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Article ; Online: Assessment of sexual dysfunction in patients with multiple sclerosis: a perspective from neurologist.

Gaviria-Carrillo, Mariana / Bueno-Florez, Silvia Juliana / Ortiz-Salas, Paola Andrea

2022 Volume 22, Issue 1, Page(s) 372

Abstract: Background: Sexual dysfunction (SD) is a common comorbidity in people with multiple sclerosis (pwMS). It affects the quality of life and remains an overlooked condition. The objective of this study was to describe how Colombian neurologists assess and ... ...

Abstract	Background: Sexual dysfunction (SD) is a common comorbidity in people with multiple sclerosis (pwMS). It affects the quality of life and remains an overlooked condition. The objective of this study was to describe how Colombian neurologists assess and treat SD and explore the barriers during sexual function evaluation. Methods: In this observational cross-sectional study we developed a questionnaire for neurologists with 4 sections (demographic data, evaluation and treatment of SD, and possible reasons for not discussing sexual dysfunction.) It was sent via email to 326 Colombian neurologists. We grouped the answers according to the type of consultation (neurologists from a MS program or no MS program). We described through absolute frequencies and proportions. Results: Fifty neurologists answered the survey. 64% stated that they usually study sexual dysfunction in neurological disorders. The main methods employed were private reading (86%) and attending conferences (14%). 5/50 participants have never attend pwMS; the Sect. 2-4 was not answered by them. 29% work in a MS program, all of them asked their patients about sexual function, but 18.75% of physicians working outside an MS program have never asked about it. Main reasons for not talking about sexual dysfunction were lack of knowledge (65.1%), presence of a companion (65.1%) and lack of time (55.8%). 91% of the neurologists reported that their patients usually and frequently ask about sexual function. Neurologists use informal questions to assess sexual function (80%), although 64.4% said that they are aware of SD questionnaires. When sexual dysfunction is detected, 91% of neurologists refer patients to another specialist and 87% do not start any treatment. Conclusions: Colombian neurologists are concerned with sexual function in pwMS, however it remains an underdiagnosed an undertreated condition. It is necessary to strengthen knowledge about the diagnosis and treatment of sexual dysfunction in pwMS, for neurologists and patients. It is also imperative to eliminate barriers around the topic and include sexual function evaluation and treatment as the routine care of pwMS.
MeSH term(s)	Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/therapy ; Neurologists ; Quality of Life ; Sexual Dysfunction, Physiological/diagnosis ; Sexual Dysfunction, Physiological/epidemiology ; Sexual Dysfunction, Physiological/etiology ; Surveys and Questionnaires
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-022-02884-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health Professions Students' Knowledge, Skills, and Attitudes Toward Transgender Healthcare.

Vasudevan, Anita / García, Antonio D / Hart, Bethany G / Kindratt, Tiffany B / Pagels, Patti / Orcutt, Venetia / Campbell, Tad / Carrillo, Mariana / Lau, May

Journal of community health

2022 Volume 47, Issue 6, Page(s) 981–989

Abstract: Most graduate medical education programs dedicate almost no time in their curricula to the topic of transgender health. This study aimed to assess medical (MD), physician assistant (PA), and clinical nutrition (CN) students' self-reported knowledge, ... ...

Abstract	Most graduate medical education programs dedicate almost no time in their curricula to the topic of transgender health. This study aimed to assess medical (MD), physician assistant (PA), and clinical nutrition (CN) students' self-reported knowledge, skills, and attitudes toward healthcare for transgender patients and identify differences between groups. This cross-sectional study was conducted at a single United States academic health center. Students were surveyed using a questionnaire with 16 Likert-type items. A total of 178 MD, 96 PA, and 28 CN students completed the survey. Most (67%) respondents reported a "high" level of personal comfort in caring for a transgender patient, with no difference between groups (p = .57). MD students were more likely than PA or CN students to report greater knowledge of gender dysphoria management (p < .001) and transgender care guidelines (p < .001), as well as a greater skill level in caring for patients with gender dysphoria (p = .009) and inquiring about gender identity (p < .001). All three groups, however, reported overall "low" or "intermediate" levels of knowledge and skills. Our research demonstrates that MD, PA, and CN students exhibit an equally high degree of personal comfort in caring for transgender patients but lack the knowledge and skills to confidently care for them.
MeSH term(s)	Humans ; Female ; Male ; United States ; Transgender Persons ; Cross-Sectional Studies ; Attitude of Health Personnel ; Gender Identity ; Students, Health Occupations ; Students, Medical ; Health Occupations
Language	English
Publishing date	2022-08-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	426631-6
ISSN	1573-3610 ; 0094-5145
ISSN (online)	1573-3610
ISSN	0094-5145
DOI	10.1007/s10900-022-01135-y
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Article: Development of Antiepileptic Drugs throughout History: From Serendipity to Artificial Intelligence.

Corrales-Hernández, María Gabriela / Villarroel-Hagemann, Sebastián Kurt / Mendoza-Rodelo, Isabella Esther / Palacios-Sánchez, Leonardo / Gaviria-Carrillo, Mariana / Buitrago-Ricaurte, Natalia / Espinosa-Lugo, Santiago / Calderon-Ospina, Carlos-Alberto / Rodríguez-Quintana, Jesús Hernán

Biomedicines

2023 Volume 11, Issue 6

Abstract: This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used ... ...

Abstract	This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used today, such as phenobarbital and valproic acid. Subsequently, it delves into the historical progression of crucial preclinical models employed in the development of novel AEDs, including the maximal electroshock stimulation test, pentylenetetrazol-induced test, kindling models, and other animal models. Moving forward, a concise overview of the clinical advancement of major AEDs is provided, highlighting the initial milestones and the subsequent refinement of this process in recent decades, in line with the emergence of evidence-based medicine and the implementation of increasingly rigorous controlled clinical trials. Lastly, the article explores the contributions of artificial intelligence, while also offering recommendations and discussing future perspectives for the development of new AEDs.
Language	English
Publishing date	2023-06-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11061632
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Article ; Online: Experience of Subcutaneous Levetiracetam in Palliative Care.

Gaviria-Carrillo, Mariana / Mora-Muñoz, Laura / Diaz-Forero, Andres Felipe / Vargas-Osorio, Juliana / Torres-Ballesteros, Viviana / Estrada, Jhonatan / Vélez Van Meerbeke, Alberto / Rodríguez, Jesús Hernán

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

2023 Volume 32, Issue 1, Page(s) 90–95

Abstract: Background: Seizures are common in palliative care patients and its control is essential in the management of these patients as it helps to reduce suffering at the end of life. Subcutaneous levetiracetam has been used off-license for seizure control in ... ...

Abstract	Background: Seizures are common in palliative care patients and its control is essential in the management of these patients as it helps to reduce suffering at the end of life. Subcutaneous levetiracetam has been used off-license for seizure control in palliative care. Objective: The objective of the study was to describe our experience with subcutaneous levetiracetam in two hospitals in Bogota, Colombia. Methods: We conducted a retrospective review of patients treated with subcutaneous levetiracetam in two hospitals in Colombia during 2019-2021. Data were extracted from medical records, and participants were followed up as outpatients. Results: Twenty-one patients were included into the study. No severe adverse effects or rise in ictal frequency were documented. Twelve patients died during hospitalization and nine continued treatments as outpatients. The principal diagnosis was structural focal epilepsy. The daily dose of levetiracetam ranged from 1,000 mg to 3,000 mg, and the duration of treatment varied among subjects between 1 and 360 days. Conclusion: Subcutaneous levetiracetam was well tolerated and effective in controlling seizures in palliative care when oral administration or intravenous access was not an option. Randomized controlled trials are needed to elucidate the efficacy and tolerability of subcutaneous levetiracetam in clinical practice.
MeSH term(s)	Humans ; Levetiracetam/therapeutic use ; Anticonvulsants/therapeutic use ; Anticonvulsants/adverse effects ; Palliative Care ; Piracetam/therapeutic use ; Piracetam/adverse effects ; Seizures/drug therapy ; Treatment Outcome
Chemical Substances	Levetiracetam (44YRR34555) ; Anticonvulsants ; Piracetam (ZH516LNZ10)
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	News
ZDB-ID	645108-1
ISSN	1423-0151 ; 1011-7571
ISSN (online)	1423-0151
ISSN	1011-7571
DOI	10.1159/000529461
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Article ; Online: The "diet model" and metabolic syndrome components: Results from the Cordoba Health and Dietary Habits Investigation.

Muñoz, Sonia E / Díaz, Maria Del Pilar / Reartes, Gabriela A / Aballay, Laura R / Niclis, Camila / Román, María D / Coquet, Julia Becaria / Carrillo, Mariana N Del V / Canale, Marcela G

Nutrition (Burbank, Los Angeles County, Calif.)

2022 Volume 102, Page(s) 111739

Abstract: Objectives: Diet, one of the main risk factors for both metabolic syndrome (MetS) and non-communicable diseases (NCDs), is a multidimensional feature whose complexity relies on the individual and contextual characteristics of foods. The aim of this ... ...

Abstract	Objectives: Diet, one of the main risk factors for both metabolic syndrome (MetS) and non-communicable diseases (NCDs), is a multidimensional feature whose complexity relies on the individual and contextual characteristics of foods. The aim of this study was to build a "diet model" and estimate its relationship with MetS components in two Argentinian populations. Methods: This was a population-based cross-sectional study that assessed bio-socio-anthropometrical variables and dietary habits using food frequency questionnaires. Dietary patterns (DPs) were drawn out using exploratory factor analysis (EFA). A structural equation model (SEM) was used to explore and confirm theoretical and empirical relationships between DPs and the diet model. The association between individuals' adherence to DPs and MetS were assessed using a multiple logistic regression analysis. We selected two cities in central Argentina according to socio-eco-environmental characteristics. Participants included 493 men and women (1:1 ratio) from 35 to 65 y of age. Results: We identified four DPs: traditional Argentine (TA; processed meats, meats and eggs, fats, starchy vegetables), prudent (Pr; vegetables, fruits, milk, and yogurt), alcohol and snacks (AS), and sweets (S; candies and sodas). TA and AS DPs were associated with increased waist circumference. The S DP showed a strong effect on hypertension. Moderate adherence to the TA DP was positively associated with dyslipidemia but negatively with hypertension whenever individuals did not adhere to the AS DP. TA was positively correlated to AS and S, but inversely with Pr. Conclusion: This diet model integrated those food groups in an associative structure describing per se a synthesis of the Argentine dietary habits and their association with three of the five components of MetS.
MeSH term(s)	Cross-Sectional Studies ; Diet ; Feeding Behavior ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/etiology ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology
Language	English
Publishing date	2022-05-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2022.111739
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Article: The "Diet Model" and Metabolic Syndrome Components: Results from the Cordoba Health and Dietary Habits Investigation (CoHDHI)

Muñoz, Sonia E. / del Pilar Diaz, Maria / Reartes, Gabriela A. / Aballay, Laura R. / Niclis, Camila / Román, María D. / Coquet, Julia Becaria / Carrillo, Mariana N. / Canale, Marcela G.

Nutrition. 2022 May 09,

2022

Abstract: Diet, one of the main risk factors for both Metabolic Syndrome (MetS) and non-communicable diseases (NCD), is a multidimensional feature whose complexity relies upon foods, individual and contextual characteristics. The objective was to build a “Diet ... ...

Abstract	Diet, one of the main risk factors for both Metabolic Syndrome (MetS) and non-communicable diseases (NCD), is a multidimensional feature whose complexity relies upon foods, individual and contextual characteristics. The objective was to build a “Diet model” and estimate its relationship with MetS components in two populations of Argentina. A population-based cross-sectional study was conducted. Bio-socio-anthropometrical variables and dietary habits were assessed using Food Frequency Questionnaires. Dietary Patterns (DP) were drawn out using Exploratory Factor Analysis (EFA). A Structural Equation Model (SEM) was used to explore and confirm theoretical and empirical relationships between DP and the “Diet Model”. People adherence to DP and MetS components associations were assessed using a Multiple logistic regression analysis (MLRA). Two cities of central Argentina selected according to socio-eco-environmental characteristics. 493 subjects (Men:women 1:1) 35-65 years old. We identified 4 DPs: Traditional Argentine (-TA- processed meats, meats and eggs, fats, starchy vegetables), Prudent (-P-vegetables, fruits, milk and yogurt), Alcohol and snacks (AS) and, Sweet (S-candies and sodas). TA and AS were associated with Increased Waist Circumference. S showed a strong effect on hypertension, moderate adherence to TA was positively associated with Dyslipidemia but negatively with HT whenever people do not adhere to AS. TA was positively correlated to AS and S, but inversely with P. This “Diet model” integrates those food groups in an associative structure describing per se a synthesis of the Argentine dietary habits and their association with 3 of the 5 components of MetS.
Keywords	alcohols ; cross-sectional studies ; factor analysis ; hyperlipidemia ; hypertension ; metabolic syndrome ; milk ; people ; regression analysis ; structural equation modeling ; waist circumference ; yogurt ; Argentina
Language	English
Dates of publication	2022-0509
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2022.111739
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Article: Apparent False Lateralization of Seizure Onset by Scalp EEG in Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformation: A Case Report and Overview.

Gaviria Carrillo, Mariana / López, Jonathan / Rodríguez Q, Jesús H / Gaona, Ivan / Ortiz-Guerrero, Gloria / Nava-Mesa, Mauricio O

Brain sciences

2020 Volume 10, Issue 9

Abstract: False lateralization of ictal onset by scalp electroencephalogram (EEG) is an infrequent entity that has been reported in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (HS). In these cases, a tendency for rapid ... ...

Abstract	False lateralization of ictal onset by scalp electroencephalogram (EEG) is an infrequent entity that has been reported in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (HS). In these cases, a tendency for rapid seizures that spread through the frontal-limbic system and hippocampal commissural pathways to the contralateral hemisphere has been proposed. Cerebral cavernous malformations (CCMs), which constitute a collection of abnormally configured small blood vessels with irregular structures, is a well-defined epilepsy-associated pathology. Their primary association with seizures might be explained either as a result of physiological changes affecting the cerebral cortex immediately surrounding the CCM (an epileptogenic mechanism that is relevant for both, temporal and extratemporal lesions) or as a result of promoting epileptogenicity in remote but anatomo-functionally connected brain regions, a mechanism that is particularly relevant for temporal lobe lesions. To date, there have been only two publications on falsely lateralizing ictal onsets by EEG in temporal cavernoma, but not in other regions. Here, we report a rare case of apparent false lateralization of ictal onset by scalp EEG in a patient with a left medial frontal gyrus cavernoma (supplementary motor area), and discuss some relevant pathophysiological mechanisms of false lateralization.
Language	English
Publishing date	2020-08-24
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci10090584
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Article ; Online: Controversies in neuroimmunology: multiple sclerosis, vaccination, SARS-CoV-2 and other dilemas

Reyes-Niño, Saúl / Rodríguez-Orozco, Jaime Eduardo / Moutran-Barroso, Habib Georges / Kreinter-Rosembaun, Hellen / Gaviria-Carrillo, Mariana / Salej-Durán, Vanessa / Mancera-Charry, Julián / Villegas, Ana Claudia / Cuellar-Giraldo, David / Torres-Sandoval, Juan Sebastián / Gómez-Mazuera, Ángela / Duque-Samper, Aristides / Toro-Gómez, Jaime

Biomedica : revista del Instituto Nacional de Salud

2022 Volume 42, Issue Sp. 2, Page(s) 78–99

Title translation	Controversias en neuroinmunología: esclerosis múltiple, vacunación, SARS-CoV-2 y otros dilemas
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Retrospective Studies
Language	Spanish
Publishing date	2022-10-31
Publishing country	Colombia
Document type	English Abstract ; Journal Article
ZDB-ID	2059952-3
ISSN	2590-7379 ; 2590-7379
ISSN (online)	2590-7379
ISSN	2590-7379
DOI	10.7705/biomedica.6366
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Article: Development of a diabetes self-management + mHealth program: tailoring the intervention for a pilot study in a low-income setting in Mexico.

Whittemore, Robin / Vilar-Compte, Mireya / Burrola-Méndez, Soraya / Lozano-Marrufo, Annel / Delvy, Roberta / Pardo-Carrillo, Mariana / De La Cerda, Selene / Pena-Purcell, Ninfa / Pérez-Escamilla, Rafael

Pilot and feasibility studies

2020 Volume 6, Page(s) 25

Abstract: Background: Type 2 diabetes (T2D) is a public health pandemic disproportionately affecting low- and middle-income countries. The purpose of this formative research was to adapt evidence-based diabetes self-management education programs to the context of ...

Abstract	Background: Type 2 diabetes (T2D) is a public health pandemic disproportionately affecting low- and middle-income countries. The purpose of this formative research was to adapt evidence-based diabetes self-management education programs to the context of Seguro Popular clinics in Mexico. A theory-based mHealth (pictorial text messaging) component was developed. Method: Our formative research and development of the program protocol consisted of six phases: (1) interviews and focus groups with stakeholders on the challenges to T2D management, curriculum content needs, and the use of mHealth as a supplement to a DSME program; (2) review of the theoretical underpinning, curriculum, and interactive strategies of four evidence-based DSME programs and modification to meet the needs of adults with T2D and systems of care in Mexico City; (3) development of theory-based illustrated text messages; (4) evaluation of text messaging acceptability and access in adults with T2D via focus groups; (5) development of program manual; and (6) development of a training program for health care providers. Results: The ¡Sí, Yo Puedo Vivir Sano Con Diabetes! included 7 group-based weekly lessons; simple, interactive content; weekly empowerment messages; video novellas; group activities; and goal setting. Adaptations to the cultural context of Mexico included content/activities on diabetes etiology (addressing cultural misconceptions), nutrition (indigenous foods and plate method), self-blood glucose monitoring, and diabetes-related stress/coping. We used the Health Action Process Approach to guide the text message development, which posits that adoption, initiation, and maintenance of health behaviors require the development of intentions, plans, coping, and self-efficacy. Our final text message bank consisted of 181 messages. There were approximately 20-30 messages for each process of behavior change (e.g., action planning, maintenance self-efficacy) and 30 messages for each content topic (e.g., eating healthy, physical activity). There were 96 messages that were illustrated. Training materials were also developed. Discussion: We used a systematic approach, collaboration with stakeholders, and a well-established behavior change theory to develop an evidence-based intervention to an international context and system of care. Collectively, this process has the potential to enhance the feasibility, acceptability, and efficacy of the program.
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2809935-7
ISSN	2055-5784
ISSN	2055-5784
DOI	10.1186/s40814-020-0558-7
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Article ; Online: ¡Sí, Yo Puedo Vivir Sano con Diabetes!

Whittemore, Robin / Vilar-Compte, Mireya / De La Cerda, Selene / Delvy, Roberta / Jeon, Sangchoon / Burrola-Méndez, Soraya / Pardo-Carrillo, Mariana / Lozano-Marrufo, Annel / Pérez-Escamilla, Rafael

Current developments in nutrition

2020 Volume 4, Issue 5, Page(s) nzaa074

Abstract: Background: Type 2 diabetes (T2D) is a worldwide epidemic and a leading cause of death in Mexico, with a prevalence of 15.9%, and >70% of diagnosed adults have poor glycemic control [glycated hemoglobin (HbA1c) >7.5%]. We developed a diabetes self- ... ...

Abstract	Background: Type 2 diabetes (T2D) is a worldwide epidemic and a leading cause of death in Mexico, with a prevalence of 15.9%, and >70% of diagnosed adults have poor glycemic control [glycated hemoglobin (HbA1c) >7.5%]. We developed a diabetes self-management education program contextualized to the study population, including dietary preferences, health literacy, and health system. Objectives: We aimed to evaluate the efficacy of a self-management + text message program ( Methods: Participants were recruited at public primary healthcare centers ( Results: Participants were 55.5 ± 8.8 y of age (mean ± SD), 68% female, 88.6% overweight/obese, and 57% lived in food-insecure households. Mean ± SD T2D duration was 11.9 ± 7.8 y and HbA1c was 9.2% ± 1.5%. There was 89% attendance at sessions and 6.4% attrition across both groups at 6 mo. Group-by-time effects were seen in self-monitoring of blood glucose ( Conclusions: The program was associated with clinically significant improvements in T2D self-management, self-efficacy, and HbA1c over time. Thus, T2D self-management skills, including diet, were improved in a vulnerable metropolitan population.This trial was registered at clinicaltrials.gov as NCT03159299.
Language	English
Publishing date	2020-04-14
Publishing country	United States
Document type	Journal Article
ISSN	2475-2991
ISSN (online)	2475-2991
DOI	10.1093/cdn/nzaa074
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