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  1. Article ; Online: Optogenetic and chemogenetic approaches to manipulate attention, impulsivity and behavioural flexibility in rodents.

    Carr, Madison R / de Vries, Taco J / Pattij, Tommy

    Behavioural pharmacology

    2018  Volume 29, Issue 7, Page(s) 560–568

    Abstract: Studies manipulating neural activity acutely with optogenetic or chemogenetic intervention in behaving rodents have increased considerably in recent years. More often, these circuit-level neural manipulations are tested within an existing framework of ... ...

    Abstract Studies manipulating neural activity acutely with optogenetic or chemogenetic intervention in behaving rodents have increased considerably in recent years. More often, these circuit-level neural manipulations are tested within an existing framework of behavioural testing that strives to model complex executive functions or symptomologies relevant to multidimensional psychiatric disorders in humans, such as attentional control deficits, impulsivity or behavioural (in)flexibility. This methods perspective argues in favour of carefully implementing these acute circuit-based approaches to better understand and model cognitive symptomologies or their similar isomorphic animal behaviours, which often arise and persist in overlapping brain circuitries. First, we offer some practical considerations for combining long-term, behavioural paradigms with optogenetic or chemogenetic interventions. Next, we examine how cell-type or projection-specific manipulations to the ascending neuromodulatory systems, local brain region or descending cortical glutamatergic projections influence aspects of cognitive control. For this, we primarily focus on the influence exerted on attentional and motor impulsivity performance in the (3-choice or) 5-choice serial reaction time task, and impulsive, risky or inflexible choice biases during alternative preference, reward discounting or reversal learning tasks.
    MeSH term(s) Animals ; Attention/drug effects ; Attention/physiology ; Behavior, Animal/drug effects ; Designer Drugs/pharmacology ; Humans ; Impulsive Behavior/drug effects ; Impulsive Behavior/physiology ; Optogenetics ; Receptors, G-Protein-Coupled/drug effects ; Rodentia
    Chemical Substances Designer Drugs ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2018-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1027374-8
    ISSN 1473-5849 ; 0955-8810
    ISSN (online) 1473-5849
    ISSN 0955-8810
    DOI 10.1097/FBP.0000000000000425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2883: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Examination of the effects of cannabinoid ligands on decision making in a rat gambling task.

    Ferland, Jacqueline-Marie N / Carr, Madison R / Lee, Angela M / Hoogeland, Myrthe E / Winstanley, Catharine A / Pattij, Tommy

    Pharmacology, biochemistry, and behavior

    2018  Volume 170, Page(s) 87–97

    Abstract: Although exposure to delta-9-tetrahydrocannabinol (THC) is perceived to be relatively harmless, mounting evidence has begun to show that it is associated with a variety of cognitive deficits, including poor decision making. THC-induced impairments in ... ...

    Abstract Although exposure to delta-9-tetrahydrocannabinol (THC) is perceived to be relatively harmless, mounting evidence has begun to show that it is associated with a variety of cognitive deficits, including poor decision making. THC-induced impairments in decision making are thought to be the result of cannabinoid CB1 receptor activation, and although clinical literature suggests that chronic activation via THC contributes to perturbations in decision making, acute CB1 receptor modulation has yielded mixed results. Using an animal model to examine how CB1-specific ligands impact choice biases would provide significant insight as to how recruitment of the endocannabinoid system may influence decision making. Here, we used the rat gambling task (rGT), a validated analogue of the human Iowa Gambling Task, to assess baseline decision making preferences in male Wistar rats. After acquisition rGT performance was measured. Animals were challenged with the CB1 receptor antagonist rimonabant, the partial agonist THC, and the synthetic agonist WIN55,212-2. Animals were also treated acutely with the fatty acid amide hydrolase (FAAH) inhibitor URB597 to selectively upregulate the endocannabinoid anandamide. Blockade of the CB1 receptor produced a trend improvement in decision making in animals who preferred the advantageous task options, yet left choice unaffected in risk-prone rats. Neither CB1 receptor agonist had strong effects on decision making, but a high dose THC decreased premature responses, whereas WIN55,212-2 did the opposite. URB597 did not affect task performance. These results indicate that although chronic CB1 receptor activation may be associated with impaired decision making, acute modulation has modest effects on choice and instead may play a substantive role in regulating impulsive responding.
    MeSH term(s) Animals ; Benzamides/pharmacology ; Benzoxazines/pharmacology ; Carbamates/pharmacology ; Decision Making/drug effects ; Dronabinol/pharmacology ; Endocannabinoids/physiology ; Gambling ; Impulsive Behavior/drug effects ; Ligands ; Male ; Morpholines/pharmacology ; Naphthalenes/pharmacology ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/physiology ; Rimonabant/pharmacology ; Task Performance and Analysis
    Chemical Substances Benzamides ; Benzoxazines ; Carbamates ; Endocannabinoids ; Ligands ; Morpholines ; Naphthalenes ; Receptor, Cannabinoid, CB1 ; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester ; (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone (5H31GI9502) ; Dronabinol (7J8897W37S) ; Rimonabant (RML78EN3XE)
    Language English
    Publishing date 2018-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 191042-5
    ISSN 1873-5177 ; 0091-3057
    ISSN (online) 1873-5177
    ISSN 0091-3057
    DOI 10.1016/j.pbb.2018.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1060: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Dorsomedial prefrontal cortex neurons encode nicotine-cue associations.

    Struik, Roeland F / Marchant, Nathan J / de Haan, Roel / Terra, Huub / van Mourik, Yvar / Schetters, Dustin / Carr, Madison R / van der Roest, Marcel / Heistek, Tim S / De Vries, Taco J

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2019  Volume 44, Issue 12, Page(s) 2011–2021

    Abstract: The role of medial prefrontal cortex (mPFC) in regulating nicotine taking and seeking remains largely unexplored. In this study we took advantage of the high time-resolution of optogenetic intervention by decreasing (Arch3.0) or increasing (ChR2) the ... ...

    Abstract The role of medial prefrontal cortex (mPFC) in regulating nicotine taking and seeking remains largely unexplored. In this study we took advantage of the high time-resolution of optogenetic intervention by decreasing (Arch3.0) or increasing (ChR2) the activity of neurons in the dorsal and ventral mPFC during 5-s nicotine cue presentations in order to evaluate their contribution to cued nicotine seeking and taking. Wistar rats were trained to self-administer intravenous nicotine in 1 h self-administration sessions twice a day for a minimum of 10 days. Subsequently, dmPFC or vmPFC neuronal activity was modulated during or following presentation of the 5-s nicotine cue, both under extinction and self-administration conditions. We also used in vivo electrophysiology to record the activity of dmPFC neurons during nicotine self-administration and extinction tests. We show that optogenetic inhibition of dmPFC neurons during, but not following, response-contingent presentations of the nicotine cue increased nicotine seeking. We found no effect on nicotine self-administration or on food seeking in an extinction test. We also show that this effect is specific to dmPFC, because optogenetic inhibition of vmPFC had no effect on nicotine seeking and taking. In vivo recordings revealed that dmPFC network neuronal activity was modulated more strongly following nicotine cue presentation in extinction, compared to following nicotine self-administration. Our results strongly suggest that a population of neurons within the dmPFC is involved in encoding the incentive value of nicotine-associated cues.
    MeSH term(s) Animals ; Conditioning, Operant/drug effects ; Conditioning, Operant/physiology ; Cues ; Drug-Seeking Behavior/physiology ; Extinction, Psychological/drug effects ; Extinction, Psychological/physiology ; Male ; Neurons/drug effects ; Neurons/physiology ; Nicotine/administration & dosage ; Optogenetics ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiology ; Rats, Wistar
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2019-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-019-0449-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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