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Article ; Online: Vitamin D3 and Omega-3 Fatty Acids: A New Approach for Cardiovascular Prevention.

Corcione, Nicola / Biondi-Zoccai, Giuseppe / Castellani, Valentina / Carnevale, Roberto

2023 Volume 81, Issue 4, Page(s) 248–250

MeSH term(s)	Humans ; Cholecalciferol ; Fatty Acids, Omega-3 ; Dietary Supplements/adverse effects ; Cardiovascular System ; Cardiovascular Diseases/prevention & control ; Double-Blind Method
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Fatty Acids, Omega-3
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001407
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Zs.A 1471: Show issues

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Article ; Online: "The portal vein in patients with cirrhosis is not an excessively inflammatory or hypercoagulable vascular bed, a prospective cohort study": comment from Violi et al.

Violi, Francesco / Carnevale, Roberto / Pignatelli, Pasquale

Journal of thrombosis and haemostasis : JTH

2022 Volume 21, Issue 1, Page(s) 186–187

MeSH term(s)	Humans ; Portal Vein/pathology ; Prospective Studies ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Thrombophilia/complications ; Thrombophilia/diagnosis ; Abdomen
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2022.09.006
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 295: Show issues

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Article: Editorial: New Insights Into Oxidative Stress and Inflammation in the Pathophysiology and Treatment of Cardiovascular Diseases.

Becatti, Matteo / Abbate, Antonio / Fiorillo, Claudia / Carnevale, Roberto / Kumar, Santosh

Frontiers in molecular biosciences

2022 Volume 9, Page(s) 940465

Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2022.940465
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Article ; Online: From the Dining Room to the Atrium: Can We Modulate Atrial Fibrillation Risk With Micronutrients?

Carnevale, Roberto / Biondi-Zoccai, Giuseppe / Giordano, Arturo / Pastori, Daniele

Journal of cardiovascular pharmacology

2022 Volume 80, Issue 2, Page(s) 197–199

MeSH term(s)	Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Catheter Ablation ; Heart Atria ; Humans ; Micronutrients
Chemical Substances	Micronutrients
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001306
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Article ; Online: Gut dysbiosis, endotoxemia and clotting activation: A dangerous trio for portal vein thrombosis in cirrhosis.

Violi, Francesco / Pignatelli, Pasquale / Castellani, Valentina / Carnevale, Roberto / Cammisotto, Vittoria

Blood reviews

2022 Volume 57, Page(s) 100998

Abstract: Liver cirrhosis (LC) is associated with portal venous thrombosis (PVT) in roughly 20% of cirrhotic patients but the underlying mechanism is still unclear. Low-grade endotoxemia by lipopolysaccharides (LPS), a component of outer gut microbiota membrane, ... ...

Abstract	Liver cirrhosis (LC) is associated with portal venous thrombosis (PVT) in roughly 20% of cirrhotic patients but the underlying mechanism is still unclear. Low-grade endotoxemia by lipopolysaccharides (LPS), a component of outer gut microbiota membrane, is detectable in the portal circulation of LC and could predispose to PVT. LPS may translocate into systemic circulation upon microbiota dysbiosis-induced gut barrier dysfunction, that is a prerequisite for enhanced gut permeability and ensuing endotoxemia. Experimental and clinical studies provided evidence that LPS behaves a pro-thrombotic molecule so promoting clotting and platelet activation. Experiments conducted in the portal circulation of cirrhotic patients showed the existence of LPS-related enhanced thrombin generation as well as endothelial dysfunction, venous stasis, and platelet activation. The review will analyze 1) the pro-thrombotic role of endotoxemia in the context of LC 2) the biological plausibility linking endotoxemia with PVT and 3) the potentially interventional tools to lower endotoxemia and eventually hypercoagulation.
MeSH term(s)	Humans ; Endotoxemia/complications ; Endotoxemia/pathology ; Portal Vein/pathology ; Lipopolysaccharides ; Dysbiosis/complications ; Dysbiosis/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Venous Thrombosis/etiology ; Thrombosis/etiology ; Thrombosis/pathology
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639015-8
ISSN	1532-1681 ; 0268-960X
ISSN (online)	1532-1681
ISSN	0268-960X
DOI	10.1016/j.blre.2022.100998
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Zs.A 2207: Show issues

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Article ; Online: Hypoalbuminemia as predictor of thrombotic events in patients with community-acquired pneumonia.

Valeriani, Emanuele / Cangemi, Roberto / Carnevale, Roberto / Romiti, Giulio Francesco / Pannunzio, Arianna / Pignatelli, Pasquale / Violi, Francesco

International journal of cardiology

2024 Volume 404, Page(s) 131942

Abstract: Background: Hypoalbuminemia complicates acute diseases and infections and is associated with a worst prognosis. The aim is to evaluate whether hypoalbuminemia is associated with higher incidence and risk of thrombotic events in community-acquired ... ...

Abstract	Background: Hypoalbuminemia complicates acute diseases and infections and is associated with a worst prognosis. The aim is to evaluate whether hypoalbuminemia is associated with higher incidence and risk of thrombotic events in community-acquired pneumonia. Methods: We retrospectively collected data from a prospective study investigating the incidence of thrombotic events in community-acquired pneumonia hospitalized patients from 2011 to 2016 at University-Hospital Policlinico Umberto I. Baseline characteristics and outcomes were collected. Incidence of outcomes were calculated. Kaplan-Meier curves were created, Cox model used to identify predictors for the outcomes, and competing risk analysis performed. Results: From a total of 231 patients, 130 (56.3%) and 101 (43.7%) had or not hypoalbuminemia. Age, proportion of female, BMI, major comorbidities, and severity of pneumonia were similar between two subgroups. A less proportion of patients with hypoalbuminemia received antithrombotic and statin therapy. Median hospital stay was 11 days in both subgroups. Patients with hypoalbuminemia had higher D-dimer and high- sensitivity C-reactive-protein values with an inverse relation between albumin values and these markers. Incidence of thrombotic events was 26 and 11 per 1000 patient-days in patient with and without hypoalbuminemia. At Cox model, hypoalbuminemia was associated with thrombotic events development in univariable (hazard ratio; 2.67, 95% confidence intervals, 1.30-5.40) and multivariable (hazard ratio 3.19; 95% confidence intervals, 1.48-6.89) analysis. Conclusions: More than a half of patients with community acquired pneumonia had hypoalbuminemia that is associated with a doubled incidence and a three-fold increased risk of thrombotic events. The inverse relation between baseline albumin and D-dimer values confirms this association.
MeSH term(s)	Humans ; Female ; Hypoalbuminemia/diagnosis ; Hypoalbuminemia/epidemiology ; Hypoalbuminemia/etiology ; Retrospective Studies ; Prospective Studies ; Risk Factors ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; Pneumonia/complications ; C-Reactive Protein ; Albumins ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/epidemiology
Chemical Substances	C-Reactive Protein (9007-41-4) ; Albumins
Language	English
Publishing date	2024-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2024.131942
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Zs.A 1673: Show issues

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Article ; Online: Gut dysbiosis-derived low-grade endotoxemia: A common soil for liver and cardiovascular disease.

Violi, Francesco / Nocella, Cristina / Bartimoccia, Simona / Castellani, Valentina / Carnevale, Roberto / Pignatelli, Pasquale / Cammisotto, Vittoria

Kardiologia polska

2023

Abstract: Gut dysbiosis is characterized by bacteria overgrowth that ultimately leads to increased intestinal barrier permeability and bacteria or bacteria product translocation such as lipopolysaccharide (LPS) in the portal and eventually systemic circulation. ... ...

Abstract	Gut dysbiosis is characterized by bacteria overgrowth that ultimately leads to increased intestinal barrier permeability and bacteria or bacteria product translocation such as lipopolysaccharide (LPS) in the portal and eventually systemic circulation. Intestinal epithelial cells and hepatocytes encompass enzymatic armamentarium to counteract the LPS toxic effect, however impaired degradation results in LPS accumulation in hepatocytes and endothelial wall. Experimental and clinical study documented that in patients with liver disease, such as non-alcoholic fatty acid liver disease (NAFLD), low-grade endotoxemia by LPS is implicated in liver inflammation and thrombosis via interaction with its Toll-like receptor 4 (TLR4) expressed by hepatocytes and platelets. Furthermore, studies in patients with severe atherosclerosis documented that LPS localizes into atherosclerotic plaque in close association with activated macrophages expressing TLR4 suggesting a role for LPS in vascular inflammation, atherosclerotic progression, and thrombosis. Finally, LPS may directly interact with myocardial cells to induce electric and functional changes leading to atrial fibrillation or heart failure. This review will focus on experimental and clinical evidence suggesting low-grade endotoxemia as mechanism potentially accounting for vascular damage occurring at level of hepatic and systemic circulation and myocardial cells.
Language	English
Publishing date	2023-05-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.a2023.0115
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Zs.B 598: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 474: Show issues

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Article ; Online: Association of proprotein convertase subtilisin/kexin type 9 (PCSK9) levels with abnormally high ankle-brachial index in atrial fibrillation.

Menichelli, Danilo / Galardo, Gioacchino / Cammisotto, Vittoria / Bartimoccia, Simona / Carnevale, Roberto / Pignatelli, Pasquale / Pastori, Daniele

Kardiologia polska

2023 Volume 81, Issue 4, Page(s) 381–387

Abstract: Background: High ankle-brachial index (ABI) has been associated with increased risk of worse outcomes in the general population. Few data on atrial fibrillation (AF) exist. Experimental data suggest that proprotein convertase subtilisin/kexin type 9 ( ... ...

Abstract	Background: High ankle-brachial index (ABI) has been associated with increased risk of worse outcomes in the general population. Few data on atrial fibrillation (AF) exist. Experimental data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) contributes to vascular calcification but clinical data on this association are lacking. Aims: We wanted to investigate the relationship between circulating PCSK9 levels and an abnormally high ABI in patients suffering from AF. Methods: We analyzed data from 579 patients included in the prospective ATHERO-AF study. An ABI≥1.4 was considered high. PCSK9 levels were measured coincidentally with ABI measurement. We used optimized cut-offs of PCSK9 for both ABI and mortality obtained from Receiver Operator Characteristic (ROC) curve analysis. All-cause mortality according to the ABI value was also analyzed. Results: One hundred and fifteen patients (19.9%) had an ABI ≥1.4. The mean (standard deviation [SD]) age was 72.1 (7.6) years, and 42.1% of patients were women. Patients with ABI ≥1.4 were older, more frequently male, and diabetic. Multivariable logistic regression analysis showed an association between ABI ≥1.4 and serum levels of PCSK9 > 1150 pg/ml (odds ratio [OR], 1.649; 95% confidence interval [CI], 1.047-2.598; P = 0.031). During a median follow-up of 41 months, 113 deaths occurred. In multivariable Cox regression analysis, an ABI ≥1.4 (hazard ratio [HR], 1.626; 95% CI, 1.024-2.582; P = 0.039), CHA2DS2-VASc score (HR, 1.249; 95% CI, 1.088-1.434; P = 0.002), antiplatelet drug use (HR, 1.775; 95% CI, 1.153-2.733; P = 0.009), and PCSK9 > 2060 pg/ml (HR, 2.200; 95% CI, 1.437-3.369; P < 0.001) were associated with all-cause death. Conclusions: In AF patients, PCSK9 levels relate to an abnormally high ABI ≥1.4. Our data suggest PCSK9 role in contributing to vascular calcification in AF patients.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Ankle Brachial Index ; Atrial Fibrillation/blood ; Atrial Fibrillation/metabolism ; Proprotein Convertase 9 ; Prospective Studies ; Risk Factors ; Subtilisins ; Vascular Calcification
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-)
Language	English
Publishing date	2023-03-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.a2023.0067
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Zs.B 598: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 474: Show issues

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Article ; Online: Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis.

Maggio, Enrico / Bocchini, Valeria Proietti / Carnevale, Roberto / Pignatelli, Pasquale / Violi, Francesco / Loffredo, Lorenzo

Nutrition reviews

2023

Abstract: Context: A previous study showed that vitamin E is effective in reducing the incidence of myocardial infarction only when it is taken in the absence of other antioxidants. It is unclear if it also reduces the incidence of stroke.: Objective: The aim ... ...

Abstract	Context: A previous study showed that vitamin E is effective in reducing the incidence of myocardial infarction only when it is taken in the absence of other antioxidants. It is unclear if it also reduces the incidence of stroke. Objective: The aim of this meta-analysis is to compare the effect of vitamin E supplementation alone or combined with other antioxidants on the incidence of stroke. Data sources: A search was performed in the following databases: PubMed, ISI Web of Science, SCOPUS, and Cochrane Library. Data extraction: Sixteen randomized controlled trials were selected to evaluate the effect of vitamin E supplementation on stroke. Data analysis: The range of vitamin E doses used was 33-800 IU. The follow-up period ranged from 6 months to 9.4 years. Compared with controls, when vitamin E was given alone it did not reduce the incidence of ischemic and hemorrhagic stroke. Conversely, compared with controls, supplementation of vitamin E with other antioxidants reduced ischemic stroke (random effects, RR: 0.91; 95% CI: 0.84-0.99; P = 0.02) but with a significant increase in hemorrhagic stroke (random effects, RR: 1.22; 95% CI: 1.0-1.48; P = 0.04). Conclusions: Supplementation with vitamin E alone is not associated with stroke reduction. Instead, supplementation of vitamin E with other antioxidants reduces the incidence of ischemic stroke but increases the risk of hemorrhagic stroke, cancelling any beneficial effect derived. Thus, vitamin E is not recommended in stroke prevention. Systematic review registration: PROSPERO registration no. CRD42022258259.
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	82067-2
ISSN	1753-4887 ; 0029-6643
ISSN (online)	1753-4887
ISSN	0029-6643
DOI	10.1093/nutrit/nuad114
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Zs.A 3388: Show issues

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Article ; Online: Gut microbiota and myocardial infarction.

Violi, Francesco / Nocella, Cristina / Carnevale, Roberto

European heart journal

2020 Volume 41, Issue 23, Page(s) 2221–2222

MeSH term(s)	Gastrointestinal Microbiome ; Humans ; Myocardial Infarction
Language	English
Publishing date	2020-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehaa222
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Zs.MO 640: Show issues

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