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  1. Article ; Online: Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

    Arrieche, Dioni / Cabrera-Pardo, Jaime R. / San-Martin, Aurelio / Carrasco, Héctor / Taborga, Lautaro

    Mar Drugs. 2023 Jan. 29, v. 21, no. 2

    2023  

    Abstract: Fungi are a prolific source of bioactive molecules. During the past few decades, many bioactive natural products have been isolated from marine fungi. Chile is a country with 6435 Km of coastline along the Pacific Ocean and houses a unique fungal ... ...

    Abstract Fungi are a prolific source of bioactive molecules. During the past few decades, many bioactive natural products have been isolated from marine fungi. Chile is a country with 6435 Km of coastline along the Pacific Ocean and houses a unique fungal biodiversity. This review summarizes the field of fungal natural products isolated from Antarctic and Chilean marine environments and their biological activities.
    Keywords biodiversity ; coasts ; fungi ; Antarctic region ; Chile ; Pacific Ocean
    Language English
    Dates of publication 2023-0129
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21020098
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance.

    Arrieche, Dioni / Cabrera-Pardo, Jaime R / San-Martin, Aurelio / Carrasco, Héctor / Taborga, Lautaro

    Marine drugs

    2023  Volume 21, Issue 2

    Abstract: Fungi are a prolific source of bioactive molecules. During the past few decades, many bioactive natural products have been isolated from marine fungi. Chile is a country with 6435 Km of coastline along the Pacific Ocean and houses a unique fungal ... ...

    Abstract Fungi are a prolific source of bioactive molecules. During the past few decades, many bioactive natural products have been isolated from marine fungi. Chile is a country with 6435 Km of coastline along the Pacific Ocean and houses a unique fungal biodiversity. This review summarizes the field of fungal natural products isolated from Antarctic and Chilean marine environments and their biological activities.
    MeSH term(s) Chile ; Biological Products ; Antarctic Regions ; Biodiversity ; Fungi
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21020098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Secondary Metabolites Isolated from Chilean Marine Algae: A Review.

    Arrieche, Dioni / Carrasco, Héctor / Olea, Andrés F / Espinoza, Luis / San-Martín, Aurelio / Taborga, Lautaro

    Marine drugs

    2022  Volume 20, Issue 5

    Abstract: Chile is in the extreme southwestern part of America, and it has an extreme length, of approximately 4300 km that increases to 8000 km considering the Chilean Antarctic Territory. Despite the large extent of its coastal territory and the diversity of ... ...

    Abstract Chile is in the extreme southwestern part of America, and it has an extreme length, of approximately 4300 km that increases to 8000 km considering the Chilean Antarctic Territory. Despite the large extent of its coastal territory and the diversity of geographic environments and climates associated with Chilean coasts, the research on marine resources in Chile has been rather scarce. From marine organisms found in Chilean coastal waters, algae have been the most studied, since they contain a wide range of interesting secondary metabolites that have some structural traits that make them unique and uncharacteristic. Thus, a wide structural variety of natural products including terpenoids (monoterpenes, sesquiterpenes, diterpenes, and meroterpenoids), furanones, and C
    MeSH term(s) Antarctic Regions ; Aquatic Organisms/metabolism ; Biological Products/chemistry ; Bioprospecting ; Chile
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20050337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Phytochemical Profiling and Assessment of Anticancer Activity of Leptocarpha rivularis Extracts Obtained from In Vitro Cultures

    Rubio, Julia / Arias, Guisselle / Robles-Kelly, Christian / Silva-Moreno, Evelyn / Espinoza, Luis / Carrasco, Héctor / Olea, Andrés F.

    Plants. 2022 Feb. 18, v. 11, no. 4

    2022  

    Abstract: Plant cell culture is a source of plant material from which bioactive metabolites can be extracted. In this work, the in vitro propagation of Leptocarpha rivularis, an endemic Chilean shrub with anticancer activity, is described. Different media were ... ...

    Abstract Plant cell culture is a source of plant material from which bioactive metabolites can be extracted. In this work, the in vitro propagation of Leptocarpha rivularis, an endemic Chilean shrub with anticancer activity, is described. Different media were tested and optimized for the introduction, propagation, and rooting steps of the micropropagation process. At the end of this process, 83% of plants were successfully acclimatized under greenhouse conditions. Callus induction from the internodal stem segment was performed using various combinations of phytohormones. Green-colored, friable, and non-organogenic callus was generated with a callus induction index higher than 90%. The chemical composition of extracts and callus, obtained from clonal plants, was assessed and the results indicate that the phytochemical profiles of extracts from micropropagated plants are like those found for plants collected from natural habitats, leptocarpine (LTC) being the major component. However, no LTC was detected in callus extract. HeLa and CoN cells, treated with LTC or extract of micropropagated plants, exhibit important diminution on cell viability and a drastic decrease in gene expression of IL-6 and mmp2, genes associated with carcinogenic activity. These effects are more important in cancer cells than in normal cells. Thus, micropropagated L. rivularis could be developed as a potential source of efficient antiproliferative agents.
    Keywords antineoplastic activity ; callus ; carcinogenicity ; cell culture ; cell viability ; chemical composition ; gene expression ; greenhouses ; interleukin-6 ; internodes ; metabolites ; micropropagation ; plant hormones ; shrubs
    Language English
    Dates of publication 2022-0218
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11040546
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Misrecognition and Critical Consciousness - An 18-Month-Old Boy with Pneumonia and Chronic Malnutrition.

    Carrasco, Héctor / Messac, Luke / Holmes, Seth M

    The New England journal of medicine

    2019  Volume 380, Issue 25, Page(s) 2385–2389

    MeSH term(s) Community-Acquired Infections/etiology ; Cultural Competency ; Humans ; Infant ; Male ; Malnutrition/complications ; Malnutrition/prevention & control ; Malnutrition/rehabilitation ; Mexico ; Pneumonia/etiology ; Social Medicine
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1902028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Phytochemical Profiling and Assessment of Anticancer Activity of

    Rubio, Julia / Arias, Guisselle / Robles-Kelly, Christian / Silva-Moreno, Evelyn / Espinoza, Luis / Carrasco, Héctor / Olea, Andrés F

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Plant cell culture is a source of plant material from which bioactive metabolites can be extracted. In this work, the in vitro propagation ... ...

    Abstract Plant cell culture is a source of plant material from which bioactive metabolites can be extracted. In this work, the in vitro propagation of
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11040546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antifungal Activity of 2-Allylphenol Derivatives on the

    Olea, Andres F / Rubio, Julia / Sedan, Claudia / Carvajal, Denisse / Nuñez, Maria / Espinoza, Luis / Llovera, Ligia / Nuñez, Gerard / Taborga, Lautaro / Carrasco, Héctor

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: ... Botrytis ... ...

    Abstract Botrytis cinerea
    MeSH term(s) Antifungal Agents/chemistry ; Fungicides, Industrial/chemistry ; Botrytis
    Chemical Substances Antifungal Agents ; 2-allylphenol (1745-81-9) ; Fungicides, Industrial
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Synthesis and Biological Activity of New Brassinosteroid Analogs of Type 24-Nor-5β-Cholane and 23-Benzoate Function in the Side Chain.

    Soto, Nitza / Ferrer, Karoll / Díaz, Katy / González, César / Taborga, Lautaro / Olea, Andrés F / Carrasco, Héctor / Espinoza, Luis

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: Brassinosteroids are polyhydroxysteroids that are involved in different plants' biological functions, such as growth, development and resistance to biotic and external stresses. Because of its low abundance in plants, much effort has been dedicated to ... ...

    Abstract Brassinosteroids are polyhydroxysteroids that are involved in different plants' biological functions, such as growth, development and resistance to biotic and external stresses. Because of its low abundance in plants, much effort has been dedicated to the synthesis and characterization of brassinosteroids analogs. Herein, we report the synthesis of brassinosteroid 24-nor-5β-cholane type analogs with 23-benzoate function and 22,23-benzoate groups. The synthesis was accomplished with high reaction yields in a four-step synthesis route and using hyodeoxycholic acid as starting material. All synthesized analogs were tested using the rice lamina inclination test to assess their growth-promoting activity and compare it with those obtained for brassinolide, which was used as a positive control. The results indicate that the diasteroisomeric mixture of monobenzoylated derivatives exhibit the highest activity at the lowest tested concentrations (1 × 10
    MeSH term(s) Arabidopsis/growth & development ; Benzoates/chemical synthesis ; Benzoates/chemistry ; Brassinosteroids/chemical synthesis ; Brassinosteroids/chemistry ; Cholanes/chemical synthesis ; Cholanes/chemistry ; Deoxycholic Acid/chemical synthesis ; Deoxycholic Acid/chemistry ; Molecular Structure ; Oryza/chemistry ; Plant Development ; Plant Growth Regulators ; Steroids, Heterocyclic/chemistry
    Chemical Substances Benzoates ; Brassinosteroids ; Cholanes ; Plant Growth Regulators ; Steroids, Heterocyclic ; Deoxycholic Acid (005990WHZZ) ; hyodeoxycholic acid (7A33Y6EHYK) ; brassinolide (Y9IQ1L53OX)
    Language English
    Publishing date 2021-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: El TLCAN y la comercialización de hortalizas de exportación de Sinaloa

    Gaxiola Carrasco, Héctor Enrique

    (Economía)

    2013  

    Author's details Héctor Enrique Gaxiola Carrasco
    Series title Economía
    Keywords Free trade ; Fruit trade ; Vegetable trade ; Gemüsebau ; Gemüse ; Export ; Wettbewerbsvorteil ; Freihandelszone ; Sinaloa ; NAFTA-Staaten ; Sinaloa (Mexico : State) ; United States
    Language Spanish
    Size 484 pages, Ill., graph. Darst., Kt., 23 cm
    Edition Segunda edición corregida y aumentada
    Publisher Universidad Autónoma de Sinaloa
    Publishing place Culiacán, México
    Document type Book
    Note Includes bibliographical references (pages 469-484)
    ISBN 6079230909 ; 9786079230906
    Database ECONomics Information System

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  10. Article: Natural history of the relict marsupial Monito del Monte at the most extreme altitudinal and latitudinal location

    Mejías, Carlos / Castro‐Pastene, Carlos A. / Carrasco, Héctor / Quintero‐Galvis, Julian F. / Soto‐Gamboa, Mauricio / Bozinovic, Francisco / Nespolo, Roberto F.

    Ecosphere. 2021 June, v. 12, no. 6

    2021  

    Abstract: Until a few years ago, the “monito del monte” (Dromiciops gliroides) was considered the sole surviving species of Microbiotheria, the sister group of Australidelphia (Australian marsupials). However, the recent identification of a new species relegated ... ...

    Abstract Until a few years ago, the “monito del monte” (Dromiciops gliroides) was considered the sole surviving species of Microbiotheria, the sister group of Australidelphia (Australian marsupials). However, the recent identification of a new species relegated to the northern range (Dromiciops bozinovici) and newly discovered populations of Dromiciops beyond the known limits for the geographic range demands for new studies in extreme locations. In this report, we describe the northernmost population of D. bozinovici at a high Andean location (Reserva Nacional Altos de Lircay [RNAL], which represents a record of Dromiciops distribution both in latitude [35° S] and in altitude [1696 m a.s.l.]). We live‐trapped individuals, performed behavioral observations, and extracted mtDNA (Cytb) for analyzing phylogenetic affinities. Together with confirming the phylogenetic position of RNAL within the D. bozinovici clade, interesting aspects of this isolated population arose, such as the sympatry with a didelphid marsupial (Thylamys elegans), and phylogenetic closeness with populations 300 km southward coastal. Our trapping effort yielded approximately 9.3 individuals/ha, which is relatively high compared with other small mammal populations, but typical for Dromiciops. Using in situ thermographic imaging during a night transect, we detected free‐ranging animals running vertically at ~3.6 km/h through the logs of mature trees (Nothofagus pumilio), which is fast compared with other small runners (e.g., cursorial rodents), and also compared with Dromiciops from other locations. We compared the critical time to escape, of RNAL individuals which resulted significantly higher than Dromiciops from Nahuelbuta and Valdivia, suggesting that animals from RNAL are more tolerant to human presence than other populations, which is probably due to the high level of isolation of this population. According to the IUCN the northernmost distribution of Dromiciops reaches Cauquenes, thus this report extends the distribution in 120 km to the North East. Interesting aspects, such as hibernation at freezing temperatures and the existence of a viable D. bozinovici population northward of RNAL, warrant further research on this interesting location.
    Keywords Microbiotheria ; Nothofagus pumilio ; Thylamys elegans ; altitude ; geographical distribution ; hibernation ; humans ; latitude ; natural history ; new species ; phylogeny ; small mammals ; sympatry ; thermography ; Andes region
    Language English
    Dates of publication 2021-06
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2572257-8
    ISSN 2150-8925
    ISSN 2150-8925
    DOI 10.1002/ecs2.3577
    Database NAL-Catalogue (AGRICOLA)

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