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Article ; Online: Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases.

Caño-Carrillo, Sheila / Castillo-Casas, Juan Manuel / Franco, Diego / Lozano-Velasco, Estefanía

2024 Volume 13, Issue 3

Abstract: Effective intercellular communication is essential for cellular and tissue balance maintenance and response to challenges. Cellular communication methods involve direct cell contact or the release of biological molecules to cover short and long distances. ...

Abstract	Effective intercellular communication is essential for cellular and tissue balance maintenance and response to challenges. Cellular communication methods involve direct cell contact or the release of biological molecules to cover short and long distances. However, a recent discovery in this communication network is the involvement of extracellular vesicles that host biological contents such as proteins, nucleic acids, and lipids, influencing neighboring cells. These extracellular vesicles are found in body fluids; thus, they are considered as potential disease biomarkers. Cardiovascular diseases are significant contributors to global morbidity and mortality, encompassing conditions such as ischemic heart disease, cardiomyopathies, electrical heart diseases, and heart failure. Recent studies reveal the release of extracellular vesicles by cardiovascular cells, influencing normal cardiac function and structure. However, under pathological conditions, extracellular vesicles composition changes, contributing to the development of cardiovascular diseases. Investigating the loading of molecular cargo in these extracellular vesicles is essential for understanding their role in disease development. This review consolidates the latest insights into the role of extracellular vesicles in diagnosis and prognosis of cardiovascular diseases, exploring the potential applications of extracellular vesicles in personalized therapies, shedding light on the evolving landscape of cardiovascular medicine.
MeSH term(s)	Humans ; Cardiovascular Diseases/metabolism ; Extracellular Vesicles/metabolism ; Signal Transduction ; Cell Communication/physiology ; Heart Diseases/metabolism
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13030265
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Article ; Online: Pediatric extracorporeal cardiopulmonary resuscitation for yew cardiotoxicity.

Daniels, Zachary / Hays, Hannah / Carrillo, Sergio / Kamp, Anna / Gauntt, Jennifer

Perfusion

2023 , Page(s) 2676591231210452

Abstract: Introduction: English yew is an evergreen conifer frequently planted in household gardens and, when ingested in large doses, results in severe cardiotoxicity characterized by difficult to control ventricular arrhythmias with high rates of mortality.: ... ...

Abstract	Introduction: English yew is an evergreen conifer frequently planted in household gardens and, when ingested in large doses, results in severe cardiotoxicity characterized by difficult to control ventricular arrhythmias with high rates of mortality. Case report: A previously healthy teenage female presented as an out-of-hospital cardiac arrest with refractory ventricular arrhythmias and severe biventricular dysfunction. Due to rapid deterioration in her clinical status, she was cannulated onto venoarterial extracorporeal membrane oxygenation (ECMO) which resulted in rapid normalization of her rhythm and ventricular function. Discussion: Our case highlights the importance of keeping a broad differential diagnosis when considering etiologies of ventricular arrhythmias in the pediatric population. The final diagnosis was not made until after discharge and implantable cardiac defibrillator (ICD) placement. Conclusion: The delayed diagnosis of this intentional English yew ingestion ultimately resulted subsequent ICD removal. Early ECMO activation in cases of English yew toxicity can be essential for patient survival.
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/02676591231210452
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Article ; Online: Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches.

Sosa-Carrillo, Sebastián / Galez, Henri / Napolitano, Sara / Bertaux, François / Batt, Gregory

Nature communications

2023 Volume 14, Issue 1, Page(s) 3028

Abstract: Optimizing the production of recombinant proteins is a problem of major industrial and pharmaceutical importance. Secretion of the protein by the host cell considerably simplifies downstream purification processes. However, for many proteins, this is ... ...

Abstract	Optimizing the production of recombinant proteins is a problem of major industrial and pharmaceutical importance. Secretion of the protein by the host cell considerably simplifies downstream purification processes. However, for many proteins, this is also the limiting production step. Current solutions involve extensive engineering of the chassis cell to facilitate protein trafficking and limit protein degradation triggered by excessive secretion-associated stress. Here, we propose instead a regulation-based strategy in which induction is dynamically adjusted to an optimal strength based on the current stress level of the cells. Using a small collection of hard-to-secrete proteins, a bioreactor-based platform with automated cytometry measurements, and a systematic assay to quantify secreted protein levels, we demonstrate that the secretion sweet spot is indicated by the appearance of a subpopulation of cells that accumulate high amounts of proteins, decrease growth, and face significant stress, that is, experience a secretion burnout. In these cells, adaptations capabilities are overwhelmed by a too strong production. Using these notions, we show for a single-chain antibody variable fragment that secretion levels can be improved by 70% by dynamically keeping the cell population at optimal stress levels using real-time closed-loop control.
MeSH term(s)	Recombinant Proteins/metabolism ; Protein Transport ; Bioreactors ; Single-Chain Antibodies/metabolism
Chemical Substances	Recombinant Proteins ; Single-Chain Antibodies
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38807-9
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Article: Assessment of

González-Vallejo, Norma Emilia / Amador-Carrillo, Stephanie

ZooKeys

2021 Volume 1016, Page(s) 49–61

Abstract: As part of a study on holothurians from the southern Gulf of Mexico, ... ...

Abstract	As part of a study on holothurians from the southern Gulf of Mexico, some
Language	English
Publishing date	2021-02-11
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1016.55071
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Article ; Online: Amblyopic stereo vision is efficient but noisy.

Alarcon Carrillo, Sara / Hess, Robert F / Mao, Yu / Zhou, Jiawei / Baldwin, Alex S

Vision research

2023 Volume 210, Page(s) 108267

Abstract: People with amblyopia demonstrate a reduced ability to judge depth using stereopsis. Our understanding of this deficit is limited, as standard clinical stereo tests may not be suited to give a quantitative account of the residual stereo ability in ... ...

Abstract	People with amblyopia demonstrate a reduced ability to judge depth using stereopsis. Our understanding of this deficit is limited, as standard clinical stereo tests may not be suited to give a quantitative account of the residual stereo ability in amblyopia. In this study we used a stereo test designed specifically for that purpose. Participants identified the location of a disparity-defined odd-one-out target within a random-dot display. We tested 29 amblyopic (3 strabismic, 17 anisometropic, 9 mixed) participants and 17 control participants. We obtained stereoacuity thresholds from 59% of our amblyopic participants. There was a factor of two difference between the median stereoacuity of our amblyopic (103 arcsec) and control (56 arcsec) groups. We used the equivalent noise method to evaluate the role of equivalent internal noise and processing efficiency in amblyopic stereopsis. Using the linear amplifier model (LAM), we determined the threshold difference was due to a greater equivalent internal noise in the amblyopic group (238 vs 135 arcsec), with no significant difference in processing efficiency. A multiple linear regression determined 56% of the stereoacuity variance within the amblyopic group was predicted by the two LAM parameters, with equivalent internal noise predicting 46% alone. Analysis of control group data aligned with our previous work, finding that trade-offs between equivalent internal noise and efficiency play a greater role. Our results allow a better understanding of what is limiting amblyopic performance in our task. We find this to be a reduced quality of disparity signals in the input to the task-specific processing.
MeSH term(s)	Humans ; Amblyopia ; Depth Perception ; Noise ; Vision, Binocular ; Vision, Ocular ; Visual Acuity ; Case-Control Studies
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	200427-6
ISSN	1878-5646 ; 0042-6989
ISSN (online)	1878-5646
ISSN	0042-6989
DOI	10.1016/j.visres.2023.108267
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Article ; Online: Estimating the size of populations at risk for malaria: a case study in cattle herders and agricultural workers in Northern Namibia.

Rerolle, Francois / Jacobson, Jerry O / Smith Gueye, Cara / Bennett, Adam / Carrillo, Sidney / Ntuku, Henry / Smith, Jennifer L

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7160

Abstract: Cattle herders and agricultural workers have been identified has key high-risk populations for malaria in northern Namibia. Population size estimates for these groups are lacking but are important for planning, monitoring and evaluating the effectiveness ...

Abstract	Cattle herders and agricultural workers have been identified has key high-risk populations for malaria in northern Namibia. Population size estimates for these groups are lacking but are important for planning, monitoring and evaluating the effectiveness of targeted strategies towards malaria elimination in the region. In this analysis, we extend population size estimation methods routinely used in HIV research, specifically social mapping and multiple source capture-recapture, to the context of malaria to estimate how many cattle herders and agricultural workers lived in two regions of northern Namibia over the course of the 2019-2020 malaria season. Both methods estimated two to three times more agricultural workers than cattle herders but size estimates based on the multiple source capture-recapture method were two to three times greater than the mapping-based, highlighting important methodological considerations to apply such methods to these highly mobile populations. In particular, we compared open versus closed populations assumptions for the capture-recapture method and assessed the impact of sensitivity analyses on the procedure to link records across multiple data sources on population size estimates. Our results are important for national control programs to target their resources and consider integrating routine population size estimation of high risk populations in their surveillance activities.
MeSH term(s)	Cattle ; Animals ; Humans ; Namibia/epidemiology ; Farmers ; Malaria/epidemiology ; Risk Factors ; Population Density
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56810-y
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Article ; Online: Lifestyle behaviors, social and economic disadvantages, and all-cause and cardiovascular mortality: results from the US National Health Interview Survey.

Duarte Junior, Miguel Angelo / Pintos Carrillo, Salud / Martínez-Gómez, David / Sotos Prieto, Mercedes / Rodríguez-Artalejo, Fernando / Cabanas Sánchez, Verónica

Frontiers in public health

2024 Volume 12, Page(s) 1297060

Abstract: Aim: To examine the independent relationships of lifestyle and social and economic factors with all-cause and cardiovascular disease (CVD) mortality in a large representative sample of the US adult population. Furthermore, the association between the ... ...

Abstract	Aim: To examine the independent relationships of lifestyle and social and economic factors with all-cause and cardiovascular disease (CVD) mortality in a large representative sample of the US adult population. Furthermore, the association between the combination of lifestyle and social and economic factors with mortality was analyzed in detail. Methods: The sample included 103,314 participants with valid records and eligible for mortality follow-up, and information on lifestyle factors and social and economic disadvantages (NHIS waves 2000, 2005, 2010, and 2015). An unhealthy lifestyle score was constructed using information on physical activity, alcohol consumption, diet, and smoking status. Social and economic disadvantages were assessed using information on education, receipt of dividends, employment, family's home, and access to private health. Information on mortality data was determined by the National Death Index records. Results: Compared with favorable lifestyle, unfavorable lifestyle was associated with higher all-cause (HR 2.07; 95% CI 1.97-2.19) and CVD (HR 1.84; 95% CI 1.68-2.02) mortality. Higher social and economic disadvantages were also associated with higher all-cause (HR 2.44; 95% CI 2.30-2.59) and CVD mortality (HR 2.44; 95% CI 2.16-2.77), compared to low social and economic disadvantages. In joint associations, participants in the high social and economic disadvantage and unfavorable lifestyle showed a greater risk of all-cause (HR 4.06; 95% CI 3.69-4.47) and CVD mortality (HR 3.98; 95% CI 3.31-4.79). Conclusion: Lifestyle and social and economic disadvantages are associated with all-cause and CVD mortality. The risk of mortality increases as the number of social and economic disadvantages and unhealthy lifestyles increases.
MeSH term(s)	Adult ; Humans ; Risk Factors ; Life Style ; Cardiovascular Diseases/epidemiology ; Surveys and Questionnaires ; Social Behavior
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1297060
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Article ; Online: Factors limiting sensitivity to binocular disparity in human vision: Evidence from a noise-masking approach.

Alarcon Carrillo, Sara / Baldwin, Alex S / Hess, Robert F

Journal of vision

2020 Volume 20, Issue 3, Page(s) 9

Abstract: Our visual system uses the disparity between the images received by the two eyes to judge three-dimensional distance to surfaces. We can measure this ability by having subjects discriminate the disparity of rendered surfaces. We wanted to know the basis ... ...

Abstract	Our visual system uses the disparity between the images received by the two eyes to judge three-dimensional distance to surfaces. We can measure this ability by having subjects discriminate the disparity of rendered surfaces. We wanted to know the basis of the individual differences in this ability. We tested 53 adults with normal vision using a relative disparity detection task. Targets were wedge-shaped surfaces formed from random dots. These were presented in either crossed or uncrossed disparity relative to a random dot background. The threshold disparity ranged from 24 arc seconds in the most-able subject to 275 arc seconds in the least-able subject. There was a small advantage for detecting crossed-disparity targets. We used the noise-masking paradigm to partition subject performance into two factors. These were the subject's equivalent internal noise and their processing efficiency. The parameters were estimated by fitting the linear amplifier model. We found both factors contributed to the individual differences in stereoacuity. Within subjects, those showing an advantage for one disparity direction had enhanced efficiency for that direction. Some subjects had a higher equivalent internal noise for one direction that was balanced out by an increased efficiency. Our approach provides a more thorough account of the stereo-ability of our subjects compared with measuring thresholds alone. We present a normative set of results that can be compared with clinical populations.
MeSH term(s)	Adult ; Aged ; Depth Perception/physiology ; Female ; Humans ; Male ; Middle Aged ; Noise ; Perceptual Masking/physiology ; Vision Disparity/physiology ; Vision, Binocular/physiology ; Vision, Ocular/physiology ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2106064-2
ISSN	1534-7362 ; 1534-7362
ISSN (online)	1534-7362
ISSN	1534-7362
DOI	10.1167/jov.20.3.9
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Article ; Online: Combined blue light and daily thermocycles enhance zebrafish growth and development.

de Alba, Gonzalo / Carrillo, Sherezade / Sánchez-Vázquez, Francisco Javier / López-Olmeda, José Fernando

Journal of experimental zoology. Part A, Ecological and integrative physiology

2022 Volume 337, Issue 5, Page(s) 501–515

Abstract: In the wild, the light/temperature environment cyclically oscillates insofar as the temperature rises after dawn and drops after dusk. In the underwater photo-environment, light is filtered through the water column so that blue photons reach greater ... ...

Abstract	In the wild, the light/temperature environment cyclically oscillates insofar as the temperature rises after dawn and drops after dusk. In the underwater photo-environment, light is filtered through the water column so that blue photons reach greater depths. This paper investigates the combined effects of both factors with two temperature regimes (constant temperature = 26°C, CTE vs. daily thermocycle = 28°C day:24°C night, TC) and three light wavelengths (white-W, blue-B, red-R) on Danio rerio embryos and larvae from fertilization to 30 days post-fertilization (dpf). It studied hatching rate, larval survival, growth, and food intake (gut content). It analyzed the expression of the genes involved in stress (crh), somatic growth (gh, ifg1a, igf2a), and food intake control (npy, agrp, ghrelin, orexin, mch1, mch2, grp, cck8) at 10 and 30 dpf. The results revealed that the lowest hatching rate was in R regardless of the temperature regime. The highest growth rate was for the larvae reared with B + TC, which was consistent with the highest expression values of the growth factors. The highest feeding and expression levels of the genes involved in food intake were for the larvae in B (regardless of the temperature regime) and W + TC. Conversely, the R + CTE combination obtained the worst growth and feeding results. These findings indicate that the best larval performance can be achieved with combinations of blue wavelengths and cyclic temperature regimes that come closer to those in the natural environment. These results should be considered when optimizing rearing protocols to improve the growth and welfare of the fish larvae.
MeSH term(s)	Animals ; Larva ; Light ; Temperature ; Zebrafish
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1474896-4
ISSN	2471-5646 ; 1932-5223 ; 2471-5646 ; 1932-5231 ; 1552-499X
ISSN (online)	2471-5646 ; 1932-5223
ISSN	2471-5646 ; 1932-5231 ; 1552-499X
DOI	10.1002/jez.2584
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Article ; Online: Rigorous dynamic model of a silicon ring resonator with phase change material for a neuromorphic node.

Lugnan, Alessio / García-Cuevas Carrillo, Santiago / Wright, C David / Bienstman, Peter

Optics express

2022 Volume 30, Issue 14, Page(s) 25177–25194

Abstract: The photonics platform has been considered increasingly promising for neuromorphic computing, due to its potential in providing low latency and energy efficient large-scale parallel connectivity. Phase change materials (PCMs) have been recently employed ... ...

Abstract	The photonics platform has been considered increasingly promising for neuromorphic computing, due to its potential in providing low latency and energy efficient large-scale parallel connectivity. Phase change materials (PCMs) have been recently employed to introduce all-optical non-volatile memory in integrated photonic circuits, especially finding application as non-volatile weighting element in photonic artificial neural networks. Interestingly, these weighting elements can potentially be used as building blocks for large-scale networks that can autonomously adapt to their input, i.e. presenting the property of plasticity, similarly to the biological brain. In this work, we develop a computationally efficient dynamical model of a silicon ring resonator (RR) enhanced by a phase change material, namely Ge
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.459364
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