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  1. Article ; Online: Stand-alone surgery for atrial fibrillation.

    Carnero-Alcázar, Manuel / Maroto-Castellanos, Luis / González-Ferrer, Juan José

    Revista espanola de cardiologia (English ed.)

    2023  Volume 76, Issue 6, Page(s) 398–401

    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Stroke ; Catheter Ablation ; Treatment Outcome
    Language Spanish
    Publishing date 2023-01-18
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2022.10.018
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  2. Article ; Online: Mixed models: an essential tool for non-independent data analysis.

    Carnero-Alcázar, Manuel / Montero-Cruces, Lourdes / Maroto-Castellanos, Luis

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2022  Volume 62, Issue 4

    MeSH term(s) Allografts ; Data Analysis ; Humans ; Linear Models ; Models, Statistical ; Outcome Assessment, Health Care ; Pulmonary Valve
    Language English
    Publishing date 2022-09-27
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezac462
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  3. Article ; Online: Turn off the lights when leaving the operating room.

    Carnero-Alcázar, Manuel / Pérez-Camargo, Daniel

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 60, Issue 6, Page(s) 1332–1333

    MeSH term(s) Humans ; Operating Rooms
    Language English
    Publishing date 2021-08-20
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab411
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  4. Article ; Online: Debate: The role of coronary artery bypass grafting for left main disease after EXCEL and NOBLE trials.

    Carnero-Alcázar, Manuel / Maroto-Castellanos, Luis Carlos

    Revista espanola de cardiologia (English ed.)

    2021  Volume 74, Issue 8, Page(s) 648–650

    MeSH term(s) Coronary Artery Bypass ; Coronary Artery Disease/surgery ; Drug-Eluting Stents ; Humans
    Language Spanish
    Publishing date 2021-03-11
    Publishing country Spain
    Document type Editorial ; Comment
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2020.12.015
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  5. Article ; Online: In-hospital outcomes after PCI and TAVI versus combined aortic valve replacement and coronary surgery.

    Carnero Alcázar, Manuel / López Menéndez, José / Rodríguez-Roda Stuart, Jorge / Maroto Castellanos, Luis Carlos

    Revista espanola de cardiologia (English ed.)

    2023  Volume 76, Issue 10, Page(s) 834–835

    MeSH term(s) Humans ; Aortic Valve/surgery ; Percutaneous Coronary Intervention ; Coronary Artery Disease/surgery ; Heart Valve Prosthesis ; Coronary Artery Bypass ; Aortic Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement ; Treatment Outcome ; Risk Factors ; Heart Valve Prosthesis Implantation
    Language Spanish
    Publishing date 2023-04-28
    Publishing country Spain
    Document type Letter
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2023.02.015
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  6. Article ; Online: Advanced considerations in survival analysis.

    Carnero-Alcázar, Manuel / Montero-Cruces, Lourdes / Cobiella-Carnicer, Javier / Pérez-Camargo, Daniel / Maroto Castellanos, Luis

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2024  Volume 65, Issue 2

    Abstract: Investigation of survival during the follow-up period is common in cardiovascular research and has intrinsic issues that require precise knowledge, such as survival or censoring. Besides, as the follow-up period lengthens and events other than mortality ... ...

    Abstract Investigation of survival during the follow-up period is common in cardiovascular research and has intrinsic issues that require precise knowledge, such as survival or censoring. Besides, as the follow-up period lengthens and events other than mortality are studied, the analysis becomes more complex, so Kaplan-Meier analyses or Cox models are not always sufficient. In this primer, we provide the reader with detailed information on the interpretation of the most common survival analyses and delve into methods to analyse competing risks or alternatives to the conventional methods when the proportional hazards assumption is not met.
    MeSH term(s) Humans ; Survival Analysis ; Proportional Hazards Models ; Kaplan-Meier Estimate ; Heart
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezae020
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Neurological outcomes of transcatheter aortic valve implantation with or without cerebral embolic protection devices: A meta-analysis.

    Pérez-Camargo, Daniel / Travieso, Alejandro / Carnero-Alcázar, Manuel / Taramasso, Maurizio / Cobiella-Carnicer, Javier / Maroto-Castellanos, Luis C

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2022  Volume 31, Issue 9, Page(s) 106605

    Abstract: Introduction: Cerebral embolic protection devices (CEPDs) are designed to prevent embolization of debris during transcatheter aortic valve implantation (TAVI). Current evidence from randomized clinical trials (RCTs) and observational studies is ... ...

    Abstract Introduction: Cerebral embolic protection devices (CEPDs) are designed to prevent embolization of debris during transcatheter aortic valve implantation (TAVI). Current evidence from randomized clinical trials (RCTs) and observational studies is controversial.
    Aims: The purpose of this meta-analysis was to study the influence of CEPDs on stroke, silent ischemic lesions and neurocognitive function.
    Methods: A systematic search was conducted including RCTs or adjusted observational studies comparing TAVI with or without CEPDs. Pooled odds ratios, risk ratios or standardized mean differences with 95% confidence intervals were calculated using the inverse of variance method. Risk of bias sensitivity analyses and meta regression for CEPD type were also conducted.
    Results: Five RCTs and five adjusted observational studies were included (n= 159,865). Mean age of the patients was 81.1 (SD 1.04) years in CEPDs and 81 (SD 1.86) in non-CEPD. The overall quality of evidence using the GRADE system for each endpoint was low to very low, mainly due to serious risk of bias, inconsistency and imprecision. Random effects meta-analysis detected no significant differences between CEPD and non-CEPD (OR= 0.74; 95% CI 0.51-1.07; P= 0.105; I
    Conclusion: In the present meta- analysis of five RCTs and five adjusted observational studies, the use of a CEPD during TAVI was not associated with a significant benefit on 30- day stroke, total lesion volume per patient, number of ischemic lesions per patient and neurocognitive function assessments.
    MeSH term(s) Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Embolic Protection Devices ; Humans ; Intracranial Embolism/diagnostic imaging ; Intracranial Embolism/etiology ; Risk Factors ; Stroke/diagnosis ; Stroke/etiology ; Stroke/prevention & control ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2022.106605
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    Zs.A 3519: Show issues Location:
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  8. Article ; Online: Combined off-pump mitral repair and thoracoscopic maze surgery.

    Carnero-Alcázar, Manuel / Cobiella-Carnicer, Javier / Mahia-Casado, Patricia / Maroto-Castellanos, Luis Carlos

    Asian cardiovascular & thoracic annals

    2020  Volume 29, Issue 3, Page(s) 217–219

    Abstract: A 67-year-old man with severe mitral regurgitation and paroxysmal atrial fibrillation was admitted to our institution for surgical repair. The procedure was carried out off-pump. We first performed a totally thoracoscopic maze box lesion set with ... ...

    Abstract A 67-year-old man with severe mitral regurgitation and paroxysmal atrial fibrillation was admitted to our institution for surgical repair. The procedure was carried out off-pump. We first performed a totally thoracoscopic maze box lesion set with epicardial transmural radiofrequency, and clipped the left atrial appendage. The mitral valve prolapse was repaired by implanting three transapical neochordae. Six months later, the patient was in sinus rhythm with minimal residual mitral regurgitation on echocardiography. This novel approach is less invasive than the standard surgical correction and should ensure a faster recovery with similar safety and efficacy in selected cases.
    MeSH term(s) Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Heart Valve Prosthesis Implantation ; Humans ; Male ; Maze Procedure ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Recovery of Function ; Severity of Illness Index ; Thoracoscopy ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/0218492320963978
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    Zs.A 5193: Show issues Location:
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  9. Article ; Online: Ultrafast track versus conventional fast track in patients undergoing cardiac surgery: a propensity score-matched analysis.

    Carnero-Alcázar, Manuel / Beltrao-Sial, Rosa / Montero-Cruces, Lourdes / López-Vyzcaino, Miguel / Pérez-Camargo, Daniel / Sánchez, Rubén / Cobiella-Carnicer, Javier / Fernández-Velasco, David / Maroto-Castellanos, Luis C

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 37, Issue 2

    Abstract: Objectives: We aimed at comparing the risk of major adverse events and length of stay between patients undergoing ultrafast track and conventional fast track.: Methods: Retrospective cohort study adjusted by propensity score matching, including ... ...

    Abstract Objectives: We aimed at comparing the risk of major adverse events and length of stay between patients undergoing ultrafast track and conventional fast track.
    Methods: Retrospective cohort study adjusted by propensity score matching, including patients operated on between March 2020 and December 2022 of any of the following: coronary, valve surgery or ascending aorta surgery. Patients were divided into 2 groups: ultrafast track: extubation in the operating room and fast track: extubation attempted in the first 6 postoperative hours. The primary objective was to compare the risk of the combined event death, lung respiratory outcomes (reintubation, mechanical ventilation longer than 24 h or pneumonia), or acute renal failure.
    Results: A total of 1126 patients were included. A total of 579 (51.4%) were extubated in the operating room. A total of 331 pairs were available after matching by propensity score. The risk of the primary outcome was 11.8% (n = 39) in the fast-track group and 6.3% (n = 21) in the ultrafast-track group (P = 0.013), mostly driven by lung adverse events (6.9% vs 2.4%, P = 0.011) while no significant differences were detected in the risk of death (2.4% vs 1.8%, P = 0.77) or acute renal failure (8% vs 6.3%, P = 0.56). The risk of myocardial infarction was higher in the fast-track group (2.7% vs 0%, P = 0.039). The median length of stay in the postoperative intensive care unit was longer in the fast-track group [24.7 h (interquartile range 21.5; 62.9) vs 23.5 h (interquartile range 22; 46), P = 0.015].
    Conclusions: In patients undergoing cardiac surgery, extubation in the operating room is associated to a lower risk of postoperative complications (mostly driven by lung adverse events) and length of stay in intensive care unit as compared to fast track.
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad143
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  10. Article ; Online: 5-Year haemodynamic performance of three aortic bioprostheses. A randomized clinical trial.

    Montero Cruces, Lourdes / Carnero Alcázar, Manuel / Pérez Camargo, Daniel / Cobiella Carnicer, Javier / Campelos Fernández, Paula / Reguillo Lacruz, Fernando José / Maroto Castellanos, Luis Carlos

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 64, Issue 2

    Abstract: Objectives: The Carpentier Perimount (CP) Magna Ease, the Crown Phospholipid Reduction Treatment (PRT) and the Trifecta bovine pericardial valves have been widely used worldwide. The primary end point of this study was to compare the haemodynamic ... ...

    Abstract Objectives: The Carpentier Perimount (CP) Magna Ease, the Crown Phospholipid Reduction Treatment (PRT) and the Trifecta bovine pericardial valves have been widely used worldwide. The primary end point of this study was to compare the haemodynamic performance quantified by in vivo echocardiograms of these 3 aortic prostheses.
    Methods: The "BEST-VALVE" (comparison of 3 contemporary cardiac bioprostheses: mid-term valve haemodynamic performance) was a single-centre randomized clinical trial to compare the haemodynamic and clinical outcomes of the aforementioned bioprostheses. The 5-year results are assessed in this manuscript.
    Results: A total of 154 patients were included. The CP Magna Ease (n = 48, 31.2%), Crown PRT (n = 51, 32.1%) and Trifecta (n = 55, 35.7%) valves were compared. Significant differences were observed among the 3 bioprostheses 5 years after the procedure. The following haemodynamic differences were found between the CP Magna Ease and the Crown PRT bioprostheses [mean aortic gradient: 12.3 mmHg (interquartile range {IQR} 7.8-17.5) for the CP Magna Ease vs 15 mmHg (IQR 10.8-31.9) for the Crown PRT, P < 0.001] and between the CP Magna Ease and the Trifecta prostheses [mean aortic gradient: 12.3 mmHg (IQR 7.8-17.5) for the CP Magna Ease vs 14.7 mmHg (IQR 8.2-55) for the Trifecta, P < 0.001], with a better haemodynamic performance of the CP Magna Ease. The cumulative incidence of severe structural valve degeneration was 9.5% in the Trifecta group at 6 years of follow-up. The 1-, 3- and 5-year survival from all-cause mortality was 91.5%, 83.5% and 74.8%, respectively (log rank P = 0.440). Survival from the composite event at the 1-, 3- and 5-year follow-up was 92.8%, 74.6% and 59%, respectively (log rank P = 0.299).
    Conclusions: We detected significant differences between the 3 bioprostheses; the CP Magna Ease had the best haemodynamic performance at the 5-year follow-up.
    MeSH term(s) Humans ; Animals ; Cattle ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/methods ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Bioprosthesis ; Hemodynamics ; Prosthesis Design ; Aortic Valve Stenosis/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-07-20
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad261
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