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  1. Article ; Online: Novel risk loci for COVID-19 hospitalization among admixed American populations

    Carracedo, Ángel

    medRxiv

    Abstract: The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific ... ...

    Abstract The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.
    Keywords covid19
    Language English
    Publishing date 2023-08-15
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.08.11.23293871
    Database COVID19

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  2. Article ; Online: Forensic Science International: Genetics Reviewer Hall of Fame 2020.

    Carracedo, Angel

    Forensic science international. Genetics

    2021  Volume 52, Page(s) 102480

    MeSH term(s) Awards and Prizes ; Forensic Sciences ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2021-02-04
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2021.102480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Forensic DNA typing protocols

    Carracedo, Angel

    (Methods in molecular biology ; 297)

    2005  

    Author's details ed. by Angel Carracedo
    Series title Methods in molecular biology ; 297
    Collection
    Keywords DNA Fingerprinting / methods ; Polymorphism, Single Nucleotide / genetics ; DNS ; Gerichtliche Chemie ; Genetischer Fingerabdruck
    Subject Forensische Chemie ; Toxikologisch-forensische Chemie ; Forensische Analyse ; Gerichtschemie ; Genetic finger-print ; DNS-Fingerprinting ; DNA-Fingerprinting ; Daktylogramm ; DNA-Profiling ; DNS-Profiling ; DNA-Test ; DNS-Test ; Desoxyribonucleinsäure ; DNA ; DNA-Molekül ; Desoxyribonukleinsäure
    Language English
    Size X, 280 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014096489
    ISBN 1-58829-264-9 ; 978-1-58829-264-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 2293 order for loan Magazin

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  4. Article ; Online: HLA alleles: important pieces to the COVID-19 puzzle.

    Castro-Santos, Patricia / Carracedo, Ángel / Díaz-Peña, Roberto

    Trends in immunology

    2023  Volume 44, Issue 10, Page(s) 754–756

    Abstract: Research on human leukocyte antigen (HLA) molecules in coronavirus disease 2019 (COVID-19) raised high expectations but has yielded limited results. Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic ... ...

    Abstract Research on human leukocyte antigen (HLA) molecules in coronavirus disease 2019 (COVID-19) raised high expectations but has yielded limited results. Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic COVID-19, representing an important contribution to genetics in COVID-19.
    MeSH term(s) Humans ; COVID-19/genetics ; Alleles ; Histocompatibility Antigens Class I/genetics ; HLA Antigens/genetics ; HLA-B Antigens/genetics
    Chemical Substances Histocompatibility Antigens Class I ; HLA Antigens ; HLA-B Antigens
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: UTMOST, a single and cross-tissue TWAS (Transcriptome Wide Association Study), reveals new ASD (Autism Spectrum Disorder) associated genes.

    Rodriguez-Fontenla, Cristina / Carracedo, Angel

    Translational psychiatry

    2021  Volume 11, Issue 1, Page(s) 256

    Abstract: Autism spectrum disorders (ASD) is a complex neurodevelopmental disorder that may significantly impact on the affected individual's life. Common variation (SNPs) could explain about 50% of ASD heritability. Despite this fact and the large size of the ... ...

    Abstract Autism spectrum disorders (ASD) is a complex neurodevelopmental disorder that may significantly impact on the affected individual's life. Common variation (SNPs) could explain about 50% of ASD heritability. Despite this fact and the large size of the last GWAS meta-analysis, it is believed that hundreds of risk genes in ASD have yet to be discovered. New tools, such as TWAS (Transcriptome Wide Association Studies) which integrate tissue expression and genetic data, are a great approach to identify new ASD susceptibility genes. The main goal of this study is to use UTMOST with the publicly available summary statistics from the largest ASD GWAS meta-analysis as genetic input. In addition, an in silico biological characterization for the novel associated loci was performed. Our results have shown the association of 4 genes at the brain level (CIPC, PINX1, NKX2-2, and PTPRE) and have highlighted the association of NKX2-2, MANBA, ERI1, and MITF at the gastrointestinal level. The gastrointestinal associations are quite relevant given the well-established but unexplored relationship between ASD and gastrointestinal symptoms. Cross-tissue analysis has shown the association of NKX2-2 and BLK. UTMOST-associated genes together with their in silico biological characterization seems to point to different biological mechanisms underlying ASD etiology. Thus, it would not be restricted to brain tissue and it will involve the participation of other body tissues such as the gastrointestinal.
    MeSH term(s) Autism Spectrum Disorder/genetics ; Cell Cycle Proteins ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; Transcriptome ; Tumor Suppressor Proteins
    Chemical Substances Cell Cycle Proteins ; PINX1 protein, human ; Tumor Suppressor Proteins
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-021-01378-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In memoriam: Peter Schneider.

    Butler, John M / Rittner, Christian / Carracedo, Angel

    Forensic science international. Genetics

    2022  Volume 63, Page(s) 102809

    Language English
    Publishing date 2022-11-24
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2022.102809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Liquid Biopsy Biomarkers for Immunotherapy in Non-Small Cell Lung Carcinoma: Lessons Learned and the Road Ahead.

    Hita-Millan, Jesus / Carracedo, Angel / Fernandez-Rozadilla, Ceres

    Journal of personalized medicine

    2021  Volume 11, Issue 10

    Abstract: Over the recent years, advances in the development of anti-cancer treatments, particularly the implementation of ICIs (immune checkpoint inhibitors), have resulted in increased survival rates in NSCLC (non-small cell lung cancer) patients. However, a ... ...

    Abstract Over the recent years, advances in the development of anti-cancer treatments, particularly the implementation of ICIs (immune checkpoint inhibitors), have resulted in increased survival rates in NSCLC (non-small cell lung cancer) patients. However, a significant proportion of patients does not seem respond to immunotherapy, and some individuals even develop secondary resistance to treatment. Therefore, it is imperative to correctly identify the patients that will benefit from ICI therapy in order to tailor therapeutic options in an individualised setting, ultimately benefitting both the patient and the health system. Many different biomarkers have been explored to correctly stratify patients and predict response to immunotherapy, but liquid biopsy approaches have recently arisen as an interesting opportunity to predict and monitor treatment response due to their logistic accessibility. This review summarises the current data and efforts in the field of ICI response biomarkers in NSCLC patients and highlights advantages and limitations as we discuss the road to clinical implementation.
    Language English
    Publishing date 2021-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11100971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Forensic science International: Genetics Reviewer Hall of Fame 2019.

    Carracedo, Angel / Smith, Alexander J

    Forensic science international. Genetics

    2019  Volume 45, Page(s) 102231

    Language English
    Publishing date 2019-12-20
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2019.102231
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  9. Article ; Online: Editorial considerations for publication in Forensic Science International: Genetics.

    Kayser, Manfred / Gill, Peter / Parson, Walther / Gusmão, Leonor / Linacre, Adrian / Vallone, Peter / Carracedo, Angel

    Forensic science international. Genetics

    2023  Volume 65, Page(s) 102877

    MeSH term(s) Humans ; Forensic Sciences ; Forensic Genetics
    Language English
    Publishing date 2023-04-20
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2023.102877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Deletion of the

    Facal, Fernando / Portela, Begoña / Gil-Rodríguez, Almudena / Barros, Francisco / Maroñas, Olalla / Carracedo, Angel

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1237446

    Abstract: ... ...

    Abstract CYP2D6
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1237446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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