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  1. Article ; Online: Corrigendum to 'Frailty and heart response to physical activity' [Archives of Gerontology and Geriatrics 93 (2021) 104323].

    Toosizadeh, Nima / Ehsani, Hossein / Parthasarathy, Sairam / Carpenter, Ben / Ruberto, Kayleigh / Mohler, Jane / Parvaneh, Saman

    Archives of gerontology and geriatrics

    2021  Volume 97, Page(s) 104506

    Language English
    Publishing date 2021-09-24
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2021.104506
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    Zs.A 1729: Show issues Location:
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  2. Article ; Online: Quality of Life and Social and Psychological Outcomes in Adulthood Following Allogeneic HSCT in Childhood for Inborn Errors of Immunity

    Nicholson, Bethany / Goodman, Rupert / Day, James / Worth, Austen / Carpenter, Ben / Sandford, Kit / Morris, Emma C. / Burns, Siobhan O. / Ridout, Deborah / Titman, Penny / Campbell, Mari

    J Clin Immunol. 2022 Oct., v. 42, no. 7, p. 1451-1460

    2022  , Page(s) 1451–1460

    Abstract: BACKGROUND: Hematopoietic stem cell transplant (HSCT) is well established as a corrective treatment for many inborn errors of immunity (IEIs) presenting in childhood. Due to improved techniques, more transplants are undertaken and patients are living ... ...

    Abstract BACKGROUND: Hematopoietic stem cell transplant (HSCT) is well established as a corrective treatment for many inborn errors of immunity (IEIs) presenting in childhood. Due to improved techniques, more transplants are undertaken and patients are living longer. However, long-term complications can significantly affect future health and quality of life. Previous research has focused on short-term medical outcomes and little is known about health or psychosocial outcomes in adulthood. OBJECTIVE: This project aimed to ascertain the long-term social and psychological outcomes for adults who underwent HSCT for IEI during childhood. METHODS: Adult patients, who had all undergone HSCT for IEI during childhood at two specialist immunology services at least 5 years previously, were invited to participate in the study. Questionnaires and practical tasks assessed their current functioning and circumstances. Information was also gathered from medical notes. Data was compared with population norms and a control group of participant-nominated siblings or friends. RESULTS: Eighty-three patients and 46 matched controls participated in the study. Patients reported significantly better physical health-related quality of life than the general population norm, but significantly worse than matched controls. Patient’s self-reported physical health status and the perceived impact of their physical health on everyday life were worse than matched controls and patients reported higher levels of anxiety and lower mood than the general population. For those where their IEI diagnosis was not associated with a learning disability, cognitive function was generally within the normal range. CONCLUSIONS: Patients who have had a HSCT in childhood report mixed psychosocial outcomes in adulthood. More research is needed to establish screening protocols and targeted interventions to maximize holistic outcomes. CLINICAL IMPLICATIONS: Screening for holistic needs and common mental health difficulties should be part of routine follow-up. Information should be provided to patients and families in order to support decision-making regarding progression to transplant and the early identification of any difficulties.
    Keywords adulthood ; adults ; anxiety ; childhood ; cognition ; decision making ; health status ; hematopoietic stem cells ; immunity ; mental health ; patients ; physical health ; quality of life
    Language English
    Dates of publication 2022-10
    Size p. 1451-1460
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01286-6
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  3. Article ; Online: Biallelic deleterious germline

    Blombery, Piers / Pazhakh, Vahid / Albuquerque, Adriana S / Maimaris, Jesmeen / Tu, Lingge / Briones Miranda, Brenda / Evans, Florence / Thompson, Ella R / Carpenter, Ben / Proctor, Ian / Curtin, Julie A / Lambert, Jonathan / Burns, Siobhan O / Lieschke, Graham J

    EJHaem

    2023  Volume 4, Issue 2, Page(s) 463–469

    Abstract: ... ...

    Abstract SH2B3
    Language English
    Publishing date 2023-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.698
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  4. Article ; Online: Frailty and heart response to physical activity.

    Toosizadeh, Nima / Ehsani, Hossein / Parthasarathy, Sairam / Carpenter, Ben / Ruberto, Kayleigh / Mohler, Jane / Parvaneh, Saman

    Archives of gerontology and geriatrics

    2020  Volume 93, Page(s) 104323

    Abstract: Background: Although previous studies showed that frail older adults are more susceptible to develop cardiovascular diseases, the underlying effect of frailty on heart rate dynamics is still unclear. The goal of the current study was to measure heart ... ...

    Abstract Background: Although previous studies showed that frail older adults are more susceptible to develop cardiovascular diseases, the underlying effect of frailty on heart rate dynamics is still unclear. The goal of the current study was to measure heart rate changes due to normal speed and rapid walking among non-frail and pre-frail/frail older adults, and to implement heart rate dynamic measures to identify frailty status.
    Methods: Eighty-eight older adults (≥65 years) were recruited and stratified into frailty groups based on the five-component Fried frailty phenotype. While performing gait tests, heart rate was recorded using a wearable ECG and accelerometer sensors. Groups consisted of 27 non-frail (age = 78.70 ± 7.32) and 61 pre-frail/frail individuals (age = 81.00 ± 8.14). The parameters of interest included baseline heart rate measures (mean heart rate and heart rate variability), and heart rate dynamics due to walking (percentage change in heart rate and required time to reach the maximum heart rate).
    Results: Respectively for normal and rapid walking conditions, pre-frail/frail participants had 46% and 44% less increase in heart rate, and 49% and 27% slower occurrence of heart rate peak, when compared to non-frail older adults (p < 0.04, effect size = 0.71 ± 0.12). Measures of heart rate dynamics showed stronger associations with frailty status compared to baseline resting-state measures (sensitivity = 0.75 and specificity = 0.65 using heart rate dynamics measures, compared to sensitivity = 0.64 and specificity = 0.62 using baseline parameters).
    Conclusions: These findings suggest that measures of heart rate dynamics in response to daily activities may provide meaningful markers for frailty screening.
    MeSH term(s) Aged ; Exercise ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Gait ; Geriatric Assessment ; Humans
    Language English
    Publishing date 2020-12-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2020.104323
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  5. Article ; Online: Interleukin-1 blockade with anakinra in acute leukaemia patients with severe COVID-19 pneumonia appears safe and may result in clinical improvement.

    Day, James W / Fox, Thomas A / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D

    British journal of haematology

    2020  Volume 190, Issue 2, Page(s) e80–e83

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1/antagonists & inhibitors ; Leukemia/drug therapy ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16873
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  6. Article: Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia.

    Cuadrado, Maria M / Ahmed, Asia / Carpenter, Ben / Brown, Jeremy S

    Respiratory medicine case reports

    2017  Volume 20, Page(s) 184–187

    Abstract: We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a ... ...

    Abstract We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a predominantly central peribronchial pattern. All patients presented with evidence of active CMV pneumonitis which was treated successfully with anti-viral therapy but was followed by persistent severe dyspnoea, cough and hypoxia. High resolution computed tomography (HRCT) imaging showed widespread central peribronchial consolidation with traction bronchiectasis. There was a marked clinical and physiological improvement after treatment with systemic corticosteroids. However, in all patients the lung function remained abnormal and in some cases imaging revealed a fibrosing lung disease. These cases represent a previously undescribed central peribronchial pattern of organising pneumonia complicating CMV pneumonitis that can result in chronic lung damage.
    Language English
    Publishing date 2017-02-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2017.02.005
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  7. Article ; Online: Impact of positron emission tomography - computed tomography status on progression-free survival for relapsed follicular lymphoma patients undergoing autologous stem cell transplantation.

    Eyre, Toby A / Barrington, Sally F / Okosun, Jessica / Abamba, Clementina / Pearce, Rachel M / Lee, Julia / Carpenter, Ben / Crawley, Charles R / Bloor, Adrian J C / Gilleece, Maria / Nicholson, Emma / Shah, Nimish / Orchard, Kim / Malladi, Ram / Townsend, William M

    Haematologica

    2023  Volume 108, Issue 3, Page(s) 785–796

    Abstract: The optimum management approach for patients with relapsed or refractory follicular lymphoma remains uncertain. Autologous stem cell transplantation (autoSCT) is considered a standard option in suitable, younger patients with relapsed follicular lymphoma. ...

    Abstract The optimum management approach for patients with relapsed or refractory follicular lymphoma remains uncertain. Autologous stem cell transplantation (autoSCT) is considered a standard option in suitable, younger patients with relapsed follicular lymphoma. AutoSCT is associated with very durable remissions in a minority of subjects, but also with significant, well-established toxicities. Although positron emission tomography (PET) status prior to autoSCT is an established prognostic factor in diffuse large B-cell lymphoma and Hodgkin lymphoma, no data exist in follicular lymphoma. We describe survival outcomes according to pre-transplant PET status, classified by the Lugano criteria into complete metabolic remission (CMR) versus non-CMR, in 172 patients with relapsed or refractory follicular lymphoma within a national, multicenter, retrospective British Society of Blood and Marrow Transplantation and Cellular Therapy registry study. The median number of lines of therapy prior to SCT was three (range, 1-6). The median follow-up after SCT was 27 months (range, 3-70). The median progression-free survival for all patients after autoSCT was 28 months (interquartile range, 23- 36). There was no interaction between age at transplantation, sex, number of months since last relapse, Karnofsky performance status or comorbidity index and achieving CMR prior to autoSCT. Superior progression-free survival was observed in 115 (67%) patients obtaining CMR versus 57 (33%) non-CMR patients (3-year progression-free survival 50% vs. 22%, P=0.011) and by pre-SCT Deauville score (continuous variable 1-5, hazard ratio [HR]=1.32, P=0.049). PET status was independently associated with progression-free status (non-CMR HR=2.02, P=0.003), overall survival (non-CMR HR=3.08, P=0.010) and risk of relapse (non-CMR HR=1.64, P=0.046) after autoSCT by multivariable analysis. Our data suggest that pre- SCT PET status is of clear prognostic value and may help to improve the selection of patients for autoSCT.
    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation/methods ; Transplantation, Autologous ; Progression-Free Survival ; Lymphoma, Follicular/diagnostic imaging ; Lymphoma, Follicular/therapy ; Retrospective Studies ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/therapy ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Disease-Free Survival ; Stem Cell Transplantation
    Language English
    Publishing date 2023-03-01
    Publishing country Italy
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.280287
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  8. Article ; Online: Quality of Life and Social and Psychological Outcomes in Adulthood Following Allogeneic HSCT in Childhood for Inborn Errors of Immunity.

    Nicholson, Bethany / Goodman, Rupert / Day, James / Worth, Austen / Carpenter, Ben / Sandford, Kit / Morris, Emma C / Burns, Siobhan O / Ridout, Deborah / Titman, Penny / Campbell, Mari

    Journal of clinical immunology

    2022  Volume 42, Issue 7, Page(s) 1451–1460

    Abstract: Background: Hematopoietic stem cell transplant (HSCT) is well established as a corrective treatment for many inborn errors of immunity (IEIs) presenting in childhood. Due to improved techniques, more transplants are undertaken and patients are living ... ...

    Abstract Background: Hematopoietic stem cell transplant (HSCT) is well established as a corrective treatment for many inborn errors of immunity (IEIs) presenting in childhood. Due to improved techniques, more transplants are undertaken and patients are living longer. However, long-term complications can significantly affect future health and quality of life. Previous research has focused on short-term medical outcomes and little is known about health or psychosocial outcomes in adulthood.
    Objective: This project aimed to ascertain the long-term social and psychological outcomes for adults who underwent HSCT for IEI during childhood.
    Methods: Adult patients, who had all undergone HSCT for IEI during childhood at two specialist immunology services at least 5 years previously, were invited to participate in the study. Questionnaires and practical tasks assessed their current functioning and circumstances. Information was also gathered from medical notes. Data was compared with population norms and a control group of participant-nominated siblings or friends.
    Results: Eighty-three patients and 46 matched controls participated in the study. Patients reported significantly better physical health-related quality of life than the general population norm, but significantly worse than matched controls. Patient's self-reported physical health status and the perceived impact of their physical health on everyday life were worse than matched controls and patients reported higher levels of anxiety and lower mood than the general population. For those where their IEI diagnosis was not associated with a learning disability, cognitive function was generally within the normal range.
    Conclusions: Patients who have had a HSCT in childhood report mixed psychosocial outcomes in adulthood. More research is needed to establish screening protocols and targeted interventions to maximize holistic outcomes.
    Clinical implications: Screening for holistic needs and common mental health difficulties should be part of routine follow-up. Information should be provided to patients and families in order to support decision-making regarding progression to transplant and the early identification of any difficulties.
    MeSH term(s) Adult ; Humans ; Quality of Life ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Mental Health ; Health Status ; Anxiety
    Language English
    Publishing date 2022-06-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01286-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Interleukin-1 blockade with anakinra in acute leukaemia patients with severe COVID-19 pneumonia appears safe and may result in clinical improvement

    Day, James W / Fox, Thomas A / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D

    Br J Haematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #327255
    Database COVID19

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  10. Article ; Online: Interleukin‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement

    Day, James W. / Fox, Thomas A. / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D.

    British Journal of Haematology

    2020  Volume 190, Issue 2

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16873
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