Ceratonia siliqua ; carob ; microsporogenesis ; anther culture ; androecium ; haploidy ; flowering ; culture media ; pollen ; 2,4-D ; benzyladenine ; kinetin ; zeatin ; cytokinins ; embryo (plant) ; callus
Language	English
Dates of publication	2005-0315
Size	p. 65-77.
Document type	Article
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2810: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Simultaneous Measurement of ν_{μ} Quasielasticlike Cross Sections on CH, C, H_{2}O, Fe, and Pb as a Function of Muon Kinematics at MINERvA.

Kleykamp, J / Akhter, S / Ahmad Dar, Z / Ansari, V / Ascencio, M V / Sajjad Athar, M / Bashyal, A / Bercellie, A / Betancourt, M / Bodek, A / Bonilla, J L / Bravar, A / Budd, H / Caceres, G / Cai, T / Carneiro, M F / Díaz, G A / da Motta, H / Dytman, S A /

Felix, J / Fields, L / Filkins, A / Fine, R / Gago, A M / Gallagher, H / Gilligan, S M / Gran, R / Granados, E / Harris, D A / Henry, S / Jena, D / Jena, S / Klustová, A / Kordosky, M / Last, D / Lozano, A / Lu, X-G / Maher, E / Manly, S / Mann, W A / Mauger, C / McFarland, K S / Messerly, B / Miller, J / Moreno, O / Morfín, J G / Naples, D / Nelson, J K / Nguyen, C / Olivier, A / Paolone, V / Perdue, G N / Plows, K-J / Ramírez, M A / Ransome, R D / Ray, H / Ruterbories, D / Schellman, H / Solano Salinas, C J / Su, H / Sultana, M / Syrotenko, V S / Valencia, E / Vaughan, N H / Waldron, A V / Wret, C / Yaeggy, B / Zazueta, L

Physical review letters

2023 Volume 130, Issue 16, Page(s) 161801

Abstract: This Letter presents the first simultaneous measurement of the quasielasticlike neutrino-nucleus cross sections on C, water, Fe, Pb, and scintillator (hydrocarbon or CH) as a function of longitudinal and transverse muon momentum. The ratio of cross ... ...

Abstract	This Letter presents the first simultaneous measurement of the quasielasticlike neutrino-nucleus cross sections on C, water, Fe, Pb, and scintillator (hydrocarbon or CH) as a function of longitudinal and transverse muon momentum. The ratio of cross sections per nucleon between Pb and CH is always above unity and has a characteristic shape as a function of transverse muon momentum that evolves slowly as a function of longitudinal muon momentum. The ratio is constant versus longitudinal momentum within uncertainties above a longitudinal momentum of 4.5 GeV/c. The cross section ratios to CH for C, water, and Fe remain roughly constant with increasing longitudinal momentum, and the ratios between water or C to CH do not have any significant deviation from unity. Both the overall cross section level and the shape for Pb and Fe as a function of transverse muon momentum are not reproduced by current neutrino event generators. These measurements provide a direct test of nuclear effects in quasielasticlike interactions, which are major contributors to long-baseline neutrino oscillation data samples.
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.161801
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Measurement of the axial vector form factor from antineutrino-proton scattering.

Cai, T / Moore, M L / Olivier, A / Akhter, S / Dar, Z Ahmad / Ansari, V / Ascencio, M V / Bashyal, A / Bercellie, A / Betancourt, M / Bodek, A / Bonilla, J L / Bravar, A / Budd, H / Caceres, G / Carneiro, M F / Díaz, G A / da Motta, H / Felix, J /

Fields, L / Filkins, A / Fine, R / Gago, A M / Gallagher, H / Gilligan, S M / Gran, R / Granados, E / Harris, D A / Henry, S / Jena, D / Jena, S / Kleykamp, J / Klustová, A / Kordosky, M / Last, D / Le, T / Lozano, A / Lu, X-G / Maher, E / Manly, S / Mann, W A / Mauger, C / McFarland, K S / Messerly, B / Miller, J / Moreno, O / Morfín, J G / Naples, D / Nelson, J K / Nguyen, C / Paolone, V / Perdue, G N / Plows, K-J / Ramírez, M A / Ransome, R D / Ray, H / Ruterbories, D / Schellman, H / Salinas, C J Solano / Su, H / Sultana, M / Syrotenko, V S / Valencia, E / Vaughan, N H / Waldron, A V / Wascko, M O / Wret, C / Yaeggy, B / Zazueta, L

Nature

2023 Volume 614, Issue 7946, Page(s) 48–53

Abstract: Scattering of high energy particles from nucleons probes their structure, as was done in the experiments that established the non-zero size of the proton using electron ... ...

Abstract	Scattering of high energy particles from nucleons probes their structure, as was done in the experiments that established the non-zero size of the proton using electron beams
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05478-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Risk assessment of 22 chemical elements in dry and canned petfoods

Paulelli, A. C. C. / Martins Jr, A. C. / de Paula, E. S. / Souza, J. M. O. / Carneiro, M. F. H. / Júnior, F. B. / Batista, B. L.

Journal of consumer protection and food safety

2018 Volume 13, Issue 4, Page(s) 359

Language	German ; English
Document type	Article
ZDB-ID	2232114-7
ISSN	1661-5751
Database	Current Contents Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Z 7689: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Article ; Online: Calibration and multi-source consistency analysis of reconstructed precipitation series in Portugal since the early 17th century

Santos, J.A. / Carneiro, M.F. / Alcoforado, M.J. / Leal, S. / Luz, A.L. / Camuffo, D. / Zorita, E.

The Holocene ; 0959-6836

2015

Abstract: A calibration of reconstructed winter, spring and autumn precipitation series in Portugal from 1600 onwards is undertaken in the present study using new instrumental sources for the period of 1815–2012. As summer precipitation in Portugal is scarce and ... ...

Abstract	A calibration of reconstructed winter, spring and autumn precipitation series in Portugal from 1600 onwards is undertaken in the present study using new instrumental sources for the period of 1815–2012. As summer precipitation in Portugal is scarce and irregular, it is not considered. A consistency analysis of the calibrated time series is then undertaken using: (1) precipitation indices for Portugal in 1675–1799; (2) teleconnections between seasonal precipitation and large-scale atmospheric flow; (3) two paleoclimatic experiments (ERIK1 and ERIK2), generated from a global/regional climate model chain (ECHO-G/MM5); and (4) tree-ring records from oak trees in Portugal (Serra do Buçaco). These are the first multi-centennial records of tree-ring growth in Portugal (the earliest series begin in 1675). General agreement is found between indices and calibrated precipitation for their common period on an annual basis. Overall, the atmospheric teleconnection patterns are dynamically coherent between the instrumental and pre-instrumental periods. The inter-annual to inter-decadal variability in the calibrated series reveals similar distributions as in the paleoclimatic simulations. Low-frequency variability in spring precipitation is validated by 12 tree-ring series. This study provides calibrated seasonal precipitation series in Portugal from 1600 onwards, revealing high consistency with several independent sources for winter and spring, enabling future applications to climate research.
Keywords	Marine ; Coastal and Polar Systems ; 551
Publisher	GKSS Forschungszentrum Geesthacht GmbH
Publishing country	de
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Article ; Online: New insights into the reconstructed temperature in Portugal over the last 400 years

Santos, J.A. / Carneiro, M.F. / Correia, A. / Alcoforado, M.J. / Zorita, E. / Gomez-Navarro, J.J.

Climate of the Past ; 1814-9324

2015

Abstract: The consistency of an existing reconstructed annual (December–November) temperature series for the Lisbon region (Portugal) from 1600 onwards, based on a European-wide reconstruction, with (1) five local borehole temperature–depth profiles; (2) synthetic ...

Abstract	The consistency of an existing reconstructed annual (December–November) temperature series for the Lisbon region (Portugal) from 1600 onwards, based on a European-wide reconstruction, with (1) five local borehole temperature–depth profiles; (2) synthetic temperature–depth profiles, generated from both reconstructed temperatures and two regional paleoclimate simulations in Portugal; (3) instrumental data sources over the twentieth century; and (4) temperature indices from documentary sources during the late Maunder Minimum (1675–1715) is assessed. The low-frequency variability in the reconstructed temperature in Portugal is not entirely consistent with local borehole temperature–depth profiles and with the simulated response of temperature in two regional paleoclimate simulations driven by reconstructions of various climate forcings. Therefore, the existing reconstructed series is calibrated by adjusting its low-frequency variability to the simulations (first-stage adjustment). The annual reconstructed series is then calibrated in its location and scale parameters, using the instrumental series and a linear regression between them (second-stage adjustment). This calibrated series shows clear footprints of the Maunder and Dalton minima, commonly related to changes in solar activity and explosive volcanic eruptions, and a strong recent-past warming, commonly related to human-driven forcing. Lastly, it is also in overall agreement with annual temperature indices over the late Maunder Minimum in Portugal. The series resulting from this post-reconstruction adjustment can be of foremost relevance to improve the current understanding of the driving mechanisms of climate variability in Portugal.
Keywords	Marine ; Coastal and Polar Systems ; 551
Subject code	550
Publisher	GKSS Forschungszentrum Geesthacht GmbH
Publishing country	de
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Article ; Online: New insights into the reconstructed temperature in Portugal over the last 400 years

Santos, J.A. / Carneiro, M.F. / Correia, A. / Alcoforado, M.J. / Zorita, E. / Gomez-Navarro, J.J.

Climate of the Past Discussions [Online Ressource] ; 1814-9340

2015

Abstract: The reliability of an existing reconstructed annual (December–November) temperature series for the Lisbon region (Portugal) from 1600 onwards is assessed in the present study. The consistency of this series with: (1) five local borehole temperature-depth ...

Abstract	The reliability of an existing reconstructed annual (December–November) temperature series for the Lisbon region (Portugal) from 1600 onwards is assessed in the present study. The consistency of this series with: (1) five local borehole temperature-depth profiles; (2) synthetic temperature-depth profiles generated from both reconstructed temperatures and paleoclimate simulations in Portugal; (3) instrumental data sources over the twentieth century; and (4) temperature indices from documentary sources during the late Maunder Minimum (1675–1715) is assessed. It is found that reconstructed annual mean temperature series in Portugal, after European-wide reconstructions, is not consistent with both borehole profiles and paleoclimate simulations in their long-term variability and trends. Hence, the non-linear trend in the paleoclimate simulations is estimated and added to the reconstructed series (first-stage calibration). The annual reconstructed series is then calibrated in its location and scale parameters, using the instrumental series and a linear regression between them (second-stage calibration). The resulting calibrated series is then in clear accordance with the low-frequency variability of both borehole temperature-depth profiles and paleoclimate simulations. This calibrated series shows clear footprints of the Maunder and Dalton minima, mainly attributed to changes in solar activity and explosive volcanic eruptions, and a strong recent-past warming, attributed to human-driven forcing. Lastly, it is also in overall agreement with independently-derived annual temperature indices for the late Maunder Minimum. Thus, the series resulting of this re-calibration process for Lisbon can be of foremost relevance to improve the current understanding of the driving mechanisms of climate variability in Portugal.
Keywords	Marine ; Coastal and Polar Systems ; 551
Subject code	550
Publisher	GKSS Forschungszentrum Geesthacht GmbH
Publishing country	de
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED