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  1. Conference proceedings ; Online: Wildlife health in the One Health concept

    Caron, Alexandre

    2023  

    Keywords one health approach ; capacity building
    Language English
    Publishing date 2023-11-29T11:01:25Z
    Publisher Centre de coopération internationale en recherche agronomique pour le développement
    Publishing country fr
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Conference proceedings ; Online: Work Package 4 update

    Caron, Alexandre

    Delivery of One Health solutions

    2023  

    Keywords one health approach ; capacity building
    Language English
    Publishing date 2023-11-29T11:01:25Z
    Publisher International Livestock Research Institute
    Publishing country fr
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Mise en place d’indicateurs de protection des abords vasculaires (IPAV) en dialyse : une innovation dans la qualité des soins.

    Pena Prado, Angeline / Caron, Alexandre

    Revue de l'infirmiere

    2024  Volume 73, Issue 300, Page(s) 30–33

    Abstract: Between 2013 and 2021, indicators of vascular access protection (IPAV) integrating a census of haematomas and multiple punctures were set up on the active file of chronic kidney failure patients with a vascular access dialyzed in Monaco's private ... ...

    Title translation Implementing vascular access protection indicators (VAPI) in dialysis: an innovation in quality of care.
    Abstract Between 2013 and 2021, indicators of vascular access protection (IPAV) integrating a census of haematomas and multiple punctures were set up on the active file of chronic kidney failure patients with a vascular access dialyzed in Monaco's private haemodialysis center. They could help reduce the occurrence of complications and improve the quality of care offered to patients. This article reports on the results obtained before and after the introduction of this quality approach.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Kidney Failure, Chronic/therapy ; Quality Indicators, Health Care ; Quality of Health Care/standards ; Renal Dialysis/standards ; Vascular Access Devices/standards
    Language French
    Publishing date 2024-04-09
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2024.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Conference proceedings ; Online: COHESA Work Package 4 - Delivering One Health Solutions

    Caron, Alexandre

    2022  

    Keywords one health approach ; capacity building
    Language English
    Publishing date 2022-11-23T06:49:43Z
    Publisher International Livestock Research Institute
    Publishing country fr
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Conference proceedings ; Online: CIRAD in southern Africa

    Caron, Alexandre

    2022  

    Keywords one health approach ; research
    Language English
    Publishing date 2022-02-18T10:01:46Z
    Publisher CIRAD
    Publishing country fr
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Outcomes for 15 cats with bilateral sacroiliac luxation treated with transiliosacral toggle suture repair

    Froidefond, Baptiste / Moinard, Mathieu / Caron, Alexandre

    Veterinary Surgery. 2023 Oct., v. 52, no. 7 p.983-993

    2023  

    Abstract: OBJECTIVE: To report a surgical technique and outcomes of transiliosacral toggle suture repair to treat feline bilateral sacroiliac luxation/fracture (SILF). STUDY DESIGN: Retrospective study. ANIMALS: Fifteen client‐owned cats. METHODS: The medical ... ...

    Abstract OBJECTIVE: To report a surgical technique and outcomes of transiliosacral toggle suture repair to treat feline bilateral sacroiliac luxation/fracture (SILF). STUDY DESIGN: Retrospective study. ANIMALS: Fifteen client‐owned cats. METHODS: The medical records of cats with bilateral SILF treated using a transiliosacral toggle suture repair were reviewed. Short‐ and medium‐term outcomes were assessed through standard postoperative clinical evaluation and radiographs, including measurements of angle of deviation (AoD), percentage of reduction (PoR), and pelvic canal width ratio (PCWR). Long‐term functional follow up was obtained from a questionnaire derived from the Feline Musculoskeletal Pain Index (FMPI). RESULTS: Fifteen cats were enrolled retrospectively, among which 13 survived to discharge. One minor wound complication, treated by secondary intention healing, was encountered. No major complication was reported. Immediately postoperatively, the mean absolute PoR values were 88.1 ± 11.2% and 91 ± 11.6% on the right and left side, respectively. The mean absolute AoD was 3.1 ± 2.8°, and the mean PCWR was 1.24 ± 0.08. The medium‐term radiographic follow up at a median of 205 (71–682) days postsurgery revealed the good stability of the repair. Excellent functional outcomes were identified upon the analysis of 12 long‐term questionnaires at a median of 365 (119–798) days postsurgery. CONCLUSION: Anatomic reduction was satisfactory and comparable with previously described techniques with good implant placement documented. Functional outcomes based on FMPI‐derived questionnaires were good to excellent in our population. CLINICAL SIGNIFICANCE: Transiliosacral toggle suture stabilization of bilateral SILF was associated with good outcomes in cats. Further studies are required to compare biomechanical properties and outcomes between this technique and previously described transiliosacral stabilization.
    Keywords biomechanics ; cats ; clinical examination ; musculoskeletal system ; pain ; questionnaires ; radiography ; retrospective studies ; surgery
    Language English
    Dates of publication 2023-10
    Size p. 983-993.
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1491071-8
    ISSN 1532-950X ; 0161-3499
    ISSN (online) 1532-950X
    ISSN 0161-3499
    DOI 10.1111/vsu.14008
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: A critical update on the leptin-melanocortin system.

    Lavoie, Olivier / Michael, Natalie Jane / Caron, Alexandre

    Journal of neurochemistry

    2023  Volume 165, Issue 4, Page(s) 467–486

    Abstract: The discovery of leptin in 1994 was an "eureka moment" in the field of neurometabolism that provided new opportunities to better understand the central control of energy balance and glucose metabolism. Rapidly, a prevalent model in the field emerged that ...

    Abstract The discovery of leptin in 1994 was an "eureka moment" in the field of neurometabolism that provided new opportunities to better understand the central control of energy balance and glucose metabolism. Rapidly, a prevalent model in the field emerged that pro-opiomelanocortin (POMC) neurons were key in promoting leptin's anorexigenic effects and that the arcuate nucleus of the hypothalamus (ARC) was a key region for the regulation of energy homeostasis. While this model inspired many important discoveries, a growing body of literature indicates that this model is now outdated. In this review, we re-evaluate the hypothalamic leptin-melanocortin model in light of recent advances that directly tackle previous assumptions, with a particular focus on the ARC. We discuss how segregated and heterogeneous these neurons are, and examine how the development of modern approaches allowing spatiotemporal, intersectional, and chemogenetic manipulations of melanocortin neurons has allowed a better definition of the complexity of the leptin-melanocortin system. We review the importance of leptin in regulating glucose homeostasis, but not food intake, through direct actions on ARC POMC neurons. We further highlight how non-POMC, GABAergic neurons mediate leptin's direct effects on energy balance and influence POMC neurons.
    MeSH term(s) Leptin ; Melanocortins/metabolism ; Pro-Opiomelanocortin/genetics ; Pro-Opiomelanocortin/metabolism ; Hypothalamus/metabolism ; Arcuate Nucleus of Hypothalamus ; Energy Metabolism/physiology
    Chemical Substances Leptin ; Melanocortins ; Pro-Opiomelanocortin (66796-54-1)
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15765
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    Ui II Zs.170: Show issues Location:
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  8. Article ; Online: Outcomes for 15 cats with bilateral sacroiliac luxation treated with transiliosacral toggle suture repair.

    Froidefond, Baptiste / Moinard, Mathieu / Caron, Alexandre

    Veterinary surgery : VS

    2023  Volume 52, Issue 7, Page(s) 983–993

    Abstract: Objective: To report a surgical technique and outcomes of transiliosacral toggle suture repair to treat feline bilateral sacroiliac luxation/fracture (SILF).: Study design: Retrospective study.: Animals: Fifteen client-owned cats.: Methods: The ...

    Abstract Objective: To report a surgical technique and outcomes of transiliosacral toggle suture repair to treat feline bilateral sacroiliac luxation/fracture (SILF).
    Study design: Retrospective study.
    Animals: Fifteen client-owned cats.
    Methods: The medical records of cats with bilateral SILF treated using a transiliosacral toggle suture repair were reviewed. Short- and medium-term outcomes were assessed through standard postoperative clinical evaluation and radiographs, including measurements of angle of deviation (AoD), percentage of reduction (PoR), and pelvic canal width ratio (PCWR). Long-term functional follow up was obtained from a questionnaire derived from the Feline Musculoskeletal Pain Index (FMPI).
    Results: Fifteen cats were enrolled retrospectively, among which 13 survived to discharge. One minor wound complication, treated by secondary intention healing, was encountered. No major complication was reported. Immediately postoperatively, the mean absolute PoR values were 88.1 ± 11.2% and 91 ± 11.6% on the right and left side, respectively. The mean absolute AoD was 3.1 ± 2.8°, and the mean PCWR was 1.24 ± 0.08. The medium-term radiographic follow up at a median of 205 (71-682) days postsurgery revealed the good stability of the repair. Excellent functional outcomes were identified upon the analysis of 12 long-term questionnaires at a median of 365 (119-798) days postsurgery.
    Conclusion: Anatomic reduction was satisfactory and comparable with previously described techniques with good implant placement documented. Functional outcomes based on FMPI-derived questionnaires were good to excellent in our population.
    Clinical significance: Transiliosacral toggle suture stabilization of bilateral SILF was associated with good outcomes in cats. Further studies are required to compare biomechanical properties and outcomes between this technique and previously described transiliosacral stabilization.
    MeSH term(s) Humans ; Cats/surgery ; Animals ; Retrospective Studies ; Bone Screws/veterinary ; Sacroiliac Joint ; Joint Dislocations/veterinary ; Fractures, Bone/veterinary ; Sutures ; Treatment Outcome ; Cat Diseases/surgery
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491071-8
    ISSN 1532-950X ; 0161-3499
    ISSN (online) 1532-950X
    ISSN 0161-3499
    DOI 10.1111/vsu.14008
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  9. Article ; Online: Pathophysiological Mechanisms That Alter the Autonomic Brain-Liver Communication in Metabolic Diseases.

    Silva, Anisia / Caron, Alexandre

    Endocrinology

    2021  Volume 162, Issue 11

    Abstract: The brain influences liver metabolism through many neuroendocrine and autonomic mechanisms that have evolved to protect the organism against starvation and hypoglycemia. Unfortunately, this effective way of preventing death has become dysregulated in ... ...

    Abstract The brain influences liver metabolism through many neuroendocrine and autonomic mechanisms that have evolved to protect the organism against starvation and hypoglycemia. Unfortunately, this effective way of preventing death has become dysregulated in modern obesogenic environments, although the pathophysiological mechanisms behind metabolic dyshomeostasis are still unclear. In this Mini-Review, we provide our thoughts regarding obesity and type 2 diabetes as diseases of the autonomic nervous system. We discuss the pathophysiological mechanisms that alter the autonomic brain-liver communication in these diseases, and how they could represent important targets to prevent or treat metabolic dysfunctions. We discuss how sympathetic hyperactivity to the liver may represent an early event in the progression of metabolic diseases and could progressively lead to hepatic neuropathy. We hope that this discussion will inspire and help to frame a model based on better understanding of the chronology of autonomic dysfunctions in the liver, enabling the application of the right strategy at the right time.
    MeSH term(s) Animals ; Autonomic Nervous System/pathology ; Autonomic Nervous System/physiopathology ; Brain/metabolism ; Brain/physiopathology ; Cell Communication ; Humans ; Liver/innervation ; Liver/metabolism ; Liver/physiopathology ; Metabolic Diseases/physiopathology ; Metabolic Diseases/psychology ; Neurosecretory Systems/physiopathology
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqab164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.72: Show issues Location:
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  10. Article ; Online: New Horizons: Is Obesity a Disorder of Neurotransmission?

    Caron, Alexandre / Jane Michael, Natalie

    The Journal of clinical endocrinology and metabolism

    2021  Volume 106, Issue 12, Page(s) e4872–e4886

    Abstract: Obesity is a disease of the nervous system. While some will view this statement as provocative, others will take it as obvious. Whatever our side is, the pharmacology tells us that targeting the nervous system works for promoting weight loss. It works, ... ...

    Abstract Obesity is a disease of the nervous system. While some will view this statement as provocative, others will take it as obvious. Whatever our side is, the pharmacology tells us that targeting the nervous system works for promoting weight loss. It works, but at what cost? Is the nervous system a safe target for sustainable treatment of obesity? What have we learned-and unlearned-about the central control of energy balance in the last few years? Herein we provide a thought-provoking exploration of obesity as a disorder of neurotransmission. We discuss the state of knowledge on the brain pathways regulating energy homeostasis that are commonly targeted in anti-obesity therapy and explore how medications affecting neurotransmission such as atypical antipsychotics, antidepressants, and antihistamines relate to body weight. Our goal is to provide the endocrine community with a conceptual framework that will help expending our understanding of the pathophysiology of obesity, a disease of the nervous system.
    MeSH term(s) Energy Metabolism ; Homeostasis ; Humans ; Obesity/chemically induced ; Obesity/epidemiology ; Obesity/pathology ; Prognosis ; Psychotropic Drugs/adverse effects ; Synaptic Transmission/drug effects
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab421
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