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  1. Article ; Online: Neurocognition as a Biomarker for Psychosis Onset: Exploring the Impact of Age.

    Carrión, Ricardo E / Cornblatt, Barbara A

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2022  Volume 7, Issue 1, Page(s) 5–6

    MeSH term(s) Biomarkers ; Humans ; Neuropsychological Tests ; Psychotic Disorders/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2021.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Peak alpha frequency and electroencephalographic microstates are correlated with aggression in schizophrenia.

    Murphy, Michael / Carrión, Ricardo E / Rubio, Jose / Malhotra, Anil K

    Journal of psychiatric research

    2024  Volume 175, Page(s) 60–67

    Abstract: Large scale retrospective studies have shown an association between schizophrenia and risk of violence. Overall, this increase in risk is small and does not justify or support stigmatizing public perceptions or media depictions of people with ... ...

    Abstract Large scale retrospective studies have shown an association between schizophrenia and risk of violence. Overall, this increase in risk is small and does not justify or support stigmatizing public perceptions or media depictions of people with schizophrenia. Nonetheless, in some situations, some symptoms of schizophrenia can increase the risk of violent behavior. Prediction of this behavior would allow high impact preventive interventions. However, to date the neurobiological correlates of violent behavior in schizophrenia are not well understood, precluding the development of prognostic biomarkers. We used electroencephalography to measure alpha activity and microstates from 31 patients with schizophrenia and 18 age matched controls. Participants also completed multiple assessments of current aggressive tendencies and their lifetime history of aggressive acts. We found that individual alpha peak frequency was negatively correlated with aggression scores in both patients and controls (largest Spearman's r = -0.45). Furthermore, this result could be replicated in data taken from a single frontal channel suggesting that this may be possible to obtain in routine clinical settings (largest Spearman's r = -0.40). We also found that transitions between microstates corresponding to auditory and visual networks were inversely correlated with aggression scores. Finally, we found that, within patients, aggression was correlated with the degree of randomness between microstate transitions. This suggests that aggression is related to inappropriate switching between large scale brain networks and subsequent failure to appropriately integrate complicated environmental and internal stimuli. By elucidating some of the electrophysiological correlates of aggression, these data facilitate the development of prognostic biomarkers.
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2024.04.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Authors' reply to comments on: Recreational cannabis use over time in individuals at clinical high risk for psychosis: Lack of associations with symptom, neurocognitive, functioning, and treatment patterns.

    Cornblatt, Barbara A / McFarlane, William R / Carrión, Ricardo E

    Psychiatry research

    2023  Volume 330, Page(s) 115594

    MeSH term(s) Humans ; Cannabis ; Psychotic Disorders/psychology ; Marijuana Abuse/complications ; Marijuana Abuse/therapy ; Marijuana Abuse/diagnosis
    Language English
    Publishing date 2023-11-05
    Publishing country Ireland
    Document type Letter
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2023.115594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Fetal brain vulnerability to SARS-CoV-2 infection.

    McMahon, Courtney L / Castro, Joshua / Silvas, Jesus / Muniz Perez, Aranis / Estrada, Manuel / Carrion, Ricardo / Hsieh, Jenny

    Brain, behavior, and immunity

    2023  Volume 112, Page(s) 188–205

    Abstract: Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has been controversial; however, recent evidence such as viral RNA detection in umbilical cord blood and amniotic fluid, as well as the discovery of additional entry ... ...

    Abstract Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has been controversial; however, recent evidence such as viral RNA detection in umbilical cord blood and amniotic fluid, as well as the discovery of additional entry receptors in fetal tissues suggests a potential for viral transmission to and infection of the fetus. Furthermore, neonates exposed to maternal COVID-19 during later development have displayed neurodevelopmental and motor skill deficiencies, suggesting the potential for consequential neurological infection or inflammation in utero. Thus, we investigated transmission potential of SARS-CoV-2 and the consequences of infection on the developing brain using human ACE2 knock-in mice. In this model, we found that viral transmission to the fetal tissues, including the brain, occurred at later developmental stages, and that infection primarily targeted male fetuses. In the brain, SARS-CoV-2 infection largely occurred within the vasculature, but also within other cells such as neurons, glia, and choroid plexus cells; however, viral replication and increased cell death were not observed in fetal tissues. Interestingly, early gross developmental differences were observed between infected and mock-infected offspring, and high levels of gliosis were seen in the infected brains 7 days post initial infection despite viral clearance at this time point. In the pregnant mice, we also observed more severe COVID-19 infections, with greater weight loss and viral dissemination to the brain, compared to non-pregnant mice. Surprisingly, we did not observe an increase in maternal inflammation or the antiviral IFN response in these infected mice, despite showing clinical signs of disease. Overall, these findings have concerning implications regarding neurodevelopment and pregnancy complications of the mother following prenatal COVID-19 exposure.
    MeSH term(s) Pregnancy ; Female ; Male ; Humans ; Animals ; Mice ; COVID-19 ; SARS-CoV-2 ; Pregnancy Complications, Infectious ; Brain ; Inflammation
    Language English
    Publishing date 2023-06-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  5. Article: Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID50 Assays

    Keiser, Patrick T / Anantpadma, Manu / Staples, Hilary / Carrion, Ricardo / Davey, Robert A

    Microorganisms. 2021 Jan. 12, v. 9, no. 1

    2021  

    Abstract: Ongoing efforts to develop effective therapies against filoviruses rely, to different extents, on quantifying the amount of viable virus in samples by plaque, TCID₅₀, and focus assays. Unfortunately, these techniques have inherent variance, and ... ...

    Abstract Ongoing efforts to develop effective therapies against filoviruses rely, to different extents, on quantifying the amount of viable virus in samples by plaque, TCID₅₀, and focus assays. Unfortunately, these techniques have inherent variance, and laboratory-specific preferences make direct comparison of data difficult. Additionally, human errors such as operator errors and subjective bias can further compound the differences in outcomes. To overcome these biases, we developed a computer-based automated image-processing method for a focus assay based on the open-source CellProfiler software platform, which enables high-throughput screening of many treatment samples at one time. We compared virus titers calculated using this platform to plaque and TCID₅₀ assays using common stocks of virus for 3 major Filovirus species, Zaire ebolavirus, Sudan ebolavirus, and Marburg marburgvirus with each assay performed by multiple operators on multiple days. We show that plaque assays give comparable findings that differ by less than 3-fold. Focus-forming unit (FFU) and TCID₅₀ assays differ by 10-fold or less from the plaque assays due a higher (FFU) and lower (TCID₅₀) sensitivity. However, reproducibility and accuracy of each assay differs significantly with Neutral Red Agarose Overlay plaque assays and TCID₅₀ with the lowest reproducibility due to subjective analysis and operator error. Both crystal violet methylcellulose overlay plaque assay and focus assays perform best for accuracy and the focus assay performs best for speed and throughput.
    Keywords Marburg marburgvirus ; Sudan Ebola virus ; Zaire Ebola virus ; accuracy ; agarose ; assays ; automation ; bias ; computer software ; gentian violet ; high-throughput screening methods ; humans ; methylcellulose ; reproducibility ; sampling ; variance ; viral load ; viruses
    Language English
    Dates of publication 2021-0112
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9010156
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Deconstructing the Psychosis Risk Syndrome: Moving the Field of Prevention Forward.

    Cornblatt, Barbara A / Carrión, Ricardo E

    JAMA psychiatry

    2016  Volume 73, Issue 2, Page(s) 105–106

    MeSH term(s) Humans ; Psychotic Disorders/classification ; Risk
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2015.2454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.235: Show issues Location:
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  7. Article: Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID

    Keiser, Patrick T / Anantpadma, Manu / Staples, Hilary / Carrion, Ricardo / Davey, Robert A

    Microorganisms

    2021  Volume 9, Issue 1

    Abstract: Ongoing efforts to develop effective therapies against filoviruses rely, to different extents, on quantifying the amount of viable virus in samples by plaque, ... ...

    Abstract Ongoing efforts to develop effective therapies against filoviruses rely, to different extents, on quantifying the amount of viable virus in samples by plaque, TCID
    Language English
    Publishing date 2021-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9010156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SARS-CoV-2 targets glial cells in human cortical organoids.

    McMahon, Courtney L / Staples, Hilary / Gazi, Michal / Carrion, Ricardo / Hsieh, Jenny

    Stem cell reports

    2021  Volume 16, Issue 5, Page(s) 1156–1164

    Abstract: Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem cell-derived ... ...

    Abstract Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem cell-derived brain organoids offer a valuable in vitro approach to study the cellular effects of SARS-CoV-2 on the brain. Here we used human embryonic stem cell-derived cortical organoids to investigate whether SARS-CoV-2 could infect brain tissue in vitro and found that cortical organoids could be infected at low viral titers and within 6 h. Importantly, we show that glial cells and cells of the choroid plexus were preferentially targeted in our model, but not neurons. Interestingly, we also found expression of angiotensin-converting enzyme 2 in SARS-CoV-2 infected cells; however, viral replication and cell death involving DNA fragmentation does not occur. We believe that our model is a tractable platform to study the cellular effects of SARS-CoV-2 infection in brain tissue.
    MeSH term(s) COVID-19/pathology ; Cells, Cultured ; Choroid Plexus/cytology ; Choroid Plexus/pathology ; Choroid Plexus/virology ; Human Embryonic Stem Cells/cytology ; Humans ; Neuroglia/pathology ; Neuroglia/virology ; Neurons/virology ; Organoids/cytology ; Organoids/innervation ; Organoids/pathology ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2021.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The immediate impact of the COVID-19 pandemic on attenuated positive symptoms and functioning in individuals at clinical high risk for psychosis: A pilot study.

    Carrión, Ricardo E / Auther, Andrea M / McLaughlin, Danielle / Cornblatt, Barbara A

    Schizophrenia research

    2021  Volume 236, Page(s) 9–11

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Pilot Projects ; Prodromal Symptoms ; Psychotic Disorders/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2021-07-14
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2021.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 543: Show issues

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  10. Article ; Online: Author Correction: Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.

    Liu, Ying / Ye, Ling / Lin, Fang / Gomaa, Yasmine / Flyer, David / Carrion, Ricardo / Patterson, Jean L / Prausnitz, Mark R / Smith, Gale / Glenn, Gregory / Wu, Hua / Compans, Richard W / Yang, Chinglai

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13705

    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-40413-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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