Article ; Online: Current perspectives on tractography-guided deep brain stimulation for the treatment of mood disorders.
Expert review of neurotherapeutics
2024 Volume 24, Issue 1, Page(s) 11–24
Abstract: Introduction: Deep brain stimulation (DBS) is an emerging therapy for mood disorders, particularly treatment-resistant depression (TRD). Different brain areas implicated in depression-related brain networks have been investigated as DBS targets and ... ...
| Abstract | Introduction: Deep brain stimulation (DBS) is an emerging therapy for mood disorders, particularly treatment-resistant depression (TRD). Different brain areas implicated in depression-related brain networks have been investigated as DBS targets and variable clinical outcomes highlight the importance of target identification. Tractography has provided insight into how DBS modulates disorder-related brain networks and is being increasingly used to guide DBS for psychiatric disorders. Areas covered: In this perspective, an overview of the current state of DBS for TRD and the principles of tractography is provided. Next, a comprehensive review of DBS targets is presented with a focus on tractography. Finally, the challenges and future directions of tractography-guided DBS are discussed. Expert opinion: Tractography-guided DBS is a promising tool for improving DBS outcomes for mood disorders. Tractography is particularly useful for targeting patient-specific white matter tracts that are not visible using conventional structural MRI. Developments in tractography methods will help refine DBS targeting for TRD and may facilitate symptom-specific precision neuromodulation. Ultimately, the standardization of tractography methods will be essential to transforming DBS into an established therapy for mood disorders. |
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| MeSH term(s) | Humans ; Mood Disorders/therapy ; Diffusion Tensor Imaging ; Deep Brain Stimulation ; Magnetic Resonance Imaging ; Brain/diagnostic imaging | |||||
| Language | English | |||||
| Publishing date | 2024-01-08 | |||||
| Publishing country | England | |||||
| Document type | Review ; Journal Article | |||||
| ZDB-ID | 2112534-X | |||||
| ISSN | 1744-8360 ; 1473-7175 | |||||
| ISSN (online) | 1744-8360 | |||||
| ISSN | 1473-7175 | |||||
| DOI | 10.1080/14737175.2023.2289573 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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