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  1. Article: Solid Lipid Nanoparticles Enhancing the Leishmanicidal Activity of Delamanid.

    Santamaría-Aguirre, Javier / Jacho, Daniela / Méndez, Miguel A / Poveda, Ana / Carrión, Javier / Fanarraga, Mónica L

    Pharmaceutics

    2023  Volume 16, Issue 1

    Abstract: Leishmaniasis, a zoonotic parasitic disease transmitted by infected sandflies, impacts nearly 1 million people yearly and is endemic in many countries across Asia, Africa, the Americas, and the Mediterranean; despite this, it remains a neglected disease ... ...

    Abstract Leishmaniasis, a zoonotic parasitic disease transmitted by infected sandflies, impacts nearly 1 million people yearly and is endemic in many countries across Asia, Africa, the Americas, and the Mediterranean; despite this, it remains a neglected disease with limited effective treatments, particularly in impoverished communities with limited access to healthcare. This study aims to repurpose approved drugs for an affordable leishmaniasis treatment. After the screening of potential drug candidates by reviewing databases and utilizing molecular docking analysis, delamanid was chosen to be incorporated into solid lipid nanoparticles (SLNPs). Both in cellulo and in vivo tests confirmed the successful payload release within macrophages and through the epidermis following topical application on murine skin. The evaluation of macrophages infected with
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanisms of immunity to Leishmania major infection in mice: the contribution of DNA vaccines coding for two novel sets of histones (H2A-H2B or H3-H4).

    Carrión, Javier

    Comparative immunology, microbiology and infectious diseases

    2011  Volume 34, Issue 5, Page(s) 381–386

    Abstract: The immune phenotype conferred by two different sets of histone genes (H2A-H2B or H3-H4) was assessed. BALB/c mice vaccinated with pcDNA3H2AH2B succumbed to progressive cutaneous leishmaniosis (CL), whereas vaccination with pcDNA3H3H4 resulted in partial ...

    Abstract The immune phenotype conferred by two different sets of histone genes (H2A-H2B or H3-H4) was assessed. BALB/c mice vaccinated with pcDNA3H2AH2B succumbed to progressive cutaneous leishmaniosis (CL), whereas vaccination with pcDNA3H3H4 resulted in partial resistance to Leishmania major challenge associated with the development of mixed T helper 1 (Th1)/Th2-type response and a reduction in parasite-specific Treg cells number at the site of infection. Therefore, the presence of histones H3 and H4 may be considered essential in the development of vaccine strategies against CL based on the Leishmania histones.
    MeSH term(s) Animals ; Cytokines/immunology ; Disease Resistance ; Female ; Forkhead Transcription Factors/immunology ; Genetic Vectors/genetics ; Genetic Vectors/metabolism ; Histones/genetics ; Histones/immunology ; Histones/metabolism ; Immunity, Cellular ; Immunity, Humoral ; Leishmania major/genetics ; Leishmania major/immunology ; Leishmania major/pathogenicity ; Leishmaniasis Vaccines/genetics ; Leishmaniasis Vaccines/immunology ; Leishmaniasis Vaccines/metabolism ; Leishmaniasis, Cutaneous/immunology ; Leishmaniasis, Cutaneous/parasitology ; Lymph Nodes/immunology ; Mice ; Mice, Inbred BALB C ; Nucleosomes/genetics ; Nucleosomes/immunology ; Nucleosomes/metabolism ; Parasite Load ; Plasmids/genetics ; Plasmids/metabolism ; Spleen/immunology ; T-Lymphocytes, Regulatory/immunology ; Vaccination ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology ; Vaccines, DNA/metabolism
    Chemical Substances Cytokines ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Histones ; Leishmaniasis Vaccines ; Nucleosomes ; Vaccines, DNA
    Language English
    Publishing date 2011-09
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2011.06.002
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: A Framework for Implementing Metaheuristic Algorithms Using Intercellular Communication.

    Ortiz, Yerko / Carrión, Javier / Lahoz-Beltrá, Rafael / Gutiérrez, Martín

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 660148

    Abstract: Metaheuristics (MH) are Artificial Intelligence procedures that frequently rely on evolution. MH approximate difficult problem solutions, but are computationally costly as they explore large solution spaces. This work pursues to lay the foundations of ... ...

    Abstract Metaheuristics (MH) are Artificial Intelligence procedures that frequently rely on evolution. MH approximate difficult problem solutions, but are computationally costly as they explore large solution spaces. This work pursues to lay the foundations of general mappings for implementing MH using Synthetic Biology constructs in cell colonies. Two advantages of this approach are: harnessing large scale parallelism capability of cell colonies and, using existing cell processes to implement basic dynamics defined in computational versions. We propose a framework that maps MH elements to synthetic circuits in growing cell colonies to replicate MH behavior in cell colonies. Cell-cell communication mechanisms such as quorum sensing (QS), bacterial conjugation, and environmental signals map to evolution operators in MH techniques to adapt to growing colonies. As a proof-of-concept, we implemented the workflow associated to the framework: automated MH simulation generators for the
    Language English
    Publishing date 2021-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.660148
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  4. Article ; Online: A Tailored Approach to Leishmaniases Vaccination: Comparative Evaluation of the Efficacy and Cross-Protection Capacity of DNA vs. Peptide-Based Vaccines in a Murine Model.

    Mas, Alicia / Hurtado-Morillas, Clara / Martínez-Rodrigo, Abel / Orden, José A / de la Fuente, Ricardo / Domínguez-Bernal, Gustavo / Carrión, Javier

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Zoonotic leishmaniases are a worldwide public health problem for which the development of effective vaccines remains a challenge. A vaccine against leishmaniases must be safe and affordable and should induce cross-protection against the different disease- ...

    Abstract Zoonotic leishmaniases are a worldwide public health problem for which the development of effective vaccines remains a challenge. A vaccine against leishmaniases must be safe and affordable and should induce cross-protection against the different disease-causing species. In this context, the DNA vaccine pHisAK70 has been demonstrated to induce, in a murine model, a resistant phenotype against
    MeSH term(s) Animals ; Mice ; Vaccines, DNA ; Disease Models, Animal ; Leishmaniasis/prevention & control ; Vaccination ; DNA ; Leishmaniasis Vaccines ; Mice, Inbred BALB C ; Leishmania infantum/genetics ; Leishmaniasis, Visceral ; Antigens, Protozoan
    Chemical Substances Vaccines, DNA ; DNA (9007-49-2) ; Leishmaniasis Vaccines ; Antigens, Protozoan
    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease.

    Robledo, Sara M / Pérez-Silanes, Silvia / Fernández-Rubio, Celia / Poveda, Ana / Monzote, Lianet / González, Víctor M / Alonso-Collado, Paloma / Carrión, Javier

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: In 2020, the WHO established the road map for neglected tropical diseases 2021-2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on ...

    Abstract In 2020, the WHO established the road map for neglected tropical diseases 2021-2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on Antimicrobial Resistance. In this context, the achievement of innovative strategies as an alternative to replace conventional therapies is a first-order socio-sanitary priority, especially regarding endemic zoonoses in poor regions, such as those caused by
    Language English
    Publishing date 2023-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Curcuma longa

    Sánchez Juárez, A / Carrión, Fabián / Carrión, Javier / Castillo, Darwin / Padilla-Martínez, J P / Cruz-Félix, Ángel

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 12

    Abstract: In this research, we present a prototype optical system that offers significant advances in detecting hydrochloric acid (HCl) and ammonia (NH3) vapors. The system utilizes a natural pigment sensor based ... ...

    Abstract In this research, we present a prototype optical system that offers significant advances in detecting hydrochloric acid (HCl) and ammonia (NH3) vapors. The system utilizes a natural pigment sensor based on
    MeSH term(s) Ammonia ; Hydrochloric Acid ; Curcuma ; Gases ; Water
    Chemical Substances Ammonia (7664-41-7) ; Hydrochloric Acid (QTT17582CB) ; Gases ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23125602
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  7. Book ; Online: Going beyond communication intensity for estimating tie strengths in social networks

    Ureña-Carrion, Javier / Saramäki, Jari / Kivelä, Mikko

    2020  

    Abstract: Even though the concept of tie strength is central in social network analysis, it is difficult to quantify how strong social ties are. One typical way of estimating tie strength in data-driven studies has been to simply count the total number or duration ...

    Abstract Even though the concept of tie strength is central in social network analysis, it is difficult to quantify how strong social ties are. One typical way of estimating tie strength in data-driven studies has been to simply count the total number or duration of contacts between two people. This, however, disregards many features that can be extracted from the rich data sets used for social network reconstruction. Here, we focus on contact data with temporal information. We systematically study how features of the contact time series are related to topological features usually associated with tie strength. We analyze a large mobile-phone dataset and measure a number of properties of the call time series for each tie, and use these to predict the so-called neighbourhood overlap, a feature related to strong ties in the sociological literature. We observe a strong relationship between temporal features and the neighbourhood overlap, with many features outperforming simple contact counts. Features that stand out include the number of days with calls, number of bursty cascades, typical times of contacts, and temporal stability. Our results suggest that these measures could be adapted for use in social network construction and indicate that the best results can be achieved by combining multiple temporal features.

    Comment: 15 pages, 6 figures on main text + 17 pages of supplementary informaiton (one pdf). Submitted to EPJ Data Science. Conference talk on NetSci 2020
    Keywords Physics - Physics and Society ; Computer Science - Social and Information Networks ; Physics - Data Analysis ; Statistics and Probability
    Subject code 306
    Publishing date 2020-07-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Mechanisms of immunity to Leishmania major infection in mice: The contribution of DNA vaccines coding for two novel sets of histones (H2A–H2B or H3–H4)

    Carrión, Javier

    Comparative immunology, microbiology, and infectious diseases. 2011 Sept., v. 34, no. 5

    2011  

    Abstract: The immune phenotype conferred by two different sets of histone genes (H2A–H2B or H3–H4) was assessed. BALB/c mice vaccinated with pcDNA3H2AH2B succumbed to progressive cutaneous leishmaniosis (CL), whereas vaccination with pcDNA3H3H4 resulted in partial ...

    Abstract The immune phenotype conferred by two different sets of histone genes (H2A–H2B or H3–H4) was assessed. BALB/c mice vaccinated with pcDNA3H2AH2B succumbed to progressive cutaneous leishmaniosis (CL), whereas vaccination with pcDNA3H3H4 resulted in partial resistance to Leishmania major challenge associated with the development of mixed T helper 1 (Th1)/Th2-type response and a reduction in parasite-specific Treg cells number at the site of infection. Therefore, the presence of histones H3 and H4 may be considered essential in the development of vaccine strategies against CL based on the Leishmania histones.
    Keywords CD4-positive T-lymphocytes ; Leishmania major ; cutaneous leishmaniasis ; genes ; histones ; immunity ; mice ; phenotype ; recombinant vaccines ; vaccination ; vaccine development
    Language English
    Dates of publication 2011-09
    Size p. 381-386.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2011.06.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1443: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Transcriptomic Profile of Canine DH82 Macrophages Infected by

    Mas, Alicia / Martínez-Rodrigo, Abel / Carrión, Javier / Orden, José Antonio / Alzate, Juan F / Domínguez-Bernal, Gustavo / Horcajo, Pilar

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Zoonotic visceral leishmaniosis caused ... ...

    Abstract Zoonotic visceral leishmaniosis caused by
    MeSH term(s) Animals ; Cell Line ; Dogs/genetics ; Dogs/parasitology ; Gene Expression Regulation ; Gene Ontology ; Leishmania infantum/growth & development ; Leishmania infantum/pathogenicity ; Leishmaniasis, Visceral/genetics ; Leishmaniasis, Visceral/parasitology ; Leishmaniasis, Visceral/veterinary ; Life Cycle Stages/physiology ; Macrophages/metabolism ; Macrophages/parasitology ; NLR Proteins/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Transcriptome/genetics ; Virulence
    Chemical Substances NLR Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031466
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  10. Article ; Online: Cumulative effects of triadic closure and homophily in social networks.

    Asikainen, Aili / Iñiguez, Gerardo / Ureña-Carrión, Javier / Kaski, Kimmo / Kivelä, Mikko

    Science advances

    2020  Volume 6, Issue 19, Page(s) eaax7310

    Abstract: Social network structure has often been attributed to two network evolution mechanisms-triadic closure and choice homophily-which are commonly considered independently or with static models. However, empirical studies suggest that their dynamic interplay ...

    Abstract Social network structure has often been attributed to two network evolution mechanisms-triadic closure and choice homophily-which are commonly considered independently or with static models. However, empirical studies suggest that their dynamic interplay generates the observed homophily of real-world social networks. By combining these mechanisms in a dynamic model, we confirm the longheld hypothesis that choice homophily and triadic closure cause induced homophily. We estimate how much observed homophily in friendship and communication networks is amplified due to triadic closure. We find that cumulative effects of homophily amplification can also lead to the widely documented core-periphery structure of networks, and to memory of homophilic constraints (equivalent to hysteresis in physics). The model shows that even small individual bias may prompt network-level changes such as segregation or core group dominance. Our results highlight that individual-level mechanisms should not be analyzed separately without considering the dynamics of society as a whole.
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aax7310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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